5-Year Study Published in Diabetologia Demonstrated Long-Term Safety of Lantus(R) Compared to NPH
... respectively, p=0.0439) and mean yearly rates of symptomatic
hypoglycemia (7.08+/-16.49 vs 5.13+/-12.79, ... similar degree in both treatment groups. Rates of symptomatic
and clinically important hypoglycaemia were ... respectively, p=0.0439) and mean yearly rates of symptomatic
hypoglycemia (7.08+/-16.49 vs 5.13+/-12.79, ...
MitraClip(R) Therapy Data Shows Important Clinical Benefit in High Risk Patients With Functional Mitral Regurgitation at 12-Month Follow Up
... EVEREST High-Risk Registry Data Shows Improved symptomatic
Status and Cardiac Function in Functional MR ... valve repair using the MitraClip(R) system in symptomatic
high-risk surgical patients with functional ... treatment options. Without MR reduction, these symptomatic
patients have a poor quality of life, are ...
Analysis of Earlier European Stroke Trial Supports Treatment Regimen for Viprinex(TM) in Current International Phase 3 Clinical Trials
... ) today announced that previously
found excess symptomatic
intracranial hemorrhage in an earlier ... outcome similar to placebo,
but a higher rate of symptomatic
intracranial hemorrhages. When the drug
safety ... treated with ancrod in ESTAT who had symptomatic
hemorrhages were more likely to have ...
Shire to add New Orphan Drug to its HGT Portfolio - EU Launch Imminent
... is a first-in-class orphan drug
developed for the symptomatic
treatment of acute attacks of ... a
high unmet medical need and treats a morbidly symptomatic
orphan designation in both Europe ... has been
granted orphan drug status for the symptomatic
treatment of acute attacks
of angioedema by the ...
Pivotal Pulmonary Arterial Hypertension Study Published in The Lancet Concludes That Bosentan (Tracleer(R)) Demonstrates Benefits in Patients With Mildly Symptomatic WHO Functional Class II Disease
... in The Lancet(1) show that, in mildly symptomatic
arterial hypertension (PAH) patients ... EARLY (Endothelin Antagonist tRial in
PAH patients) trial is the first and only ... demonstrates that without
treatment, even mildly symptomatic
patients experience PAH progression
within a ...
Tracleer(R) Shows Clinical Benefit as Combination Therapy with Sildenafil for Pulmonary Arterial Hypertension
... Monotherapy on morbidity and mortality in symptomatic
with pulmonary arterial hypertenSion) ... 3 EARLY (Endothelin
Antagonist tRial in miLdlY symptomatic
PAH patients) study showed that
Tracleer improved ... disease progression
in sildenafil-treated mildly symptomatic
PAH patients. The EARLY trial was
the first study ...
Study Shows Combination Therapy Incorporating AVODART(R) and Tamsulosin Provides Continuous Symptom Improvement Over 2 Years
... new data to guide initial therapy for
men with symptomatic
BPH," said Claus Roehrborn, M.D., Professor ... and combination
therapy in reducing the risk of symptomatic
disease progression and the
risk of urinary ... AVODART is indicated for the treatment of symptomatic
in men with an enlarged ...
CardioFocus Endoscopic Ablation System Earns CE Mark to Treat Atrial Fibrillation; US Clinical Investigation Underway
centers across the country. Patients with symptomatic
fibrillation may learn about ... face in treating patients with symptomatic
fibrillation". About Atrial ... for catheter AF
ablation is the presence of symptomatic
AF, refractory or intolerant to, at
least one ...
MitraClip(R) Therapy Data Demonstrate Clinical Benefit in High-Risk Patients With Mitral Regurgitation
... EVEREST High-Risk Registry Data Show Improved symptomatic
Status, Cardiac Function and Reduced rate of Hospitalization for ... Results show percutaneous mitral repair using the MitraClip(R) system in symptomatic
high-risk surgical patients with either functional mitral regurgitation ...
AstraZeneca Submits NDA for Low Dose Aspirin/Esomeprazole Combination Product
... daily are indicated for short-term treatment (4 to 8 weeks) in healing and symptomatic
resolution of diagnostically confirmed erosive esophagitis (EE).
... adverse events with NEXIUM include headache, diarrhea, and abdominal pain. symptomatic
response to therapy does not preclude the presence of gastric malignancy. ...
Merz Pharmaceuticals Announces Results of Three Clinical Trials With NT-201 (Botulinum Neurotoxin Type A Free From Complexing Proteins) in Movement Disorder Patients
... robust U.S. data for Xeomin (the brand name for NT-201 in Europe) for the symptomatic
management of movement disorders," said Eric Pappert, M.D., Vice President ... movement disorders, and recently approved in Canada for the indications of symptomatic
management of blepharospasm, cervical dystonia and post-stroke spasticity ...
Elusys' Anthrax Anti-Toxin, Anthim(TM), Enters Second Phase I Clinical Study
... in treated rabbits vs. 0 percent in controls) when administered to symptomatic
rabbits. These results are consistent with several previous rabbit and ... significant life-saving potential even when given in a single dose to symptomatic
animals many hours after anthrax exposure. In earlier animal studies, ...
Virtual Colonoscopies Show Value for Some Patients, But Polyps Will Be Missed
... have been detected by colonoscopy. For asymptomatic high-risk patients and symptomatic
patients, the percentage of patients correctly identified as having ... and cancers that were identified by colonoscopy and between 76% and 95% of symptomatic
patients with large polyps and cancers. No firm conclusions could be drawn ...
Intellect Neurosciences, Inc. Announces Independent Studies on Copper Binding Properties of its Lead Candidate OXIGON(TM)
... the market today that slow or arrest the progression of the disease. These symptomatic
drugs are projected to generate more than US $6 billion in sales by 2010, ... both the size of the market and the demand for effective treatment beyond symptomatic
About Intellect Neurosciences, Inc.
Beating Blood Clots after Joint Replacement
... ( http://orthoinfo.aaos.org/topic.cfm?topic=A00233 ) will end up with a symptomatic
DVT or PE, according to Dr. Friedman.
Currently, there are several ... in terms of oral agents," stated Dr. Friedman.
He feels that symptomatic
rates may be cut down even more due to more prophylaxis being oral in ...
ExonHit Therapeutics Reports Advancements in the Clinical Development of EHT 0202, its Phase II Drug for Alzheimer's Disease
... it stimulates the
alpha-secretase pathway. If the neuroprotective and symptomatic
EHT 0202 demonstrated in animal models are confirmed in humans, ... disease," stated Professor
Vellas. "Current available drugs are symptomatic
only and their clinical
efficacy is limited over time, after which the ...
ViroPharma Announces Discontinuation of Maribavir Phase 3 Study in Liver Transplant Patients
... in a 1:1 allocation ratio for up to 14 weeks. If CMV disease, defined as symptomatic
CMV infection or CMV organ disease, occurred during the study drug ...
The primary efficacy endpoint was the incidence of CMV disease (either symptomatic
CMV infection or CMV organ disease) within 6 months post transplantation, ...
Algeta Completes Comprehensive Phase II Clinical Program With Alpharadin for Treating Bone Metastases in Patients With Advanced Prostate Cancer
... efficacy of different doses of Alpharadin in HRPC patients,
and asymptomatic for bone metastases, as well as evaluating
its ability to ... began enrolling patients for the global phase III ALSYMPCA
(ALpharadin in symptomatic
Prostate CAncer) study in June 2008. Approximately
750 patients are ...
Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer
... with known toxicities of the two agents.
Additionally, the incidence of symptomatic
cardiac events was 5% in the
combination group versus 4% in the monotherapy group (>/= Grade 2 cardiac
adverse events). symptomatic
congestive heart failure was reported in 1% of
subjects in both groups. ...
Research Highlights New Approaches to Prevent Blood Clots in Several High-Risk Patient Populations Including Largest Study Ever to Examine Use of Blood-Thinning Medication in Patients With Cancer
... treatment of deep-vein thrombosis.
A total of 757 patients with symptomatic
and confirmed deep-vein thrombosis were randomized to receive weekly ... of the study was occurrence of clinically relevant bleeding, death, or symptomatic
recurrent venous thromboemolism at the end of six months of therapy.
Nuvo Research presents positive Phase III study results for Pennsaid at leading rheumatology conference
... solution is efficacious for the relief of symptoms
in patients with symptomatic
knee osteoarthritis," said Dr. Marc C.
Hochberg, Head, Division of ... Topical NSAIDs should be considered in
the management of patients with symptomatic
osteoarthritis involving joints
accessible to these agents."
What is the Optimal Method of Ischemia Evaluation in WomeN: Preliminary Data from the WOMEN Study
... imaging to determine the best
method for detecting heart disease in symptomatic
women. The study goal is
to determine the best method based upon a 2 year ... enrollment and careful
follow-up to optimize diagnostic strategies in symptomatic
women," said Dr.
Gary Heller, who will be presenting data at today's ...
Society of Interventional Radiology Applauds Report's Uterine Fibroid Embolization Recommendations
... choice. It will prompt
gynecologists to discuss all treatment options for symptomatic
fibroids--including UFE--if they are not already doing so," ... who have hysterectomies
performed annually in the United States to treat symptomatic
fibroids. Many of these women can confidently choose UFE," noted ...
n-3 PUFAs Reduce Mortality and Hospital Admissions in Patients With Symptomatic Heart Failure
... and hospital admissions for cardiovascular
reasons in patients with symptomatic
GISSI-HF was a 3.9 year prospective, multicentre, ... a huge burden on society and despite major advances in
drug therapy for symptomatic
heart failure, during the past two decades,
hospitalisations continue to ...
The New England Journal of Medicine Publishes Nexavar(R) Study Demonstrating Significant Improvement in Overall Survival in Patients With Liver Cancer
... The primary endpoints of the
study included overall survival and time to symptomatic
patients administered Nexavar versus those who received ... received placebo (HR=0.69;
p=0.0006). There was no difference in time to symptomatic
between patient groups, based on a patient-reported ...
FDA Clears ExAblate Fertility Enhancement Study in Women With Uterine Fibroids
... in October 2002
and the FDA approved the system as a treatment for symptomatic
fibroids in 2004 for patients who had finished their family ... in the uterus that affect more than
30% of women of childbearing age. symptomatic
women suffer from extensive
and prolonged menstrual bleeding, anaemia, ...
Preventing Prostate Cancer and BPH: Prostate-Health Expert Available (National Men's Health Week Is June 9-15)
... and lean protein have a significantly lower risk of developing symptomatic
benign prostatic hyperplasia, or BPH, a condition associated with ... that African-American men have a 50 percent higher risk of developing symptomatic
BPH than white men.
-- The excitement about lycopene (the ...
AstraZeneca Submits sNDAs for SEROQUEL XR(TM) for the Treatment of Bipolar Mania and Bipolar Depression
... HS, Schettler PJ, et al. The Long-term Natural History of the Weekly symptomatic
Status of Bipolar I Disorder. Arch Gen Psychiatry. 2002; 59:530-537.
8. ... Prospective Investigation of the Natural History of the Long-term Weekly symptomatic
Status of Bipolar II Disorder. Arch Gen Psychiatry. 2003; 60:26 -269.
NicOx Announces TOPIGEN Initiates Phase 2 Proof of Concept Study in COPD for TPI 1020
... disease. Although current treatments improve quality of
life and provide symptomatic
relief in some patients, there are no drugs
available that can slow the ... disease. Although current treatments improve quality of
life and provide symptomatic
relief in some patients, there are no drugs
available that can slow the ...
Intellect Neurosciences, Inc. to Present Data on Alzheimer's Vaccine at 13th International Congress of Immunology Conference
... the market today that slow or arrest the progression of the
disease. These symptomatic
drugs are projected to generate approximately $4
billion in sales by 2008, ... both the size of the market and the
demand for effective treatment beyond symptomatic
improvements. About Intellect Neurosciences, Inc. Intellect ...
Video: FDA Approves INVEGA(R) SUSTENNA(TM) for the Acute and Maintenance Treatment of Schizophrenia
... met its primary endpoint of significantly improving PANSS scores relative to placebo.
The efficacy of INVEGA(R) SUSTENNA(TM) in maintaining symptomatic
control in schizophrenia was evaluated in a multicenter, randomized, double-blind, placebo-controlled, parallel-group study (n=410). Time-to-first ...
Study Results Show That Minimally Invasive Therapy is Successful for Over Two-Thirds of Stroke Patients Treated Outside the Standard Eight-Hour Window
... patients could be functionally independent) and 123 (62 percent) patients reflected acceptable outcomes. Approximately nine percent suffered a symptomatic
brain hemorrhage and the overall mortality rate was 22 percent. When analyzing what factors were most closely associated with favorable outcomes, ...
Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA
... is designed as a four-week, randomized, double-blind, placebo-controlled trial that will include up to 28 patients with carcinoid syndrome who are symptomatic
despite treatment with currently available therapy. Up to four dose levels may be evaluated in a serial ascending fashion. Once an optimal or ...
MJFF's Rapid Response Innovation Awards Hit Mid-2009 With Over $1 Million Funded in High-Risk/High-Reward Approaches to Parkinson's Disease
... PD and certain strains of influenza virus; and a proof-of-principle approach to refine deep brain stimulation (DBS) into a potentially more effective symptomatic
Rapid Response , one of the Foundation's Edmond J. Safra Core Programs for PD Research, earmarks up to $2 million annually to support ...
MADIT-CRT Trial Meets Primary Endpoint
... Landmark trial shows Boston Scientific CRT-Ds slow the progression of heart failure in asymptomatic and mildly symptomatic
NATICK, Mass., June 23 /PRNewswire-FirstCall/ -- Boston Scientific Corporation (NYSE: BSX ) and the University of Rochester Medical ...
Published Study Shows VNUS ClosureFAST(TM) System Significantly Superior to Laser for Varicose Vein Treatment
... for radiofrequency (RF) thermal ablation to be "significantly superior" to endovenous laser (EVL) for treating venous reflux, the underlying cause of symptomatic
varicose veins .
The VNUS ClosureFAST catheter is a minimally invasive device generally used in the physician's office with a local ...
Two New Clinical Studies Show That Limited Exposure to Blood Transfusion Significantly Increases Morbidity and Mortality After Surgery
... indicators" for transfusions.
Blood transfusions may be necessary to ensure survival when a patient is bleeding heavily or has severe symptomatic
anemia. However, transfusions are also given in the presence of stable anemia or when significant blood loss is expected but does not occur. These ...
New Heart Ultrasound Research Reveals Life-Saving Treatment Alternatives and Advancements for Heart Patients
... replacement result in comparable improvements in radial strain, strain rate and left ventricular ejection fraction in elderly patients with severe symptomatic
LACK OF ADHERENCE TO GUIDELINES FOR SEVERE AORTIC STENOSIS LEAVE SYMPTOMS UNIDENTIFIED AND PATIENTS WITH LIFE-THREATENING ...
Merz Pharmaceuticals Announces Results of Clinical Trials with NT-201(Botulinum neurotoxin type A free from complexing proteins) at Annual Movement Disorders Society Meeting
... has been approved for marketing in Europe since 2007 to treat various movement disorders, and more recently approved in Canada for the indications of symptomatic
management of blepharospasm, cervical dystonia and post-stroke spasticity of the upper limb. "Studies in Europe have shown non-inferiority of NT-201 ...
New Study Showed Lantus(R) Plus One, Two or Three Shots of Apidra(R) Lowered Patients' Blood Sugar
... experienced serious and severe hypoglycemia with Apidra(R) 3 times daily compared with those receiving Apidra(R) once or twice daily. The rates of symptomatic
or severe hypoglycemia were not statistically significant between groups.
"By combining basal insulin Lantus(R) plus Apidra(R) mealtime insulin ...