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Substitution in Medical Technology

Spherix Announces Positive Phase 2 Study Results

... in nature. Prior Studies with Naturlose A recent controlled animal study demonstrated that, in comparison to sucrose, equivalent substitution of Naturlose as dietary carbohydrate results in less obesity, hyperglycemia, hyperlipidemia, and atherosclerosis (Police SB, Harris JC, Lodder RA, ...

Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer

... * Severe myelosuppression may occur * DOXIL dosage should be reduced in patients with impaired hepatic function * Accidental substitution has resulted in severe side effects. Do not substitute for doxorubicin HCl on a mg per mg basis Contraindications * Patients with a ...

Comprehensive Safety Tests Published on Ruyan(R) Smoking Alternatives

... These products, varieties of replacement cartridges and their accessories are designed, manufactured and sold for the cigarette alternative/smoking substitution market. They allow smokers to satisfy their tobacco cravings in places and situations where they otherwise cannot smoke by law, regulation or common ...

Thrombosis Guidelines Emphasize Difficult Choices for Pregnant Women

... options for doing this: (1) continuing VKA but performing frequent pregnancy tests to determine when pregnancy has been achieved, followed by the substitution of LMWH or UFH as therapy; or (2) substituting VKAs with LMWH or UFH prior to conception. Although the second option eliminates the potential for ...

Two DOXIL(R) Studies to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... -- Severe myelosuppression may occur -- DOXIL dosage should be reduced in patients with impaired hepatic function -- Accidental substitution has resulted in severe side effects. Do not substitute for doxorubicin HCl on a mg per mg basis Contraindications -- Patients with a ...

BioMarin Initiates Phase 1 Clinical Study of PEG-PAL in PKU

... Phe concentrations in subjects with PKU. About PEG-PAL PEG-PAL (PEGylated recombinant phenylalanine ammonia lyase) is an investigational enzyme substitution therapy for the treatment of PKU. Pharmacology studies conducted in the PKU mouse model demonstrated that weekly subcutaneous administrations of ...

Ambrx Enters FGF-21 Type 2 Diabetes Drug Discovery Collaboration with Merck and Co. Inc.

... commercial proteins by improving their efficacy, safety and ease of use. Ambrx's core ReCODE(TM) technology enables the precise, site-specific substitution of a novel amino acid within a protein. This allows the conjugation of proteins with additional molecules that can serve to modulate their ...

Pixantrone Versus Doxorubicin in CHOP-R Therapy for First-line Treatment of Aggressive Non-Hodgkin's Lymphoma Preliminary Results Presented at American Society of Hematology (ASH) Annual Meeting

... to Improve Safety in NHL Disease) trial is a randomized controlled phase II/III combination study in up to 280 patients investigating whether the substitution of pixantrone for doxorubicin in the first-line treatment of patients with advanced aggressive NHL can provide a comparable major response rate ...

Twelve DOXIL(R) Clinical Studies to be Presented at American Society of Hematology Annual Meeting

... reactions -- Severe myelosuppression may occur -- DOXIL dosage should be reduced in patients with impaired hepatic function -- Accidental substitution has resulted in severe side effects. Do not substitute for doxorubicin HCl on a mg per mg basis Contraindications -- Patients with a history ...

Dr. Roger Kenneth Hershline PhD MD, CEO of Global Humanceuticals, Inc. Donates New HIV Drug

... backbone, obtained from an abundant natural source. The backbone is chemically bi-substituted in a random fashion, by a new reaction. "The substitution groups are different sulfur based viral de-activating groups that work together to provide viral entry inhibition at concentrations of one ....

Auxilium Announces New Data That Show Total Testosterone Blood Levels Increase Significantly Following Switch from AndroGel(R) to Testim(R)

... reviewed to identify patients who could be evaluated for the efficacy of substitution to the alternate brand of therapy due to an initial suboptimal biochemical ... symptoms improved in 76 percent of men who underwent a brand substitution following an initial inadequate response. About Hypogonadism Low ...

Evotec Reports Positive Proof-of-Concept Top-Line Results with Insomnia Drug Candidate EVT 201

... and produced only a small decremental effect on the digital symbol substitution test (DSST) assessed at nine hours post dosing. Initial analysis showed ... quality and quantity. Residual sedation was assessed by the Digit Symbol substitution Test (DSST) and a categorical patient rating. Safety measures included ...

NovaDel Announces Positive Data from Two Studies Comparing Zolpidem Oral Spray to Ambien Tablets

... Patients in both zolpidem oral spray studies performed the digital symbol substitution test (DSST). According to Dr. Tom Roth, Director of Sleep Medicine at ... Researchers administered to all participants the Digit Symbol substitution Test (DSST), a measurement of cognitive and motor functions indicative of ...

InterMune Presents Research on ITMN-191 in Hepatitis C at EASL Annual Meeting

... The NS3 sequence was found to undergo dynamic changes when exposed to increasing concentrations of ITMN-191. As was seen in previous work, substitution at position 168 of NS3 appears to be fundamental to resistance but alone is not sufficient for HCV replicon persistence at all ITMN-191 ...

Evotec AG (DE) - Evotec Reports Positive Proof-of-Concept Top-Line Results with ...

... completely without effect on subjectively assessed residual sedation the next day and produced only a small decremental effect on the digital symbol substitution test (DSST) assessed at nine hours post dosing. Initial analysis showed that EVT 201 did not impair slow wave sleep unlike many benzodiazepine full ...

Caelyx Delays Time to Disease Progression as Maintenance Therapy in Patients with Metastatic Breast Cancer

... be available for immediate use. Severe myelosuppression may occur. Dosage should be reduced in patients with impaired hepatic function. Accidental substitution of DOXIL for doxorubicin HCl has resulted in severe side effects. DO NOT SUBSTITUTE. Use of DOXIL should be limited to physicians experienced in the ...

IMPAX Presents at Movement Disorder Society's 11th International Congress of Parkinson's Disease and Movement Disorders

... daily based on objectively observed assessments. Home-based video provided an objective means to assess motor fluctuations. In this population, substitution with IPX054 maintains CD/LD efficacy and provides ease of administration which may offer improved treatment compliance. About The Movement Disorder ...

Neurogen Proprietary Insomnia Compound Data for Two Studies Presented at Associated Professional Sleep Societies Annual Meeting

... and multiple measures of PD including a visual analog scale of sedation (VAS), posturography (a method of quantifying balance), digit symbol substitution test (DSST), electroencephalogram beta frequency band (EBFB), and psychomotor vigilance testing (PVT). In the primary analysis, NG2-73 had a ...

Neurogen Announces Positive Results for Proprietary Insomnia Drug in Two Chronic Insomnia Clinical Trials

... side-effects. These measures included LPS, WASO, Total Sleep Time (TST), Sleep Efficiency (SE), Wake Time During Sleep (WTDS), Digit Symbol substitution Test (DSST) and Visual Analog Scales (VAS) on sedation. With regard to secondary endpoints, data from Study 202 - the sleep maintenance study -- were ...
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(Date:7/11/2014)... of kidney injury related to the use of hydroxyethyl ... HES molecules, according to a report in Anesthesia ... Research Society (IARS). , The "total mass of HES ... human renal proximal tubule cells (PTCs), concludes the laboratory ... Hospital Wrzburg, Austria. Other factorssuch as differences in ...
(Date:7/11/2014)... normal circumstances, astrocytes participate in normal physiological ... exhibit therapeutic and repairing effects on brain ... found that nerve cells differentiated from adipose-derived ... viability, which produces influences on subsequent studies ... Hospital, Hebei United University, China demonstrated that ...
(Date:7/11/2014)... to study the proteins that let nerve cells send ... stumbled upon a biological tactic that may offer a ... a safe and environmentally responsible way. , Their ... one species and harmless for a closely related onesuggests ... without harming beneficial species like bees. A summary of ...
Breaking Biology News(10 mins):In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3
(Date:7/13/2014)... By Serena Gordon ... -- A new type of sensor for people with ... body using saliva instead of blood, researchers report. Scientists ... successfully tested it using artificial saliva. It uses light, metal ... blood sugar. "Everybody knows that diabetics have to prick ...
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(Date:7/13/2014)... A noninvasive optical imaging device developed at Cedars-Sinai ... occur in the brain and are a classic ... from investigators conducting a clinical trial in Australia. ... 15 in an oral presentation at the Alzheimer,s ... also were invited by conference organizers to participate ...
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Breaking Medicine News(10 mins):Health News:Saliva Test Might Someday Replace Needle Prick for Diabetics 2Health News:Saliva Test Might Someday Replace Needle Prick for Diabetics 3Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 2Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 3Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 4Health News:Cheap Elegant Quinceanera Dresses Unveiled by MyDressCity.com 2Health News:Study of noninvasive retinal imaging device presented at Alzheimer's conference 2Health News:Study of noninvasive retinal imaging device presented at Alzheimer's conference 3Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 2Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 3Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 4
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