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Wyeth Reports Publication of Phase 3 Data for Bazedoxifene/Conjugated Estrogens, an Investigational Compound Being Studied for the Treatment of Menopausal Symptoms

... is characterized by Wyeth as a TSEC (tissue selective estrogen complex) as it combines a selective estrogen receptor modulator (SERM) with ... Protection in Menopausal Therapy with a Tissue selective Estrogen Complex (TSEC) Containing ...

Bionovo's Estrogen Receptor Beta Selective Drugs Have Unique Gene Expression and Cell Type Specificity

... we show that plant-derived ERb compounds are as selective as synthetic compounds, but regulate different ... the analyses of three distinct classes of ERb selective drugs. The study determines the relative ER ... of gene expression of the three classes of ERb selective compounds compared to the natural hormone ...

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome

... published today in Nature Medicine, Proteolix's selective immunoproteasome inhibitor PR-957 was shown to ... July 2009 print edition in an article titled: A selective Inhibitor of the Immunoproteasome Subunit LMP7 ... Chief Scientific Officer at Proteolix. "This selective inhibition of the immunoproteasome results in an ...

Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting

... demonstrated promising activity as a highly selective and potent inhibitor of the proteasome for ... A Phase Ib/II study of carfilzomib (CFZ), a selective proteasome inhibitor, in patients with selected ... a selective, oral proteasome inhibitor and a selective immunoproteasome inhibitor. For additional ...

Shire Announces Study Results of the Effects of INTUNIV(TM) (Guanfacine) Extended Release on Secondary Measures in Children with ADHD and Oppositional Symptoms

... on INTUNIV (guanfacine) extended release, a selective alpha-2A-agonist, at a major psychiatric meeting. ... Once available, INTUNIV will be the first selective alpha-2A receptor agonist approved for the ... understood, preclinical research suggests this selective alpha-2A agonist strengthens working memory and ...

RAPAFLO(TM) (silodosin) Provides Rapid and Sustained Benign Prostatic Hyperplasia (BPH) Symptom Relief in as Little as Three Days

... -- RAPAFLO (TM) (silodosin), a new, uniquely selective alpha blocker for the treatment of the signs and ... reduced semen), an expected treatment effect of selective alpha blockers, which occurred in 28 percent of ... RAPAFLO(TM) is an effective, uniquely selective alpha-1 adrenergic receptor antagonist. ...

Anthera's Varespladib Meets Primary Endpoint in Phase 2 FRANCIS Trial for the Treatment of Acute Coronary Syndrome

... placebo. Varespladib is a potent and highly selective oral inhibitor of secretory phospholipase A2 ... cholesterol - Varespladib's immediate and selective inhibition of sPLA2 effectively suppressed ... clinical trials, varespladib, a potent and highly selective inhibitor of secretory phospholipase A2 (sPLA2), ...

Cylene to Present Advances in its Oral Inhibitor of CK2 at AACR Annual Meeting

... molecular target. CX-4945 is a potent, selective inhibitor of CK2 and modulates key survival ... PM Discovery and characterization of CX-4945 a selective orally bioavailable small molecule inhibitor of ... April 21, 2009: 2:00 PM CX -4945, a potent and selective inhibitor of CK2, modulates PI3K/AKT signaling ...

VentiRx Pharmaceuticals Initiates Phase I Clinical Trial of VTX-1463, a Novel TLR8 Agonist for the Treatment of Allergic Rhinitis

... First selective TLR8 Agonist to Advance for Treatment of Allergy ... initiated a Phase I clinical trial of VTX-1463, a selective intranasal TLR8 agonist for the treatment of ... later this year. "VTX-1463 is the first selective TLR8 compound to reach the clinic for allergy," ...

Pharmacyclics Initiates Phase 1 Clinical Trial of Novel Oral Btk Inhibitor for Refractory B-cell Non-Hodgkin's Lymphoma

... tolerability of PCI-32765, an orally available, selective inhibitor of Bruton's tyrosine kinase, or Btk, as ... lymphoma (NHL). This is the first Btk selective inhibitor to be tested in humans, and is ... for the patient. "This is a very selective compound for B-cells, and it could represent ...

Watson Announces United States Availability of RAPAFLO(TM) (silodosin), a Novel New Treatment in Benign Prostatic Hyperplasia (BPH)

... (TM) (silodosin), the company's new, uniquely selective alpha blocker for the treatment of the signs and ... About RAPAFLO RAPAFLO(TM) is an effective, selective alpha-1 adrenergic receptor antagonist that binds ... with reduced semen), an expected effect of selective alpha blockers. Rates of discontinuing therapy ...

QuatRx Completes Enrollment of Ophena(TM)(Ospemifene Tablets) Final Pivotal Phase 3 Study in Women with Postmenopausal Vaginal Atrophy

... Phase 3 clinical trial for Ophena(TM) , a novel selective estrogen receptor modulator (SERM) for the ... preclinical program. Fispemifene is a new selective estrogen receptor antagonist that is in Phase 2 ... and other conditions in men. Sobetirome, a novel, selective thyroid receptor beta agonist, is in Phase 1 as a ...

VentiRx Pharmaceuticals Commences Phase I Clinical Trial of VTX-2337, a Novel TLR8 Agonist for the Treatment of Oncology

... First selective TLR8 Agonist to Advance to Clinical Trials ... initiated a Phase I clinical trial of VTX-2337, a selective TLR8 agonist for the treatment of cancer. The ... stage cancer. "VTX-2337 is the first selective TLR8 compound to reach the clinic and we are ...

Proteolix to Present Clinical and Preclinical Data at the 50th Annual Meeting of the American Society of Hematology

... Excluding Therapy Poster II -- The selective Proteasome Inhibitor Carfilzomib is Well ... -- Induction of Sustained Early G1 Arrest by selective Inhibition of CDK4 and CDK6 Primes ... including an oral proteasome inhibitor and a selective immunoproteasome inhibitor. For additional ...

Millennium Presents New Data on Investigational Drugs for Novel Cancer Targets at EORTC-NCI-AACR Symposium

... were presented at EORTC. -- MLN8237, an oral selective Aurora A kinase inhibitor: initial results of ... (PK), and pharmacodynamics (PD) of MLN8237, a selective Aurora A kinase inhibitor, in the United ... TAK-593 TAK-593 is a novel small molecule selective inhibitor of the tyrosine kinases for the VEGF ...

Bionovo's VG101 Shows Greater Efficacy Than Estrogen in the Treatment of Vaginal Dryness

... on the company's second estrogen receptor beta selective drug candidate that will be entering clinical ... explain the safety advantages of this more highly selective estrogen receptor modulator, VG101, when compared ... women. VG101 is a novel estrogen receptor beta selective agonist and unlike currently available hormone ...

Novel Compound Shows Promise for Treatment of Alcoholism

... and suggests that a new compound that causes selective and long-lasting reduction in ethanol consumption ... Opioid Receptor Antagonist, SoRI-9409, Produces a selective and Long-Lasting Decrease in Ethanol Consumption ... results demonstrate that this compound causes selective and long-lasting reductions of ethanol ...

Bionovo's Drug Candidate for Menopausal Symptoms Shows Effect on Neural Pathways Related to Temperature Regulation

... MF101, an estrogen receptor beta selective modulator, regulated calcium levels, which are ... estrogen receptor beta. MF101 demonstrated this selective regulation." The study was conducted by ... MF101 MF101 is an estrogen receptor beta (ER-b) selective drug for the treatment of menopausal hot flashes, ...

Shire's Investigational Nonstimulant ADHD Treatment INTUNIV(TM) (Guanfacine Extended Release) Demonstrated Significant Efficacy in Reducing ADHD Symptoms at All Measured Time Points Up to 24 Hours Postdose

... analyses of pivotal trial results of INTUNIV, a selective alpha-2A-agonist. This compound is ... label. Upon approval, INTUNIV will be the first selective alpha-2A receptor agonist indicated for the ... and frustration tolerance. The selective alpha-2A agonist strengthens working memory and ...

Pharmacyclics Reports Multiple Presentations at AACR on Its HDAC and Selective HDAC Inhibitors

... histone deacetylase (HDAC) inhibitor and HDAC-8 selective inhibitor were presented. "These presentations ... models. "We believe that PCI-34051 is a truly selective HDAC-8 inhibitor," said Sriram Balasubramanian, ... cells. Scientists have been searching for more selective inhibitors, which may offer the potential for ...

EntreMed Achieves a Key Milestone Through Initiation of ENMD-2076 Clinical Program

... selective Kinase Inhibitor Phase 1 Trial in Advanced Cancer ... ) ENMD-2076 is a novel, selective kinase inhibitor with potent activity against ... Officer commented, "ENMD-2076 is an exciting selective kinase inhibitor with potent single agent ...

FASgen Announces a New Discovery in Obesity Research

... FASgen is a leader in the field of research into selective inhibition of fatty acid synthase (FASi), and has ... (CPT-1). FAS89B was characterized in vitro as a selective inhibitor of brain CPT-1 and produced in vivo ... to create new therapeutic products based on the selective inhibition of fatty acid biosynthesis. The ...

TargeGen Announces Planned Initiation of Clinical Trial of JAK2 Inhibitor TG101348 in Myeloproliferative Disease Patients, and Presentations at ASH

... discovered, oral, potent, and highly selective JAK2 inhibitor in January, 2008. Additionally, ... presentations include: -- Catriona Jamieson -- selective Inhibition of JAK2 Driven Erythroid ... Cell Experiments with TG101348, A JAK2 selective Small Molecule Inhibitor, in the Presence of ...

New Data Confirms That a Selective, Fully Human Anti-VEGF Antibody Being Developed by Peregrine is as Effective as Avastin(R) in Preclinical Cancer Models

... at Anti-Angiogenesis Conference Shows R84, the selective Human Anti-VEGF Antibody Developed by Peregrine ... to both VEGFR2 and VEGF receptor 1 (VEGFR1). selective anti-VEGF agents may have potential advantages ... The data we previously presented on 2C3, our selective anti-VEGF mouse antibody, along with the current ...

Genaera Corporation Presents Preclinical Trodusquemine (MSI-1436) Data at the North American Association for the Study of Obesity Annual Meeting

... preclinical data shows that MSI-1436 demonstrated selective inhibition of PTP-1B but did not inhibit ... The study confirmed that MSI-1436 is a selective inhibitor of PTP-1B, and its central and ... that trodusquemine is a potent, highly selective and reversible inhibitor of PTP-1B. In vitro ...

New Data for XL880, XL647 and XL184 to Be Presented at AACR-NCI-EORTC

... PI3K pathway signaling with XL147, a potent, selective and orally bioavailable PI3K inhibitor (Abstract ... -- Biomarker development for XL765, a potent and selective oral dual inhibitor of PI3K and mTOR ... (PK) study of XL647, a novel spectrum selective kinase inhibitor, administered orally daily to ...

Preclinical Data on Lead MEK Inhibitor, RDEA119, to be Presented at the 2007 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

... - RDEA119: A Potent and selective MEK inhibitor with Favorable In Vitro and ... abstract entitled "RDEA119: A Potent and Highly selective MEK Inhibitor for the Treatment of Cancer," will ... Title: RDEA119: A Potent and Highly selective MEK Inhibitor for the Treatment of ...

QuatRx Completes Patient Enrollment in Phase 3 Study of Ophena(TM) in Women with Postmenopausal Vaginal Syndrome

... Women to Evaluate QuatRx's New-Generation selective Estrogen Receptor Modulator (SERM) ANN ARBOR, ... with menopause. Ophena(TM) is a new-generation selective estrogen receptor modulator (SERM) for ... development programs. Fispemifene is a new, selective estrogen receptor antagonist that is in Phase 2 ...

FDA Issues Complete Response Letter for INTUNIV(TM) (guanfacine) Extended Release for the Treatment of ADHD in Children and Adolescents

... Shire Specialty Pharmaceuticals. "When approved, INTUNIV will be the first selective alpha-2A receptor agonist for the treatment of ADHD, and will provide ... of ADHD is not fully understood, preclinical research suggests this selective alpha-2A agonist strengthens working memory and prefrontal cortex neuronal ...

CeNeRx BioPharma Obtains Rights to Novel Drug Candidate for Prevention and Treatment of Neurodegeneration Disorders

... Krenitsky Pharmaceuticals Inc., which also licensed the RIMA series of selective and reversible monoamine oxidase inhibitor (MAOI) compounds to CeNeRx. ... a series of novel compounds for anxiety and depression; and a series of selective cannabinoid compounds that have recently completed successful preclinical ...

Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer

... study indicate that paclitaxel poliglumex may be a uniquely active and selective radiosensitizing therapeutic. Most importantly, patient tolerability ... of severe gastrointestinal toxicity. It is likely that this is due to the selective accumulation of paclitaxel poliglumex in tumor tissue with continual slow ...

Proteolix Presents Positive Clinical Data for Carfilzomib in Multiple Myeloma at the 2009 ASCO Annual Meeting

... "In spite of advances in the treatment of multiple myeloma, new selective agents are needed for patients who have failed other available therapies," ... inhibitors, including a selective, oral proteasome inhibitor and a selective immunoproteasome inhibitor. For additional information on Proteolix, ...

Radius Initiates Phase 2a Clinical Trial of RAD1901 in Menopausal Hot Flashes

... company's proof-of-concept Phase 2a study of RAD1901, an investigational selective estrogen receptor modulator (SERM) undergoing clinical evaluation for ... effect--will be collected. About RAD1901 RAD1901 is a novel selective estrogen receptor modulator (SERM) under development at Radius as a new ...

InteKrin Therapeutics Announces Enrollment Completion of 360 Patient, 24 week Phase 2b Study

... enrollment of a 360 patient Phase 2b study of INT131, a novel, non-TZD selective modulator of PPAR gamma (SPPARM) for the treatment of Type 2 diabetes ... initiation of the INT131 Phase 3 program in 1H2010." INT131 is a selective PPAR gamma modulator which has consistently demonstrated the separation of ...

Genaera Presents Preliminary Phase 1b Data for Trodusquemine (MSI-1436)

... 1b clinical data for trodusquemine (MSI-1436), the first-in-class, highly selective inhibitor of PTP1B and Genaera's lead drug candidate for the treatment of ... About Trodusquemine (MSI-1436) Trodusquemine is the first highly selective inhibitor of protein tyrosine phosphatase 1B (PTP1B), an enzyme central to ...

Access Pharmaceuticals Presents new Combination Data on the Company's Angiolix(R) Therapeutic Monoclonal Antibody

... selectively. This provides an excellent insight into Angiolix's tumor selective mechanism. Angiolix(R) is a promising novel agent for anti-angiogenic ... in treating cancer, there is clearly a need to bring a more tumor selective product like Angiolix to the market," stated Jeffrey B. Davis, President ...

Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor of CK2

... orally administered small molecule anticancer agent that delivers highly selective and potent inhibition of CK2, a constitutively active protein kinase that ... it has an unusual active site. CX-4945 represents the first potent and selective inhibitor of CK2 with a favorable safety profile and the ability to ...

Genaera Begins Phase 1b Trial of Trodusquemine (MSI-1436) in Overweight and Obese Type 2 Diabetics

... peripherally to regulate insulin and leptin pathways through the highly selective inhibition of its novel target enzyme, PTP-1B. Study 102 will ... and peripherally-acting appetite suppressant and the first highly selective inhibitor of protein tyrosine phosphatase 1B (PTP1B), an enzyme central to ...

Schering-Plough Highlights R&D Pipeline Progress, Innovation and Breadth of Research Projects

... receiving placebo; BRIDION(R) (sugammadex), the first and only selective relaxant binding agent for reversing neuromuscular blockade in anesthesia ... that MFF met its primary endpoints; and Preladenant, a novel and selective adenosine2a receptor antagonist for Parkinson's disease (completing Phase ...

Schering-Plough Reports Preladenant Meets Primary Endpoint in Phase II Dose-Finding Trial for Parkinson's Disease

... Corporation (NYSE: SGP ) today reported that preladenant, its novel and selective adenosine2a receptor antagonist, met the primary endpoint in a Phase II ... treatment options. Its pharmacological profile as both a potent and selective adenosine type 2a receptor antagonist has previously been shown to have ...
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(Date:12/3/2009)... by a social snubbing? Your genetics, not your friends, may ... painkillers, called opioids, relieve not only physical pain, but also ... by Faculty of 1000 Biology member Markus Heilig shows that ... can determine the intensity of people,s responses to social rejection. ...
(Date:12/3/2009)... from the U.S. Department of Energy,s (DOE) Brookhaven National ... has made a major step in understanding how molecules ... to carry out important biological processes. The research, published ... Structural & Molecular Biology , confirms that many proteins ...
(Date:12/2/2009)... that people who smoke cigarettes over a long period ... cancer, even after adjusting for other risk factors. ... or to quit as soon as possible," said senior ... epidemiology and surveillance research at the American Cancer Society. ...
Breaking Biology News(10 mins):Grooving down the helix 2Grooving down the helix 3Cigarette smoking increases colorectal cancer risk 2San Francisco Home Care Workers Demand that Former Union Officials Come Clean 57261 1San Francisco Home Care Workers Demand that Former Union Officials Come Clean 57261 2San Francisco Home Care Workers Demand that Former Union Officials Come Clean 57261 3Michael J Fox Foundation Commits Up to 2412 Million for Targeted Parkinsons Therapeutic Development in 2010 5007 1Michael J Fox Foundation Commits Up to 2412 Million for Targeted Parkinsons Therapeutic Development in 2010 5007 2Michael J Fox Foundation Commits Up to 2412 Million for Targeted Parkinsons Therapeutic Development in 2010 5007 3Michael J Fox Foundation Commits Up to 2412 Million for Targeted Parkinsons Therapeutic Development in 2010 5007 4Weighing costs benefits of HIV treatments 57258 1Weighing costs benefits of HIV treatments 57258 2Weighing costs benefits of HIV treatments 57258 3
(Date:12/6/2009)... SUNDAY, Dec. 6 (HealthDay News) -- Early roots of the ... that lived thousands or millions of years ago, new research ... bit of a tiger,s genetic material, scientists say, and a ... day. That tiger, in fact, may have bitten a monkey, ... to its infection of humans. , The finding shouldn,t lead ...
(Date:12/6/2009)... 2009 A new study provides welcome news for ... thromboembolism (VTE). , The condition is estimated to ... occurs when an abnormal clot forms in a vein ... swelling. In some cases, the clot may detach from ... to the lungs, causing a potentially fatal condition known ...
(Date:12/5/2009)... have been significant scientific advances in the field of ... better understanding of how certain diseases progress in order ... the best care. Research presented today at the 51st ... optimal induction therapies for managing multiple myeloma, the importance ...
(Date:12/5/2009)... , , SATURDAY, Dec. 5 (HealthDay News) -- They,re not ... bad reactions to certain holiday traditions and need to ... to the American College of Allergy, Asthma and Immunology ... may choose to decorate with artificial plants, but both ...
(Date:12/5/2009)... most unusual places, and to do everything from growing mushrooms, making wine ... ... Who would have thought that your wine, water and vegetables would have ... a new line of turbines, for industry end users, not wind farms. ...
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