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Dirucotide Does Not Meet Primary Endpoint in Phase III MAESTRO-01 Trial in Secondary Progressive Multiple Sclerosis

... Phase III trial in patients with secondary progressive multiple sclerosis (SPMS). In addition, there ... percent of all MS patients have the secondary progressive form of the disease(vi), in which irreversible ... (viii) Multiple Sclerosis Society. "Secondary progressive Multiple Sclerosis: How do you know when you have ...

SIMPONI(TM) (golimumab) Receives Positive Opinion From CHMP for Once-Monthly Subcutaneous Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

... active rheumatoid arthritis (RA), active and progressive psoriatic arthritis (PsA) and severe, active ... with methotrexate, the treatment of active and progressive PsA in adult patients when the response to ... restriction in multiple joints. Because RA is a progressive disease, over time it can cause permanent joint ...

RAD001 Shows Potential to Reverse Resistance to Herceptin(R)* in Metastatic Breast Cancer Patients, Leading to Phase III Trial

... patients had stable disease and one patient had progressive disease. Among the nine patients evaluated in the ... patients had stable disease and one patient had progressive disease. The critical dose- limiting toxicities ... had stable disease and three patients had progressive disease. Among the six patients in the 20 mg ...

QuatRx Pharmaceuticals Announces Additional Data From Phase 3 Study for Ophena(TM) (Ospemifene Tablets) Showing Improvements in Clinical Symptoms of Vulvovaginal Atrophy

... Florida. Vulvovaginal atrophy is a common and progressive condition associated with menopause. Earlier this ... another choice for this highly prevalent and progressive condition." About Vulvovaginal Atrophy Vulvovaginal atrophy is a chronic and progressive condition characterized by symptoms including ...

New Data Offers Insights Into the Potential Role for TYKERB(R) (Lapatinib) in Non-Cytotoxic Chemotherapy-Based Treatment Regimens

... breast cancer. The primary endpoint was progressive disease rate (PDR) at week 12 as assessed by an independent review panel.(1) progressive disease rate was defined as the percent of patients who had progressive disease by week 12 or had missing evaluations at ...

Mayo Clinic Study Identifies Potential Causes of Young-Onset Dementia

... in Chicago on April 15. Dementia represents a progressive decline in a person's cognitive function that ... normal cognitive function and were evaluated for progressive cognitive decline at Mayo Clinic from 1996 to ... poor financial judgment and progressive decline in cognitive function. Now, Bishop needs ...

New Anti-TNF Golimumab Significantly Reduced Signs and Symptoms of Ankylosing Spondylitis According to Phase 3 Study Findings

... Patients with Painful and progressive Form of Inflammatory Spinal Arthritis Receiving ... joint swelling. "When treating this potentially progressive and debilitating disease, we attempt to reduce ... treatment option for patients with this chronic, progressive spondyloarthropathy." About the GO-RAISE Trial ...

QuatRx Completes Enrollment of Ophena(TM)(Ospemifene Tablets) Final Pivotal Phase 3 Study in Women with Postmenopausal Vaginal Atrophy

... atrophy is a common condition in postmenopausal women characterized by progressive long-term vaginal symptoms such as dryness, irritation and sexual pain ... Vaginal Atrophy Postmenopausal vaginal atrophy is a chronic and progressive condition characterized by symptoms including vaginal dryness, sexual pain ...

Applying Clinical Findings to the Practice of Medicine

... impact quality of life." Dupuytren's contracture is characterized by a progressive accumulation of collagen in the palm of the hand that causes "Dupuytren's cords to form, leading to a progressive flexion of the ... standard of care is surgery." Dr. Hurst and ...

Raptor Pharmaceuticals Announces Completion of Patient Enrollment in Phase 2a Clinical Trial in Non-Alcoholic Steatohepatitis (NASH)

... patients diagnosed with non-alcoholic steatohepatitis ("NASH"). NASH, a progressive form of liver disease that accounts for approximately 10% of newly ... liver failure and end-stage liver disease. In more severe cases, the progressive nature of NASH may require liver transplantation in affected patients. ...

Positive Data From Lung Study May Lead to First FDA Approved Treatment for Pulmonary Fibrosis

... the way for the first FDA-approved therapy to treat PF - a relentlessly progressive and ultimately fatal lung disease affecting more than 128,000 people and ... (PF) Pulmonary Fibrosis (PF) is a lung disorder characterized by a progressive scarring - known as fibrosis -- and deterioration of the lungs, which ...

PTC Therapeutics Completes Enrollment of Pivotal Trial in Muscular Dystrophy

... available therapies for nmDMD/BMD may alleviate the symptoms of this progressive debilitating disease, but none address the underlying cause of the ... About DMD/BMD Duchenne and Becker muscular dystrophy (DMD/BMD) are progressive muscle disorders that result in the loss of both muscle function and ...

Kyowa Hakko Kirin Announces Development Policy for Anti-Parkinson's Disease Drug KW-6002 (Istradefylline)

... phenomenon and other symptoms. * Parkinson's disease is a progressive neurodegenerative disorder which is characterized by motor symptoms such ... and postural instability. The symptoms of this disease result from the progressive degeneration of certain nerve cells located in a specific area in the ...

Arzerra(TM) (ofatumumab) Demonstrates High Response Rates in Patients With Fludarabine Refractory Chronic Lymphocytic Leukemia (CLL)

... infections (25 percent in DR; 25 percent in BFR), including one case of progressive multifocal leukoencephalopathy (PML) in a patient with progressive disease. Early death (within eight weeks from start of treatment) occurred ...

S*BIO Advances JAK2 Inhibitor SB1518 into Phase 1/2 Clinical Trial in Australia for the Treatment of Chronic Idiopathic Myelofibrosis

... option to treat patients suffering from CIMF." CIMF is a serious progressive and chronic condition whereby scar tissue develops in the bone marrow, ... as the bone marrow. CIMF is characterized by an enlarged spleen and progressive anaemia. Current therapies for CIMF are mostly palliative in nature and ...

Pivotal Data Showed SYMBICORT(R) Improved Lung Function in Adults with COPD

... which result in decreased quality of life, chronic airway inflammation and progressive loss of lung function, making it difficult to breathe normally.(8) Common ... exacerbations and improve lung function and health status.(9) COPD is a progressive disease, which means people with COPD can expect lung function to worsen ...

Clinical Update - Debio 9902 SR (ZT-1) for Alzheimer Patients Debiopharm Starts Tablet Formulations Bridging Study under IND

... treatment for Alzheimer's disease. About Alzheimer's Disease AD is a progressive brain disorder that gradually destroys a person's memory and ability to ... communicate and carry out daily activities. AD is characterised by the progressive destruction of brain cells leading to a decline in mental function and ...

Landmark COPD Trial UPLIFT(R) Shows SPIRIVA(R) HandiHaler(R) Sustained Lung Function Improvements Over Four Years

... these findings into clinical application." About COPD COPD is a progressive yet treatable disease that restricts patients' lives over time and is a ... the main symptom of COPD, is characteristically persistent and progressive and has a serious impact on patients' quality of life.(1) At its most ...

MacroChem Announces Phase 2 Data for EcoNail(R) in the Treatment of Onychomycosis

... final results showed that a meaningful proportion of patients demonstrated progressive clinical improvement and reduction of fungal disease burden. Based on the ... I was particularly impressed with the lack of skin irritation and the progressive clinical improvement." Dr. Goldfarb added, "There are at least 4 patients ...

Raptor Pharmaceuticals Enters Collaboration Agreement with UC San Diego in Liver Disease

... diagnosed with Non-Alcoholic Steatohepatitis ("NASH"). NASH is a progressive form of liver disease that accounts for approximately 10% of newly ... leads to cirrhosis and liver failure. In more severe cases, the progressive nature of NASH may require liver transplantation in affected patients. ...

ADVENTRX Announces Preliminary Response Rate Data From Discontinued Phase 3 Trial of CoFactor(R)

... arm. The data also demonstrated a 48.8% stable disease rate and 4.8% progressive disease rate in the CoFactor experimental arm compared to a 38.6% stable disease rate and 15.9% progressive disease rate in the leucovorin control arm. Objective response rate was ...

Medivation Announces Presentation of Positive MDV3100 Clinical Data in Castration-Resistant Prostate Cancer Patients at 44th ASCO Annual Meeting

... presentation entitled "Phase 1-2 study of MDV3100 in patients (pts) with progressive Castration-Resistant Prostate Cancer (CRPC)" by principal investigator, ... of disease. Prior to enrollment in this study, all these patients had progressive disease despite standard-of-care hormonal therapies, and in roughly half ...

IDM Pharma Announces Phase 2 Follow-Up Data Showing IDM-2101 is Well Tolerated With Positive Survival Trend in Non-Small Cell Lung Cancer Patients

... with IDM-2101 continued treatment for one year with no evidence of progressive disease -- 14 patients (22%) treated with IDM-2101 continued treatment for two years with no evidence of progressive disease -- Measurable immune response - 91 percent of patients treated ...

PTC Therapeutics Announces Initiation of Phase 2b Registration-Directed Clinical Trial of PTC124 in Duchenne/Becker Muscular Dystrophy

... is critical to the structural stability of muscle fibers. Patients develop progressive muscle weakness that leads to loss of ambulation, wheelchair dependency, ... Muscular Dystrophy Duchenne and Becker muscular dystrophy (DMD/BMD) are progressive muscle disorders that cause the loss of both muscle function and ...

Ceregene Presents Long-term Follow-up From Phase 1 Trial of CERE-120 in Parkinson's Disease

... in June 2007. About Parkinson's Disease Parkinson's disease is a progressive movement disorder that affects at least one million people in the United ... controlling movement and coordination, so Parkinson's patients exhibit the progressive inability to initiate and control physical movements. There is currently ...

Keryx Biopharmaceuticals, Inc. Announces Phase 1 and Phase 2 Data on KRX-0401 (Perifosine) in Patients with Relapsed/Refractory Multiple Myeloma at 49th Annual Meeting of American Society of Hematology

... 20mg (day of and day after each Velcade dose) was added in patients with progressive disease (PD) on perifosine plus Velcade alone. Sixteen patients on either ... evaluable patients (66%) achieving SD. Dex was added in 39 of 55 pts with progressive disease. Out of 29 patients currently evaluable for response on the ...

NicOx Announces TOPIGEN Initiates Phase 2 Proof of Concept Study in COPD for TPI 1020

... relief in some patients, there are no drugs available that can slow the progressive decline in lung function. NicOx (Bloomberg: COX:FP, Reuters: NCOX.PA) is ... relief in some patients, there are no drugs available that can slow the progressive decline in lung function. About NicOx S.A. NicOx is a product-driven ...

New Analysis of METEOR Study Demonstrate Effects of AstraZeneca's CRESTOR(R) (Rosuvastatin Calcium) on Atherosclerosis in Patients With Two or More Risk Factors for Cardiovascular Disease

... University School of Medicine, Winston-Salem, NC. Atherosclerosis is a progressive disease that typically begins in early adulthood and progresses as people ... a heart attack; in the brain, it causes a stroke. Atherosclerosis is a progressive disease and the main cause of cardiovascular disease -- the No.1 killer ...

National Jewish, Brigham and Women's Awarded $37 Million to Identify Genes and Other Risk Factors that Influence the Development of COPD

... are most at risk of developing the disease, who is most likely to have progressive disease, and how to more effectively treat it." "Our goal with this ... not been adequately studied. COPD is an umbrella term for a variety of progressive lung diseases, most commonly emphysema and chronic bronchitis, which ...

NicOx Reports TOPIGEN to Advance TPI-1020 Into Phase 2 for COPD Following Promising Clinical Results

... we may have a compound with a unique efficacy profile for use in COPD, a progressive disease associated with high morbidity and mortality for which there is ... relief in some patients, there are no drugs available that can slow the progressive decline in lung function. About NicOx S.A. NicOx is a product-driven ...

Mayo Clinic Study Finds Earliest Evidence of Memory Decline in Middle-Aged People at Genetic Risk for Alzheimer's Disease

... only before people develop symptoms, but even before they reach older ages." "This study highlights the idea that Alzheimer's disease is a progressive disorder that likely begins well before clinical diagnosis," said Creighton Phelps, Ph.D., who directs the Alzheimer's Disease Research Center ...

June 2009 Mayo Clinic Women's HealthSource Highlights Summer Skin Problems, Low Vision and Pilates

... balls, resistance bands or most often, a Reformer. This piece of equipment consists of a sliding seat and a series of springs and pulleys that allow progressive exercises to strengthen all muscle groups. A typical Pilates session includes a set of controlled stretches and movements, with participants ...

5-Year Study Published in Diabetologia Demonstrated Long-Term Safety of Lantus(R) Compared to NPH

... controlled study ever reported using insulin glargine. Diabetic retinopathy is a major cause of blindness in patients with diabetes. It is a progressive disease that results from cellular proliferation within the eye. The stimulation of IGF1 receptors is involved in this process. In the study of ...

Published Study Shows VNUS ClosureFAST(TM) System Significantly Superior to Laser for Varicose Vein Treatment

... VNUS Medical Technologies (NASDAQ: VNUS ) is a worldwide leader in medical devices for the minimally invasive treatment of venous reflux disease, a progressive condition that is the underlying cause of varicose veins . VNUS sells the Closure system, which consists of a proprietary radiofrequency (RF) ...

New Analysis Shows Efficacy of SIMPONI(TM) (golimumab) in Anti-TNF Experienced Rheumatoid Arthritis Patients

... than three million people in Europe. Signs and symptoms of RA include pain, stiffness and motion restriction in multiple joints. Because RA is a progressive disease, it can cause permanent joint deformity and severe disability if not diagnosed early or if initial treatment is delayed. RA can occur at any ...

Two-Year Data Show Patients Receiving SIMPONI(TM) (golimumab) Experienced Sustained Improvement in Signs and Symptoms of Psoriatic Arthritis and Ankylosing Spondylitis

... most commonly between the ages 30 and 50, in the peak of their productive years. About Ankylosing Spondylitis AS is a painful and progressive form of spinal arthritis, and symptoms of inflammatory back pain often first present in people under the age of 35 years. It typically begins in the ...

Boehringer Ingelheim Unveils Diabetes Pipeline

... said Dr. Thor Voigt, senior vice president, Medicine and Drug Regulatory Affairs, Boehringer Ingelheim Pharmaceuticals, Inc. "Type 2 diabetes is a progressive chronic condition that frequently requires long-term treatment. A range of treatment options and combination regimens are needed so physicians can ...

CuraGen Updates CR011-vcMMAE Data at ASCO

... trial that evaluated the efficacy and safety of CR011-vcMMAE 1.88 mg/kg administered intravenously once every three weeks. Eligible patients had progressive disease at trial entry and may have received one prior cytotoxic regimen and any number of prior immunotherapies. Of the patients enrolled, 94% had ...

AIMSPRO is Awarded TGA Orphan Status for the Treatment of Amyotrophic Lateral Sclerosis

... from hyperimmune caprine serum and is currently under Phase II trialling in Europe for advanced Scleroderma and for bladder dysfunction in Secondary progressive Multiple Sclerosis. Both trials are expected to report in the first quarter of 2010. Additional open label experience with AIMSPRO, over an extended ...

Lilly Advances Second Alzheimer's Disease Treatment Candidate Into Late-Stage Testing by Launching Two Global Trials

... Japan, Korea, Poland, Russia, Spain, Sweden, Taiwan, United Kingdom, and United States. About Alzheimer's Disease Alzheimer's disease is a progressive neurodegenerative condition that is the most common cause of dementia, accounting for 60 to 80 percent of cases(ii). Estimates show that 6-8 percent ...
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(Date:12/17/2014)... , Dec. 15, 2014 Research and Markets ... addition of the "Samsung Galaxy S5 - ... report to their offering. ... totally different sensing technology than the iPhone 5S, ... sensor in its product. The Galaxy ...
(Date:12/17/2014)... , Dec. 16, 2014  Automation is fundamentally ... more evident than at international borders. Over the ... scanners have allowed veteran travelers to self process ... Control (APC) Kiosks at an increasing number of ... According to Maxine Most ...
(Date:12/11/2014)... PAUL, Minn. , Dec. 10, 2014 /PRNewswire/ ... wireless physiologic monitoring, has released a new series ... needs of preclinical toxicology researchers. M series, part ... help toxicologists collect the best possible physiologic data ... Adding functional endpoints to toxicology studies ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
(Date:12/19/2014)... -- A new study suggests a possible link between ... and night sweats -- and higher rates of hip ... during menopause, affecting about 60 percent of women. The ... since they then face a higher risk of weakened ... exhibit moderate or severe menopausal symptoms are more likely ...
(Date:12/19/2014)... Dotinga HealthDay Reporter ... including ibuprofen, might slightly reduce your risk of developing ... of ibuprofen (Advil, Motrin) and naproxen (Aleve) appear to ... 15 percent, the researchers concluded after reviewing nine prior ... sun exposure. These painkillers "have potential ...
(Date:12/19/2014)... HealthDay Reporter THURSDAY, Dec. 18, ... leg for at least 20 seconds you may be at ... on one leg may indicate that small strokes or tiny ... serious strokes is high, the investigators reported online Dec. 18 ... while standing on one leg, as well as problems walking, ...
(Date:12/17/2014)... Mass. (PRWEB) December 17, 2014 ... of Osteopathic Medicine (ACOM), which welcomed its inaugural ... Desktop Infrastructure (VDI) to seamlessly support bring your ... – and teaching – experience. The solution, comprised ... NetScaler , Dell server and storage infrastructure ...
(Date:12/17/2014)... December 17, 2014 A group of 127 ... Longevity, today, in reaction to a recent statement by the ... brain training and derogated the efficacy of all brain exercises. ... with the parts of the center’s statement critical of brain ... center had also overstated its case, in a document it ...
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