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Sepsis in Medical Technology

Sirius Genomics Announces New Collaboration with Assistance Publique-Hopitaux de Paris

... (AP-HP) to study genomic correlations in severe sepsis patients. The agreement focuses on the continued ... the trademark Xigris (R)) in patients with severe sepsis at high risk of death. "Access to AP-HP's severe sepsis patients will be critical in the validation of ...

Agennix Initiates A Randomized Double-Blind, Placebo-Controlled Phase 2 Study of Oral Talactoferrin in Severe Sepsis

... is the first clinical trial of talactoferrin in sepsis and is based on both the mechanism of action of ... of deaths in patients with severe sepsis." sepsis is a clinical syndrome defined by the presence of ... cytokine surge induced by endotoxin. "Severe sepsis is a serious medical condition that is associated ...

Spectral presents data on the clinical utility of EAA(TM) at 13th Annual Critical Care for Endotoxemia conference in Japan

... product in the United States." Debra Foster, Director of Spectral's sepsis Program, presented data on the use of EAA(TM) in the management of intra-abdominal sepsis following surgical intervention. Following the conference, these findings ...

ERBITUX(R) Meets Primary Endpoint of Increasing Survival in Phase III Lung Cancer Study

... of severe dermatologic toxicities, complications including S. aureus sepsis and abscesses requiring incision and drainage were reported. Sun exposure ... dermatologic toxicity (1%), interstitial lung disease (0.4%), fever (5%), sepsis (3%), kidney failure (2%), pulmonary embolus (1%), dehydration (5% in ...

Great Basin Scientific, Inc. Raises $3.6 Million in Bridge Funding to Prepare for Launch of First Product

... In addition to its first product for MRSA testing, the company is also developing tests for Group B Streptococcus - the most common cause of sepsis and meningitis in newborns, and Human Papilloma Virus (HPV), the most common sexually transmitted infection of which certain types can lead to ...

Two New Clinical Studies Show That Limited Exposure to Blood Transfusion Significantly Increases Morbidity and Mortality After Surgery

... transfusion of 1U to 2U of packed red blood cells is associated with increased 30-day mortality, surgical site infection, pneumonia, and sepsis in general surgery patients. Journal of the American College of Surgeons. 2009; 208:931-937. (2) Surgenor SD et al, for the Northern New ...

IMPACT Study Showed Longer Valcyte(R) (valganciclovir hydrochloride tablets) Treatment Demonstrated Better Protection Against Cytomegalovirus (CMV) Disease One Year Post-Transplant

... with Valcyte, occurred in the 100-day treatment group and took place in France, Belgium and Romania. They were attributed to hemorrhage (one), sepsis (one) or septic shock (two). About CMV CMV belongs to the family of herpes viruses and, as such, is very common among the general ...

Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer

... and/or VELCADE - Persistent severe myelosuppression may result in superinfection, neutropenic fever, or hemorrhage - sepsis occurring during neutropenia has resulted in discontinuation of treatment and in rare cases of death * DOXIL may potentiate the ...

Phase III Trial Results Show Elitek(R) (rasburicase) Significantly Reduced Plasma Uric Acid Levels versus Allopurinol in Adults with Hematologic Cancers at Risk for Tumor Lysis Syndrome

... 1% of which were Grade 3 or higher. The most common serious adverse reactions regardless of the relationship to the study drug were neutropenic sepsis (5.4% / 1.1% / 3.3%), neutropenic infection (5.4% / 4.3% / 8.8%), and febrile neutropenia (4.3% / 3.3% / 5.5%), pulmonary hemorrhage (1.1% / 3.3% / ...

Cepheid Molecular Diagnostic Test for Positive Blood Culture Bottles Categorized 'Moderate Complexity' by FDA

... MRSA/SA BC processes positive blood culture specimens to determine if a patient's blood is infected with MRSA or SA, which are frequent causes of sepsis in hospitalized patients. This may enable physicians to quickly de-escalate from broad-spectrum antibiotic treatment to a more effective targeted ...

Continuous Treatment With Abbott's HUMIRA(R) Achieves Superior Long-Term Efficacy for Psoriasis Patients Compared to Interrupting Treatment

... with active infections until infections are controlled. HUMIRA should not be used by patients with active TB or other severe infections such as sepsis and opportunistic infections. If latent tuberculosis is diagnosed, appropriate treatment for latent tuberculosis must be initiated with ...

Vion Pharmaceuticals Announces Presentation of Interim Data from Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Acute Myelogenous Leukemia at the ASCO(R) Annual Meeting

... induction deaths were either due to progression of disease or infection. Myelosuppression was the primary toxicity, with pneumonia, infection and sepsis and non-infectious pulmonary disorders (hypoxia and dyspnea) being the most common severe adverse events (greater than or equal to grade 3). Dr. ...

Two DOXIL(R) Studies to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... and/or VELCADE -- Persistent severe myelosuppression may result in superinfection, neutropenic fever, or hemorrhage -- sepsis occurring during neutropenia has resulted in discontinuation of treatment and in rare cases of death -- DOXIL may potentiate the ...

CAPHOSOL(R) Relieves Oral Mucositis (OM) and Improves Quality-of-Life in Cancer Patients Receiving Chemoradiation

... mucosa, which can then become susceptible to oral opportunistic infections, possibly resulting in bacteremia (the presence of bacteria in the blood), sepsis (the presence of pathogenic microorganisms in the blood) or other potentially fatal complications. The economic impact of mucositis can be ...

Arbios Receives Approval From the FDA to Initiate Pivotal Trial for SEPET(TM) Liver Assist Device

... These substances would otherwise progressively accumulate in the patient's bloodstream during liver failure, causing hypotension, increasing risk of sepsis development and accelerating damage to the liver, lungs and other organs, including the brain and kidneys, and suppressing the function and ...

Arbios Receives Conditional Approval from the FDA to Initiate Pivotal Clinical Trial for SEPET(TM)

... These substances would otherwise progressively accumulate in the patient's bloodstream during liver failure, causing hypotension, increasing risk of sepsis development and accelerating damage to the liver, lungs and other organs, including the brain and kidneys, and suppressing the function and ...

Diagnostic Center for Disease: Prostate Biopsy Spreads Prostate Cancer Cells

... in question (sampling error). Regardless of the rationale for a biopsy, all men suffer the potential risk for bleeding, scarring, infection or sepsis and needless intrusion that has reportedly resulted in impotency and/or incontinence in some patients. A more important issue that is often not ...

Long-Term Soliris(R) Therapy Improved or Stabilized Kidney Function in Patients With PNH

... were headache, nasopharyngitis (runny nose) and upper respiratory tract infection. The presentation noted that there were two cases of meningococcal sepsis during 382 patient years of therapy (0.52 per 100 patient yrs), consistent with earlier clinical trial experience, which were promptly treated and ...

Twelve DOXIL(R) Clinical Studies to be Presented at American Society of Hematology Annual Meeting

... of DOXIL and/or VELCADE -- Persistent severe myelosuppression may result in superinfection, neutropenic fever, or hemorrhage -- sepsis occurring during neutropenia has resulted in discontinuation of treatment and in rare cases of death -- DOXIL may potentiate the toxicity of ...

Cytokine Announces Oral Efficacy of Anti-Cytokine Semapimod

... the only options for many patients." The new salts have demonstrated their ability to reduce cytokine levels when given orally in a preclinical sepsis model. CPSI has recently obtained a patent on these new salts (US 7,244,765), giving considerable patent life for the reformulated product. The ...

First High-Res 3-D Structures of Mammalian HSP90 Protein Solved, Key to Better Targets for AIDS, Sepsis, Cancer Drugs

... allow for the long-term development of a family of drugs that could be narrowly targeted for individual proteins, for example specifically treating sepsis only. Economic Impact -- Just as companies have been founded to develop HSP90 inhibitors, the same potential exists here. "This will spur a new line ...

Arbios Provides Clinical Strategy for SEPET(TM) Pivotal Trial

... These substances would otherwise progressively accumulate in the patient's bloodstream during liver failure, causing hypotension, increasing risk of sepsis development and accelerating damage to the liver, lungs and other organs, including the brain and kidneys, and suppressing the function and ...

Biosite Reports on Presentation of Preliminary Data From Sepsis Program

... potentially aid in the assessment for risk of sepsis progression. sepsis is an often fatal condition with limited ... useful tool in the assessment of risk of sepsis progression within 72 hours of ...

Survival Data Available from Erbitux Study in First-Line Treatment of Advanced Head and Neck Cancer

... of severe dermatologic toxicities, complications including S. aureus sepsis and abscesses requiring incision and drainage were reported. Sun exposure ... toxicity (1%), interstitial lung disease (0.4%), fever (5%), sepsis (3%), kidney failure (2%), pulmonary embolus (1%), dehydration (5% in ...

Survival Data Available From Erbitux Study in First-Line Treatment of Advanced Head and Neck Cancer

... of severe dermatologic toxicities, complications including S. aureus sepsis and abscesses requiring incision and drainage were reported. Sun exposure ... toxicity (1%), interstitial lung disease (0.4%), fever (5%), sepsis (3%), kidney failure (2%), pulmonary embolus (1%), dehydration (5% in ...

Data Available from Erbitux Phase III Study in First-Line Treatment of Advanced Pancreatic Cancer

... of severe dermatologic toxicities, complications including S. aureus sepsis and abscesses requiring incision and drainage were reported. Sun exposure ... toxicity (1%), interstitial lung disease (0.4%), fever (5%), sepsis (3%), kidney failure (2%), pulmonary embolus (1%), dehydration (5% in ...

Randomized Phase III Trial Showed Erbitux Significantly Improved Secondary Endpoints of Progression-Free Survival and Disease Control in Metastatic Colorectal Cancer Patients

... of severe dermatologic toxicities, complications including S. aureus sepsis and abscesses requiring incision and drainage were reported. Sun exposure ... toxicity (1%), interstitial lung disease (0.4%), fever (5%), sepsis (3%), kidney failure (2%), pulmonary embolus (1%), dehydration (5% in ...

Extensive Clinical Data on Erbitux Presented at the 2007 ASCO Annual Meeting

... of severe dermatologic toxicities, complications including S. aureus sepsis and abscesses requiring incision and drainage were reported. Sun exposure ... toxicity (1%), interstitial lung disease (0.4%), fever (5%), sepsis (3%), kidney failure (2%), pulmonary embolus (1%), dehydration (5% in ...

Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer

... of severe dermatologic toxicities, complications including S. aureus sepsis and abscesses requiring incision and drainage were reported. Sun exposure ... toxicity (1%), interstitial lung disease (0.4%), fever (5%), sepsis (3%), kidney failure (2%), pulmonary embolus (1%), dehydration (5% in ...

AM-Pharma Announces Positive Results of a Phase IIa Clinical Trial with Alkaline Phosphatase in Acute Renal Failure

... active, 5 placebo) with Acute Renal Failure were treated for 24 hours as part of a double-blind, randomized, placebo-controlled Phase IIa study in 36 sepsis patients. The study took place in the Department of Intensive Care Medicine at the Radboud University Medical Centre, Nijmegen, The Netherlands. ...

Acorda Therapeutics Presents Data from its Phase 3 Study of Fampridine-SR in Multiple Sclerosis at the American Academy of Neurology Meeting

... of the 229 Fampridine-SR-treated patients, and none of the 72 patient placebo group. Three of these events were considered serious: influenza, sepsis and anxiety. The anxiety was considered probably related to treatment. A focal seizure, observed during the sepsis, was considered possibly related ...

Long-Term Extension of Ulcerative Colitis Study Shows Remicade Responders Maintained Improvement Through Two Years of Follow-Up

... that requires treatment at weeks 0, 2 and 6. Important Safety Information There are reports of serious infections, including tuberculosis (TB), sepsis and pneumonia. Some of these infections have been fatal. Tell your doctor if you have had recent or past exposure to people with TB. Your doctor will ...

MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations

... Apr 2007; 178: 128.35. -- "Targeting different isoforms of HMGB1 leads to different beneficial effects in preclinical models of sepsis and joint inflammation," J. Immunol., Apr 2007; 178: 100.6. -- Genomic-based high throughput screening and identification of small ...

Remicade Two Year Data in Ankylosing Spondylitis Show Improvement in Spinal Mobility and Spinal Inflammation

... in China where Xian-Janssen markets REMICADE. Important Safety Information There are reports of serious infections, including tuberculosis (TB), sepsis and pneumonia. Some of these infections have been fatal. Tell your doctor if you have had recent or past exposure to people with TB. Your doctor will ...

Three Studies Suggest Abbott's Humira (adalimumab) May Improve Work Productivity in Patients with Rheumatoid Arthritis

... with active infections until infections are controlled. HUMIRA should not be used by patients with active TB or other severe infections such as sepsis and opportunistic infections. Patients who develop new infections while using HUMIRA should be monitored closely. HUMIRA should be discontinued if a ...

AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis

... dephosphorylate different other substrates e.g. ATP and through this dephosphorylation interfere with several diseases, including ulcerative colitis, sepsis and acute renal failure. About Ulcerative Colitis Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease affecting the colon, ...
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