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CeNeRx BioPharma Obtains Rights to Novel Drug Candidate for Prevention and Treatment of Neurodegeneration Disorders

... CXB909 for the treatment of chemotherapy-induced peripheral neuropathy (CIPN) later this year. "Nerve ... and neuronal damage is also implicated in the peripheral neuropathies associated with diabetes, kidney ... conditions, beginning with chemotherapy-induced peripheral neuropathy, a disabling and dose-limiting side ...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... in animals by reducing levels of targets in peripheral tissues such as liver and fat without affecting ... inhibition of FGFR4 with antisense drugs in peripheral tissues could be a unique therapeutic approach ... Causes a Marked Improvement in Hepatic and peripheral Insulin Sensitivity and Improves Cardiac Glucose ...

Lower Extremity Peripheral Vascular Stent and Balloon Catheter Markets to Exceed $180 Million in Europe by 2013

... Research Group's (MRG's) European Markets for peripheral Vascular (PV) Devices 2009 report, rapid growth ... procedures that treat lower extremity peripheral artery disease in Europe is being fueled by ... procedures, which treat below-the-knee peripheral artery disease, are also growing rapidly," says ...

Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support

... from any source, including from bone marrow and peripheral blood. FT1050 was discovered by Leonard Zon, ... Possible sources of HSCs include bone marrow, peripheral blood, or cord blood. The entire procedure is ... of success, patients receiving a bone marrow or peripheral blood transplant must find a donor that matches ...

Boston Scientific Begins Clinical Trial for Next-Generation Nitinol Stent to Treat Iliac Artery Disease

... the treatment of iliac artery disease, a form of peripheral artery disease that impacts a patient's lower ... Boston Scientific's long-time leadership in the peripheral interventions market. The Company's peripheral product lines feature technologies used to ...

Study Confirms Effectiveness of Innovative Prism Glasses For Hemianopia Patients

... -- In a study of specially designed peripheral prism glasses for hemianopia patients (blinded in ... 28 patients with complete hemianopia to wear the peripheral prism glasses as much as possible for the ... to the change in visual direction produced by the peripheral prism glasses, which means that no patient had ...

Unique Cardiovascular Treatment Readied for Global Market: Proprietary Paccocath(R) Technology is the Only Drug Eluting Balloon with Clinical Data

... in the United States and Europe who suffer from peripheral Arterial Disease (PAD). These milestones include ... co-primary investigators for the U.S. clinical peripheral pivotal trials to achieve FDA approval for ... show its potential efficacy and safety in peripheral applications," said Professor Gunnar Tepe, MD, of ...

Video: ev3 Inc. Announces First Patient Enrollments in DEFINITIVE LE Post-Market Study

... Excision System for Treatment of Lower Extremity peripheral Arterial Disease PLYMOUTH, Minn., April 30 ... for endovascular treatment of lower extremity peripheral arterial disease (PAD). Stuart Harlin, M.D., of ... "ev3 has committed to advancing the science of peripheral artery disease treatment with a goal of making ...

NeurogesX Announces Publication of Phase 3 Data for QUTENZA(TM) (NGX-4010) in Postherpetic Neuralgia (PHN) by The Lancet Neurology

... Medicines Agency (EMEA) for the management of peripheral neuropathic pain. The paper in The Lancet ... therapies. Its initial focus is on chronic peripheral neuropathic pain, including postherpetic ... patch designed to manage pain associated with peripheral neuropathic pain conditions, that the Company ...

Cara Therapeutics Initiates Phase II Proof-Of-Concept Trial of Novel Analgesic in Acute Post-Operative Pain

... a Phase II clinical trial of its long-acting peripheral kappa opioid agonist, CR845. The Phase II ... of CR845 stimulated physiological biomarkers of peripheral kappa opioid receptor activity, and also produced ... studies, CR845 was highly selective for the peripheral kappa opioid receptor. Animal studies indicate ...

Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma

... with VELCADE therapy include new or worsening peripheral neuropathy, hypotension throughout therapy, ... VELCADE. Cases of severe sensory and motor peripheral neuropathy have been reported. The long-term outcome of peripheral neuropathy has not been studied in mantle cell ...

Prolonged Progression-Free Survival Demonstrated by VELCADE(R) (Bortezomib) for Injection Based Induction Regimens in Transplant-Eligible Previously Untreated Multiple Myeloma Patients

... have been reported. The long-term outcome of peripheral neuropathy has not been studied in mantle cell ... nausea (55%), diarrhea (52%), constipation (41%), peripheral neuropathy NEC (including peripheral sensory neuropathy ...

Long-term Follow Up Interim Data Show Nplate(TM) Increased and Sustained Platelet Counts in Adult Chronic ITP Patients

... -- Prior to initiation of Nplate examine the peripheral blood smear closely to establish a baseline level ... identification of a stable Nplate dose, examine peripheral blood smears and CBCs monthly for new or ... -- Monitor CBCs, including platelet counts and peripheral blood smears, prior to initiation, throughout, ...

Novel VELCADE(R) (Bortezomib) for Injection Based Four-Drug Combination Was Well Tolerated In Previously Untreated Multiple Myeloma Patients

... have been reported. The long-term outcome of peripheral neuropathy has not been studied in mantle cell ... (55%), diarrhea (52%), constipation (41%), peripheral neuropathy NEC (including peripheral sensory neuropathy ...

Research Explores the Effects of Stem Cell Source and Patient Age on Stem Cell Transplantation Outcomes

... by the source of the stem cells (bone marrow, peripheral blood, or cord blood) and by their origin - ... Leukemia: A Comparison of Unrelated Bone Marrow, peripheral Blood, and Cord Blood [Abstract #151] ... suitable alternative to mismatched bone marrow or peripheral blood transplants because cord blood is readily ...

GSK Reports PROMACTA(R) (eltrombopag) Significantly Increased Platelet Counts and Reduced Bleeding in Long-Term Study of Patients With Chronic ITP

... events (dyspepsia and peripheral edema) were significantly less likely to occur in ... Prior to initiation of PROMACTA, examine the peripheral blood smear closely to establish a baseline level ... Prior to the initiation of PROMACTA, examine the peripheral blood differential to establish the extent of red ...

Lilly Withdraws Application for Additional U.S. Indication for Cymbalta(R) for Chronic Pain

... anxiety disorder, management of diabetic peripheral neuropathic pain and management of fibromyalgia. ... disorder, and the management of diabetic peripheral neuropathic pain and fibromyalgia in adults age ... disorder, and to manage diabetic peripheral neuropathic pain and fibromyalgia. ...

FDA Approves Promacta(R) (Eltrombopag), the First Oral Medication to Increase Platelet Production for People With Serious Blood Disorder

... Prior to initiation of PROMACTA, examine the peripheral blood smear closely to establish a baseline level ... Prior to the initiation of PROMACTA, examine the peripheral blood differential to establish the extent of red ... Obtain CBCs, including platelet counts and peripheral blood smears, weekly during the dose adjustment ...

Trellis(R) Peripheral Infusion System Removes Blood Clots in Largest Reported Prospective Endovascular DVT (Deep Vein Thrombosis) Patient Series

... Symposium shows DVT treatment with the Trellis(R) peripheral Infusion System from Bacchus Vascular, Inc. ... device company dedicated to the treatment of peripheral vascular disease. Dr. Thomas Fogarty, a noted ... vision of transforming blood clot removal from peripheral blood vessels into a fast, simple, ...

Vermillion Renews Strategic Alliance Agreement With Quest Diagnostics, Inc.

... those patients who are at high risk of developing peripheral artery disease. Vermillion is developing this ... chemotherapy if detected in stage 1. About peripheral Artery Disease (PAD) PAD, a serious but often ... buildup of fat and cholesterol, or plaque, in the peripheral arteries, disrupting normal blood flow. ...

BioMarin Announces Positive Results From Phase 2A Clinical Study of 6R-BH4 in Sickle Cell Disease

... measured using the EndoPAT device to assess peripheral arterial tonometry (PAT), was common in the ... Society of Hematology Conference Abstract: peripheral Arterial Tonometry Assessment of ... Phase 2 clinical development for the treatment of peripheral arterial disease and sickle cell disease, and ...

Diffusion Pharmaceuticals Announces Initiation of a Phase I/II Clinical Trial in Patients with Peripheral Arterial Disease (PAD)

... clinical trials. About Multi-Center Trial in peripheral Arterial Disease Patients: This randomized, ... found on the clinicaltrials.gov Website. About peripheral Arterial Disease and Intermittent Claudication: ... as well as chronic conditions such as peripheral arterial and vascular disease, cardiovascular ...

New England Journal of Medicine Publishes Phase III Results of VELCADE(R) (Bortezomib) for Injection in Previously Untreated Multiple Myeloma Patients

... neutropenia (49% vs 46%), nausea (48% vs 28%), peripheral neuropathy (47% vs 5%), diarrhea (46% vs 17%), ... VELCADE. Cases of severe sensory and motor peripheral neuropathy have been reported. The long-term outcome of peripheral neuropathy has not been studied in mantle cell ...

Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting

... from subjects with mild to moderate diabetic peripheral neuropathy enrolled in Sangamo's Phase 1b study ... in the legs and feet. The symptoms of diabetic peripheral neuropathy and any changes that occur during the ... in diabetics with moderate to severe diabetic peripheral sensory motor neuropathy in the legs. The trial ...

Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs

... in subjects with moderate to severe diabetic peripheral sensory motor neuropathy (DN). The study is ... in a distribution pattern that targets the major peripheral nerves in the legs and feet. The expansion ... About Diabetic Neuropathy Diabetic peripheral neuropathy is one of the most ...

Multiple Clinical Trials of VELCADE(R) (Bortezomib) for Injection Based Therapies Demonstrate High Complete Remission Rates in Patients with Newly Diagnosed Multiple Myeloma

... thrombocytopenia, neutropenia, hyperglycemia and peripheral neuropathy. VELCADE, ... manageable and included hematologic toxicity and peripheral neuropathy. Safety and Efficacy of ... with VELCADE. Cases of severe sensory and motor peripheral neuropathy have been reported. The long-term ...

VELCADE(R) (Bortezomib) for Injection Based Treatment Delivers Impressive Complete Response and Survival in Patients With Newly Diagnosed Multiple Myeloma

... with VELCADE. Cases of severe sensory and motor peripheral neuropathy have been reported. The long-term outcome of peripheral neuropathy has not been studied in mantle cell ... nausea (55%), diarrhea (52%), constipation (41%), peripheral neuropathy NEC ...

Lilly Submits Cymbalta(R) Supplemental New Drug Application for Chronic Pain to U.S. Food and Drug Administration

... previously completed pain studies in diabetic peripheral neuropathic pain (DPNP) and fibromyalgia. ... disorder and the management of diabetic peripheral neuropathic pain, all in adults (18+). Cymbalta ... generalized anxiety disorder and manage diabetic peripheral neuropathic pain. Antidepressants can increase ...

New Data Support High Complete Remission Rates With VELCADE(R) (Bortezomib) for Injection Based Therapies in Patients With Newly Diagnosed Multiple Myeloma

... with VELCADE. Cases of severe sensory and motor peripheral neuropathy have been reported. The long-term outcome of peripheral neuropathy has not been studied in mantle cell ... nausea (55%), diarrhea (52%), constipation (41%), peripheral neuropathy NEC ...

Eribulin Mesylate Demonstrated Anti-Tumor Activity in Heavily Pretreated Patients with Advanced Breast Cancer

... eribulin mesylate. Patients with up to Grade 2 peripheral neuropathy were included in the study. The most ... (10%; no Grade 4 events). Grade 3 peripheral neuropathy (a functional disturbance or damage to ... was reported in 5.5% of patients. No Grade 4 peripheral neuropathy events were reported. No correlation ...

Anesiva Announces Publication of Phase 3 Zingo(TM) Data in the Journal Pediatrics

... Zingo Demonstrates Quick, Effective Analgesia for peripheral Venous Access Procedures in Children Three ... to date on local anesthetic use for peripheral venous access procedures in children. ... local anesthetics has long been urged to reduce peripheral venous access pain in children, but use of those ...

NeurogesX Announces Preliminary Results from Second Phase 3 Clinical Trial in HIV-DSP

... a selective TRPV1 agonist, designed to manage peripheral neuropathic pain. The Company has previously ... therapies. Its initial focus is on chronic peripheral neuropathic pain, including PHN, painful HIV- DSP ... patch designed to manage pain associated with peripheral neuropathic pain conditions, that the ...

Millennium Expands VELCADE(R) (Bortezomib) For Injection Program In Non-Hodgkin's Lymphoma

... with VELCADE. Cases of severe sensory and motor peripheral neuropathy have been reported. The long-term outcome of peripheral neuropathy has not been studied in mantle cell ... nausea (55%), diarrhea (52%), constipation (41%), peripheral neuropathy NEC ...

Thalidomide Pharmion(R) Receives Positive Opinion for Treatment of First-line Multiple Myeloma from European Medicines Agency

... risk of Grade 3 and 4 venous thromboembolism and peripheral neuropathy. "Our study results demonstrate the ... are: deep vein thrombosis, constipation, peripheral oedema, tremor, dizziness, fatigue, asthenia, somnolence, peripheral neuropathy, neutropenia, lymphopenia, ...

EpiCept Provides Update on Clinical and Regulatory Progress with Ceplene(TM) and EpiCept(TM) NP-1 Cream

... NP-1 cream in patients suffering from diabetic peripheral neuropathy (DPN) in the near future. This study ... to provide long-term relief from the pain of peripheral neuropathies. Peripheral neuropathies are medical conditions caused by damage to the nerves in the peripheral nervous system. ...

Interim Safety Analysis Supports Continuation of Allos Therapeutics' Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-cell Lymphoma

... option for patients with relapsed or refractory peripheral T-cell lymphoma, a patient population for ... safety assessments of trial results. About peripheral T-cell Lymphoma peripheral T-cell lymphomas, or PTCLs, are a biologically ...

YMed, Inc. Successfully Completes First Clinical Cases With Innovative VascuTraK(TM) II PTA Dilatation Catheter

... for vascular intervention of a wide range of peripheral arteries including the treatment of obstructive ... in technology for the treatment of patients with peripheral vascular disease (PVD), especially below the knee ... business professionals from within the cardio and peripheral vascular industry. This team develops, ...

Twelve DOXIL(R) Clinical Studies to be Presented at American Society of Hematology Annual Meeting

... (31% vs 31%), mucositis/stomatitis (20% vs 5%), peripheral neuropathy (42% vs 45%), neuralgia (17% vs ... with VELCADE. Cases of severe sensory and motor peripheral neuropathy have been reported. The long-term outcome of peripheral neuropathy has not been studied in mantle cell ...

Sangamo BioSciences Announces Completion of Enrollment of Phase 2 Clinical Trial of ZFP Therapeutic for Diabetic Neuropathy

... targets the skeletal muscle adjacent to the major peripheral nerves in the legs and feet. The symptoms of diabetic peripheral neuropathy and any changes that occur during the ... dosing. About Diabetic Neuropathy Diabetic peripheral neuropathy is one of the most ...

New Data to Support VELCADE(R) (Bortezomib) For Injection Based Therapies as Setting New Standards in The Care of Newly Diagnosed Patients With Multiple Myeloma

... with VELCADE. Cases of severe sensory and motor peripheral neuropathy have been reported. The long-term outcome of peripheral neuropathy has not been studied in mantle cell ... nausea (55%), diarrhea (52%), constipation (41%), peripheral neuropathy (39%), thrombocytopenia (36%), ...
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