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Protein in Medical Technology

Octapharma Accepting Applications for Research Grants on Immunotherapy, Coagulation Disorders and Critical Care

... or pre-clinical research focused on human protein therapies in coagulation disorders, ... patients with the safest, highest quality human protein therapies available is stronger than ever," said ... production and sale of high quality human protein therapies, including immune globulin ...

Cognition Therapeutics Closes Series A Financing to Advance Drug Candidates for Alzheimer's Disease

... activity of the toxic oligomeric form of Abeta protein that interferes with normal learning and memory. ... that the memory deficits caused by the oligomeric protein are among the earliest changes seen in ... indicate that blocking the effects of this protein may halt or reverse Alzheimer's disease. ...

Fruitfly Model of a Neuropathic Disease Demonstrates Novel Role for Proteins in the Family of aTyr Pharma's Product Class

... aTyr Pharma's new class of naturally occurring protein agents. The aminoacyl tRNA synthetases are universal and essential components of protein synthesis machinery found in all organisms, but ... with cell signaling activities distinct from the protein synthesis activities. In this recently ...

Sangamo BioSciences Announces Achievement of Key Milestone in Cell Engineering Agreement With Genentech

... with novel characteristics for pharmaceutical protein production purposes using Sangamo's proprietary zinc finger DNA-binding protein nuclease (ZFN) technology. Genentech scientists ... being used by major players in pharmaceutical protein production to streamline the process of cell line ...

Alfacell Provides Shareholder Update

... gene1 and the multidrug resistance associated protein gene make proteins which act like pumps to keep ... if Onconase is able to down regulate the protein produced by the MDR1 gene. There is ample ... ribonuclease (RNase) technology. A natural protein isolated from the leopard frog, ONCONASE has been ...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... that antisense reduction of retinal binding protein 4 (RBP4) caused significant improvements in ... Inhibition of cAMP Response Element Binding protein (CREB) Expression Lowers Plasma Glucose and ... of Carbohydrate Response Element Binding protein (ChREBP) in Liver Protects Against Fructose ...

Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy

... human breast carcinomas and discovered that the protein EZH-2 was expressed in 74 percent of those cases. ... "We wanted to see how much expression of the protein was present. We were surprised that 74 percent of ... The discovery of the high rate of EZH-2 protein expression in breast cancer cases opens up a new ...

AMT Receives EMEA Orphan Drug Designation for Acute Intermittent Porphyria

... PBGD gene result in insufficient activity of a protein necessary for the synthesis of heme. This leads ... AMT-021, results in normalization of the PBGD protein in an animal model of AIP. In this model, the ... to provide long-term normalization of the PBGD protein in order to prevent acute porphyric attacks and ...

Raptor Pharmaceuticals Receives Notices of Allowance for Two NeuroTrans(TM) Patent Applications

... comprising administering receptor-associated protein ("RAP") fragments conjugated to active agents ." ... is Raptor's proprietary receptor-associated protein ("RAP")-based technology program designed to ... has also been conjugated to a variety of protein drugs, including enzymes and growth factors, ...

Processed Tomato Products May Protect Against Inflammation, According to a Study Presented at the Experimental Biology Meeting

... tomatoes on vasodilatation and C-reactive protein in overweight and obese men and women, presented ... lower serum C-reactive protein. C-reactive protein is a recognized biomarker of inflammation. ... through dietary strategies) and C-reactive protein on overweight and obese men and women. Within the ...

Cylene to Present Advances in its Oral Inhibitor of CK2 at AACR Annual Meeting

... of CX-4945, a first-in-class oral inhibitor of protein kinase CK2. CK2 overexpression is well ... orally bioavailable small molecule inhibitor of protein kinase CK2: Phase I initiated - Experimental ... inhibitors of cancer-linked serine/threonine protein kinases, as well as innovative nucleolus ...

Osprey Pharmaceuticals U.S.A., Inc. Initiates Phase Ib Clinical Trial in IgA Nephropathy

... is developing novel chemokine-enzyme fusion protein therapeutics, known as Leukocyte Population ... U.S.A. is focused on the development of protein therapeutics for the treatment of inflammatory ... a pipeline of proprietary LPMs, novel fusion protein therapeutics designed to selectively and ...

Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib

... oral cancer treatment to directly target mTOR, a protein inside the cell that controls tumor cell division ... globally(1). Afinitor inhibits mTOR, a protein in the cancer cell that controls tumor cell ... cells, Afinitor continuously targets mTOR, a protein that acts as a central regulator of tumor cell ...

Key Protein May Lead to Faster Acting Anti-Depression Drugs

... in the Journal of Neuroscience that the brain protein called p11 could lead pharmaceutical companies to ... of 5-HT4 Receptor Stimulation , solidifies the protein p11 as a key determinant of vulnerability to ... Physiology, helped establish p11 as an important protein that regulates signaling in the brain by the ...

Intellect Neurosciences, Inc. Announces Independent Studies on Copper Binding Properties of its Lead Candidate OXIGON(TM)

... physical interaction between the beta amyloid protein and melatonin, a close structural homolog of ... species produced in the brain by beta-amyloid protein bound primarily to copper ions," commented ... with other compounds, referred to as metal protein attenuating compounds, which have begun to show ...

PTC Therapeutics Completes Enrollment of Pivotal Trial in Muscular Dystrophy

... formation of functioning dystrophin, the missing protein in patients with nmDMD/BMD." This is the ... to terminate translation before a full-length protein is generated. This causes the protein to be truncated and non-functioning. Ataluren is ...

Medgenics Announces Positive Data From Phase I/II Clinical Trial of EPODURE Treatment of Anemia in Chronic Kidney Disease

... safety and efficacy for the sustained protein therapy of anemia in patients with chronic kidney ... delivering the low dose of 18-25 IU/kg/day of the protein erythropoietin (EPO), was sufficient to sustain ... first practical treatment to provide sustained protein therapy and serve as an alternative to expensive, ...

Modigene Announces Positive Results of Pilot Toxicity Study of Its Long-Acting Human Growth Hormone hGH-CTP

... protein, CTP extends the time that the protein is active in the body. The potential utility of ... and the effectiveness of Modigene's long-acting protein programs, that are made pursuant to the safe ... commercial products based upon its long-acting protein technology, including any long-acting versions of ...

Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor of CK2

... a Phase I clinical trial of its oral CK2 protein kinase inhibitor, CX-4945, in patients with ... potent inhibition of CK2, a constitutively active protein kinase that is overexpressed in a wide range of ... Affairs. About CX-4945, an oral CK2 protein kinase inhibitor CX-4945 is a first-in-class ...

Synvista Therapeutics Announces Published Data Demonstrating Elevation of Carboxymethyl-Lysine (CML) Is Associated with Decline in Renal Function and Arterial Stiffness in Older Adults

... through further oxidation, the resulting modified protein is described as an Advanced Glycation End Product ... heart, kidney and skin among others. Collagen (a protein normally found in connective and structural tissue) is an example of a protein that can be converted into an A.G.E. As a ...

Vical Pandemic Influenza Vaccines Achieve T-Cell Responses and Cross-Clade Reactivity in Humans

... of DNA) encoding the hemagglutinin (HA) surface protein from the H5N1 influenza virus strain, ... to elicit antibody responses against the H5 protein but could elicit T-cell responses against H5 as ... proteins: nucleoprotein (NP) and ion channel protein (M2). The trivalent vaccine was designed to ...

SARS Vaccine Achieves Neutralizing Responses in First U.S. Human Trial

... diseases or cancer, in which the expressed protein is an immunogen; cancer immunotherapeutics, in which the expressed protein is an immune system stimulant; and cardiovascular therapies, in which the expressed protein is an angiogenic growth factor. The company is ...

Vical Signs Binding Letter of Intent for Sales and Marketing of Allovectin-7(R) in Turkey

... for cancer, in which the expressed protein is an immune system stimulant; DNA vaccines for infectious diseases, in which the expressed protein is an immunogen; and cardiovascular therapies, in which the expressed protein is an angiogenic growth factor. The company is ...

Vical Receives Milestone Payment from Merck & Co., Inc. Triggered by Planned Initiation of Investigational Cancer DNA Vaccine Trial

... diseases or cancer, in which the expressed protein is an immunogen; cancer immunotherapeutics, in which the expressed protein is an immune system stimulant; and cardiovascular therapies, in which the expressed protein is an angiogenic growth factor. The company is ...

New Insight Into the Controls on a Go-To Enzyme

... control, which is the job of another protein called calpastatin. A central question has been ... In this widely used method of determining protein structure, researchers first crystallize a protein to be studied. Then, they direct X-rays through ...

Vical Completes Enrollment and Reports Positive Interim Data in CMV Vaccine Phase 2 Trial

... or cancer, in which the expressed protein is an immunogen; cancer immunotherapeutics, in which the expressed protein is an immune system stimulant; and cardiovascular therapies, in which the expressed protein is an angiogenic growth factor. The company is ...

U.S. Navy and U.S. Army to Develop Dengue DNA Vaccine Formulated With Vical's Vaxfectin(R) Adjuvant

... or cancer, in which the expressed protein is an immunogen; cancer immunotherapeutics, in which the expressed protein is an immune system stimulant; and cardiovascular therapies, in which the expressed protein is an angiogenic growth factor. The company is ...

Raptor Pharmaceuticals Provides Update on Targeting Platforms

... Enters Collaboration on Receptor Associated protein (RAP) Supports NeuroTrans(TM) Platform with ... derived from the human receptor-associated protein ("RAP") and related proteins. The Company signed ... derived from the human receptor-associated protein ("RAP") and related proteins to that are designed ...

PTC Announces Data Showing That PTC124 Causes Statistically Significant Improvements in Chloride Channel Function in Cystic Fibrosis Patients

... conductance regulator (CFTR) protein and a statistically significant decrease in the ... and in apical expression of CFTR protein in nasal epithelium. The study enrolled 30 ... goal of demonstrating that increasing functional protein levels in patients with nonsense mutation genetic ...

Insmed Initiates Clinical Study for Follow-on Biologic Version of Neulasta(R)

... of our FOB portfolio, utilizing our unique protein drug development capabilities and technical ... glycol is attached to the protein. The pegylated protein has a prolonged biological activity after it is ... Inc. is a biopharmaceutical company with unique protein process development and manufacturing experience ...

Protein Shown to Play a Key Role in Normal Development of Nervous System

... PHILADELPHIA, Oct. 8 /PRNewswire-USNewswire/ -- A protein that enables nerve cells to communicate with each ... developing nervous system. Research into how that protein helps precise connections to form among nerve ... first study, published Oct. 1, showed that the protein GluR1, which is a receptor for the ...

Vical Expands Applications of Vaxfectin(R) Adjuvant for Infectious Disease and Cancer Vaccines; 80% to 100% of High-Dose Responders in H5N1 Clinical Trials Still Responding at 6 Months

... containing a peptide from Tyrosinase-Related protein 2 (TRP-2), an antigen commonly expressed by ... or cancerous cells. Vaxfectin(R)-formulated protein Vaccines Vical has previously reported that ... or cancer, in which the expressed protein is an immunogen; cancer immunotherapeutics, in ...

Burcon announces GRAS status for Puratein(R) & Supertein(TM)

... that its Puratein(R) and Supertein(TM) canola protein isolates are GRAS (Generally Recognized As Safe) ... dollar global protein ingredient market. protein ingredients are valued for both their nutritional ... in foods and beverages. Puratein(R) is a canola protein isolate with functional properties that include ...

Data from In Vivo Disease Models on Taligen Therapeutics' Pipeline Candidates to be Presented at the XXII International Complement Workshop

... Animal Data on Previously Disclosed Fusion protein TT30 and New Molecules TT32 and mAb171 ... Five studies testing the company's fusion protein TT30 and two new compounds, a fusion protein TT32 and a monoclonal antibody mAb171, in animal ...

InVitria Showcases Cell Culture Productivity Enhancers at BioProcess International

... formulation excipient. Cellastim is a recombinant protein and has been shown to improve mammalian cell ... to chicken lysozyme and provides higher protein yield compared with mechanical cell lysis. ... in bacterial fermentation to improve recombinant protein yields.(see http://www.Lysobac.com ) For ...

The First Direct Structural Evidence of SV2A has Been Revealed Thanks to Protein Tomography(TM), and Published in BBRC

... Summary: protein Tomography(TM) has yet Again Provided Structural ... the molecular mechanism of the Synaptic Vesicle protein 2A (SV2A) in mouse brain tissue. SV2A is the ... to either side of the membrane. Prior to this protein Tomography(TM) study, great efforts were made to ...

Karolinska Institutet to Test Vical's Vaxfectin(R) Adjuvant With Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control

... or cancer, in which the expressed protein is an immunogen; cancer immunotherapeutics, in which the expressed protein is an immune system stimulant; and cardiovascular therapies, in which the expressed protein is an angiogenic growth factor. The company is ...

Karolinska Institute to Test Vical's Vaxfectin(R) Adjuvant with Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control

... or cancer, in which the expressed protein is an immunogen; cancer immunotherapeutics, in which the expressed protein is an immune system stimulant; and cardiovascular therapies, in which the expressed protein is an angiogenic growth factor. The company is ...

ProteoTech's Exebryl-1(R) Enters Human Clinical Trials for the Treatment of Alzheimer's Disease

... small molecule drug targeting toxic beta-amyloid protein accumulation for the treatment of ... these animals. Toxic and insoluble beta-amyloid protein accumulation is believed to be an important part ... that is believed to prevent beta-amyloid protein formation, deposition, and accumulation at ...

Phase II Data on Lilly's Antibody Show It Affects Amyloid Beta, a Protein Believed To Be Associated with Alzheimer's Disease

... plaque and other forms of the amyloid beta protein in the brain may result in slowing of the ... plaques or other types of the amyloid beta protein are thought ultimately to disrupt normal nerve ... in the two major forms of the amyloid beta protein seen in blood and cerebrospinal fluid, an ...
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