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Economy is Driving Many Osteoporotic Women to Retire Later - But Their Ability to Work May Be Undermined by Sub-Optimal Management of Their Disease

... of women with PMO knew their bone density score Women with PMO were no more likely to know their bone density score than those without the disease (46 percent versus ... region and household income. Propensity score weighting was also used to adjust for ...

Human Genome Sciences and GlaxoSmithKline Announce Positive Phase 3 Study Results for BENLYSTA(TM) in Systemic Lupus Erythematosus

... by an improvement in SELENA SLEDAI score of 4 points or greater, no clinically significant ... belimumab achieved a reduction in SELENA SLEDAI score of at least 4 points by Week 52, ... by the SF-36 Physical Component Summary (PCS) score was not significantly different ...

Merz Pharmaceuticals Announce Three Studies of NT-201 - (Botulinum neurotoxin type A Free From Complexing Proteins)

... to placebo). Improvement in TWSTRS-Severity score from baseline to week 4 was -1.9 plus or minus ... to placebo). Improvement in TWSTRS-Severity score from baseline to week 4 was -1.9 plus or minus ... dose: 500 units). Changes on the Ashworth Scale score were highly statistically significant (p < ...

Dainippon Sumitomo Pharma Announces Lurasidone Phase III Data in Patients With Schizophrenia

... and Negative Syndrome Scale (PANSS) total score (primary endpoint) and the Clinical Global ... of psychotic symptoms with a PANSS total score of 80 or higher at study baseline. A total ... was change from baseline in the PANSS total score over the six-week study duration for each ...

New Studies on Once-Daily Extended Release Pramipexole Presented at American Academy of Neurology Annual Meeting

... Parkinson's Disease Rating Scale (UPDRS)* II+III score from baseline to week 18 was -5.1 points in the ... of maintenance of efficacy. The UPDRS II+III score was almost unchanged from week 18 to week 33 in ... mean change from baseline in the UPDRS II+III score was -11.5 points at week 33 and -11.8 points at ...

Stallergenes S.A.: Positive Results From a Phase IIb/III Clinical Trial on the House Dust Mite Desensitization Tablet

... The endpoint was the adjusted average symptom score on nasal symptoms assessed during the three last ... the period. The adjusted average symptom score has been improved by 20% in both treated groups. In particular, the nasal congestion score has been improved by 40% (median) and the nasal ...

Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen

... hepatitis, and hepatic decompensation (Child-Pugh score greater than 6; class B and C) in cirrhotic CHC ... in hepatic decompensation with Child-Pugh score greater than or equal to 6 in cirrhotic CHC ... discontinued if decompensation (Child-Pugh score greater than or equal to 6) is observed. Ischemic ...

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

... hepatitis, and hepatic decompensation (Child-Pugh score greater than 6; class B and C) in cirrhotic CHC ... in hepatic decompensation with Child-Pugh score greater than or equal to 6 in cirrhotic CHC ... discontinued if decompensation (Child-Pugh score >=6) is observed. Ischemic and hemorrhagic ...

SYNTAX Analysis Finds Treatment With TAXUS(R) Express2(TM) Stents More Cost Effective Than Bypass Surgery in Many Patients With Complex Coronary Artery Disease

... of the SYNTAX trial outcomes based on the SYNTAX score also demonstrated that among patients with a SYNTAX score in the upper tercile -- those with the most ... similar rates of MACCE at 12 months. The SYNTAX score characterizes coronary anatomy based on lesion ...

Neurocrine Announces Top-Line Results From 702 Study (Lilac PETAL Study) of Elagolix for Treatment of Endometriosis Pain

... of Change (% subjects score < /=2) 33% 67%** 62%** ... to placebo. The non-menstrual pelvic pain score of 0.9 was low at baseline and decreased across ... or greater pain (CPSSS non-menstrual pelvic pain score at baseline >/=2); which accounted for ...

FDA Approves an Expanded Indication for Peginterferon-Based Combination Therapy for Patients With Chronic Hepatitis C

... (245/507), with a range of responses by fibrosis score (F4-F2) of 39-55 percent. Patients infected with ... (196/281), with a range of responses by fibrosis score (F4-F2) of 60-83 percent. For all HCV genotypes, ... hepatitis, and hepatic decompensation (Child-Pugh score greater than 6 [class B and C]) in cirrhotic CHC ...

Alexza's AZ-004 (Staccato(R) Loxapine) Meets Primary Endpoint of Treating Acute Agitation in Patients with Bipolar Disorder in Phase 3 Trial

... and Negative Symptom Scale) Excited Component score (also known as PEC score), measured at 2 hours ... significant improvement in the PEC score (p < 0.0001), compared to placebo. The 10 mg ... scale. A responder was defined as having a CGI-I score at 2 hours after the first dose of either a ...

New Study Shows that PEGASYS(R) Regimen Provides Higher Sustained Virological Response Rates for Hepatitis C Patients

... hepatitis, and hepatic decompensation (Child-Pugh score greater than 6; class B and C) in cirrhotic ... in hepatic decompensation with Child-Pugh score greater than or equal to 6 in cirrhotic CHC ... discontinued if decompensation (Child-Pugh score greater than or equal to 6) is observed. Ischemic ...

BioMarin Announces Positive Results From Phase 2A Clinical Study of 6R-BH4 in Sickle Cell Disease

... in the trial had endothelial dysfunction (PAT score less than or equal to 1.67), consistent with ... 20 mg/kg). -- The mean endothelial function PAT score improved from the abnormal to the normal range (>1.67) in SCD patients with an abnormal PAT score at baseline. -- Improvement in endothelial ...

SYNTAX Data Show Comparable Safety for Complex Patients Treated with TAXUS(R) Express2(TM) Stents and Bypass Surgery

... New SYNTAX score shows similar safety and efficacy outcomes for ... will also be able to consider the SYNTAX score analysis, demonstrating no difference in safety ... treatment for their patients." The SYNTAX score is breaking new ground by scientifically defining ...

Sirion Therapeutics Announces Positive Pivotal Uveitis Data for Durezol(TM)

... 3, the Durezol group had a reduction in mean pain score of 58% vs 51% in the Pred Forte group. At Day 7, ... group achieved a mean reduction in total symptom score of 76% vs 71% for Pred Forte at Day 14. This ... with the Durezol group reducing the total symptom score by 86% vs 76% for the Pred Forte group. The ...

Alexza's AZ-004 (Staccato(R) Loxapine) Phase 3 Trial Meets Primary Endpoint of Treating Acute Agitation in Schizophrenic Patients

... and Negative Symptom Scale) Excited Component score (also known as PEC score), measured at 2 hours ... statistically significant improvement in the PEC score (p < 0.0001), compared to placebo. The 10 mg dose ... scale. A responder was defined as having a CGI-I score at 2 hours after the first dose of either a 1 ...

Stallergenes: New Study VO 56 Highly Positive Results Conducted in an Allergen Challenge Chamber

... versus placebo (p=0.0003) on the average symptom score (RTSS). The magnitude of efficacy (34%)1 was ... and VO52 (in a paediatric population) - A Cohen score of 0.79 corresponding to a large effect size ... on the average Rhinoconjunctivitis Total Symptom score (sneezing, rhinorrhea, nasal pruritus, nasal ...

Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting

... examination using the Neurological Impairment score - Lower Limbs (NIS-LL) and quantitative sensory ... systems. These include the Total Neuropathy score (TNS) and the narrower Neuropathy Impairment score in the Lower Limbs (NIS-LL). The NIS-LL is a ...

Leading Academic Institutions Collaborate on 800-Patient Study of Effectiveness of Cryoablation for Men With Recurrent Prostate Cancer

... after radiation therapy. The study, called score (Salvage Cryotherapy Registry Evaluation) is ... to normal activity within a few days. The score Study is the largest prospective trial ever ... to speak to a patient advocate about score or salvage cryotherapy. About Endocare ...

New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease

... of moderately to severely active UC (total Mayo score of 6 to 12) and an endoscopy sub-score of at ... defined as a decrease from baseline in the Mayo score by at least 30 percent and at least three points, ... 0 or 1, and clinical remission, defined as a Mayo score less than or equal to two points, with no ...

PEGASYS(R)/COPEGUS(R) Show Benefit in Hard-to-Treat Latino Population with Hepatitis C

... hepatitis, and hepatic decompensation (Child-Pugh score greater than 6; class B and C) in cirrhotic ... in hepatic decompensation with Child-Pugh score greater than or equal to 6 in cirrhotic CHC ... discontinued if decompensation (Child-Pugh score greater than or equal to 6) is observed. Ischemic ...

Alseres Pharmaceuticals Announces 12 Month Interim Results from the Phase I/IIa Cethrin(R) Clinical Trial in Acute Spinal Cord Injury

... D. -- Subgroup analysis of 12-month mean motor score changes showed improvement in both the 1 and ... the cervical-injured patients with mean motor score changes of 16.3 points in the 1 mg and 27.3 ... ASIA Impairment Scale grade and ASIA Motor score changes suggest that the most effective ...

New Lacosamide Data Provides Evidence for Long-Term Efficacy in Diabetic Neuropathic Pain

... treatment, patients had an average daily pain score of 6.5. After more than a year of open-label treatment, the mean pain score was 2.5, the baseline score of the withdrawal sub-trial. A total of 106 ...

Shire's Investigational Nonstimulant ADHD Treatment INTUNIV(TM) (Guanfacine Extended Release) Demonstrated Significant Efficacy in Reducing ADHD Symptoms at All Measured Time Points Up to 24 Hours Postdose

... in the ADHD Rating Scale (ADHD-RS-IV) total score from baseline to endpoint. All patient groups ... placebo. Using the change in the ADHD-RS-IV total score from baseline to endpoint as the primary efficacy ... defined as those with a 25 percent reduction in score from baseline to endpoint. Findings from the ...

Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidone's Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events

... demonstrated that rates of worsened BAS(6) total score was similar between iloperidone and placebo (8.3% ... a change from baseline to endpoint PANSS-T score of -20.12 (p=0.000093) -- The highest ... with a change from baseline to endpoint PANSS-T score of -15.02 (p=0.00017) -- None of the six ...

Patients Treated with Risperidone Long-Acting Injection had a Significantly Longer Time to Relapse Compared to Quetiapine in International Clinical Study

... necessary AND .25 percent increase in PANSS total score from baseline or an increase of 10 points if the baseline score was .40; Significant clinical deterioration defined as a CGI-C score of 6 (much worse); Deliberate self-injury; ...

New Data on SEROQUEL XR(TM) in Treatment of Both Major Depressive Disorder and Generalized Anxiety Disorder Presented at APA Annual Meeting

... XR groups had significantly reduced mean MADRS score versus placebo (-11.07): -13.56 (p (p ... XR groups significantly reduced mean MADRS score versus placebo (-3.27): -4.91 (p mg/day; ... placebo plus an AD for 1) change in MADRS total score at Week 6 (-14.70 versus -11.7; p Week 1 ...

Data Presented at AAN Show That Lacosamide Significantly Reduced Pain and was Generally Well Tolerated in Patients With Diabetic Neuropathic Pain

... Phase II, flexible-dose trial (SP614). The pain score was based on an 11-point Likert Scale ranging ... possible pain). The mean reduction in pain score reached the level of statistical significance in ... a significant mean reduction in pain score of -2.14 for the lacosamide group compared with ...

Controversial Shoulder Surgery for First-time Dislocation Proven Effective Long-Term

... The mean American Shoulder and Elbow Surgeons score was 90.9. The patients compared their repaired ... again with 10 being "very likely," the average score was 9.1, according to the study. In terms of ... to 77.7 prior to their injuries. The mean score of the Army Physical Fitness Test was 282.2 out ...

REMICADE-Treated Patients Experienced Rapid and Substantial Improvement in Psoriasis in Critical Regions of Body

... percent body surface area (BSA), a minimum PASI score of 12 and who were candidates for phototherapy or ... involving at least 10 percent BSA, a minimum PASI score of 12 and who were candidates for phototherapy or ... patients whose Physician Global Assessment (PGA) score indicated moderate to severe disease (n=114) were ...

Abbott's HUMIRA(R) (adalimumab) Receives FDA Approval For Moderate to Severe Chronic Plaque Psoriasis

... and Physician's Global Assessment (PGA). The PASI score measures the extent and severity of psoriasis. ... efficacy of therapy. On a six-point scale, a zero score means no signs, one means minimal and a five ... percent of HUMIRA-treated patients achieved a PGA score of clear or minimal (0 or 1) compared to 4 ...

Roche responds to announcement of 'IDEAL' hepatitis C trial results

... hepatitis, and hepatic decompensation (Child-Pugh score greater than 6; class B and C) in cirrhotic ... in hepatic decompensation with Child-Pugh score greater than or equal to 6 in cirrhotic CHC ... discontinued if decompensation (Child-Pugh score .6) is observed. The most common adverse events ...

New Study Results Show Asenapine More Effective Than Placebo in the Treatment of Acute Schizophrenia

... The primary endpoint was changes in PANSS total score from baseline to day 42. PANSS score changes were significantly greater for asenapine ... greater reductions in PANSS positive subscale score vs. placebo (-7.5, -6.9 and -7.3 vs. ...

Multiple Studies Presented at San Antonio Breast Cancer Symposium Reinforce Clinical Utility of Oncotype DX(R)

... results for the Oncotype DX Recurrence score result in early-stage estrogen receptor-positive ... to benefit those with low Oncotype DX Recurrence score results, despite the presence of positive ... in patients with high Oncotype DX Recurrence score results. These results join a suite of ...

Genomic Health Announces Eight Oncotype DX(R) Studies to Be Presented at 30th Annual San Antonio Breast Cancer Symposium

... and predictive value of the 21-gene Recurrence score assay in postmenopausal, node-positive, ER ... Abstract #1043 Poster presentation: Recurrence score by Oncotype DX evaluated on the primary breast ... study of the impact of the 21-gene Recurrence score assay on patient satisfaction, anxiety and ...

Avicena Announces Positive Phase II Data for a Combination Trial Involving AL-08 for the Treatment of Amyotrophic Lateral Sclerosis (ALS)

... showed a smaller mean decline in ALS- Functional score compared to those taking the AL- 08/minocycline ... showed less of a decline in ALS-Functional score compared to AL-08 and minocycline and historical ... slowed deterioration in ALS- Functional score compared to the other treatment and believe that ...

Post-Hoc Data Show Daily Activity Participation, Independence and Sleep Quality Improved in Adults with Moderate to Severe Rheumatoid Arthritis After Treatment with ORENCIA(R) (Abatacept)

... that included these two factors. Change in mean score on Factor 1 (socio-emotional role ... group (p-value less than 0.0001). Change in mean score on Factor 2 (physical independence) was 0.499 for ... commonly used measurement tools (Disease Activity score 28, Health Assessment Questionnaire ...

Five-Year Data Demonstrate Long-Term Efficacy and Safety with ORENCIA(R) (abatacept) in Adults with Rheumatoid Arthritis Who had an Inadequate Response to Methotrexate

... component summary was 9.7 at Year 1 (mean score 40.6) and was stable at 9.7 at Year 5 (mean score 41.7). The mean improvement in the mental ... Year 1 (mean score 52.3) and 5.4 at Year 5 (mean score 50.8). Improvements in all individual component ...

Phase 3 Data Show New Anti-TNF, Golimumab, Significantly Improved Arthritis, Skin and Nail Manifestations in Patients with Psoriatic Arthritis

... the Maastricht Ankylosing Spondylitis Enthesitis score (MASES) index modified for Psoriatic Arthritis; ... measured by percent change in dactylitis score compared with placebo at week 14 (66 percent ... responders as measured by the Disease Activity score 28 (DAS28), which measures tender and swollen ...
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