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Sequence in Medical Technology

Raptor Pharmaceuticals Provides Update on Targeting Platforms

... with Brigham and Women's Hospital focuses on RAP sequence variants engineered for improved binding affinity ... and researchers at Raptor will test RAP sequence variants designed to withstand temperatures, pH ... Blacklow's lab to develop effective RAP-based sequence variants that could increase the utility of ...

Panacea Pharmaceuticals Announces Issuance of a U.S. Patent Covering Anti-HAAH Antibodies

... Panacea is developing PAN-622, an all-human sequence anti-HAAH monoclonal antibody covered under this ... the efficacy of PAN-622, an all-human sequence anti-HAAH monoclonal antibody, in animal models ... Institute of Technology. "PAN-622 as an all-human sequence monoclonal antibody is particularly exciting, and ...

Microarray Sequence Capture Speeds Large-Scale Resequencing of Targeted Genomic Regions

... In light of the success of the current sequence capture technology, Baylor's Human Genome ... as an early access customer to Roche NimbleGen's sequence capture technology. As presented on October 10, ... PCR is limited in the length of sequence it can amplify, is difficult to scale or ...

NOVAVAX Achieves Pandemic H1N1 Influenza Production Milestone

... This milestone was accomplished in only 11 weeks after receiving the gene sequence for the H1N1 strain from the U.S. Centers for Disease Control. The ... countries. A detailed timeline describing the process from gene sequence to cGMP manufacturing is available on the Novavax website ...

AlphaVax Announces Results from Initial Testing of Its H1N1 (Swine) Influenza Vaccine

... The studies performed at AlphaVax utilized the California 04/2009 HA sequence obtained from the WHO GISAID database on April 25th. Mice inoculated with ... which is less than three full months from our initial receipt of the gene sequence from the WHO. We are currently scaling up the process used to manufacture ...

Swine Flu (H1N1) Infectivity to Increase Markedly and Lethality to Remain Low According to Latest Replikin* Peptide Genomic Data

... ( www.replikins.com ) last week analyzed the most recent peptide genomic sequence data available and determined that the infectivity of the H1N1 virus will ... future. The company's quantitative analysis of the most recent sequence data available on PubMed, a standard scientific repository for published ...

First Jatropha Genome Completed by Synthetic Genomics Inc. and Asiatic Centre for Genome Technology

... Accomplishment for Partners who Announced Complete Oil Palm Genome sequence in 2008 LA JOLLA, Calif. and KUALA LUMPUR, Malaysia, May 20 ... life around the jatropha tree using environmental genomic techniques to sequence and analyze jatropha's root, soil and leaf bacterial and fungal ...

deCODE Receives California Clinical Laboratory License

... underpins deCODE's global leadership in the discovery of variations in the sequence of the human genome conferring risk of common diseases. The same staff and ... on deCODE's global leadership in the discovery of common variations in the sequence of the human genome conferring increased risk of common diseases. ...

J. Craig Venter, Ph.D. Receives Double Helix Medal from Cold Spring Harbor Laboratory

... That publication was the first human genome publication since the first sequence and analysis of the human genome published in Science in 2001 by Dr. ... and his team are continuing to analyze his genome and are planning to sequence and analyze hundreds to thousands of genomes over the next decade. He has ...

Complete Genomics and the Institute for Systems Biology Announce Partnership to Conduct the First Human Genome Population Study

... Complete Genomics will use its proprietary DNA sequencing technology to sequence five genomes from samples provided by ISB. Then, once proof-of-concept has ... ISB and Complete Genomics plan to expand this collaboration to sequence the genomes of 100 individuals in 2009 and 2,000 individuals in 2010. ...

Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of 'Knock-Out' Cell Lines

... knocked out. ZFNs were used to place a double strand break in the DNA sequence precisely within the gene to be eliminated. The process then takes ... proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can ...

Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week

... research and development at 454 Life Sciences. "Researchers were able to sequence ancient and degraded DNA, obtain a paired-end map of structural variation ... are its simple, unbiased sample preparation and long, highly accurate sequence reads, including paired reads. 454 Sequencing technology has enabled many ...

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo also is ...

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

... and allelotyping, copy number variation analysis, quantitative gene expression analysis, quantitative methylation marker analysis, comparative sequence analysis of haploid organisms, SNP discovery, and oligonucleotide quality control. About SEQUENOM SEQUENOM is a life sciences company ...

deCODE-led Megastudy Finds New Genetic Clues to Causes of Schizophrenia

... -- The largest study of the genetics of schizophrenia ever undertaken has revealed several new common single-letter variants in the sequence of the human genome (SNPs) linked to risk of the disease. The study, by a multinational consortium of scientists led by a team from deCODE genetics ...

New Data Supports Significant Economic and Clinical Value of MENOPUR(R) in IVF

... (4) incremental cost-effectiveness; (5) impact of inclusion of maternal and neonatal costs arising from successful pregnancies. After a sequence of one fresh and up to two frozen or fresh cycles, the cumulative live-birth rate was 53.7% for HP-hMG and 44.6% for rFSH (p<0.005). The use of ...

Sangamo BioSciences Announces Achievement of Key Milestone in Cell Engineering Agreement With Genentech

... zinc finger DNA-binding protein (ZFP) technology for therapeutic gene regulation and modification. By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also ...

Cephalon Provides Clinical Update on Lestaurtinib in Relapsed Acute Myelogenous Leukemia

... (AML) expressing FLT3 activating mutations. The study was designed to show the benefit of lestaurtinib in this patient population when given in sequence with standard induction chemotherapy compared to those treated with standard induction chemotherapy alone. An analysis of the study showed that ...

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

... novel T-cell modulation platform technology that enables CEL-SCI to design and synthesize proprietary immunogens. Any disease for which an antigenic sequence has been identified, such as infectious, parasitic, malignant or autoimmune diseases and allergies, are potential therapeutic or preventive sites for ...

Siemens Corporate Research Develops RAPID2 System for Fast Discovery of Discriminative Pathogen Signatures

... bacteria. "The advantage of our RAPID2 system is that it provides an efficient framework for quickly identifying new biomarkers based on the genomic sequence of a particular pathogen," says Dr. Wittenberg. "In the event of a pandemic, such as the recent H1N1 Flu outbreak, our system would enable a rapid ...

Smithfield Sends Update to Employees on Testing Process at Veracruz Joint Venture

... we submitted samples from our farm in Veracruz for further testing under the direction of Mexican governmental authorities, including genetic sequence analysis that will determine what, if any, strains of flu are present. The results will enable us to conclude with certainty that the A(H1N1) strain ...

Sangamo BioSciences Announces Presentations at Two Upcoming Investor Conferences

... engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also ...

Adlyfe Strikes Translational Medicine Partnership With Wyeth Pharmaceuticals for Alzheimer's Biomarker Assay

... Venture Partners. The Company's novel technology is based on the synthesis of small peptides, or Pronucleon(TM) peptides, that are amino acid sequence matched to target amyloids of interest. Ligand sequences are selected based on regions of the target protein known to undergo conformational changes ...

deCODE Breakthrough in Thyroid Cancer May Enable More Targeted Risk Assessment and Earlier Intervention

... Feb. 6 /PRNewswire-FirstCall/ -- Scientists at deCODE genetics (Nasdaq: DCGN ) today present the discovery of two single letter variations in the sequence of the human genome (SNPs) conferring substantial increased risk of thyroid cancer. The two SNPs, located on chromosomes 9q22 and 14q13, are the ...

Modigene Announces Positive Results of Pilot Toxicity Study of Its Long-Acting Human Growth Hormone hGH-CTP

... ABOUT CTP Modigene's CTP technology was discovered by researchers at Washington University in St. Louis and is based on a short amino acid sequence that occurs naturally in humans, the carboxyl terminal peptide (CTP). When attached to a therapeutic protein, CTP extends the time that the protein ...

MRI Emerges As Vital Resource in Treatment of Back Pain

... ways to gather this important information, MRI can be used to identify or display almost every type of spinal tissue or pathology. The imaging sequence can be modified to meet many different clinical needs." Those include: Back pain Infection Tumor Trauma and ...

Quality Colonoscopy Exam Remains Best Strategy for Detection of Polyps and Cancers According to Experts From the American College of Gastroenterology

... colonoscopy," commented Dr. Quigley. "Because of its excellent sensitivity in detecting polyps and its potential for removing them and breaking the sequence of polyp to cancer in a single diagnostic and therapeutic intervention, colonoscopy is one of the most powerful preventive tools in clinical ....

Major deCODE-led Study Underscores Role of the Brain in Obesity

... genome analysis service, and subscribers will receive an update to their personal profiles. The paper, entitled "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity," is published today in the online edition of Nature Genetics at ...

Video: Femara(R) First Aromatase Inhibitor to Indicate Survival Benefit Versus Tamoxifen When Taken for Five Years After Breast Cancer Surgery

... please visit http://www.novartis.com . References 1. Mouridsen H for the BIG 1-98 Collaborative Group, Letrozole Alone or in sequence with Tamoxifen for Postmenopausal Women with Early Breast Cancer. Presented at: the 31st Annual Meeting of the CTRC-AACR San Antonio Breast Cancer ...

Neuronetrix Announces Preliminary Alzheimer's Study Results at the Society for Neuroscience Conference

... Center for Aging. The COGNISION(TM) System uses event-related potentials (ERP) to record brain activity while the patient listens to a sequence of sounds. Subjects with Alzheimer's process auditory information differently than healthy individuals and that difference can be detected with the ...

Sangamo BioSciences Provides Update on Company's 2008 Progress and 2009 Objectives

... engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also ...

GeneThera Announces it is Set to Begin Commercial Testing for Johne's Disease as Soon as January, 2009.

... It is the method of choice to quantitatively measure starting amounts of DNA, cDNA or RNA. PCR is therefore often used to determine whether a DNA sequence is present in a sample and the number of its copies in the sample. Another advantage of Real-Time PCR is rapidity of the assay, since it is not ...

Grapes May Aid a Bunch of Heart Risk Factors, U-M Animal Study Finds

... who have high blood pressure related to diet, and who develop heart failure over time because of prolonged hypertension. "The inevitable downhill sequence to hypertension and heart failure was changed by the addition of grape powder to a high-salt diet," he says. "Although there are many natural ...

Despite Advances in the Accuracy of CT Colonography in Detecting Polyps, Digestive Health Experts Urge Patients to Consider Risks and Realities

... reduces colorectal cancer mortality. Because of its excellent sensitivity in detecting polyps and its potential for removing them and breaking the sequence of polyp to cancer in a single diagnostic and therapeutic intervention, complete colonoscopy is one of the most powerful preventive tools in ...

New Research Shows Physical Therapy as Effective as Arthroscopic Knee Surgery

... designed to help improve motion. Activities in this phase might include water walking, swimming, and flexibility exercises. -- An exercise sequence to restore strength including a functional progression, that is, a gradual return to normal activities using exercises that simulate the knee ...

Data Suggest CEL-SCI's CEL-2000 Vaccine Prevents or Retards Permanent Damage of Rheumatoid Arthritis

... novel T-cell modulation platform technology that enables CEL-SCI to design and synthesize proprietary immunogens. Any disease for which an antigenic sequence has been identified, such as infectious, parasitic, malignant or autoimmune diseases and allergies, are potential therapeutic or preventive sites for ...

Sangamo BioSciences Initiates Phase 2 Clinical Trial of Treatment for Amyotrophic Lateral Sclerosis (ALS)

... engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also ...

deCODE and SGENE Consortium Discover Deletions in the Human Genome Linked to Risk of Schizophrenia

... States, report the discovery of three rare deletions in the human genome that confer risk of schizophrenia. Such deletions are gaps in the normal sequence of the genome that can arise spontaneously during the recombination or reshuffling of the genome that takes place in the creation of sperm and eggs. ...

Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant T Cells

... engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) that can control gene expression and, consequently, cell function. Sangamo is also ...

FDA Files Application To Convert ONTAK(R) (Denileukin Diftitox) to Full Approval for Use in Cutaneous T-Cell Lymphoma (CTCL)

... engineered fusion toxin protein consisting of the amino acid sequences for the enzymatically-active portion of diphtheria toxin fused to the sequence of human interleukin-2, resulting in a molecule that is cytotoxic for cells bearing the target IL-2 receptor. ONTAK is indicated for the treatment ...
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(Date:9/15/2014)... evolution experiment scientists from GEOMAR Helmholtz Centre for ... Sea Fisheries have demonstrated for the first time, ... the world,s oceans, Emiliania huxleyi , can ... temperatures. In their study, the researchers found no ... to these two aspects of climate change would ...
(Date:9/15/2014)... that the proteins in our cells cooperate with one ... tens of thousands of different proteins find the correct ... human body, brain and nervous system. A recent breakthrough ... busted down the door and provided a look at ... , Professor emeritus Jens Jrgen Led of the University ...
(Date:9/15/2014)... September 15, 2014: Globally, cardiovascular disease (CVD) claims 17 ... pressure take an additional 9.4 million. 1 New ... Fed Lipid Congress in Montpellier, France on September 15, ... a beneficial role. , At the Milk ... association between milk and risk for hypertension and CVD ...
Breaking Biology News(10 mins):Small algae with great potential 2Small algae with great potential 3Protein courtship revealed through chemist's lens 2Protein courtship revealed through chemist's lens 3Dairy consumption linked to lower blood pressure and cardiovascular disease risk 2
(Date:9/16/2014)... Dotinga HealthDay Reporter , MONDAY, ... baldness may face a higher risk of developing an aggressive ... new study suggests. But, the study authors noted that ... of baldness should be concerned. Their study only found an ... did not prove cause and effect. "It is conceivable ...
(Date:9/16/2014)... After working together for eight years and ... fertility centers in the late 1990s and early 2000s, Dr. ... hometown of New York City to launch Chelsea Fertility of ... , Chelsea Fertility NYC offers full service fertility treatment ... New York Tri-State Area, and provides equal access to care ...
(Date:9/16/2014)... New Jersey (PRWEB) September 16, 2014 ... Infinity Development Partners of San Antonio, TX. has been ... Army facilities located throughout the US, including Alaska and ... Army’s Energy Initiatives Task Force (EITF) and the Corps ... a $7 Billion MATOC primarily to fund renewable and ...
(Date:9/16/2014)... Alachua, FL (PRWEB) September 16, 2014 ... technology company focused on the peripheral nerve repair market, ... the American Society for Surgery of the Hand (ASSH) ... John B. Hynes Convention Center in Boston, MA. , ... outcomes in surgical nerve repair, featuring a discussion by ...
(Date:9/16/2014)... September 16, 2014 Much of the ... major extended drought crisis that in many regions affects ... the many individuals who are dedicated to solving the ... solutions overlook large portion of the problem. Partial solutions, ... crises.     , Grigg explained his, “total water management” concept ...
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