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Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression of Structural Joint Damage in Rheumatoid Arthritis Patients

... (Toci LI zumab Safety and THE Prevention of structural Joint Damage) study demonstrated that a greater ... a significant inhibition in the progression of structural joint damage compared with patients treated with ... a significant inhibition in the progression of structural joint damage, as measured by the change in the ...

Two-Year Data Reinforce Effect of ACTEMRA(R) (tocilizumab) in Inhibiting Progression of Joint Damage and Improving Physical Function in Rheumatoid Arthritis Patients

... (Toci LI zumab Safety and THE Prevention of structural Joint Damage) study demonstrated that ACTEMRA(R) ... continued to inhibit the progression of structural damage to joints in patients with rheumatoid ... significantly inhibited the progression of structural joint damage, which is a major cause of ...

New Insight Into the Controls on a Go-To Enzyme

... fellow in Green's laboratory, performed X-ray structural analysis on such a protein crystal that consisted ... the calpastatin molecule attached to calpain. The structural picture obtained of the two proteins clutched ... effective regulator. The researchers' structural information also showed how calpain changes its ...

New Study Demonstrated ACTEMRA(R) (tocilizumab) Inhibited Progression of Joint Damage in Rheumatoid Arthritis Patients

... significantly inhibited the progression of structural joint damage in patients with rheumatoid ... LITHE (TociLIzumab Safety and THE Prevention of structural Joint Damage), a three-arm, randomized, ... methotrexate in RA patients for the prevention of structural joint damage, improvement in physical function ...

VAI Finding Could Lead to New Drugs for Anxiety, Depression

... /PRNewswire/ -- Researchers in the Laboratory of structural Sciences at Van Andel Institute (VAI) ... precisely binds to its receptor. This detailed structural information can help drug developers design new ... target, and we are the first to determine the structural details necessary to develop an ideal drug." ...

The First Direct Structural Evidence of SV2A has Been Revealed Thanks to Protein Tomography(TM), and Published in BBRC

... Protein Tomography(TM) has yet Again Provided structural Proof of a Drug Target Function. A Study ... has together with UCB published the first direct structural evidence of the molecular mechanism of the ... of UCB). The result shows the first direct structural proof of the "alternating access model" that ...

CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year

... for the inhibition of the progression of structural joint damage compared with placebo ... more effective in inhibiting the progression of structural joint damage compared with placebo plus ... pegol plus methotrexate can significantly inhibit structural joint damage, which is important for patients who ...

Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week

... "Paired-End Mapping Reveals Extensive Genomic structural Variation in Humans," published today suggests ... level of resolution, detecting most of the structural variation in the human genome. The presence of ... and degraded DNA, obtain a paired-end map of structural variation throughput the human genome ...

ActiveSight and CHDI Leverage Fragment-Based Lead Discovery for Huntington Disease Therapies

... for HD soon." ActiveSight's high-throughput structural biology capabilities will facilitate rapid ... Automated data collection and structural determination will be facilitated by Rigaku's ... provider of fragment-based lead discovery and structural biology for drug discovery. Utilizing ...

Prospective Clinical Advantages of Trabecular Metal(TM) Technology Highlighted in Comparative Study

... acetabular implants." Trabecular Metal material is a structural biomaterial whose cellular architecture resembles bone and approximates its physical and structural properties more closely than other prosthetic materials. The unique, ...

New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease

... Reducing signs and symptoms, inhibiting the progression of structural damage and improving physical function in patients with moderately to ... signs and symptoms of active arthritis, inhibiting the progression of structural damage and improving physical function in patients with PsA. ...

MRI Emerges As Vital Resource in Treatment of Back Pain

... who suffer from claustrophobia. For these individuals, CT can provide structural information needed for diagnosis in many back pain cases. However, CT ... thorough medical history and physical examination. Also, there are often structural findings or "abnormalities" on MRI that are not clinically relevant and ...

Sequoia Pharmaceuticals Presents In Vitro and First-in-Human Data Supporting Further Development of SPI-256, a Novel Investigational Protease Inhibitor

... data were also presented in this poster. These data demonstrated how the structural design elements of SPI-256 present a high genetic barrier to the emergence of resistant strains of HIV. Additionally, the unique structural properties of SPI-256 explain its high potency when tested against a panel ...

New Findings Show Efficacy of REMICADE(R) Compared With Azathioprine in Treatment of Crohn's Disease According to First-of-its Kind Study

... -- Reducing signs and symptoms, inhibiting the progression of structural damage and improving physical function in patients with moderately to ... signs and symptoms of active arthritis, inhibiting the progression of structural damage and improving physical function in patients with PsA. -- ...

deCODE Files IND for DG071, a Novel PDE4 Modulator Being Developed for Alzheimer's and Other Cognitive Disorders

... and reflects the exceptional capabilities of our drug discovery and structural biology groups. Our teams used protein crytallography to determine the ... and biology capabilities including protein production, multifaceted structural studies, lead identification, ex vivo and in vivo assays, cGMP ...

Abbott Presents Long-Term Data From Extension Study Showing Adult Crohn's Patients Treated With HUMIRA(R) (Adalimumab) Maintained Remission

... symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in adult patients with moderately ... signs and symptoms of active arthritis, inhibiting the progression of structural damage and improving physical function in patients with psoriatic ...

New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease

... -- Reducing signs and symptoms, inhibiting the progression of structural damage and improving physical function in patients with moderately to ... signs and symptoms of active arthritis, inhibiting the progression of structural damage and improving physical function in patients with PsA. -- ...

New Study Demonstrates ACTEMRA(R) (tocilizumab) Inhibits Progression of Joint Damage in Rheumatoid Arthritis Patients

... that ACTEMRA(TM) (tocilizumab) can significantly inhibit progression of structural damage to joints in patients with rheumatoid arthritis (RA), a critical ... over 52 weeks achieved a significant reduction in the progression of structural joint damage, which is critical to RA patients because joint damage leads ...

Repligen Receives FDA Fast Track Designation for RG1068 for Pancreatic Imaging

... results of the study showed an improvement in sensitivity of detection of structural abnormalities of the pancreatic duct of approximately 20% with no loss in ... significant increases in physician confidence in their ability to identify structural abnormalities, the number of pancreatic duct segments visualized and ...

U.S. Food and Drug Administration Approves ORENCIA(R) (abatacept) for the Treatment of Moderate-to-Severe Polyarticular Juvenile Idiopathic Arthritis (JIA) in Patients Six Years and Older

... symptoms, inducing major clinical response, inhibiting the progression of structural damage and improving physical function in adult patients with moderately ... symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in adult patients with moderately ...

Repligen Initiates Phase 3 Clinical Trial of RG1068 for Pancreatic MRI Imaging

... results of the study showed an improvement in sensitivity of detection of structural abnormalities of the pancreatic duct of approximately 20% with no loss in ... significant increases in physician confidence in their ability to identify structural abnormalities, the number of pancreatic duct segments visualized and ...

REMICADE-Treated Patients Experienced Rapid and Substantial Improvement in Psoriasis in Critical Regions of Body

... -- Reducing signs and symptoms, inhibiting the progression of structural damage and improving physical function in patients with moderately to ... signs and symptoms of active arthritis, inhibiting the progression of structural damage and improving physical function in patients with PsA. -- ...

Abbott's HUMIRA(R) (adalimumab) Receives FDA Approval For Moderate to Severe Chronic Plaque Psoriasis

... inducing major clinical response, inhibiting the progression of joint structural damage, and improving physical function in adult patients with moderately ... the signs and symptoms of active arthritis, inhibiting the progression of structural damage and improving physical function in patients with psoriatic ...

Abbott's m2000(TM) Molecular Diagnostic Instrument and RealTime HIV-1 Test Win Chicago Innovation Award

... symptoms, inducing major clinical response, inhibiting the progression of structural damage and improving physical function in adult patients with moderately ... the signs and symptoms of active arthritis, inhibiting the progression of structural damage and improving physical function in patients with psoriatic ...

First High-Res 3-D Structures of Mammalian HSP90 Protein Solved, Key to Better Targets for AIDS, Sepsis, Cancer Drugs

... as an HWI senior research scientist, Gewirth is an associate professor of structural Biology at the University at Buffalo. Prior to joining HWI in 2005, ... specializing in the area of fundamental biomedical research known as structural biology. Hauptman-Woodward's team of more than 75 staff members is ...

Statement From The National Conclave on HIV/AIDS Policy for Black Clergy

... AIDS Plan, the Elimination Act will highlight and address the key structural drivers of the AIDS epidemic, like poverty, low literacy, stigma, unemployment, incarceration, racial disparities and other structural drivers of the epidemic in the United States. -- The Elimination Act ...

Juvenile Diabetes Research Foundation, The Genomics Institute of the Novartis Research Foundation Announce Innovative Diabetes Drug Discovery and Development Partnership

... the life sciences, and include genomics and proteomics tools, medicinal chemistry, cell-based ultra high throughput screening of genes or compounds, structural genomics, and forward/reverse mammalian genetics. The mission of the Institute is to exploit these technologies to identify new biological ...

2,500 Cases Completed With the Magnetic Irrigated Catheter

... remains at 0.1% "The irrigated tip is a great asset for creating deep lesions in patients with ventricular tachycardias in the setting of structural heart disease," said Dr. Raul Weiss, associate professor of medicine at The Ohio State University and an electrophysiologist at the Ross Heart ...

deCODE Discovers Second Common Genetic Risk Factor for Atrial Fibrillation and Stroke

... deCODE BreastCancer, for the common forms of breast cancer. Its lead therapeutic programs, which leverage the company's expertise in chemistry and structural biology, include DG041, an antiplatelet compound being developed for the prevention of arterial thrombosis; DG051 and DG031, compounds targeting the ...

St. Francis Surgeon Uses Tissue Regeneration Technology to Rebuild Patients' Heart Structures

... added Gerdisch. The CorMatrix ECM is derived from porcine small intestines and is processed in a way that removes all cells, leaving the complex structural matrix intact. Once surgically implanted, it serves as a scaffold, allowing the patient's cells to infiltrate and ultimately replace the ECM ....

deCODE-led Megastudy Finds New Genetic Clues to Causes of Schizophrenia

... the treatment, diagnosis and prevention of common diseases. Its lead therapeutic programs, which leverage the company's expertise in chemistry and structural biology, include DG041, an antiplatelet compound being developed for the prevention of arterial thrombosis; DG051 and DG031, compounds targeting the ...

SIMPONI(TM) (golimumab) Receives Positive Opinion From CHMP for Once-Monthly Subcutaneous Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

... entire population. It typically begins in the late teens and early 20s, and in severe cases can result in fusing of the spinal vertebrae and cause structural damage to hips and other joints. Often misdiagnosed as "just back pain" or undifferentiated arthritis, AS is a systemic inflammatory disease that, in ...

ADHD Genes Found; Known to Play Roles in Neurodevelopment

... at Children's Hospital, was a co-first author with Elia. Other collaborators were from Children's Hospital and Penn. Elia et al, "Rare structural Variants Found in Attention-Deficit Hyperactivity Disorder Are Preferentially Associated with Neurodevelopmental Genes," Molecular Psychiatry , ...

Two-Year Data Show Patients Receiving SIMPONI(TM) (golimumab) Experienced Sustained Improvement in Signs and Symptoms of Psoriatic Arthritis and Ankylosing Spondylitis

... age of 35 years. It typically begins in the late teens and early twenties and in severe cases can result in fusing of the spinal vertebrae and cause structural damage to hips and other joints. Often misdiagnosed as "just back pain" or undifferentiated arthritis, AS is a systemic inflammatory disease that, ...

Access Pharmaceuticals Announces Publication of Thiarabine Combination Data

... treatment with a reduced side-effect profile." Prior clinical studies have shown that the effectiveness of cytarabine , or Ara-C, (a close structural analog of thiarabine which is widely used in treating leukemia patients) can be improved by combining it with clofarabine in the treatment of ...

Encouraging First Data on New Targeted Treatment for Patients With Melanoma - the Deadliest Form of Skin Cancer

... breast cancer. Plexxikon's proprietary Scaffold-Based Drug Discovery(TM) platform integrates multiple state-of-the-art technologies, including structural screening as one key component that provides a significant competitive advantage over other drug discovery approaches. To date, the company has ...

New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)

... and one controlled trial in adults. Adderall XR is indicated for the treatment of ADHD. Tell the doctor about any heart conditions, including structural abnormalities, that you, your child, or a family member, may have. Inform the doctor immediately if you or your child develops symptoms that ...

InspireMD Announces the Enrollment of the 1st Patient in the MGuard iMOS Registry, the Registry Will Enroll 1000 Patients

... the strength characteristics of the fiber material. The sleeve is designed to expand seamlessly when the stent is deployed, without effecting the structural integrity of the stent. The MGuard(TM) coronary stent provides permanent embolic protection, without complicating deliverability. Reduced injury to ...

First Year Results of the AXA Research Fund: Over Euro 13 Million Allocated for Research in 2008

... University Belfast) Project dedicated to assessing civil conflict risks (Universitat Autonoma of Barcelona) Project entitled A structural approach to inflation and term structure (EDHEC Business School of Lille) 58 young researchers of promise, working in 13 countries ...

Astrocytes Help Separate Man From Mouse

... of astrocytic domain organization and a decrease in cognitive function. In people, cells known as fibrous astrocytes, which are mainly for structural support, are on average more than twice as large as their counterparts in mice and rats. Also, people have another type of cell known as interlaminar ...
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(Date:10/31/2014)... in cities is good for attracting species, but it may ... University of Iowa study has found. , The researchers surveyed ... and recorded the abundance of two insects that interact with ... trees, black cherry and black walnut, they didn,t find a ... that feed on the walnuts and black cherries and a ...
(Date:10/31/2014)... been studying the behavior of approximately 300 wild ... They observed that ravens slowly build alliances through ... they also observed that these affiliative interactions were ... about 50 % of the cases these interventions ... ravens, intervening can be potentially risky when the ...
(Date:10/30/2014)... LANSING, Mich. – When most animals begin life, cells ... or a vital organ. However, mammals, including humans, are ... a different first choice – to become the protective ... It,s during this critical first step that research from ... published in the current issue of PLOS ...
Breaking Biology News(10 mins):Green spaces don't ensure biodiversity in urban areas 2Identifying the source of stem cells 2
(Date:10/31/2014)... to life. The last stage, when two daughter cells ... dawn of cell biology in the Victorian era. For ... study this final step, when the dividing cell creates ... given to this process by those early biologists, cytokinesis, ... a highly active and organized series of events. Scientists ...
(Date:10/31/2014)... Friday. October 31, 2014 — A team from ... and the University of California, Santa Cruz, was ... Cancer Genomics Cloud Pilot contracts with the goal ... analysis of The Cancer Genome Atlas (TCGA) and ... required computing resources in one cloud environment. This ...
(Date:10/31/2014)... 31, 2014 This Method to ... health effects for practitioners. , The Hypopresive ... of Science and Movement specializing in physical rehabilitation. ... pelvic floor reeducation that traditional abdominal exercises after ... Recti, Prolepses, etc. , The Hipopressives exercises pull ...
(Date:10/31/2014)... 31, 2014 Energy Textiles has recently ... new gear is now available online, and Energy Textile ... of Celliant infrared-active athletic gear over compression gear. , ... contract has been signed for Under Armour to provide ... next eight years. In light of this decision, Energy ...
(Date:10/31/2014)... duration of treatment and cost, patients with early ... breast irradiation (APBI) with proton therapy versus whole ... The University of Texas MD Anderson Proton Therapy ... study based on typical patient characteristics, researchers used ... eight different types of partial and whole breast ...
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