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Stool in Medical Technology

Procter & Gamble Pharmaceuticals Launches Asacol(R) HD (mesalamine) Delayed-Release Tablets

... UC, Asacol HD helped reduce rectal bleeding and stool frequency, without the use of steroids. These ... the clinical assessments of rectal bleeding, stool frequency and sigmoidoscopy findings. The ... rapid improvement in rectal bleeding and stool frequency. At three weeks, rectal bleeding ...

Napo Announces Positive Clinical Data Indicating Crofelemer, Could Effectively Treat Cholera

... averaged approximately 8.5 liters of stool volume output during the first 24 hour period. ... endpoint in this study was the reduction in stool volume output normalized to the body weight of ... of 125 mg every 6 hours reduced the amount of stool volume output normalized to body weight by 32% ...

Analysis of Ulcerative Colitis (UC) Time to Symptom Resolution Data from Pivotal Study of LIALDA(TM) (mesalamine) Presented at DDW

... resolution (rectal bleeding or normalization of stool frequency or both) or the time between the ... resolution of rectal bleeding, normalization of stool frequency or both was assessed by a ... symptoms was defined for both rectal bleeding and stool frequency as a modified UC-DAI sub-score of 0. ...

Napo Announces Successful Clinical Results in Phase 2 Study of Crofelemer in Acute Adult Infectious Diarrhea

... The primary endpoints of the trial were stool weight, duration of diarrhea, stool frequency and stool consistency; additional endpoints ... three days. Details regarding the stool weight, stool ...

Microbia and Forest Laboratories Announce Preliminary Results of Linaclotide Phase 2b Studies

... other top-line efficacy endpoints-SBM frequency, stool consistency, abdominal pain, bloating, abdominal ... bowel movements (CSBM) compared to baseline, stool consistency using the Bristol stool Form Scale (BSFS), and straining. ...

Study Data Show Asacol(R) (Mesalamine) is Effective in Treating All Extents of Ulcerative Colitis Including Isolated Proctitis

... had mucosal healing and 57 percent had reduced stool frequency. These data were presented today at the ... left-sided disease experienced an improvement in stool frequency and 70 percent achieved mucosal ... with pancolitis, 70 percent had improvement of stool frequency and 71 percent experienced mucosal ...

Ironwood and Forest Present Additional Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

... in the first week (p<0.005). There was also significant improvement in stool frequency, stool consistency, straining, adequate relief, and global relief during the ...

Medarex Announces Primary Endpoint Achieved in MDX-1100 Anti-IP-10 Antibody Phase 2 Trial for Rheumatoid Arthritis

... response is based on the Mayo score, a composite endpoint that assesses stool frequency and the amount of bloody stool per day as recorded in a patient diary, physician global assessment and ...

Tioga Pharmaceuticals' Asimadoline Demonstrates Positive Results in a Phase 2b Clinical Trial for the Treatment of Irritable Bowel Syndrome

... secondary endpoints: urgency, adequate relief of IBS symptoms, stool frequency, bloating and daily pain. Statistically significant ... least three weeks per month. The secondary endpoints were abdominal pain, stool frequency and consistency, urgency, bloating, adequate relief of IBS ...

Ironwood Pharmaceuticals and Forest Laboratories Announce Presentation of Linaclotide Phase 2b Chronic Constipation Study Results

... SBMs and CSBMs compared to baseline, stool consistency using the Bristol stool Form Scale (BSFS), and straining. Patient-reported outcomes included ... by the patient self-reporting a feeling of complete evacuation. Bristol stool Form Scale (BSFS): A seven-point scale measuring stool consistency. BSFS ...

Safety and Efficacy Results Presented From Largest Prospective Controlled Clinical Study of Ulcerative Colitis

... the PGA (which was based on the clinical assessments of rectal bleeding, stool frequency, and sigmoidoscopy) and no worsening in any of the individual ... efficacy in secondary endpoints: clinical remission, rectal bleeding, stool frequency and sigmoidoscopy improvement. About Ulcerative Colitis (UC) ...

New Analysis of Study Data Shows That Asacol(R) (Mesalamine) Delivers Rapid Symptom Relief for Ulcerative Colitis Patients

... three consecutive days of resolution of both rectal bleeding and increased stool frequency. The time to clinical remission endpoint utilized in this ... was defined as resolution (score=0) of both rectal bleeding (RB) and stool frequency (SF). Resolution of RB was defined as the absence of visible ...

New Analyses of Long-Term LIALDA(TM) (mesalamine) Data Presented at ACG

... score of less than or equal to 1 with scores of 0 for rectal bleeding and stool frequency, a combined Physician's Global Assessment and sigmoidoscopy ... initial symptom resolution of rectal bleeding and normalization of stool frequency. Patients with active, mild-to-moderate UC were randomized to ...

Advance in Bowel Cancer Test Research

... test for detecting bowel cancer and significant pre-cancer lesions. "If we can now show that the levels of these biomarkers in blood or stool also correlate strongly with disease state in a large group of patients with cancer or pre-cancer lesions (ie adenomatous polyps) we may have the ...

Clinical Genomics Continues Progress in Developing Biomarker Portfolio for Colorectal Cancer Testing

... Enterix Inc., manufacturer of the FDA- cleared InSure(R) fecal immunochemical test (FIT) for aiding the detection of colorectal cancer based on stool testing. Quest Diagnostics also made an equity investment in Clinical Genomics, which was formed as a spin off from Enterix's research and ...

Mission Pharmacal Launches CitraNatal(R) Assure Prescription Prenatal Vitamin

... during pregnancy, a gentle dual-iron formulation of carbonyl iron and ferrous gluconate for gentle absorption, tolerability and safety, and a stool softener to help ease constipation often associated with pregnancy. The CitraNatal family of products offers four unique formulations of ...

ASGE and The Pancreatic Cancer Action Network Partner to Raise Awareness About Pancreatic Cancer

... in the pancreas can block the flow of these substances into the small intestine. This can cause the skin and eyes to turn yellow (jaundice) and the stool to turn pale. It can also cause pain, weight loss, nausea, vomiting, and itchy skin. The symptoms of pancreatic cancer can be confused with those of ...

Ironwood and Forest Present Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

... pain, improvement was even more pronounced (-0.8 to -1.3 v -0.2; p = 0.0236 to <0.0001). Results for spontaneous bowel movement (SBM) frequency, stool consistency, straining, abdominal discomfort, bloating, IBS symptom severity, and global assessments were statistically significant for the 300 ug ...

Ironwood and Forest to Present Positive Data From Linaclotide Phase 2b IBS-C Study at ACG Annual Scientific Conference

... Linaclotide-treated patients also experienced improvements in all other top-line efficacy endpoints-spontaneous bowel movement (SBM) frequency, stool consistency, bloating, abdominal discomfort, adequate relief, and IBS-C symptom severity-and these improvements were statistically significant for at ...

August 2008 Mayo Clinic Women's HealthSource Highlights Avoiding Blood Pressure Increase at Menopause, Healthful Benefits of Dark Chocolate and Scheduling a Colorectal Exam

... blood test and fecal immunochemical test. Two new colon cancer screenings are: CT colonoscopy (also called virtual colonoscopy) and DNA-based stool testing, a simple noninvasive exam done at home. Colonoscopy remains a preferred screening method. The doctor uses a long, flexible lighted tube ...

BD Announces CE Marking of a New Molecular Test to Diagnose Patients with Clostridium difficile Infections

... which are difficult to perform and require several days to yield results. "The BD GeneOhm Cdiff assay provides a simple and rapid stool test with excellent sensitivity and specificity that allows same-day identification of toxigenic Clostridium difficile," said Thomas Davis, M.D., ...

Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis

... response rate at 8 weeks. Clinical response is based on the Mayo score, a composite endpoint that assesses stool frequency and the amount of bloody stool per day as recorded in a patient diary, physician global assessment and the assessment of colon mucosal inflammation ascertained by endoscopy. ...

NKTR-118 Shows Substantial Oral Bioavailability and Extended Half-Life in Phase 1 Clinical Data Presented at American Pain Society Meeting

... were written for opioids in 2007 in the United States, alone. Currently, there are no specific oral drugs approved that are indicated to treat OIC. stool softeners or laxatives may be ineffective for many patients with OIC and they are often associated with side effects like diarrhea and stomach ....

Oxygen Relieves IBS and Constipation Symptoms in New Clinical Studies

... Constipation Irritable Bowel Syndrome Relief for Feelings of Blockage 99% Improvement 100% Improvement Improvement in stool Quality 89% Improvement 100% Improvement Relief for Abdominal Pain (assoc. with change in frequency of stools) n/a ...

Surgeons Develop Innovative Life-Saving Treatments to Correct Massive Bleeding in Trauma Patients

... enough to fix. Once you get to it, you sew it up and you control the bleeding. But what if you have an injury to the abdomen and there is spillage of stool in the abdomen or an injury to the liver or the spleen that continues to spill blood? This study looked at a realistic lifelike trauma scenario," Dr. ...

Positive Results for NKTR-118 (oral PEG-naloxol) Presented at American Academy of Pain Management Meeting

... significant constipation and other symptoms of OBD. Currently, there are no specific drugs approved that are indicated to treat OBD or OIC. stool softeners or laxatives may be ineffective for many patients with OIC and they are often associated with side effects like diarrhea and cramping. ...

Phase 2a Diarrhea Predominant Irritable Bowel Syndrome Results from 2006 Presented at Digestive Disease Week in Washington, D.C.

... 50 years old. IBS symptoms (pain, urgency, stool frequency and consistency, and adequate relief) ... baseline period as defined by a mean daily stool frequency greater than or equal to 2/day, pain score greater than or equal to 1 and stool consistency greater than or equal to 3 (5-point ...

Eurand's Zentase Effective in Treating Exocrine Pancreatic Insufficiency, Studies Show

... on improving EPI symptoms including stool consistency and symptom scores including measures ... notable for patients with abnormal stool at baseline. -- Improved Malabsorption ... In addition, Zentase treatment decreased stool frequency and oily stools vs baseline. The mean ...

Microbia Announces Positive Phase 2 Results for Its Investigational Compound Linaclotide

... Patients receiving linaclotide also showed significant improvements in stool consistency (i.e., stools were less hard), stool frequency, straining, and time to first bowel movement. Measurements of ...

AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis

... "returning towards normal", and gaining weight. The Mayo score looks at stool frequency, rectal bleeding, findings of flexible proctosigmoidoscopy, and ... remission is defined as complete resolution of stool frequency (normal stool frequency), rectal bleeding (no rectal bleeding), patient's functional ...

Eurand Announces Positive Phase III Clinical Study Results

... and without signs and symptoms of malabsorption after one and two weeks of treatment. Secondary endpoints included weight change, nutritional status, stool frequency and consistency, incidences of bloating, pain and flatulence as well as physician and parent or guardian judgment of clinical symptoms ...

Callisto Intends to Move Guanilib into Clinical Trials in Ulcerative Colitis

... IL-23, and tumor necrosis factor (TNF), key cytokines that are known to be involved in etiology of IBD in humans. Guanilib treatment also improved stool consistency and removed intestinal blockage in treated animals. "These are important findings and suggest a possible mechanism of action of ...

Salix Pharmaceuticals Previews Digestive Disease Week 2007

... diarrhea caused by noninvasive strains of Escherichia coli. XIFAXAN should not be used in patients with diarrhea complicated by fever or blood in the stool or diarrhea due to pathogens other than Escherichia coli. XIFAXAN should be discontinued if diarrhea symptoms get worse or persist more than 24-48 ...

Analysis of Ulcerative Colitis (UC) Remission Rates from Long-term Safety Study of Lialda (mesalamine) Presented at DDW

... and endoscopic criteria: modified UC Disease Activity Index (UC-DAI) score of less than or equal to 1, with scores of 0 for rectal bleeding and stool frequency, a combined Physician's Global Assessment and sigmoidoscopy score of less than or equal to 1, with a sigmoidoscopy score reduction ...

Separate Sets of Research Show Treatment Improved Quality of Life in as Early as Three Weeks; Patient Adherence to Medication is Multifactorial

... at week 6 in Physician Global Assessment score accompanied by an improvement in at least one other clinical parameter (rectal bleeding, stool frequency, patient functional assessment, or sigmoidoscopy) and no worsening in any of the remaining clinical features. "The ultimate goals ...
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