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Retina in Medical Technology

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting

... and subretinal fibrosis (scarring). When the retina becomes separated from the retinal pigment ... cell types are present in the space between the retina and the RPE, subretinal fibrosis is the result ... recovery of photoreceptor cells even though the retina is reattached. When such cells grow on the ...

Bayer and Regeneron Extend Development Program for VEGF Trap-Eye to Include Central Retinal Vein Occlusion

... in retinal injury and loss of vision. The retina can also become "ischemic" (starved for oxygen), ... in retinal injury and loss of vision. The retina can also become "ischemic" (starved for oxygen), ... the growth of abnormal new blood vessels in the retina in patients with CRVO. About the Phase 3 ...

Scientists Discover a Role for the Growth Factor TGF-beta in Maintaining Health of Retinal Blood Vessels

... essential to the health of blood vessels in the retina and that blocking it can cause retinal ... efficiently through the smaller vessels into the retina tissue, and fluid was leaking out of the vessels, ... set of controls that keeps blood vessels and the retina healthy. Future studies are aimed at ...

St. Jude Defines Eye Cancer Gene's Role in Retinal Development

... a gene called N-myc coordinates the growth of the retina and other eye structures to ensure the retina has ... scientists inactivated N-myc, the volume of the retina was significantly smaller than in mice ... of reactions that control development of the retina and other eye components. Therefore, when ...

Ellex 2RT Study Demonstrates Clinical Efficacy in Treatment of Diabetic Macular Edema

... results of an ongoing study for non-thermal retina Regeneration Therapy (Ellex 2RT(TM)). Results ... the initial clinical trial results today at the retina Subspecialty Day of the annual meeting of the ... that lead to atrophic cell death of the central retina or macula, which is required for fine vision used ...

ThromboGenics Completes Patient Enrolment for Phase II Trial of Microplasmin for the Treatment of Diabetic Macular Edema (MIVI II DME)

... 20-60. Diabetic Macular Edema (DME) is a condition where swelling of the retina occurs in patients with diabetic retinopathy, due to a leakage of fluid ... represent a major advance in this area, as detaching the vitreous from the retina has been associated with greatly reducing the growth of new blood vessels ...

NeoVista Unveils 18-month Data on Novel Wet AMD Therapy at Retina Society Meeting

... macular degeneration (AMD) at the 41st Scientific Meeting of the retina Society. The long-term data from the study, which was initiated to test ... by the Doheny reading center. The data were presented at the retina Society Meeting by Nelson R. Sabates, MD, Professor and Chairman, ...

Newly Published Study Shows OPKO's siRNA Bevasiranib Is Taken Up by Target Tissues in the Eye

... Molecular Vision - - Results Show Good Distribution of Bevasiranib to retina and RPE Cells after a Single Intravitreal Injection - ... studies in rabbits, results showed that bevasiranib was present in the retina and in targeted retinal pigment epithelium (RPE) cells following ...

Bayer and Regeneron Dose First Patient in Second Phase 3 Study for VEGF Trap-Eye in Wet Age-Related Macular Degeneration

... vessels in the eye leak fluid and blood into the macula, the area of the retina that allows for vision of fine details. This can lead to a rapid loss of ... blood and fluid. This leakage causes disruption and dysfunction of the retina creating blind spots in central vision, and it can account for blindness ...

Gene Therapy Improves Vision in Patients with Congenital Retinal Disease

... The LCA gene therapy vector showed no signs of causing inflammation in the retina or other toxic side effects. One of the three patients had an adverse event, a hole in the retina that did not affect eyesight and may have been surgery-related, rather ...

St. Jude Identifies the Specific Cell That Causes Eye Cancer, Disproving Long-Held Theory

... showed that retinoblastoma can arise from fully matured nerves in the retina called horizontal interneurons. This disproves the scientific principle ... showed that when the activity of the Rb family of genes was reduced in the retina of mouse models, fully differentiated horizontal neurons could multiply ...

Tiny Cup Attached to Eye Improves Drug Delivery For Retinal Diseases

... fibrous, protective outer layer of the eye. The tiny cup administers the drug slowly by passive diffusion through the sclera, where it reaches the retina and vitreous. The device is so small the patient should feel little or no discomfort and it does not hinder normal vision. Currently, drugs ...

ThromboGenics' Microplasmin Phase III Program Progressing According to Schedule

... Focal vitreomacular adhesion is a condition in which the vitreous gel, in the center of the eye, has an abnormally strong adhesion to the retina at the back of the eye. These adhesions can cause vessel and retinal distortion which results in deterioration in the patient's vision. ...

Harvard Study Shows Folic Acid, B Vitamins in Animi-3(R) May Prevent Vision Loss

... omega-3 fat, to address various conditions, including heart disease, arthritis, eye health, and depression." "DHA is highly concentrated in the retina of the eye, which is one of the reasons why a DHA deficiency may be important to vision," added President Jack Schramm, PBM Pharmaceuticals, Inc., ...

Laser Burn Injuries in One Eye Can Disrupt Protective Immune Privilege in Both Eyes, Study Finds

... BOSTON, Feb. 26 /PRNewswire-USNewswire/ -- Scientists at Schepens Eye Research Institute have shown for the first time that a laser burn to one retina can cause both eyes to lose a special protective ability known as immune privilege. Immune privilege protects the eye without the inflammation of the ...

ThromboGenics Begins Phase III Program With Microplasmin for the Non-surgical Treatment of Back of the Eye Disease

... adhesion. Focal vitreomacular adhesion is a condition in which the vitreous gel, in the center of the eye, has an abnormally strong adhesion to the retina at the back of the eye. These adhesions can cause vessel and retinal distortion which results in deterioration in the patient's vision. ...

Durezol(TM) in the Treatment of Uveitis and Ganciclovir in the Treatment of Herpetic Keratitis: Studies of Treatments for Leading Causes of Blindness to Be Presented

... will be presented by investigator Thomas Flynn, M.D., Assistant Professor of Clinical Ophthalmology, Columbia University, and Ellsworth Uveitis & retina Care, in his presentation, "Durezol Compared to Pred Forte in the Treatment of Endogenous Anterior Uveitis." The randomized, multicenter, ...

'Snapshots' of Eyes Could Serve as Early Warning of Diabetes or Diabetic Eye Disease, U-M Researchers Report

... of diabetes but haven't been diagnosed. "Our objective in performing this study was to determine whether we could detect abnormal metabolism in the retina of patients who might otherwise remain undiagnosed based on clinical examination alone," says Elner, professor, Department of Ophthalmology and ...

ESBATech's Lead Antibody Fragment Enters Clinical Development for Ophthalmic Indications

... of ESBA105 were observed throughout the anterior (front) and the posterior (back) segments of the eye, the latter including the vitreous humor, retina and choroid. Peter Lichtlen, M.D., Ph.D., Head of Clinical Development at ESBATech AG, commented, "ESBA105 shows an entirely novel and unique ...

ThromboGenics Completes Patient Enrolment in the Phase IIb Trial of Microplasmin in Vitrectomy (MIVI III)

... involves removing the vitreous via suction. Microplasmin is a proteolytic enzyme that cleaves important molecules which link the vitreous to the retina and therefore has the potential to facilitate vitrectomy and induce PVD without the risks inherent in detachment by surgical intervention. MIVI III ...

DSMB Again Supports Continuation of the Phase III Clinical Trial of Medidur(TM) FA for the Treatment of DME

... degeneration (AMD). Medidur, a tiny, injectable insert, is being studied as a way to deliver fluocinolone acetonide, a corticosteroid, to the retina for up to three years as a treatment for diabetic macular edema (DME). Using a proprietary 25 gauge injector system, an eye care professional injects ...

Dynamis Therapeutics, Inc. Discovers RAGE Inhibitor

... cancers, and aging. A patent has been filed on the discovery. A team of Dynamis Therapeutics' scientists significantly decreased kidney and retina RAGE in aged rats that were orally dosed with Dynamis Therapeutics' RAGE inhibitor for 32 weeks, as compared to non-treated rats. In addition, ...

MacuSight(TM) Announces Positive Preliminary Results From Phase 1 Study of Sirolimus in Wet Age-Related Macular Degeneration

... in patients with DME. These findings corroborate the preliminary results which MacuSight announced in October 2007 at the 40th Annual Meeting of The retina Society. "We are very encouraged by this study's findings as they provide a compelling demonstration of sirolimus' potential therapeutic activity ...

Enrollment Complete in Pivotal Phase 3 Trial of Medidur(TM) FA for Diabetic Macular Edema

... Alimera CEO Dan Myers. Medidur, a tiny, injectable insert, is being studied as a way to deliver fluocinolone acetonide, a corticosteroid, to the retina for up to three years as a treatment for diabetic macular edema (DME). Using a proprietary 25 gauge injector system, an eye care professional injects ...

MacuSight(TM) Announces Positive Initial Results From Phase 1 Study of Sirolimus in Diabetic Macular Edema

... reductions for up to 180 days following a single administration of sirolimus. These findings were presented at the 40th Annual Meeting of The retina Society by Mark Blumenkranz, M.D., chairman of MacuSight's scientific advisory board and professor and chairman of the department of ophthalmology, ...

Enrollment Begins on Human PK Study for Medidur(TM) FA

... during an in-office procedure, which is being studied as a way to deliver a very low dose of fluocinolone acetonide (FA), a corticosteroid, to the retina for up to three years as a treatment for DME. Medidur FA is currently in a Phase III global clinical trial, the FAME(TM) (Fluocinolone Acetonide in ...

Schepens Scientists Identify Key to Integrating Transplanted Nerve Cells Into Injured Tissue

... down barriers on the outer surface of a damaged retina and allow healthy donor cells to integrate and ... transplantation of donor photoreceptors (in whole retina transplants) may prove to be more beneficial ... are triggered by the body to protect the injured retina or other nerve tissue from further damage. This ...

Positive Interim Phase 2 Data Reported for VEGF Trap-Eye in Age-Related Macular Degeneration

... (exudative). In wet AMD, new blood vessels grow beneath the retina and leak blood and fluid. This leakage causes disruption and dysfunction of the retina creating blind spots in central vision and can account for blindness in wet AMD patients. About Regeneron Pharmaceuticals Regeneron is a ...

Scientists Implicate Gene in Vitiligo and Other Autoimmune Diseases

... parts of the body. Similar patches also appear on both the mucous membranes (tissues that line the inside of the mouth and nose), and perhaps in the retina (inner layer of the eyeball). The hair that grows on areas affected by vitiligo sometimes turns white. The researchers began a search for genes ...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

... their fast and easily visible development. Small molecules that inhibit DNMT1 should produce terminal differentiation abnormalities of the gut tube, retina and exocrine pancreas, all of which are easily visualized. This screen allows quick validation of DNMT1 inhibition in vivo, as well as important data ...

VEGF Trap-Eye Phase 2 Wet AMD Results Reported at ARVO Annual Meeting

... (exudative). In wet AMD, new blood vessels grow beneath the retina and leak blood and fluid. This leakage causes disruption and dysfunction of the retina creating blind spots in central vision, and it can account for blindness in wet AMD patients. About DME Diabetic Macular Edema (DME) is the most ...
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