Nektar Announces Positive Results from Phase 2 Study of Oral NKTR-118 in Patients with Opioid-Induced Constipation (OIC)

... Results Achieved at Two Dose Levels with No reversal of Analgesia SAN CARLOS, Calif., March 2 ... in the 25 mg and 50 mg dose cohorts, there was no reversal of analgesia as measured by a change in pain ... treatment period without opiate withdrawal or reversal of analgesia. There are no oral therapies to ...

Research Highlights New Approaches to Prevent Blood Clots in Several High-Risk Patient Populations Including Largest Study Ever to Examine Use of Blood-Thinning Medication in Patients With Cancer

... last idrabiotaparinux treatment led to a rapid reversal of the anti-Factor Xa activity, or the ... therapy. A final objective included the reversal of the anticoagulant effect of idrabiotaparinux, ... to reverse the effects of an anticoagulant. The reversal of the anticoagulant effect was measured after a ...

Regado Biosciences Completes Patient Enrollment for Phase IIa Study of REG1 Anticoagulation System

... anticoagulant, RB006, and its matched, active reversal agent, RB007, which specifically binds to and ... controllable by a matched reversal agent. Regado is developing REG1 for use in ... of an aptamer-based anticoagulant and its matched reversal agent. The anticoagulant component, RB006, is a ...

Schering-Plough Announces European Launch of BRIDION(R) (Sugammadex)

... rocuronium or vecuronium and for immediate reversal of rocuronium in adults, and for routine ... facilitate intubation and mechanical ventilation. reversal agents reverse the effects of muscle relaxants, ... function sooner and breathe on their own. Current reversal agents are slow and are associated with certain ...

Regado Biosciences Reports Clinical Results for REG1 Anticoagulation System at European Society of Cardiology Congress 2008

... RB006, and its matched, active reversal agent, RB007, which binds to and neutralizes ... anticoagulant controllable by its matched reversal agent. Regado is developing REG1 for use in ... of an aptamer-based anticoagulant and its matched reversal agent. The REG1 anticoagulant component, RB006, ...

Journal of the American Dental Association Publishes Key Clinical Data for the Use of OraVerse(TM) a Local Anesthetic Reversal Agent

... mesylate) injection as a local dental anesthetic reversal agent in the August 2008 issue of the Journal of ... efficacy and safety of OraVerse to accelerate the reversal of soft-tissue local anesthesia in children aged ... procedures. OraVerse is indicated for the reversal of soft-tissue anesthesia, i.e., anesthesia ...

BRIDION(R) (sugammadex) Injection - First and Only Selective Relaxant Binding Agent - Approved in European Union

... in two decades. BRIDION is indicated for routine reversal of the commonly used muscle relaxants rocuronium or vecuronium and for immediate reversal of rocuronium in adults, and for routine reversal following rocuronium in children and adolescents ...

European Union's CHMP Issues Positive Opinion on Sugammadex

... approval of sugammadex for routine reversal of the muscle relaxants rocuronium or vecuronium and for immediate reversal of rocuronium in adults, and for routine reversal following rocuronium in children and adolescents ...

Sugammadex Trials Demonstrate Rapid Recovery from Profound Neuromuscular Blockade During General Anesthesia

... sugammadex and neostigmine/glycopyrrolate for the reversal of profound rocuronium (Zemuron(R)/ ... and one of the lead Signal trial investigators. reversal agents are used during general anesthesia to ... called neuromuscular blocking agents (NMBAs). reversal of neuromuscular blockade enables spontaneous ...

New Study Shows BENICAR(R) (olmesartan medoxomil) Reverses Blood Vessel Damage Independent of Blood Pressure Lowering

... of ACE inhibitors or other angiotension II receptor blockers (ARBs) in the reversal of vascular hypertrophy in hypertensive subjects.(6,7,8,9,10,11,12) ... N Engl J Med 2001;345:861-9. 17. Dahlof B, Pennert K, Hansson L. reversal of left ventricular hypertrophy in hypertensive patients. A ...

Regado Biosciences Announces Publication in Circulation of Clinical Trial Results of REG1 Anticoagulation System

... 1b Study is First to Show RNA Aptamer Drug:Antidote Pair Offers Rapid reversal of Anticoagulant Effect in Patients with Coronary Artery ... RB006. The binding of RB007 to RB006 causes the predictable and rapid reversal of RB006 that allows the patient's blood to return to normal. About ...

FDA Advisory Committee Unanimously Recommends U.S. Approval of Sugammadex, the First and Only Selective Relaxant Binding Agent

... rapid and can even be used in emergency situations when immediate reversal of rocuronium is needed. Schering-Plough acquired sugammadex through its ... Schering-Plough's 2007 10-K/A. Reference: (1) Jones K et al. Faster reversal of Profound Rocuronium-Induced Neuromuscular Blockade with Sugammadex ...

FDA Issues Complete Response Letter for INTUNIV(TM) (guanfacine) Extended Release for the Treatment of ADHD in Children and Adolescents

... 2005; 57:1377-1385. 8. Steere JC, Arnsten AFT. The alpha-2A noradrenergic agonist, guanfacine, improves visual object discrimination reversal performance in rhesus monkeys. Behav Neurosci. 1997;111:1-9. 9. Mao Z-M, Arnsten AFT, Li B-M. Local infusion of alpha-1 adrenergic agonist ...

Ascenta Therapeutics Announces Positive Preliminary Results with AT-101 in Docetaxel Refractory Prostate Cancer

... data set demonstrating the broad therapeutic potential of AT-101," said Mel Sorensen, MD, CEO of Ascenta Therapeutics. "The evidence of resistance reversal from this refractory population supplements the earlier clinical data demonstrating robust activity with the same regimen in docetaxel-naive ....

Modigene Announces Positive Results of Pilot Toxicity Study of Its Long-Acting Human Growth Hormone hGH-CTP

... estimated at $2.5 billion. In addition to its use for medical indications, hGH has been shown to promote a number of "lifestyle" benefits including reversal of non-voluntary weight loss, increased energy levels, enhanced sexual performance, lower cholesterol and improved appearance of the skin. ...

Thermogard XP(TM) Studies to Be Presented at American Society of Anesthesiologists Annual Meeting

... During Cardiac Surgery -- Use of a Warming Catheter To Treat Perioperative Hypothermia in a Patient Undergoing Salvage Off-Pump RVAD Insertion -- reversal of Stroke by the Early Institution of Therapeutic Hypothermia after Cardiac Surgery "Patients undergoing cardiac surgery are at risk for developing ...

Neuronascent, Inc. Receives Multiple Fundings for Its Neurogenesis Therapeutic Programs

... neurons critical to cognition and memory and enhance neuroprotection against neurodegenerative diseases. Results from recent animal studies show a reversal of cognitive loss in aged mice to young levels. "Our lead compound for Alzheimer's disease may represent the first disease-modifying therapeutic ...

Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease

... http://www.gleevec.com, http://www.us.tasigna.com and http://www.novartisoncology.us . References 1. Schermuly RT et al. reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest. 2005 Oct;115(10):2811-21. 2. National Library of Medicine Medical ...

Senate Told Brain Technology Can Impact Public Policy

... that this can be done in ways that generalize to everyday life and persist after the training ends. These gains are large -- roughly equivalent to a reversal in the normal decline we see over a decade in an average person over age 50." Dr. Mahncke also said that independent studies of these ...

U.S. FDA Issues Action Letter for Sugammadex

... SGP ) today announced that the U.S. Food and Drug Administration (FDA) has issued a "not-approvable" letter for sugammadex sodium injection for the reversal of muscle relaxation during general anesthesia. "We are surprised and disappointed with this action, especially given that sugammadex received a ...

Nuvelo Announces Positive Proof-of-Concept Data With Anticogulant NU172

... anticoagulation for medical and surgical procedures through its potential to produce rapid and predictable onset of anticoagulation followed by rapid reversal once the infusion is discontinued." The single-center, Phase 1 trial examined the safety, tolerability and pharmacokinetics of escalating bolus ...

CorMatrix(R) Announces Intramyocardial Injection of Emulsified ECM Technology(TM) Demonstrates Enhanced Angiogenesis and Improved Cardiac Function in a Preclinical Model

... at three, seven, 21 and 42 days. "The animals that received injections of the ECM Technology in an emulsified version demonstrated a significant reversal of cardiac damage and sustained improvements in ejection fraction and overall cardiac function," said Robert Matheny, M.D., Chief Scientific Officer, ...

Mayo Clinic Finds Capsule Endoscopy Can Detect Intestinal Damage Caused by Celiac Disease

... complications and increase the risk of death. However, when a medically supervised diet plan is implemented, patients can experience almost complete reversal of symptoms and complications from the disease. "Capsule endoscopy allows us to look at the entire 30 feet of the small intestine, not just the ...

Immunosyn Corporation Releases SF-1019 Study Results

... was an increase in motor strength, lessening of fatigue, walking, alleviation of numbness and pain, coordination and, in one patient, a measurable reversal of osteoporosis. "Although preliminary, the results were extraordinary. It appears that SF-1019 is safe and effective as a single form of therapy ...

Regado Biosciences Presents Early Stage Clinical Data for REG1 Anticoagulation System at American Heart Association 2007 Scientific Sessions

... component, RB007, is a complementary nucleic acid that binds to and neutralizes RB006. The binding of RB007 to RB006 causes the predictable and rapid reversal of RB006 that allows the patient's blood to return to normal. About Regado Biosciences Regado Biosciences is pioneering a new therapeutic field ...

Regado Biosciences Presents Positive Data From REG1 Anticoagulation System Phase Ic Study at American Heart Association 2007 Scientific Sessions

... component, RB007, is a complementary nucleic acid that binds to and neutralizes RB006. The binding of RB007 to RB006 causes the predictable and rapid reversal of RB006 that allows the patient's blood to return to normal. About Regado Biosciences Regado Biosciences is pioneering a new therapeutic field ...

Regado Biosciences Initiates Phase IIa Clinical Study of REG1 Anticoagulation System

... component, RB007, is a complementary nucleic acid that binds to and neutralizes RB006. The binding of RB007 to RB006 causes the predictable and rapid reversal of RB006 that allows the patient's blood to return to normal. About Regado Biosciences Regado Biosciences is pioneering a new therapeutic field ...

Positive Five-Year Safety Data for TAXUS(R) Stent Reported in Boston Scientific Trial

... cumulative rate of stent thrombosis rate through five years being identical -- 2.5% for the TAXUS Stent and 2.5% for BMS (p=0.94). "With the recent reversal of the SCAAR study, positive results from the Ontario database and excellent five-year data reported for TAXUS II and now TAXUS IV, the TAXUS Stent ...

Organon's Sugammadex Demonstrated a 9-12 Times Faster Recovery in Phase III Pivotal Trial Compared to Neostigmine

... in a Phase III pivotal trial a 9-12 times faster reversal of neuromuscular blockade as compared to ... efficacy of sugammadex and neostigmine for the reversal of shallow neuromuscular blockade induced by ... has shown a rapid and complete reversal in this pivotal trial without evidence of PORC or ...

Organon's Sugammadex Demonstrated a 9-12 Times Faster Recovery in Phase III Pivotal Trial as Compared to Neostigmine

... efficacy of sugammadex and neostigmine for the reversal of shallow neuromuscular blockade induced by ... "Sugammadex has shown a rapid and complete reversal in this pivotal trial without evidence of PORC or ... of neuromuscular blockade. Effective reversal is critically important to ensure that patients ...

Cellerant Therapeutics Reversed Autoimmune Disease in Lupus Mice with Transplant of Purified Donor Blood Stem Cells

... al., DOI 10.1182/BLOOD-2007-03-081497). "The demonstration of successful reversal of the disease using purified stem cells with non-myeloablative ... cells. Subjects with established autoimmune disease experienced a reversal of symptoms, including decreased appearance of proteinuria, of circulating ...

Critical Therapeutics Announces the Publication of Data for ZyfloCR (Zileuton) Extended-Release Tablets in the Journal of Asthma

... of age and older. ZYFLO CR and ZYFLO are not indicated for use in the reversal of bronchospasm in acute asthma attacks, but can be continued during acute ... of age and older. ZYFLO CR and ZYFLO are not indicated for use in the reversal of bronchospasm in acute asthma attacks. Therapy with ZYFLO CR and ZYFLO ...

Two New Imaging Studies Show Higher Dose Lipitor Stopped the Progression of Atherosclerosis

... in cIMT, high-risk patients who took Lipitor 80 mg experienced regression in atherosclerosis compared with patients who took other statins. In the reversal trial, Lipitor patients experienced a halting of plaque progression compared with pravastatin, and Lipitor patients experienced a ...

Xanthus Presents Novel Approach for Autoimmune Disease Reversal with Symadex

... while in control animals the disease symptoms and damage remained unchanged. In chronic EAE disease models, clinical and pathological disease reversal and tissue recovery were observed with Symadex treatment. At the same time, Symadex did not affect circulating immune cell numbers, suggesting that ...

Ceregene Presents Interim Phase 1 Clinical Data of CERE-110 for the Treatment of Alzheimer's Disease

... region where cholinergic cell degeneration occurs in Alzheimer's disease. The cholinergic system is important in memory and cognitive function, and a reversal in the blockade of this system may restore memory. Delivery of NGF using an AAV vector may have the potential to induce sustained expression of NGF, ...

Digital vs. Analog Mammography

... tube (CRT) monitors or liquid crystal display (LCD), allowing for unlimited manipulation of the contrast and brightness of the image, including image reversal and electronic magnification. Studies find several advantages to digital mammography systems, including: A higher detected quantum ...