Research Teams at J. Craig Venter Institute and Ludwig Institute for Cancer Research Uncover New Chromosomal Alterations in Cancer Using Transcriptome Sequencing Approach

... cancer cell line by using 454 Life Sciences sequencing technology. The work, led by Qi Zhao of JCVI and ... and cost efficiencies of next generation DNA sequencing technologies are enabling this more precise and ... cancer. By conducting the in-depth transcript sequencing in this study and comparing these data to the ...

Complete Genomics and the Institute for Systems Biology Announce Partnership to Conduct the First Human Genome Population Study

... Complete Genomics will use its proprietary DNA sequencing technology to sequence five genomes from samples ... in 2010. "Using Complete Genomics' human genome sequencing services to gather populationwide human genetic ... "This collaboration demonstrates the value of our sequencing service business model and underscores our vision ...

Microarray Sequence Capture Speeds Large-Scale Resequencing of Targeted Genomic Regions

... capture technology, Baylor's Human Genome sequencing Center (HGSC) has signed on as an early access ... the gap between next-generation DNA sequencing technology and current sample preparation methods ... genomic regions for downstream analysis. 454 sequencing technology is ideal for this ...

Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week

... and Eusociality", and "Whole-Genome Shotgun sequencing of Mitochondria from Ancient Hair Shafts" appear ... publications illustrate the flexibility of 454 sequencing and its ability to deliver scientifically ... Behavior and Eusociality," researchers used 454 sequencing to examine messenger RNA from the brains of wasps ...

454 Sequencing(TM) in Science Today: Researchers Uncover a Genetic Basis for Different Social Behaviors in Wasps

... sequencing. Specific applications include de novo sequencing and re-sequencing of whole genomes, metagenomics, RNA analysis, and targeted sequencing of DNA regions of interest. The hallmarks of 454 ... sequence reads, including paired reads. 454 sequencing technology has enabled many peer-reviewed studies ...

Researchers Identify Virus Possibly Responsible for Declining Honeybee Population Using 454 Sequencing Technology from Roche

... ahead of print, in the journal Science. Using 454 sequencing technology, Dr. Ian Lipkin, Professor ... is a significant marker for CCD." "Unbiased 454 sequencing technology enabled us to rapidly assemble ... of 454 Life Sciences. "The chief advantage of 454 sequencing technology is how it quickly enables researchers ...

First Jatropha Genome Completed by Synthetic Genomics Inc. and Asiatic Centre for Genome Technology

... it an ideal subject for genetically engineered improvements. The sequencing of the genome, using both traditional Sanger sequencing and next generation sequencing, has revealed that the jatropha genome is ...

SeqWright's Clinical Trial Support Contributes to the Approval of Two HPV Diagnostic Systems

... in vitro diagnostic tests. SeqWright provided FDA submission quality DNA sequencing of multiple HPV strains and bioinformatics support to validate two Hologic ... Practices (GLPs) as specified in the Code of Federal Regulations. sequencing for Hologic's clinical trials was performed under GLP guidelines ...

Video: Femara(R) First Aromatase Inhibitor to Indicate Survival Benefit Versus Tamoxifen When Taken for Five Years After Breast Cancer Surgery

... during the first five years following breast cancer surgery and the sequencing of both agents to determine the most effective approach to minimizing the ... of Femara after surgery. This analysis (from randomization) revealed that sequencing hormone therapy following surgery is not superior to five years of Femara ...

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

... (14.5%) of 124 cervical scraping samples that were positive by HC2 for high-risk HPV were negative by PCR-MS. In all these cases, degenerate DNA sequencing failed to detect any of the 13 high-risk HPV types included in the HC2 test, reflecting false positive results in the HC2 test. ...

Fruitfly Model of a Neuropathic Disease Demonstrates Novel Role for Proteins in the Family of aTyr Pharma's Product Class

... emerging in early adulthood, including loss of muscle mass, pain and sensitivity, foot deformations and difficulties in walking. Human genome sequencing revealed that some CMT patients have mutations in a gene encoding tyrosyl-tRNA synthetase. While tRNA synthetases play an essential role in protein ...

deCODE-led Megastudy Finds New Genetic Clues to Causes of Schizophrenia

... fact that rare variants may well carry a significant part of the genetic risk of schizophrenia, so our next task is to use the ever more affordable sequencing technologies to find more of them," said Kari Stefansson, CEO of deCODE and corresponding author on the paper. In the first phase of the ...

Siemens Corporate Research Develops RAPID2 System for Fast Discovery of Discriminative Pathogen Signatures

... process for the development of rapid diagnostic tests. This system marries the power of information technology with today's improved genomic sequencing to quickly identify genomic signatures unique to the set of organisms to be detected. These signatures are the foundation for a new generation of ...

PTC Therapeutics Completes Enrollment of Pivotal Trial in Muscular Dystrophy

... States, Europe, Canada, Australia, and Israel. "This trial represents a critical milestone for the entire DMD/BMD community - 20 years after sequencing the dystrophin gene we have the first pivotal study for a potential disease-modifying therapy," said Brenda Wong, MD, associate professor of ...

Gene Abnormality Found to Predict Childhood Leukemia Relapse

... leukemia (i.e. a high chance of relapse) who had been treated in an existing COG study. They conducted their analysis using microarrays and DNA sequencing -- technologies which allow researchers to quickly and efficiently identify and analyze multiple genes simultaneously in the same cell. Using these ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... include: New data, presented in an oral session, from major international BIG 1-98 trial evaluating Femara vs. tamoxifen and the sequencing of the two therapies show evidence of optimal treatment strategy for postmenopausal women with breast cancer (SABCS Abstract #13; Thursday, ...

Rubicon Provides Genome Amplification for the Cancer Genome Atlas Project

... (IGC) is a non-profit medical research foundation established to expand upon the discoveries of the Human Genome Project and other systematic sequencing efforts by combining world- class genomic research, bioinformatics, and diagnostic technologies in the fight against cancer and other complex genetic ...

febit and TGen Collaborate to Study New DNA Capture Method

... the efficient selection capabilities of Geniom Technology. "We are delighted to have TGen as our first U.S. pilot user of HybSelect with the latest sequencing instrumentation," said Cord F. Staehler, president of febit. "We will obtain important data from TGen that will help us as we prepare for the ...

Transgenomic Establishes Collaboration With the National Cancer Institute to Investigate Mitochondrial Genome and Associated Nuclear Genes in Cancer Cell Lines

... genetic analysis and services company, today announced the National Cancer Institute had approved a proposal to perform mutational analysis and sequencing of the mitochondrial genes in the NCI 60 cancer cell line panel. Mitochondrial damage is increasingly recognized as an early warning signal in ...

Major Deficiencies in Design; Funding of Clinical Trials Affects Future of Scientific Innovation

... the influence of genetic and non-genetic factors on individual and group responses to treatments, now possible as a result of the successful sequencing of the human genome. Findings from the large amount of genetic data generated to date show that more than 90 percent of the observed genetic ...

Genetic Analysis Systems Enter the Clinical Mainstream

... genetic analyzer designed for a wide range of sequencing and fragment analysis applications and suitable ... users to automate applications from de novo sequencing to SNP validation and linkage mapping. ... the system. Optional software packages support sequencing analysis and gene mapping. The optional MicroSeq ...

Vertex Pharmaceuticals Announces New Data for Investigational HCV Protease Inhibitor Telaprevir to be Presented at 42nd Annual Meeting of the European Association for the Study of the Liver (EASL)

... treatment duration, and in vivo and in vitro viral replication and viral sequencing dynamic modeling studies that suggest telaprevir-resistant variants have ... treatment duration; (iii) in vivo and in vitro viral replication and viral sequencing dynamic modelling studies suggest that telaprevir-resistant variants have ...

Newly Published Study Reveals Femara Improves Chances for Harder to Treat Early Breast Cancer Relapse in Postmenopausal Women

... physicians will be eagerly awaiting the results of the BIG 1-98 sequencing arms, which hope to indicate the optimal strategy for using Femara post ... only clinical trial that incorporates both a head-to-head comparison and a sequencing of Femara and tamoxifen as adjuvant treatment for postmenopausal women ...

ViroPharma Announces Presentation of Additional HCV-796 Data at Meeting of The European Association for the Study of the Liver

... toxicities were identified across the range of study doses. Genetic sequencing NS5B sequencing was performed on 36 subjects (11 on peg-IFN alone; 25 HCV- 796 and ...

Researchers Identify New Genetic Risk Factors for Type 2 Diabetes

... identify the complex genetic factors involved in common diseases, such as type 2 diabetes. Now, thanks to the tools and technologies generated by the sequencing of the human genome and subsequent mapping of common human genetic variations, we finally are making significant progress,” said NHGRI Director ...

Enzo Biochem Individualized Oral Immune Regulation Therapy May Be Effective Approach to Treating Crohn's Disease

... techniques, as well as providing diagnostic services to the medical community. The company's proprietary labeling and detection products for gene sequencing and genetic analysis are sold to the life sciences market throughout the world. Enzo Biochem owns or licenses over 200 patents worldwide. Except ...

Promising Data on Cognitive Effects of Safinamide in Early Parkinson's Disease

... screen. The participant must learn which target is correct by choosing one of the stimuli following computer-generated feedback. 3 Auditory Number sequencing (attention, working memory, executive function): Subjects hear a series of numbers (e.g. “9.. 3.. 6“; minimum=2 digits, maximum=8 digits) ...