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Structure in Medical Technology

Rib-X Pharmaceuticals Novel Antibiotic Delafloxacin Named One of R&D Directions 100 Great Investigational Drugs of 2009

... of delafloxacin in complicated skin and skin structure infections (cSSSI). Delafloxacin successfully ... About cSSSI Complicated skin and skin structure infections (cSSSI) encompass a wide range of ... on its proprietary high-resolution crystal structure of the ribosome, which performs an essential role ...

Quark Pharmaceuticals Announces Dosing of the First Patient in Phase I/II Clinical Trial for Systemically Delivered siRNA Drug Candidate for Delayed Graft Function

... QPI-1007 drug candidate, utilizing a novel siRNA structure developed by Quark, is being evaluated in ... modified siRNA discovered by Quark with structure covered under licenses from Silence Therapeutics ... which is a siRNA that utilizes a novel siRNA structure developed by Quark and is being evaluated in ...

Rib-X Pharmaceuticals Reports Positive Top-Line Results from Phase 2 Study of Delafloxacin

... in the treatment of complicated skin and skin structure infections (cSSSI). Additionally, when evaluated ... About Complicated Skin and Skin structure Infections (cSSSI) Complicated skin and skin structure infection (cSSSI) is a term used to group a wide ...

Rib-X Pharmaceuticals Reports Positive Phase 2 Study Results for Next Generation Oxazolidinone at 2008 ICAAC/IDSA Joint Meeting

... adult patients with uncomplicated skin and skin structure infections (uSSSI). The study assessed the ... Infections (uSSSI) Uncomplicated skin and skin structure infection (uSSSI) is a term used to group a wide ... on its proprietary high-resolution crystal structure of the ribosome, which performs an essential role ...

VAI Finding Could Lead to New Drugs for Anxiety, Depression

... Researchers determine molecular structure of promising drug target using ... VAI researchers determined the molecular structure of the part of the CRF receptor that sticks ... the drug more potent. Researchers determined the structure of the receptor in three different scenarios -- ...

New Study Shows BENICAR(R) (olmesartan medoxomil) Reverses Blood Vessel Damage Independent of Blood Pressure Lowering

... beta-blocker (atenolol) on vascular function and structure in patients with Stage 1 hypertension, ... early blockade of angiotensin II, improved the structure abnormalities of resistance arteries in patients ... HD, Touyz RM. Correction of arterial structure and endothelial dysfunction in human essential ...

Rib-X Pharmaceuticals Renews Collaborative Agreement with the Medical Research Council

... agreement in the area of ribosome and antibiotic structure and function for an additional year. Under the ... to jointly explore the high resolution crystal structure of the 70S ribosome. "Using information ... on its proprietary high-resolution crystal structure of the ribosome, which performs an essential role ...

First High-Res 3-D Structures of Mammalian HSP90 Protein Solved, Key to Better Targets for AIDS, Sepsis, Cancer Drugs

... to solve the first high-resolution structure of this protein from mammalian origins, to ... a member of the HSP90 family of proteins. The structure and activity patterns of this protein prove ... of protein function. It is also the first structure of a mammalian member of the hsp90 family. This ...

Quark Pharmaceuticals Presents at Asia TIDES Conference

... surgery and of delayed graft function in kidney transplantation. For the structure of these products Quark has licenses from Silence Therapeutics and from Alnylam Pharmaceuticals. QPI-1007, a siRNA that utilizes a proprietary structure developed by Quark, is being evaluated in advanced IND-enabling ...

Rendell Administration Announces Health Research Grants From Tobacco Settlement Funds

... are limited. Studies that investigate genetic factors, brain function and structure are needed to improve our understanding of how the minds of autistic ... behavior of children with an ASD, including a study of how genes, brain structure and brain function impact treatment response. Findings from the research ...

J. Craig Venter, Ph.D. Receives Double Helix Medal from Cold Spring Harbor Laboratory

... Inaugurated in 2006, the medal is named for the iconic "winding-staircase" structure of the DNA molecule, discovered by Dr. Watson along with Dr. Francis Crick ... Nobel Prize along with Francis Crick in 1962 for their description of the structure of DNA. Dr. Watson is credited for developing the modern vision for Cold ...

Pivotal Phase III Data Confirm the Efficacy and Safety of Arpida's Intravenous Iclaprim in Treating Patients With Complicated Skin and Skin Structure Infections

... comparator drug, linezolid, in the treatment of complicated skin and skin structure infections (cSSSI) caused by Gram-positive bacteria, including ... were gathered from the ASSIST-1 and ASSIST-2, (Arpida's Skin and Skin structure Infection STudy) pivotal Phase III studies involving a total of 991 ...

Trius Antibiotics to be Highlighted in 18 Presentations at ICAAC/IDSA

... in our recently initiated Phase 2 study in complicated skin and skin structure infections (cSSSIs). It is also exciting to see that the results of ... Subjects (Poster Session 197, 11:15 am - 12:15 pm) -- F2-2070: structure Guided Design of Pyrimidine Antibacterials Targeting Methionyl-tRNA ...

Paratek to Present Clinical Data in Late Breaker Presentation at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy

... of PTK 0796: Results of the Phase 2 Study in Complicated Skin and Skin structure Infections Following IV and Oral Step-down Therapy. About Paratek ... a recently completed Phase 2 clinical study in complicated skin and skin structure infections (cSSSI). In addition to amadacycline, Paratek is also ...

Arpida Announces Review of Iclaprim NDA by FDA Advisory Committee in November 2008

... Application (NDA) for intravenous iclaprim in complicated Skin and Skin structure Infections (cSSSI) during its meeting on 18-20 November 2008. An Advisory ... The clinical programme for the first indication, complicated skin and skin structure infections (cSSSI), has been completed. The submission of the NDA to the ...

Arpida Completes Enrolment in Phase II "Intravenous-to-Oral" Switch Trial With Oral Iclaprim

... switch trial with oral iclaprim in patients with complicated Skin and Skin structure Infections (cSSSI). The trial was designed as a multi-centre, ... The clinical programme for the first indication, complicated skin and skin structure infections (cSSSI), has been completed. The submission of the NDA to the ...

Quark Pharmaceuticals Announces First Patient Dosing by Pfizer in Phase II Trial of RNAi Therapy in Diabetic Macular Edema

... siRNA delivered systemically in a human clinical trial. The Company has structure related technology licenses from Silence Therapeutics and from Alnylam. ... Quark has a broad pipeline of siRNA drug candidates based a novel structure developed internally. The Company expects to utilize the structure to ...

Rib-X Pharmaceuticals Initiates Phase 2 Trial for RX-3341 In Complicated Skin and Skin Structure Infections

... antibiotic compound RX-3341 in the treatment of complicated skin and skin structure infections (cSSSIs). The safety and efficacy study will be conducted at 35 ... discovery engine capitalizes on its proprietary high-resolution crystal structure of the ribosome, which performs an essential role in the fundamental ...

Wyeth Receives Approvable Letter from FDA for TYGACIL for the Treatment of Patients with Community-Acquired Pneumonia

... intra-abdominal infections (cIAI) and complicated skin and skin structure infections (cSSSI). Wyeth has achieved significant success in bringing ... is indicated for the treatment of adults with: Complicated skin and skin structure infections (cSSSI) caused by Escherichia coli, Enterococcus faecalis ...

Human Genome Sciences Reports Progress With Late-Stage Products and New Initiatives

... by enabling the exploration of new alliances with a more optimal structure that could bring development expertise and resources, commercial ... and will shortly start discussions with regulators regarding the structure of the darapladib Phase 3 program. Darapladib has the potential to be ...

Arpida Enrols First Patients in "Intravenous-to-Oral" Switch Trial With Oral Iclaprim

... switch trial with oral iclaprim in complicated Skin and Skin structure Infections (cSSSI). Enrolment remains on track for completion in 2008. ... The clinical programme for the first indication, complicated skin and skin structure infections (cSSSI), has been completed. The submission of the NDA to the ...

Arpida Provides Further Comments on the Pivotal Phase III Trials

... clinical programme with intravenous iclaprim in complicated Skin and Skin structure Infections (cSSSI). Extensive data on ASSIST-1 has been presented at last ... The clinical programme for the first indication, complicated skin and skin structure infections (cSSSI), has been completed. The submission of the NDA to the ...

Arpida Invited to Present Data on Iclaprim at Scientific Conference

... Phase III trial with intravenous iclaprim in complicated Skin and Skin structure Infections (cSSSI). Moreover, data from Phase I studies with intravenous ... The clinical programme for the first indication, complicated skin and skin structure infections (cSSSI), has been completed. The submission of the NDA to the ...

Rib-X Pharmaceuticals to Present at 10th Annual Superbugs & Superdrugs Conference

... proprietary computational tools and knowledge of the three dimensional structure of the 50S subunit of the ribosome. An oxazolidinone antibiotic that ... discovery engine capitalizes on its proprietary high-resolution crystal structure of the ribosome, which performs an essential role in the fundamental ...

Synvista Therapeutics Presents New Preclinical Data Demonstrating the Value of Haptoglobin Genotype Testing In Diabetes at ACC Scientific Sessions

... Model of Diabetes with Haptoglobin 2-2 Genotype Show Modification of HDL structure and Defective Reverse Cholesterol Transport MONTVALE, N.J., March 31 ... complex may result in a modification of high-density lipoprotein (HDL) structure and defective reverse cholesterol transport. These findings, which were ...

'Stereo' Mammography Takes Breast Imaging to a New Dimension

... a stereo display workstation, the radiologist is able to see the internal structure of the breast in three dimensions. In the ongoing clinical trial, ... to view the breast in depth. "Stereo viewing is the only way to see the structure within the breast volume in true depth," said Dr. Getty, who has been ...

Quark Pharmaceuticals, Inc. Announces First Systemic siRNA Dosing in Humans

... discovered and patented by Quark that has an AtuRNAi technology-based structure licensed from Silence Therapeutics. Quark has also licensed certain ... of acute renal failure both of which have an AtuRNAi technology-based structure licensed from Silence Therapeutics, as well as a license from Alnylam. The ...

New Risk Factor for Heart Disease Identified in Very Young Children, According to Study at American Heart Association Scientific Sessions

... showed for the first time that obesity in children directly affects structure and function of the heart, which could lead to increased risk for ... that morbid obesity in children and adolescents directly affects the structure of their hearts and puts them at increased risk for future heart attack. ...

A Sociolinguistic Analysis of In-Office Dialogue Reveals Psychiatrists and Parents Have Significantly Different Perceptions on ADHD and Psychiatric Comorbidities

... accepted sociolinguistic methodologies to evaluate the tone, content and structure of in-office visits, was presented recently at the 20th annual U.S. ... genetic therapies (HGT), gastrointestinal (GI) and renal diseases. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to ...

New Data Show Ceftobiprole as Effective as Combination Therapy in Treating Patients with Diabetic Foot Infections

... MRSA has become more prevalent as a cause of complicated skin and skin structure infections, including diabetic foot infections, which are particularly ... of ceftobiprole in adults for the treatment of complicated skin and skin structure infections, including diabetic foot infections (without concomitant ...

Researchers at Cleveland Clinic Identify Site of 'Dysfunction' in HDL, Carrier of Good Cholesterol

... Nature Structural & Molecular Biology in a paper entitled "The Refined structure of Nascent HDL Reveals a Key Functional Domain for Particle Maturation and ... Dr. Hazen said. "With our enhanced detail of the HDL molecule structure we are better able to understand the location and mechanics of dysfunction ...

Thiarabine Demonstrates a Reduction of Both Inflammatory and Erosive Disease Parameters in Rheumatoid Arthritis

... efficacy in the prevention and treatment of rheumatoid arthritis (RA). In a well-established animal model for RA, an exceptional restoration of joint structure was observed in the studies, which were conducted at Wayne State University School of Medicine and at Southern Research Institute. As a ...

Responses After Completion of Therapy Increase Pixantrone Complete Remission (CR)/Unconfirmed Complete Remission (CRu) Rate to 24% and Overall Response Rate (ORR) to 40% Compared to 7% and 14% for Comparator Agents in Phase III EXTEND Trial in 3rd Line Th

... on a named-patient basis. About Pixantrone Pixantrone (BBR 2778), is a novel major groove binder with an aza-anthracenedione molecular structure that differentiates it from the anthracyclines and other related chemotherapy agents. Anthracyclines are the cornerstone therapeutic for the ...

Study Demonstrates Efficacy of Pitavastatin in Elderly Patients

... of HMG-CoA reductase used for primary hypercholesterolemia and combined dyslipidemia. Pitavastatin has a unique cyclopropyl group on the base structure common to the statin class. Since its 2003 launch in Japan, pitavastatin has accumulated millions of patient-years of exposure. Many of these ...

Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections

... evaluating the safety and efficacy of oral torezolid (TR-701), its investigational antibiotic for the treatment of severe complicated skin and skin structure infections (cSSSI) caused by gram-positive bacteria, especially drug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA). ...

Pixantrone in Combination with Chemotherapy Regimens Produces Overall Response Rates of 58-74% with Complete Remission Rates of 37-57% in Relapsed/Refractory Aggressive or Indolent NHL

... Weston Park Hospital, Shefield. About Pixantrone Pixantrone (BBR 2778), is a novel major groove binder with an aza-anthracenedione molecular structure that differentiates it from the anthracyclines and other related chemotherapy agents. Anthracyclines are the cornerstone therapeutic for the ...

Study Demonstrating Lurasidone Is Effective in Patients With Schizophrenia Published in The Journal of Clinical Psychiatry

... by Dainippon Sumitomo Pharma Co., Ltd. (DSP), as a potential psychotropic agent for the treatment of schizophrenia. Lurasidone has a unique chemical structure that differs from conventional and atypical antipsychotic agents. It possesses high affinities for dopamine D(2), serotonin 5-HT(7), 5-HT(2A), ...

Pixantrone Produces High Rates of Complete and Partial Remissions Even Among Aggressive NHL Patients With Extensive Prior Doxorubicin Treatment or Prior Rituximab Treatment

... on a named patient basis. About Pixantrone Pixantrone (BBR 2778), is a novel major groove binder with an aza-anthracenedione molecular structure that differentiates it from the anthracyclines and other related chemotherapy agents. Anthracyclines are the cornerstone therapeutic for the ...

Pixantrone Phase 3 Data to be Presented at the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting

... the fourth quarter of 2009. About Pixantrone Pixantrone (BBR 2778), is a novel major groove binder with an aza-anthracenedione molecular structure that differentiates it from the anthracyclines and other related chemotherapy agents. Anthracyclines are the cornerstone therapeutic for the ...

Autism Genes Discovered; Help Shape Connections Among Brain Cells

... an underlying problem in ASDs. "These molecules are expressed on the cell surfaces of neurons, and they are involved with shaping both the physical structure of the developing brain and the functional connections among different brain regions," Hakonarson said. "Although a particular gene variant may ...
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(Date:7/9/2014)... Sexual selection refers to species, selection for traits that ... of natural selection enhances opportunities to mate, the tail ... at the University of California, Riverside have now found ... a placenta are linked. Describing the life histories ... family Poeciliidae, the researchers found that species with placentas ...
(Date:7/9/2014)... (TCGA) Research Network have identified novel mutations in ... most common subtype of lung cancer. Knowledge of ... possible therapeutic targets for this disease and potentially ... mutations because many potent cancer drugs that target ... funded and managed by the National Cancer Institute ...
(Date:7/9/2014)... With grilling season upon us, many backyard cooks are ... fatty hot dogs. But low fat can sometimes mean ... addressing the texture problem in low-fat wieners that are ... study was published in ACS, Journal of Agricultural ... colleagues note that hot-dog consumers have come to expect ...
Breaking Biology News(10 mins):Biologists link sexual selection and placenta formation 2Biologists link sexual selection and placenta formation 3Biologists link sexual selection and placenta formation 4Study identifies novel genomic changes in the most common type of lung cancer 2Study identifies novel genomic changes in the most common type of lung cancer 3
(Date:7/9/2014)... The liver is one of the most important organs ... that we utilize our food properly this is ... removed from our organism this is its detoxification ... and unhealthy food all damage the liver. The resulting ... deposits, cirrhoses, and life-threatening liver failure. According to the ...
(Date:7/9/2014)... studies linking older age with kidney and heart disease ... donation among older adults. However, in the first study ... Perelman School of Medicine at the University of Pennsylvania ... enjoy similar life expectancy and cardiovascular health as very ... In light of the ever increasing organ transplant waitlists, ...
(Date:7/9/2014)... has risen dramatically in Western societies. One frequently cited ... and have fewer infections than previous generations, thereby delaying ... researchers at Sahlgrenska Academy, University of Gothenburg, monitored children ... the immune system in relation to allergic disease. All ... Vstra Gtaland Region, half of them on farms that ...
(Date:7/8/2014)... awarded up to $15 million by the Defense Advanced ... aiming to help brain-injured people restore lost memory functions. ... psychology and physics will collaborate to create, surgically implant, ... Memory is the process in which neurons in certain ... retrieve it. Certain types of illnesses and injuries disrupt ...
(Date:7/8/2014)... found to be three times higher when auditors were ... auditors present, according to a study in a major ... "Quantification of the Hawthorne effect in hand hygiene compliance ... study," published today on-line in the BMJ Quality ... Srigley, who did the study as part of her ...
Breaking Medicine News(10 mins):Health News:Telemedicine for patients with chronic liver diseases 2Health News:Telemedicine for patients with chronic liver diseases 3Health News:Penn study finds living kidney donation does not increase risk of death or heart disease for older 2Health News:DARPA awards UCLA $15 million to restore lost memory 2Health News:DARPA awards UCLA $15 million to restore lost memory 3Health News:Health-care worker hand hygiene rates increase three-fold when auditors visible 2Health News:Health-care worker hand hygiene rates increase three-fold when auditors visible 3
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