Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)
... with denosumab treatment was not statistically
superior compared to Zometa (adjusted p=0.06) (secondary ... also numerically greater but not statistically
superior compared to Zometa (hazard ratio 0.90, 95 percent ... endpoints were to evaluate if denosumab is
superior to Zometa with respect to the first on-study SRE, ...
Denosumab Demonstrates Superiority Over Zometa(R) in Pivotal Phase 3 Head-to-Head Trial in Breast Cancer Patients With Bone Metastases
... primary and secondary endpoints and demonstrated
superior efficacy compared to Zometa. Superiority was ... endpoints were to evaluate if denosumab was
superior to Zometa with respect to the first on-study SRE, ... have lower prices, established reimbursement,
superior performance, are easier to administer, or that ...
Published Study Shows VNUS ClosureFAST(TM) System Significantly Superior to Laser for Varicose Vein Treatment
... radiofrequency catheter was statistically
superior to laser treatment in providing a fast and ... and quality-of-life parameters were
superior in the ClosureFAST group, and minor complications ... as performed with the ClosureFAST catheter,
superior to EVL as measured by a comprehensive array of ...
Access Pharmaceuticals Announces Publication of Thiarabine Combination Data
... models. "In all cases, thiarabine demonstrated
superior tumor growth inhibition than clofarabine when the ... of these two agents, efficacy was dramatically
superior to the use of either agent alone. Tumor ... combinations have significantly
superior efficacy to cytarabine/clofarabine combinations ...
FDA Approves Vanda Pharmaceuticals' Fanapt(TM) for the Treatment of Schizophrenia
... for schizophrenia, and Fanapt(TM) was shown to be
superior to placebo in controlling symptoms of ... (Geodon(R)), the 24 mg/day Fanapt(TM) dose was
superior to placebo in the Positive and Negative Syndrome ... (Risperdal(R)), both doses of Fanapt(TM) were
superior to placebo on the Brief Psychiatric Rating Scale ...
Pharmasset Announces Clevudine and R7128 Presentations at HEP-DART
... .
Clevudine was
superior to Lamivudine in the Patients with ... 48-weeks of dosing with clevudine 30mg showed
superior viral
suppression to lamivudine 100mg without the ... at Day 15.
Twice-daily (BID) administration was
superior to once-daily (QD)
administration for antiviral ...
Takeda Provides Update on the Investigational Fixed-Dose Combination of alogliptin and ACTOS(R) (pioglitazone HCl)
... better health for individuals and progress in medicine by developing
superior pharmaceutical products. Additional information about Takeda is available ... better health for individuals and progress in medicine by developing
superior pharmaceutical products. To learn more about these Takeda companies, visit ...
Ferring Pharmaceuticals Unveils Six-Month Efficacy Data for EUFLEXXA(R) for the Treatment of Osteoarthritis Knee Pain
... Results Show
superior Decrease in Pain Scores Compared to Saline
PARSIPPANY, N.J., May 13 ... osteoarthritis (OA) at 26 weeks. The study showed that EUFLEXXA (R) is
superior to saline in decreasing pain at 26 weeks in patients with OA of the ...
ISTA Pharmaceuticals Highlights Bepreve(TM) Clinical Data at the Association for Research in Vision and Ophthalmology (ARVO) 2009 Annual Meeting
... in the CAC model for at least 8 hours after dosing and statistically
superior to placebo in reducing ocular itching at CAC tests conducted 15 minutes, 8 ... spaced two weeks apart. The results showed Bepreve 1.5% was statistically
superior to placebo for at least 8 hours after ophthalmic dosing for reducing ...
MedNet Solutions to Share Industry Expertise at the 13th Annual EDC & Beyond Conference in Orlando, FL
... traditional monitoring inefficiencies can be dramatically reduced through
superior data visibility, workflow enhancements and productivity tools. Mr. Friend ... spanning 6 continents and more than 40 countries. MedNet delivers a
superior customer experience from beginning to end. For more information, please ...
Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting
...
In the primary analysis, PEGINTRON maintenance therapy was not
superior to observational control in preventing the occurrence of clinical events. ... virologic response (SVR)(3) with 72-week treatment was not statistically
superior to the 48-week treatment in slow responders (47.9 percent (35/73) vs. 43.0 ...
Acanya(TM) Gel, a New Treatment for Moderate to Severe Acne, Launched by Coria Laboratories
... of acne.
In pivotal Phase III clinical trials, Acanya Gel showed
superior efficacy to the vehicle gel and either individual active ingredient, while ... product. In pivotal Phase III clinical trials, Acanya Gel showed
superior efficacy to the vehicle gel and either individual active ingredient, while ...
Independent Data Monitoring Committee Recommends Resuming Enrollment of Non-Squamous NSCLC Patients in the Motesanib MONET1 Trial
... better health for individuals and progress in medicine by developing
superior pharmaceutical products. Additional information about Takeda is available ... against products that have lower prices, established reimbursement,
superior performance, are easier to administer, or that are otherwise competitive ...
Longevity Seekers Advised to Consume Modest Doses of Red Wine Molecules in Dietary Supplements (Longevinex(R)) Rather than Mega-Dose Resveratrol Alone
... dose resveratrol accompanied by an array of other small molecules
may be
superior to resveratrol alone. According to a mouse study conducted ... Researchers at
Appalachian State University found Longevinex(R) had
superior antioxidant and
anti-inflammatory action among endurance athletes compared ...
Arthritis Advisory Committee Recommends FDA Approval of Febuxostat for the Treatment of Hyperuricemia in Patients With Gout
... better health for individuals and progress in medicine by developing
superior pharmaceutical products. Additional information about Takeda is available ... better health for individuals and progress in medicine by developing
superior pharmaceutical products. To learn more about these Takeda companies, visit ...
Bionovo's VG101 Shows Greater Efficacy Than Estrogen in the Treatment of Vaginal Dryness
... include direct comparisons to existing estrogen
therapies, showing VG101's
superior efficacy at a cellular level.
"Vaginal dryness is a very painful, day to ... given the data we have developed
on this drug candidate, VG101 could be a
superior treatment for the
millions of women who want to improve both their quality ...
Addrenex Pharmaceuticals Announces Positive Phase III Clinical Results for Clonicel to Treat ADHD
... by next year."
The study showed that Clonicel was statistically
superior to placebo on
the primary endpoint, the ADHD Rating Scale of 18 symptoms. Clonicel was
also statistically
superior to placebo on several secondary scales
completed by clinicians and ...
Sanofi Aventis: People With Type 2 Diabetes Treated With LANTUS(R) and APIDRA(R) Achieved Greater Reductions in A1C Than Those Treated With Pre-mixed Insulin
... GINGER (a clinical trial) and LACE (real life patient data)
confirmed the
superior efficacy of LANTUS(R)/APIDRA(R) basal-bolus therapy
when compared to ... intensified insulin therapy with LANTUS(R) and APIDRA(R)
results in
superior glycemic control. The number of patients who reached
A1C <7.0% at endpoint ...
Data Suggest CEL-SCI's CEL-2000 Vaccine Prevents or Retards Permanent Damage of Rheumatoid Arthritis
... conducted in mice
treated similarly, CEL-2000 was equivalent or possibly
superior to Enbrel
in slowing disease progression and lessening symptoms. The new ... arthritis damage in humans.
CEL-2000 was as good as, and possibly
superior to, Enbrel in slowing
further disease progression as evaluated by these ...
New Subset Analysis of AndroGel(R) Data Highlights Efficacy - Regardless of BMI
... AndroGel was effective in
restoring testosterone levels and in some cases,
superior to a transdermal
testosterone patch. In 2004, an additional follow-up, ... effective in restoring
testosterone levels to normal and in some cases,
superior to a transdermal
testosterone patch.
-- AndroGel was effective in ...
Overview of Asenapine Data from Olympia Trial Program Presented at American Psychiatric Association Annual Meeting
... versus placebo;
olanzapine was also demonstrated to be statistically
superior to placebo;
there was no direct comparison between asenapine and ... and Negative Syndrome Scale (PANSS) total
score and was significantly
superior to placebo. PANSS total score is a
measure of positive symptoms (e.g., ...
Additive Anti-Tumor Activity of NKTR-102 in Combination With Bevacizumab Highlighted in Positive Preclinical Data Presented at AACR Meeting
... was well-tolerated, with minimal weight loss.
NKTR-102 also exhibited
superior pharmacokinetics in a repeated dose
study in dogs, with a 6-fold increase ... dosing in dogs"
#5742: "NKTR-102, a novel PEGylated-irinotecan, has a
superior acute safety, tolerability, and pharmacokinetic profile compared to ...
FDA Accepts Investigational New Drug Application for ARI-2243 and a First in Man Clinical Trial Set to Begin During the First Half of 2008
... volunteers. ARI-2243 is a
highly potent DPP-4 inhibitor, possessing
superior preclinical efficacy and
a high therapeutic index established in ... efficacy of ARI-2243, the company believes that
low doses will produce
superior blood glucose lowering compared with other
DPP-4 inhibitors.
Arisaph ...
Alexza's AZ-104 (Staccato(R) Loxapine) Phase 2a Trial Meets Primary Endpoint of 2-Hour Pain Relief in Patients with Migraine Headache
... for pain relief
response, all three dose groups were statistically
superior (p < 0.05) to
placebo during the 4-hour post-treatment time period that ... analysis for pain free response, all three dose groups were
statistically
superior (p < 0.05) to placebo during the 4-hour
post-treatment time period that ...
Study Data Shows VNUS ClosureFAST(TM) Catheter More than 96% Effective
... ratio of efficacy to side effects of the VNUS
ClosureFAST catheter to be
superior to any previous endovenous ablation
device," said Dr. Proebstle. "In 223 ... it clear that radiofrequency vein
ablation with the ClosureFAST device is
superior to laser ablation in terms
of patient comfort and satisfaction," said Dr. ...
IDM Pharma Announces Phase 3 Mifamurtide (L-MTP-PE) Study Demonstrating Improved Survival Published in the Journal of Clinical Oncology
... of L-MTP-PE to chemotherapy
following surgery resulted in statistically
superior Overall Survival (OS)
the first stated aim of the study.
In the past two ... Survival (EFS) additional analysis.
"These findings of statistically
superior overall survival in long-term
patient follow-up validate the survival ...
IDM Pharma Announces Updated Phase 3 Mifamurtide (L-MTP-PE) Data Confirms Statistically Superior Overall Survival in Osteosarcoma Patients
... that typically affects children and young
adults, achieved statistically
superior Overall Survival (OS) rates. "The statistically significant survival ... Phase 3 clinical trial data was further
strengthened by the statistically
superior findings in long-term patient
follow-up," said Timothy P. Walbert, ...
New Study of Concerta(R) Showed Significant Improvement of ADHD Symptom Management in Adults Compared to Placebo
... total score. The
results showed that CONCERTA(R) achieved a significantly
superior reduction
in AISRS total score compared to placebo (p=0.012) (mean change ... +/-1.06 for the placebo group. In addition, CONCERTA(R) was significantly
superior compared to placebo
for the key secondary efficacy variables: change in ...
Abbott's XIENCE(TM) V Everolimus Eluting Coronary Stent Shows Continued Superiority to TAXUS Stent in Reducing Major Adverse Cardiac Events in SPIRIT III Clinical Trial
... at one year. These MACE results are consistent with the clinically
superior 44 percent reduction in MACE observed for XIENCE V at nine months. ... XIENCE V continues to demonstrate longer-term safety
and consistently
superior efficacy results across the SPIRIT trials with
the potential to raise the ...
Dynavax's HEPLISAV(TM) Hepatitis B Vaccine Maintains Full Immunogenicity at 50 Weeks in Phase 3 Trial
... In Difficult-to-Immunize Population, Demonstrates
superior Long-Term Seroprotection Compared to Conventional Vaccine
... These data confirm earlier clinical studies showing that HEPLISAV
has
superior immunogenicity and comparable tolerability to Engerix-B. The
overall ...
Genta Initiates Phase 3 AGENDA Trial of Genasense(R) for Patients with Advanced Melanoma
... that trial suggested that patients in this
group achieved a significantly
superior outcome (see table below). "Genasense plus dacarbazine yielded
superior results in a large
randomized trial," said Dr. Agop Bedikian, Professor of ...
Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer
... competition when and as they are approved and marketed. Our products may compete against products that have lower prices, established reimbursement,
superior performance, are easier to administer, or that are otherwise competitive with our products. In addition, while we routinely obtain patents for our ...
Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis
... anabolic treatment for osteoporosis," said C. Richard Lyttle, PhD, President and CEO of Radius. "We are especially encouraged by BA058's
superior efficacy in building new bone rapidly, particularly at the femoral neck, since hip fractures are one of the most serious complications of ...
Video: FDA Approves INVEGA(R) SUSTENNA(TM) for the Acute and Maintenance Treatment of Schizophrenia
... acute symptom control studies and a longer-term maintenance study that compared INVEGA(R) SUSTENNA(TM) to placebo. INVEGA(R) SUSTENNA(TM) was
superior to placebo in improving positive and negative syndrome scale (PANSS) total scores in the acute treatment trials and significantly delayed time to ...
Covance Receives Highest Level of Phase I Accreditation
... said Rob Aspbury, M.D., managing director, clinical research services, Covance. "As an industry leader in clinical pharmacology, Covance provides
superior experience and expertise in study design and conduct to support today's increasingly complex first-in-human trials."
MHRA accreditation was ...
Study Shows Cancer Vaccines Led to Long-Term Survival for Patients with Metastatic Melanoma and to Long Periods of Disease Control After Completion of Therapy
... rate is 54% at a median follow up of 4.5 years (range 2.4 to 7.4) for the 30 surviving patients. Although not a direct comparison, the results are
superior to those observed following vaccination with irradiated tumor cells in 48 melanoma patients in a previous trial (64 vs. 31 months, p=.016). Eight ...
Neurointerventionists Expand Research to Quality of Life in Aneurysm Patients Following Minimally Invasive Coiling Treatment
... Trial (ISAT) - which ultimately was halted due to overwhelming evidence that minimally invasive coiling (an endovascular therapy) was, on average,
superior to traditional surgical clipping in the treatment of brain aneurysms - many studies have continued to prove the short- and long-term viability of ...
Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology
... approximately 90 percent of the rat's 25,000-30,000 estimated genes are analogous to those in humans and mice, and their larger size makes them a
superior model for drug-evaluation studies using serial sampling. Generating rats with knockout mutations has been a major challenge, but the new technique ...
Exenatide Once Weekly Provided Superior Glucose Control Compared to Lantus(R) in Head-to-Head DURATION-3 Study
... to either exenatide once weekly or Lantus((R)) (insulin glargine). Patients randomized to exenatide once weekly experienced a statistically
superior reduction in A1C, a measure of average blood sugar over three months, of 1.5 percentage points from baseline, compared to a reduction of 1.3 ...
Human Genome Sciences and GlaxoSmithKline Announce Positive Phase 3 Study Results for BENLYSTA(TM) in Systemic Lupus Erythematosus
... Vice President, Research and Development, HGS. "We are delighted to report that the efficacy of treatment with BENLYSTA plus standard of care was
superior in this study to that of placebo plus standard of care, while the safety profile was comparable overall to placebo. BENLYSTA met the primary ...