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Schizophrenia in Medical Technology

Video: FDA Approves INVEGA(R) SUSTENNA(TM) for the Acute and Maintenance Treatment of Schizophrenia

... for the acute and maintenance treatment of schizophrenia in adults on Friday, July 31, 2009. It is the ... percent of the world's population suffers from schizophrenia - a brain disorder that impairs a person's ... Unfortunately, 80 percent of patients with schizophrenia experience at least one relapse within five years ...

FDA Advisory Committee Votes in Favor of SAPHRIS(R) (asenapine) for Acute Bipolar I Disorder and Acute Schizophrenia

... adults and in favor of use in acute treatment of schizophrenia in adults. If approved by FDA, SAPHRIS would be ... a significant unmet need for patients with schizophrenia and bipolar I disorder, including patients ... and 10/0/2) for the bipolar I disorder and schizophrenia indications, respectively. In addition, the ...

deCODE-led Megastudy Finds New Genetic Clues to Causes of Schizophrenia

... -- The largest study of the genetics of schizophrenia ever undertaken has revealed several new ... suggesting a possible environmental link between schizophrenia immune response. It has long been known, for ... and controls from the International schizophrenia Consortium (ISC) and the European-American ...

ADHD Genes Found; Known to Play Roles in Neurodevelopment

... roles in many diseases, including autism and schizophrenia Everyone has CNVs in their DNA, but not all of ... neurodevelopmental disorders, including autism, schizophrenia and Tourette syndrome. The CNVs found in ADHD ... the CNVs found in ADHD that also occur in autism, schizophrenia and other neurological disorders. This overlap ...

FDA Advisory Committee Votes in Favor of Zyprexa for Two Adolescent Indications

... and acceptably safe for the acute treatment of schizophrenia or manic or mixed episodes associated with ... by their recommendations. For the proposed schizophrenia indication, the panel voted 11-5, with two ... clinical trials of Zyprexa in adolescents with schizophrenia or bipolar I disorder, including a six-week ...

Study Demonstrating Lurasidone Is Effective in Patients With Schizophrenia Published in The Journal of Clinical Psychiatry

... for lurasidone in the treatment of patients with schizophrenia have been published in The Journal of Clinical ... hospitalized for an acute exacerbation of schizophrenia (diagnosed using DSM-IV criteria). A total of ... H(1) or acetylcholine M(1) receptors. About schizophrenia ...

Dainippon Sumitomo Pharma Announces Lurasidone Phase III Data in Patients With Schizophrenia

... or CGI-S at study endpoint. "People with schizophrenia need new treatment options that offer a ... psychiatry and neuroscience and director of the schizophrenia research program at the University of Cincinnati ... acute schizophrenia. Patients were diagnosed with schizophrenia (using DSM-IV criteria) and were required to have ...

RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment Delayed the Time to Relapse in Patients with Bipolar I Disorder

... antipsychotic therapy used for the treatment of schizophrenia and the maintenance treatment of Bipolar I ... the most common side effects in the treatment of schizophrenia were headache, tremors, dizziness, restlessness, ... reactions in clinical trials in patients with schizophrenia (greater than or equal to 5%) were headache, ...

FDA Approves Vanda Pharmaceuticals' Fanapt(TM) for the Treatment of Schizophrenia

... The efficacy of Fanapt(TM) for the treatment of schizophrenia was supported by two placebo-controlled ... be superior to placebo in controlling symptoms of schizophrenia across doses of 12mg to 24mg per day. The ... other antipsychotics are tried first. About schizophrenia ...

Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Announces FDA Filings for Paliperidone Palmitate and INVEGA(R)

... treatment options for patients diagnosed with schizophrenia or schizoaffective disorder. Earlier this ... disorder is sometimes misdiagnosed as schizophrenia or bipolar disorder. For patients who frequently use mental health services, schizophrenia and schizoaffective disorder may account for ...

Omeros Receives $3.1 Million Milestone Payment from The Stanley Medical Research Institute for Schizophrenia Program

... compound optimization criteria. Omeros' schizophrenia product candidates inhibit the phosphodiesterase ... strength of the preclinical data generated by our schizophrenia program," said Gregory A. Demopulos, M.D., ... of the agreement with SMRI. About schizophrenia ...

FDA Issues a Complete Response Letter for Lilly's Olanzapine LAI for Treatment of Schizophrenia in Adults

... (LAI) for acute and maintenance treatment of schizophrenia in adults. Lilly is continuing to work with the ... for an extended period of time.(3) About schizophrenia schizophrenia is a severe and debilitating illness with such ...

Alexza's AZ-004 (Staccato(R) Loxapine) Meets Primary Endpoint of Treating Acute Agitation in Patients with Bipolar Disorder in Phase 3 Trial

... the acute treatment of agitation in patients with schizophrenia or bipolar disorder. AZ-004 is being developed ... from major psychiatric disorders, including schizophrenia and bipolar disorder. Patients experiencing ... the company believes that in the United States schizophrenia afflicts about 2.5 million adults and bipolar ...

AstraZeneca and Targacept Announce Top-Line Results from Phase IIb Study of AZD3480 in Cognitive Dysfunction in Schizophrenia

... by AstraZeneca in cognitive dysfunction in schizophrenia (CDS), known as the HALO trial. AZD3480 ... About Cognitive Dysfunction in schizophrenia schizophrenia is a chronic, severe and disabling form of ...

Memory Pharmaceuticals Achieves Enrollment Goal for Phase 2 Study of MEM 3454 in Cognitive Impairment Associated With Schizophrenia

... agonist, in cognitive impairment associated with schizophrenia (CIAS). The Company has randomized 212 patients ... a nicotinic alpha-7 receptor agonist in schizophrenia and we are pleased to have reached this important ... to include approximately 212 patients with stable schizophrenia who are receiving atypical antipsychotic therapy. ...

Study Suggests Treatment with Paliperidone ER Significantly Improves Symptoms of Schizoaffective Disorder

... condition, which encompasses the symptoms of both schizophrenia and a major mood disorder. Patients ... disorder can be difficult to distinguish from schizophrenia or bipolar disorder because the symptoms ... that frequently use mental health services, schizophrenia and schizoaffective disorder may account ...

Memory Pharmaceuticals and Roche Expand R3487/MEM 3454 Development Program

... 3454 in cognitive impairment associated with schizophrenia (CIAS). Memory Pharmaceuticals is ... The Phase 2 trial is in patients with stable schizophrenia who are receiving atypical antipsychotic therapy. ... objectives include measures of other symptoms of schizophrenia and functional capacity. About R3487/MEM 3454 ...

Olanzapine Long-Acting Injection (LAI) Shown to Maintain Treatment Benefit in Schizophrenia for up to Six Months

... have been associated with improved treatment of schizophrenia in patients who have difficulty adhering to daily ... LAI may play in the treatment of patients with schizophrenia who have benefited from olanzapine but continue ... study, a total of 1,065 adult outpatients with schizophrenia who had been stabilized previously with open- ...

deCODE and SGENE Consortium Discover Deletions in the Human Genome Linked to Risk of Schizophrenia

... individuals with certain mental disorders such as schizophrenia tend to have few children, and thus that we may ... then tested these variants for association with schizophrenia in more than 1,400 schizophrenics and 33,000 ... 15q11 and 15q13 were suggestively associated with schizophrenia in this first phase, and then validated in 3,300 ...

Olanzapine Long-Acting Injection (LAI) Data Presented at First Annual Schizophrenia International Research Society Conference

... study (HGKB) were presented at the first annual schizophrenia International Research Society (SIRS) ... LAI as a maintenance treatment for patients with schizophrenia who may have difficulty taking medication on a ... study, a total of 1,065 adult outpatients with schizophrenia who had been stabilized previously on open-label ...

Alexza Completes Enrollment in Phase 3 Clinical Trial with AZ-004 (Staccato(R) Loxapine) for Acute Agitation

... treatment of acute agitation in patients with schizophrenia or bipolar disorder. Alexza believes the novel, ... many major psychiatric disorders, including schizophrenia and bipolar disorder. According to the National ... suggests that many patients with schizophrenia or bipolar disorder are able to make informed ...

NARSAD Researchers Identify Specific Genes and Family Traits Linked to Schizophrenia, Bipolar Disorder and Depression

... genes. Donald C. Goff, MD, director of the schizophrenia Clinical and Research Program at Massachusetts ... Benefit? Do genes explain why some people with schizophrenia are helped when they take supplements of the ... low blood levels of folate and negative schizophrenia symptoms, folate is involved in many different ...

Overview of Asenapine Data from Olympia Trial Program Presented at American Psychiatric Association Annual Meeting

... of asenapine in the treatment of schizophrenia and bipolar I disorder WASHINGTON, May 8 ... from a clinical trial involving patients with schizophrenia and schizoaffective disorders. Asenapine, a ... extension and in two out of four short-term schizophrenia studies. In the third short-term schizophrenia ...

Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidone's Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events

... is effective in the short-term treatment of schizophrenia and that iloperidone is non-inferior to ... blood glucose, body weight and lipid profiles. schizophrenia is a chronic, severe and disabling disorder that ... remains among patients with schizophrenia and the physicians who treat them. The recent ...

Patients Treated with Risperidone Long-Acting Injection had a Significantly Longer Time to Relapse Compared to Quetiapine in International Clinical Study

... -- Nearly half of patients with schizophrenia fail to remain on their medication treatment, ... longer-term maintenance therapy of patients with schizophrenia or other related disorders (schizoaffective ... RLAI offers a significant benefit to people with schizophrenia in delaying the time to relapse," said Professor ...

EnVivo Pharmaceuticals Announces Initiation of Clinical Safety and Biomarker Study of Alpha-7 Nicotinic Agonist, EVP-6124, in Patients with Schizophrenia

... of its alpha-7 nicotinic agonist (EVP-6124) in schizophrenia patients chronically treated with atypical ... This trial is enrolling approximately 20 schizophrenia patients treated with a stable dose of an ... About Electrophysiological Biomarkers in schizophrenia Patients Patients ...

Memory Pharmaceuticals & Roche Expand Development Program for MEM 3454 in Schizophrenia

... measure that is abnormal in patients with schizophrenia is mismatched negativity, which is the ability to ... Both of these evoked potential abnormalities in schizophrenia have been shown to be reversed by treatment. ... CNS disorders such as Alzheimer's disease, schizophrenia and depression. For additional information, ...

Intra-Cellular Therapies Presents Data on Its Schizophrenia and Cognition in Schizophrenia Programs at the 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders

... last week at the 14th Biennial Winter Workshop on schizophrenia and Bipolar Disorders. ITI-007 is currently in ... ITI-002 to treat cognitive dysfunction in schizophrenia which remains an important quality of life issue ... with Parkinson's disease. About Schizophrenia schizophrenia is a major neuropsychiatric disorder that affects ...

FDA Advisory Committee Supports Efficacy and Safety of Zyprexa(R) Long-Acting Injection (LAI) for Schizophrenia Treatment

... for the treatment and maintenance treatment of schizophrenia in adults, Eli Lilly and Company (NYSE: LLY ) ... period of time(iii). About Schizophrenia schizophrenia is a severe and debilitating illness often ... In addition to these symptoms, patients with schizophrenia are at greater risk for medical comorbidities ...

Intra-Cellular Therapies Presents Preclinical Data From Schizophrenia and Sleep Maintenance Programs

... is developing ITI-007 for the treatment of schizophrenia and other related psychiatric conditions. In ... a personalized approach to patient treatment for schizophrenia providing an ability to 'dial-in' the optimal D2 ... significant weight gain. About Schizophrenia schizophrenia is a major neuropsychiatric disorder that affects ...

New Study Results Show Asenapine More Effective Than Placebo in the Treatment of Acute Schizophrenia

... with acute schizophrenia. "Patients with schizophrenia and their physicians need to have a variety of ... overview In the study, 448 adult patients with schizophrenia received either asenapine 5 mg twice daily, ... 10 percent for placebo. About schizophrenia schizophrenia is a chronic, disabling brain disorder ...

Vanda Presents Phase III Iloperidone Efficacy Data

... greater improvements in the symptoms of schizophrenia versus placebo and has a favorable safety ... that should be very good news for patients with schizophrenia and the physician community," said Dr. Peter ... parallel-group, six-week trial of patients with schizophrenia or schizoaffective disorder. The analysis ...

Schering-Plough Announces Asenapine NDA Accepted for Filing by the U.S. FDA

... approval from the FDA for the treatment of schizophrenia and acute mania or mixed episodes associated with ... clinical trial program thus far has consisted of schizophrenia and bipolar mania trials involving nearly 3,000 ... two years later(5). About schizophrenia schizophrenia is a chronic, disabling brain disorder ...

SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia

... for maintenance treatment of schizophrenia in adult patients. On May 17, 2007, the FDA ... treatment of schizophrenia in adult patients. schizophrenia patients experience high rates of symptom ... these patients are treated with SEROQUEL XR." schizophrenia is a serious brain disorder with symptoms ...

EnVivo Pharmaceuticals Announces Progress on Major Drug Programs Focusing on Alzheimer's, Schizophrenia and Huntington's Diseases

... several key programs for addressing Alzheimer's, schizophrenia and Huntington's diseases. EnVivo ... U.S. Food and Drug Administration for a Phase IIA schizophrenia study that is scheduled to begin in early 2008. ... compounds will improve cognitive function in schizophrenia and Alzheimer's patients. Additionally, the ...

Forest Laboratories, Inc. and Gedeon Richter Announce Results of Phase II-B Study for RGH-188 as a Treatment for Schizophrenia

... study of RGH-188, a novel antipsychotic, in 389 schizophrenia patients. The protocol-specified primary endpoint ... effect compared to placebo in the treatment of schizophrenia in the low dose arm and a numerical improvement ... the development of RGH-188 as a treatment for schizophrenia and will determine the appropriate development ...

INVEGA(TM) Significantly Reduced Symptoms of Schizophrenia Compared to SEROQUEL(R) in Acutely Ill, Hospitalized Patients

... -- Acutely ill, hospitalized patients with schizophrenia showed significant improvement in symptoms after ... tremor (20%, 8%, 15%), dizziness (4%, 15%, 1%), schizophrenia (6%, 9%, 13%) and insomnia (12%, 10%, 15%). ... reported in more than two percent of patients was schizophrenia (INVEGA 4%, SEROQUEL 2%, and placebo 0%). ...

Vanda Pharmaceuticals Submits Iloperidone New Drug Application

... instrument in the treatment of patients with schizophrenia and may help to usher the field of psychiatry ... "The application of personalized medicine in schizophrenia is significant because response to drugs varies ... Alliance on Mental Illness). Unmet Needs in schizophrenia ...

U.S. FDA Issues Complete Response Letter for SAPHRIS(TM) (ASENAPINE) in the Acute Treatment of Both Schizophrenia and Bipolar I Disorder

... for SAPHRIS(TM) (asenapine) sublingual tablets in the acute treatment of schizophrenia in adults and in the acute treatment of manic or mixed episodes associated ... data from a clinical trial program involving more than 3,000 patients in schizophrenia and bipolar mania trials. Schering-Plough is an innovation-driven, ...

Alexza's AZ-004 (Staccato(R) Loxapine) Phase 3 Trial Meets Primary Endpoint of Treating Acute Agitation in Schizophrenic Patients

... were two serious adverse events reported during the trial: exacerbation of schizophrenia (1 patient in the placebo group) and gastroenteritis (1 patient in the 10 ... common and severe symptoms of many major psychiatric disorders, including schizophrenia and bipolar disorder. According to the National Institute of Mental Health ...
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