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Probability in Medical Technology

BARACLUDE(R) (entecavir) Data Continue to Demonstrate Low Incidence of Resistance Through Five Years of Treatment in Nucleoside-naive Chronic Hepatitis B Patients

... Through five years of treatment, the cumulative probability of developing mutations in the virus that confer ... with lamivudine failed, the cumulative probability of genotypic BARACLUDE resistance was 51 percent ... studies over time is low, with a cumulative probability of genotypic BARACLUDE resistance of 1.2 percent ...

National Cancer Institute Research Identifies Unique Mechanism of Brostallicin's Anti-Tumor Effectiveness

... line. "These preclinical data provide important further insights into the specific bio-marker (tumor glutathione levels) that increases the probability of achieving improved anti-tumor effectiveness by careful selection of patients who are most likely to benefit, and is consistent with our focus on ...

Landmark Study for GSK's Cervical Cancer Vaccine Published in The Lancet

... (CIN), graded as CIN 1, 2 and 3 refers to pre-cancerous cells found on the surface of the cervix. The higher the grading number, the higher the probability the abnormal cells will become cancer cells. CIN 1, 2 and 3 refers to mild, moderate or severe cell changes respectively. CIN 2+ is the surrogate ...

IBM and EU Partners Create a Better Way to Fight AIDS Virus

... combinations for any given HIV genetic variant. EuResist is a powerful online system that helps doctors choose the treatment with the highest probability of halting virus replication and impairing evolution of drug resistance. Although there have been tremendous leaps and bounds in the management ...

Optimer Pharmaceuticals Presents Results From Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection

... minimal disruption to the normal intestinal flora. This may facilitate the return of the normal physiological conditions in the colon and reduce the probability of CDI recurrence. About Optimer Pharmaceuticals Optimer Pharmaceuticals, Inc. is a biopharmaceutical company focused on discovering, ...

China Sky One Medical, Inc. Achieves Significant Breakthrough in Research for Sudden Cardiac Death (SCD) Early Examination Kit

... Yang concluded that the existence of MicroRNA-1 in human blood is a useful predictor of SCD, and higher concentrations of MicroRNA-1 means a higher probability of SCD. The discovery was published in the Journal of Nature-Medicine. In late 2008, Prof. Yang received the national patent for this discovery. ...

Investigational Genetic Test May Help Address Common Problems in Prostate Cancer Diagnosis

... Key AUA Studies Results from selected PCA3 studies presented at the AUA meeting showed that: PCA3 scores are correlated with the probability of a positive initial prostate biopsy in men with elevated serum PSA levels. In addition, PCA3 scores were higher in men whose prostate tumors had ...

Optimer Pharmaceuticals Receives Production Patent for Lead Product Candidate Fidaxomicin

... minimal disruption to the normal intestinal flora. This may facilitate the return of the normal physiological conditions in the colon and reduce the probability of CDI recurrence. About Optimer Pharmaceuticals Optimer Pharmaceuticals, Inc. is a biopharmaceutical company focused on discovering, ...

Cardium's InnerCool Announces Positive Benefits of Cooling During Robotic-Assisted Prostate Surgery Published in Urology

... treatment. While the underlying cause for the development of prostate cancer is still unknown, factors such as age, race, and lifestyle affect the probability of developing the disease. Of these, age is the strongest risk factor, and as life spans continue to increase, more men are surviving to an age at ...

Transgenomic and Power3 Medical Complete Agreement for Exclusive License of Neurodegenerative Biomarker Test

... was developed by Power3 Medical to monitor the concentration of a panel of blood serum protein biomarkers, using biostatistical analysis to assign a probability score reflecting the likelihood a patient may have a neurodegenerative disease. The test is an objective tool that helps clinicians distinguish ...

Research Explores the Effects of Stem Cell Source and Patient Age on Stem Cell Transplantation Outcomes

... patient by comparing their human leukocyte antigens (HLAs). Current estimates from the National Marrow Donor Program donor registry suggest that the probability of finding a matched unrelated adult donor is relatively low (51 percent for Caucasians, 30 percent for Hispanics, 20 percent for Asians, and 17 ...

Studies Examine Quality of Care for Hospitalized Sickle Cell Disease Patients and Effective Methods for Detecting Risk of Stroke in Children With This Disorder

... was eight years for patients receiving hydroxyurea and five years for those who did not receive hydroxyurea. The study found that the probability of 10-year survival was 91 percent for the patients treated with hydroxyurea compared with 70 percent for the conventionally treated patients. ...

Breakthrough Mapping of Alzheimer's Genome Helps ID Four New Suspect Genes

... all of it directly into research. Cure Alzheimer's Fund(TM) is a 501c3 public charity established to fund targeted research with the highest probability of slowing, stopping or reversing Alzheimer's disease. For more information, please visit http://www.curealzfund.org . Contact: David Roscow ...

The Children's Hospital of Philadelphia Announces New Regional Participant in The National Children's Study

... be conducted in 105 previously designated study locations across the U.S., that together are representative of the nation's population. A national probability sample was used to select the counties in the study, which took into account factors including race and ethnicity, income, education level, number of ...

Cell Therapeutics Announces that the European Organization for Research and Treatment of Cancer Completes Enrollment in Phase II Clinical Trial of Brostallicin as First Line Therapy for Advanced or Metastatic Soft Tissue Sarcoma

... cells' vulnerabilities (weak spots) and where the drugs are the strongest. With these data, investigators can target those patients with the highest probability of benefiting from a particular drug. By treating only the patients with the genetic characteristics known to react well to the drug, scientists may ...

Dendreon Expects Interim Data Analysis for Phase 3 PROVENGE IMPACT Trial in October

... therapy to the many prostate cancer patients who currently have few appealing treatment options. While the final analysis of the trial has a higher probability of success, the interim analysis provides us with the potential to accelerate our BLA amendment for PROVENGE," said Mitchell H. Gold, president and ...

Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City

... and market research to maximize efficiency, increase productivity, augment the quality of our antibody drug development efforts and increase the probability of success for product candidates. "We have a world-class antibody drug development platform which allows us to enrich our pipeline with ...

CherryPharm First All-Natural Food to Improve Sleep

... decreased the time it took to fall asleep (Sleep Latency) and decreased the time spent awake after falling asleep (Wake After Sleep Onset). With probability or "P" values of .047 and .011 respectively, these results are statistically significant. Modest trends, although not statistically significant, were ...

NicOx Completes Patient Enrollment in Third Naproxcinod Pivotal Phase 3 Study

... a lower rate of positive efficacy results than knee studies. Nevertheless, we believe the stringent criteria applied to the 303 study give us a good probability of achieving a positive result on the primary endpoint." Trial design and endpoints of the 303 study The 303 study is a 13-week, double-blind, ...

Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidone's Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events

... SNPs was significantly associated with response to ziprasidone The combination of six markers defined several groups of patients with different probability of response to iloperidone. Twenty-seven percent of patients carried at least five of the most favorable genotypes and constituted a group of ...

New Gene Discovery Suggests Which Patients CTI's Brostallicin May Benefit

... cells' vulnerabilities (weak spots) and where the drugs are the strongest. With these data, investigators can target those patients with the highest probability of benefiting from a particular drug. By treating only the patients with the genetic characteristics known to react well to the drug, scientists may ...

EnVivo Pharmaceuticals Announces Initiation of Clinical Safety and Biomarker Study of Alpha-7 Nicotinic Agonist, EVP-6124, in Patients with Schizophrenia

... cognitive benefits in learning and memory and we believe we understand the dosing range in which to expect efficacy. This significantly enhances the probability of success of the upcoming biomarker and Phase II studies." About Electrophysiological Biomarkers in Schizophrenia Patients Patients with ...

Landmark ONTARGET(TM) Trial Demonstrates Micardis(R) is Equally Effective as Ramipril, with Fewer Discontinuations, in a Broad High-Risk Cardiovascular Population

... in 1,423 patients (16.7 percent) receiving telmisartan versus 1,412 patients (16.5 percent) receiving ramipril.(1) The relative risk (ratio of the probability of the event occurring in the telmisartan group versus the ramipril group) was 1.01, with a 95 percent CI of 0.94 - 1.09. Telmisartan is now the ...

Novel Small Molecule Therapy Shows Benefit for Anemic Patients Via Hydration of Red Blood Cells

... sickle cell anemia," said Dr. Ataga. "As noted in the paper, a Phase III study of senicapoc in SCD patients was recently terminated due to the low probability of achieving a reduction in crisis rate, the primary endpoint of that study. Clearly, further work is necessary to understand how the reduction in ...

Long-Term Soliris(R) Therapy Improved or Stabilized Kidney Function in Patients With PNH

... from the National Kidney Foundation; CKD was severe in 21 percent of patients. The analysis of patient data prior to study entry showed that the probability of progression of this overall untreated population of PNH patients to a major clinical kidney event, including severe renal damage, renal ...

BiPar Genomic Biomarker Data Demonstrate Overexpression of PARP-1 Gene in Multiple Cancer Types

... in San Francisco. "These results allow us to focus our clinical development plan for BSI-201 by targeting tumors types that have the greatest probability of clinical success," said BiPar Executive Vice President Barry Sherman, M.D. BiPar researchers used the Gene Logic Inc. BioExpress(R) ...

Studies Showing Significant Survival Improvement with Taxotere(R)-based Regimens in the Induction Treatment of Patients with Locally Advanced Head and Neck Cancer are Published in the Same Issue of the New England Journal of Medicine

... risk of death that was 30% lower (HR 0.70; p=0.006). This represents a more than three year absolute improvement in median overall survival. The probability to survive three years was 62% in the Taxotere arm compared to 48% in the standard arm (p=0.0058). Overall, the incidence of grade 3/4 toxicity was ...

Surgeons Develop Innovative Life-Saving Treatments to Correct Massive Bleeding in Trauma Patients

... survival and unexpected death in this study were defined by the Trauma Related Injury Severity Score (TRISS) Methodology, which determines the probability of survival on the basis of the severity of injury, the patient's condition on admission to the hospital, and age. The protocol also decreased the ...

Taxotere(R) (docetaxel) Granted FDA Approval to Treat Locally Advanced Head and Neck Cancer Prior to Chemoradiotherapy and Surgery

... vs. 30.1 months for patients receiving PF only, representing a more than three year improvement in median OS for patients treated with TPF. The probability to survive three years was 62% in the TPF arm compared to 48% in the PF arm. "The TAX 324 trial found that the addition of Taxotere to ...

AspenBio Pharma Reports Strong Results with Appendicitis Triage Blood Test from Large Multiple Hospital Study

... with a CT scan resulted in a specificity of 99% (95% CI = 97% to 99.9%). So when AppyScore and CT both are positive, there is an extremely high probability the patient truly has appendicitis. Dr. John Bealer, a Denver based pediatric surgeon, consultant to AspenBio, and co-inventor of the test noted, ...

Nabi Biopharmaceuticals Announces Continued Positive NicVAX Phase 2b Data at Nine Months

... Schedule 2 (five injections over six months) -- Most effective dose selected: 400 micrograms -- Threshold antibody level identified and probability of abstinence vs. antibody levels calculated: -- Attainment of the antibody threshold at Target Quit Date determines chronic ...

Survey Reveals Significant Public Lack of Diabetes Awareness

... propensity to be online. With a pure probability sample of 2,436 one could say with a ninety-five percent probability that the overall results would have a sampling ... account. This online survey is not based on a probability sample and therefore no theoretical sampling ...

Eighty-one Percent of U.S. Adults say that Birth Control Pills and Procedures Should Be Covered by Health Insurance

... of these words should be avoided. With pure probability samples, with 100 percent response rates, it is possible to calculate the probability that the sampling error (but not other sources of error) is not greater than some number. With pure probability samples of 2,402 one could say with a ninety-five ...

Flu Vaccine Used Last Winter Seems to Have Been Less Effective Than Vaccines Used in Previous Years

... use of these words should be avoided. With pure probability samples, with 100 percent response rates, it is possible to calculate the probability that the sampling error (but not other sources of ... is not greater than some number. With a pure probability sample of 2,563 adults one could say with ...

New Survey Finds Troubling Data on American Asthma Sufferers

... propensity to be online. With a pure probability sample of 1,105, one could say with a 95 percent probability that the overall results would have a ... account. This online survey is not based on a probability sample and therefore no theoretical sampling ...

Hypertension Education Foundation Survey Results Announced At American Society For Hypertension Annual Meeting Suggests Improved Control Of High Blood Pressure, But Misconceptions Still Exist

... to be online. With a pure probability sample of 1,245 adults, one could say with a ninety-five percent probability that the overall results have a sampling error of ... account. This online survey is not based on a probability sample and therefore no theoretical sampling ...

New Poll Shows Men, Women Incorrectly Blame Symptoms of Low Testosterone on Normal Aging

... are nationally representative. With a pure probability sample of 2,008 one could say with a 95 percent probability that the overall results would have a ... points. This online survey is not based on a probability sample and therefore no theoretical sampling ...

Survey: Migraine Patients Taking Potentially Addictive Barbiturate or Opioid Medications Not Approved by FDA as Migraine Treatments

... would have a sampling error of +/- 4.4 percentage points. With a pure probability sample of 201 one could say with a ninety-five percent probability that the overall results would have a sampling error of +/- 6.9 percentage ...

La Jolla Pharmaceutical Announces Positive Interim Antibody Results From Riquent Lupus Phase 3 Trial

... as in our previous studies. We believe that the greater reductions in antibodies to dsDNA observed with these higher doses of Riquent imply a greater probability of obtaining positive clinical results from the Phase 3 trial." "These data definitely show an increased biological effect. This will improve ...
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(Date:9/30/2014)... What do seedless watermelon, salmon, and strawberries all have ... have two sets of chromosomes and are diploid, these ... more sets of chromosomesseedless watermelon and salmon have 3 ... 10! While this might seem surprising, in fact ... was first discovered over a century ago, but only ...
(Date:9/30/2014)... (PCE) in drinking water may increase the risk ... new study led by a Boston University School ... in the journal Environmental Health , compared ... 1,766 women in Cape Cod, Ma., where water ... early 1980s by the installation of vinyl-lined asbestos ...
(Date:9/30/2014)... to using marijuana, new research, involving mice and published ... Journal of Leukocyte Biology , suggests that just ... should. That,s because a team of Italian scientists have ... long-term damage to the immune system. This damage may ... as multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis ...
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(Date:10/1/2014)... Philadelphia, PA, October 1, 2014 Patients with ... treatment, have a greatly increased risk of depression. ... therapy for chronic hepatitis C virus infection causes ... Omega-3 fatty acids, more commonly known as fish ... including lowering the risk of heart disease and ...
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Breaking Medicine News(10 mins):Health News:Omega-3 fatty acids may prevent some forms of depression 2Health News:Elderly Life Insurance - Find Life Insurance for Retired Couples! 2Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 2Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 3Health News:First Warning Systems Changes Name to Cyrcadia Health to Better Reflect Core Competency and Goals of Company 4Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3Health News:Innovations to Explore Breakthroughs in Health and Wellness in Upcoming Episode Airing Monday, October 20, 2014 via Discovery Channel 2
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