Procter & Gamble Pharmaceuticals Launches Asacol(R) HD (mesalamine) Delayed-Release Tablets
... UC, Asacol HD helped reduce rectal bleeding and stool
frequency, without the use of steroids. These ... the clinical assessments of rectal bleeding, stool
frequency and sigmoidoscopy findings. The ... rapid improvement in rectal bleeding and stool
frequency. At three weeks, rectal bleeding ...
Napo Announces Positive Clinical Data Indicating Crofelemer, Could Effectively Treat Cholera
... averaged approximately 8.5 liters of stool
during the first 24 hour period. ... endpoint in this study was the
reduction in stool
volume output normalized to the body weight of ... of 125 mg every 6 hours reduced the
amount of stool
volume output normalized to body weight by 32% ...
Analysis of Ulcerative Colitis (UC) Time to Symptom Resolution Data from Pivotal Study of LIALDA(TM) (mesalamine) Presented at DDW
... resolution (rectal bleeding or
normalization of stool
frequency or both) or the time between the ... resolution of rectal bleeding,
normalization of stool
frequency or both was assessed by a ... symptoms
was defined for both rectal bleeding and stool
frequency as a modified
UC-DAI sub-score of 0.
Napo Announces Successful Clinical Results in Phase 2 Study of Crofelemer in Acute Adult Infectious Diarrhea
primary endpoints of the trial were stool
weight, duration of diarrhea,
stool frequency and stool
consistency; additional endpoints ... three days. Details regarding the stool
Microbia and Forest Laboratories Announce Preliminary Results of Linaclotide Phase 2b Studies
... other top-line efficacy endpoints-SBM frequency, stool
abdominal pain, bloating, abdominal ... bowel movements
(CSBM) compared to baseline, stool
consistency using the Bristol stool
Scale (BSFS), and straining. ...
Study Data Show Asacol(R) (Mesalamine) is Effective in Treating All Extents of Ulcerative Colitis Including Isolated Proctitis
mucosal healing and 57 percent had reduced stool
frequency. These data were
presented today at the ... left-sided disease experienced an
improvement in stool
frequency and 70 percent achieved mucosal ... with pancolitis, 70 percent had improvement of stool
and 71 percent experienced mucosal ...
Ironwood and Forest Present Additional Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation
... in the first week (p<0.005). There was also significant improvement in stool
consistency, straining, adequate relief, and global relief during the ...
Medarex Announces Primary Endpoint Achieved in MDX-1100 Anti-IP-10 Antibody Phase 2 Trial for Rheumatoid Arthritis
... response is based on the Mayo score, a composite endpoint that assesses stool
frequency and the amount of bloody stool
per day as recorded in a patient diary, physician global assessment and ...
Tioga Pharmaceuticals' Asimadoline Demonstrates Positive Results in a Phase 2b Clinical Trial for the Treatment of Irritable Bowel Syndrome
... secondary endpoints: urgency, adequate relief of IBS symptoms, stool
frequency, bloating and daily pain. Statistically significant ... least three weeks per month. The secondary endpoints were abdominal
frequency and consistency, urgency, bloating, adequate relief
of IBS ...
Ironwood Pharmaceuticals and Forest Laboratories Announce Presentation of Linaclotide Phase 2b Chronic Constipation Study Results
... SBMs and CSBMs compared to baseline, stool
consistency using the Bristol stool
Form Scale (BSFS), and straining.
Patient-reported outcomes included ... by the patient self-reporting a feeling of complete evacuation.
Form Scale (BSFS): A seven-point scale measuring stool
consistency. BSFS ...
Safety and Efficacy Results Presented From Largest Prospective Controlled Clinical Study of Ulcerative Colitis
... the PGA (which was based on
the clinical assessments of rectal bleeding, stool
sigmoidoscopy) and no worsening in any of the individual ... efficacy in secondary endpoints:
clinical remission, rectal bleeding, stool
frequency and sigmoidoscopy
About Ulcerative Colitis (UC)
New Analysis of Study Data Shows That Asacol(R) (Mesalamine) Delivers Rapid Symptom Relief for Ulcerative Colitis Patients
... three consecutive days of resolution of both rectal bleeding
and increased stool
frequency. The time to clinical remission endpoint utilized in this ... was defined
as resolution (score=0) of both rectal bleeding (RB) and stool
(SF). Resolution of RB was defined as the absence of visible ...
New Analyses of Long-Term LIALDA(TM) (mesalamine) Data Presented at ACG
... score of less than or equal to 1 with
scores of 0 for rectal bleeding and stool
frequency, a combined Physician's
Global Assessment and sigmoidoscopy ... initial symptom resolution of rectal
bleeding and normalization of stool
frequency. Patients with active,
mild-to-moderate UC were randomized to ...
Advance in Bowel Cancer Test Research
... test for detecting bowel cancer and significant pre-cancer lesions.
"If we can now show that the levels of these biomarkers in blood or stool
also correlate strongly with disease state in a large group of patients with cancer or pre-cancer lesions (ie adenomatous polyps) we may have the ...
Clinical Genomics Continues Progress in Developing Biomarker Portfolio for Colorectal Cancer Testing
... Enterix Inc., manufacturer of the FDA-
cleared InSure(R) fecal immunochemical test (FIT) for aiding the detection of
colorectal cancer based on stool
testing. Quest Diagnostics also made an
equity investment in Clinical Genomics, which was formed as a spin off from
Enterix's research and ...
Mission Pharmacal Launches CitraNatal(R) Assure Prescription Prenatal Vitamin
... during pregnancy, a gentle dual-iron formulation of carbonyl iron and ferrous gluconate for gentle absorption, tolerability and safety, and a stool
softener to help ease constipation often associated with pregnancy.
The CitraNatal family of products offers four unique formulations of ...
ASGE and The Pancreatic Cancer Action Network Partner to Raise Awareness About Pancreatic Cancer
... in the pancreas can block the flow of these substances into the small intestine. This can cause the skin and eyes to turn yellow (jaundice) and the stool
to turn pale. It can also cause pain, weight loss, nausea, vomiting, and itchy skin. The symptoms of pancreatic cancer can be confused with those of ...
Ironwood and Forest Present Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation
... pain, improvement was even more pronounced (-0.8 to -1.3
v -0.2; p = 0.0236 to <0.0001). Results for spontaneous bowel movement
(SBM) frequency, stool
consistency, straining, abdominal discomfort,
bloating, IBS symptom severity, and global assessments were statistically
significant for the 300 ug ...
Ironwood and Forest to Present Positive Data From Linaclotide Phase 2b IBS-C Study at ACG Annual Scientific Conference
... Linaclotide-treated patients also experienced
improvements in all other top-line efficacy endpoints-spontaneous bowel
movement (SBM) frequency, stool
consistency, bloating, abdominal
discomfort, adequate relief, and IBS-C symptom severity-and these
improvements were statistically significant for at ...
August 2008 Mayo Clinic Women's HealthSource Highlights Avoiding Blood Pressure Increase at Menopause, Healthful Benefits of Dark Chocolate and Scheduling a Colorectal Exam
... blood test
and fecal immunochemical test.
Two new colon cancer screenings are: CT colonoscopy (also called
virtual colonoscopy) and DNA-based stool
testing, a simple noninvasive exam
done at home.
Colonoscopy remains a preferred screening method. The doctor uses a
long, flexible lighted tube ...
BD Announces CE Marking of a New Molecular Test to Diagnose Patients with Clostridium difficile Infections
... which are difficult to perform and require several days to yield
"The BD GeneOhm Cdiff assay provides a simple and rapid stool
excellent sensitivity and specificity that allows same-day identification
of toxigenic Clostridium difficile," said Thomas Davis, M.D., ...
Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis
... response rate at 8 weeks. Clinical
response is based on the Mayo score, a composite endpoint that assesses
stool frequency and the amount of bloody stool
per day as recorded in a
patient diary, physician global assessment and the assessment of colon
mucosal inflammation ascertained by endoscopy.
NKTR-118 Shows Substantial Oral Bioavailability and Extended Half-Life in Phase 1 Clinical Data Presented at American Pain Society Meeting
... were written for opioids in 2007 in
the United States, alone.
Currently, there are no specific oral drugs approved that are indicated
to treat OIC. stool
softeners or laxatives may be ineffective for many
patients with OIC and they are often associated with side effects like
diarrhea and stomach ....
Oxygen Relieves IBS and Constipation Symptoms in New Clinical Studies
... Constipation Irritable Bowel Syndrome
Relief for Feelings of Blockage 99% Improvement 100% Improvement Improvement in stool
Quality 89% Improvement 100% Improvement Relief for Abdominal Pain (assoc. with change in frequency of stools) n/a ...
Surgeons Develop Innovative Life-Saving Treatments to Correct Massive Bleeding in Trauma Patients
... enough to fix. Once you get to
it, you sew it up and you control the bleeding. But what if you have an
injury to the abdomen and there is spillage of stool
in the abdomen or an
injury to the liver or the spleen that continues to spill blood? This study
looked at a realistic lifelike trauma scenario," Dr. ...
Positive Results for NKTR-118 (oral PEG-naloxol) Presented at American Academy of Pain Management Meeting
... significant constipation and other symptoms of OBD. Currently,
there are no specific drugs approved that are indicated to treat OBD or
softeners or laxatives may be ineffective for many patients with
OIC and they are often associated with side effects like diarrhea and
Phase 2a Diarrhea Predominant Irritable Bowel Syndrome Results from
2006 Presented at Digestive Disease Week in Washington, D.C.
... 50 years old.
IBS symptoms (pain, urgency, stool
frequency and consistency,
and adequate relief) ... baseline period as
defined by a mean daily stool
frequency greater than or equal to
2/day, pain score greater than or equal to 1 and stool
greater than or equal to 3 (5-point ...
Eurand's Zentase Effective in Treating Exocrine Pancreatic
Insufficiency, Studies Show
... on improving EPI symptoms including
consistency and symptom scores including measures ... notable for patients with
-- Improved Malabsorption ... In addition, Zentase treatment
frequency and oily stools vs baseline. The mean ...
Microbia Announces Positive Phase 2 Results for Its Investigational
... Patients receiving linaclotide also
showed significant improvements in stool
consistency (i.e., stools
were less hard), stool
frequency, straining, and time to first
bowel movement. Measurements of ...
AM-Pharma Announces Positive Results of Phase IIa Clinical Trial
with Alkaline Phosphatase For Ulcerative Colitis
... "returning towards normal", and
The Mayo score looks at stool
frequency, rectal bleeding,
findings of flexible proctosigmoidoscopy, and ... remission is defined as complete resolution of
stool frequency (normal stool
frequency), rectal bleeding (no
rectal bleeding), patient's functional ...
Eurand Announces Positive Phase III Clinical Study Results
without signs and symptoms of malabsorption after one and two weeks
of treatment. Secondary endpoints included weight change,
nutritional status, stool
frequency and consistency, incidences of
bloating, pain and flatulence as well as physician and parent or
guardian judgment of clinical symptoms ...
Callisto Intends to Move Guanilib into Clinical Trials in
... IL-23, and tumor necrosis factor (TNF), key cytokines that
are known to be involved in etiology of IBD in humans. Guanilib
treatment also improved stool
consistency and removed intestinal
blockage in treated animals.
"These are important findings and suggest a possible mechanism
of action of ...
Salix Pharmaceuticals Previews Digestive Disease Week 2007
... diarrhea caused by noninvasive strains of
Escherichia coli. XIFAXAN should not be used in patients with
diarrhea complicated by fever or blood in the stool
or diarrhea due
to pathogens other than Escherichia coli. XIFAXAN should be
discontinued if diarrhea symptoms get worse or persist more than
Analysis of Ulcerative Colitis (UC) Remission Rates from Long-term
Safety Study of Lialda (mesalamine) Presented at DDW
... and endoscopic criteria: modified UC
Disease Activity Index (UC-DAI) score of less than or equal to 1,
with scores of 0 for rectal bleeding and stool
combined Physician's Global Assessment and sigmoidoscopy score of
less than or equal to 1, with a sigmoidoscopy score reduction ...
Separate Sets of Research Show Treatment Improved Quality of Life
in as Early as Three Weeks; Patient Adherence to Medication is
... at week 6 in Physician Global Assessment score accompanied
by an improvement in at least one other clinical parameter (rectal
frequency, patient functional assessment, or
sigmoidoscopy) and no worsening in any of the remaining clinical
"The ultimate goals ...