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Substitution in Medical Technology

Spherix Announces Positive Phase 2 Study Results

... in nature. Prior Studies with Naturlose A recent controlled animal study demonstrated that, in comparison to sucrose, equivalent substitution of Naturlose as dietary carbohydrate results in less obesity, hyperglycemia, hyperlipidemia, and atherosclerosis (Police SB, Harris JC, Lodder RA, ...

Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer

... * Severe myelosuppression may occur * DOXIL dosage should be reduced in patients with impaired hepatic function * Accidental substitution has resulted in severe side effects. Do not substitute for doxorubicin HCl on a mg per mg basis Contraindications * Patients with a ...

Comprehensive Safety Tests Published on Ruyan(R) Smoking Alternatives

... These products, varieties of replacement cartridges and their accessories are designed, manufactured and sold for the cigarette alternative/smoking substitution market. They allow smokers to satisfy their tobacco cravings in places and situations where they otherwise cannot smoke by law, regulation or common ...

Thrombosis Guidelines Emphasize Difficult Choices for Pregnant Women

... options for doing this: (1) continuing VKA but performing frequent pregnancy tests to determine when pregnancy has been achieved, followed by the substitution of LMWH or UFH as therapy; or (2) substituting VKAs with LMWH or UFH prior to conception. Although the second option eliminates the potential for ...

Two DOXIL(R) Studies to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... -- Severe myelosuppression may occur -- DOXIL dosage should be reduced in patients with impaired hepatic function -- Accidental substitution has resulted in severe side effects. Do not substitute for doxorubicin HCl on a mg per mg basis Contraindications -- Patients with a ...

BioMarin Initiates Phase 1 Clinical Study of PEG-PAL in PKU

... Phe concentrations in subjects with PKU. About PEG-PAL PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) is an investigational enzyme substitution therapy for the treatment of PKU. Pharmacology studies conducted in the PKU mouse model demonstrated that weekly subcutaneous administrations of ...

Ambrx Enters FGF-21 Type 2 Diabetes Drug Discovery Collaboration with Merck and Co. Inc.

... commercial proteins by improving their efficacy, safety and ease of use. Ambrx's core ReCODE(TM) technology enables the precise, site-specific substitution of a novel amino acid within a protein. This allows the conjugation of proteins with additional molecules that can serve to modulate their ...

Pixantrone Versus Doxorubicin in CHOP-R Therapy for First-line Treatment of Aggressive Non-Hodgkin's Lymphoma Preliminary Results Presented at American Society of Hematology (ASH) Annual Meeting

... to Improve Safety in NHL Disease) trial is a randomized controlled phase II/III combination study in up to 280 patients investigating whether the substitution of pixantrone for doxorubicin in the first-line treatment of patients with advanced aggressive NHL can provide a comparable major response rate ...

Twelve DOXIL(R) Clinical Studies to be Presented at American Society of Hematology Annual Meeting

... reactions -- Severe myelosuppression may occur -- DOXIL dosage should be reduced in patients with impaired hepatic function -- Accidental substitution has resulted in severe side effects. Do not substitute for doxorubicin HCl on a mg per mg basis Contraindications -- Patients with a history ...

Dr. Roger Kenneth Hershline PhD MD, CEO of Global Humanceuticals, Inc. Donates New HIV Drug

... backbone, obtained from an abundant natural source. The backbone is chemically bi-substituted in a random fashion, by a new reaction. "The substitution groups are different sulfur based viral de-activating groups that work together to provide viral entry inhibition at concentrations of one ....

Auxilium Announces New Data That Show Total Testosterone Blood Levels Increase Significantly Following Switch from AndroGel(R) to Testim(R)

... reviewed to identify patients who could be evaluated for the efficacy of substitution to the alternate brand of therapy due to an initial suboptimal biochemical ... symptoms improved in 76 percent of men who underwent a brand substitution following an initial inadequate response. About Hypogonadism Low ...

Evotec Reports Positive Proof-of-Concept Top-Line Results with Insomnia Drug Candidate EVT 201

... and produced only a small decremental effect on the digital symbol substitution test (DSST) assessed at nine hours post dosing. Initial analysis showed ... quality and quantity. Residual sedation was assessed by the Digit Symbol substitution Test (DSST) and a categorical patient rating. Safety measures included ...

NovaDel Announces Positive Data from Two Studies Comparing Zolpidem Oral Spray to Ambien Tablets

... Patients in both zolpidem oral spray studies performed the digital symbol substitution test (DSST). According to Dr. Tom Roth, Director of Sleep Medicine at ... Researchers administered to all participants the Digit Symbol substitution Test (DSST), a measurement of cognitive and motor functions indicative of ...

InterMune Presents Research on ITMN-191 in Hepatitis C at EASL Annual Meeting

... The NS3 sequence was found to undergo dynamic changes when exposed to increasing concentrations of ITMN-191. As was seen in previous work, substitution at position 168 of NS3 appears to be fundamental to resistance but alone is not sufficient for HCV replicon persistence at all ITMN-191 ...

Evotec AG (DE) - Evotec Reports Positive Proof-of-Concept Top-Line Results with ...

... completely without effect on subjectively assessed residual sedation the next day and produced only a small decremental effect on the digital symbol substitution test (DSST) assessed at nine hours post dosing. Initial analysis showed that EVT 201 did not impair slow wave sleep unlike many benzodiazepine full ...

Caelyx Delays Time to Disease Progression as Maintenance Therapy in Patients with Metastatic Breast Cancer

... be available for immediate use. Severe myelosuppression may occur. Dosage should be reduced in patients with impaired hepatic function. Accidental substitution of DOXIL for doxorubicin HCl has resulted in severe side effects. DO NOT SUBSTITUTE. Use of DOXIL should be limited to physicians experienced in the ...

IMPAX Presents at Movement Disorder Society's 11th International Congress of Parkinson's Disease and Movement Disorders

... daily based on objectively observed assessments. Home-based video provided an objective means to assess motor fluctuations. In this population, substitution with IPX054 maintains CD/LD efficacy and provides ease of administration which may offer improved treatment compliance. About The Movement Disorder ...

Neurogen Proprietary Insomnia Compound Data for Two Studies Presented at Associated Professional Sleep Societies Annual Meeting

... and multiple measures of PD including a visual analog scale of sedation (VAS), posturography (a method of quantifying balance), digit symbol substitution test (DSST), electroencephalogram beta frequency band (EBFB), and psychomotor vigilance testing (PVT). In the primary analysis, NG2-73 had a ...

Neurogen Announces Positive Results for Proprietary Insomnia Drug in Two Chronic Insomnia Clinical Trials

... side-effects. These measures included LPS, WASO, Total Sleep Time (TST), Sleep Efficiency (SE), Wake Time During Sleep (WTDS), Digit Symbol substitution Test (DSST) and Visual Analog Scales (VAS) on sedation. With regard to secondary endpoints, data from Study 202 - the sleep maintenance study -- were ...
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(Date:2/13/2015)... , Feb. 13, 2015 ACT ... company that aims to transform cancer genomic information ... that the company has raised US$ 8 million in ... Based in Taipei, Taiwan , ... ACTDrug™, ACTOnco™. With the aim to implement next ...
(Date:2/9/2015)... RICHARDSON, Texas , Feb. 9, 2015  Lintec ... novel fabrication methods for carbon nanotube (CNT) macrostructures, including ... Texas at Dallas (UTD). Leveraging the vast ... Tokyo, Japan , Lintec of America ... Richardson, TX , focusing on scaling ...
(Date:2/5/2015)... 2015   Marvin Test Solutions , ... test solutions for military, aerospace, and manufacturing ... TS-323 GENASYS Test Platform to ... is a high-performance PXI-based system designed to ... require performance functional testing. GENASYS features a ...
Breaking Biology News(10 mins):ACT Genomics Raises $8 Million in its First Private Funding Round 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 4
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(Date:3/2/2015)... 2015 Over the last five years ... vendors seeking to expand their geographic presence and achieve ... to reach $6.2 billion by 2019 at CAGR of ... the U.S. and Canada and a major part of ... regions such as Asia-Pacific including China and India, Latin ...
(Date:3/2/2015)... PORTLAND, Oregon (PRWEB) March 02, 2015 ... world’s largest online healthcare certification programs, including ... compliance, and dietary supplement safety and classification, ... sellers of prescription eyeglasses. The new program, ... eyeglasses prescription verification, transparency regarding the identity ...
(Date:3/2/2015)... Prairie, WI (PRWEB) March 02, 2015 ... sciences consultancy focused on quality, regulatory and technical ... role as Chief Operating Officer. , Before ... of experience leading R&D teams in all aspects ... held leadership positions at Covidien (Medtronic), Regulatory Compliance ...
(Date:3/2/2015)... The Alliance for Bangladesh Worker Safety today ... to serve as chief safety officer. In this role, ... Bangladesh and guide remediation efforts in all factories from ... that the Alliance continues to bring world-class expertise to ... workers,” said Alliance Independent Chair Ellen Tauscher. “His role ...
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