Aching Back? Cholesterol Medication Might Help
... "Lovastatin Helps Re-Differentiation of Human nucleus
Pulposus Cells During Monolayer Expansion" during ... Degeneration on Regenerative Potential of Human nucleus
Pulposus Cells," at the same meeting. The two ...
In one study, the researchers removed nucleus
pulposus tissues from six human patients. ...
CoreSpine Technologies Expands Spinal Disc Site Preparation Efforts
... on generating a complete and selective nucleus
The technology was recently ... and therapies begin
to require more effective nucleus
removal and endplate preparation through
limited ... for preparing the spinal disc for artificial nucleus
and minimally invasive fusion ...
ViroPharma Announces Discontinuation of Maribavir Phase 3 Study in Liver Transplant Patients
... currently available anti-CMV agents that inhibit CMV DNA polymerase, maribavir inhibits viral DNA assembly and egress of viral capsids from the nucleus
of infected cells. Maribavir also has demonstrated activity in vitro against strains of CMV that are resistant to current anti-CMV therapies.
Findings on Bladder-Brain Link May Point to Better Treatments for Problems in Sleep, Attention
... investigations of the neural circuits
between the bladder and the brain, the researchers found that two small
brain structures, the Barrington's nucleus
and the locus ceruleus,
developed abnormal activity as a result of the bladder obstruction. In
particular, the locus ceruleus showed persistently ...
ViroPharma Announces Completion of Enrollment in Phase 3 Study of Maribavir in Stem Cell Transplant Patients
... currently available anti-CMV agents that
inhibit CMV DNA polymerase, maribavir inhibits viral DNA assembly and
egress of viral capsids from the nucleus
of infected cells. Maribavir also
has demonstrated activity in vitro against strains of CMV that are
resistant to current anti-CMV therapies.
Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel Anticancer Agents, at AACR
... NEIs are potent, specific inhibitors of CRM1, a highly
conserved, essential protein that exports key regulatory proteins ("cargo"
proteins) from the nucleus
to the cytoplasm. Many cargo proteins that
depend on CRM1 for nuclear export, such as p53, Bcr-Abl and FOXO-3a,
function as tumor suppressors or ...
PET Scans Show Gene Therapy Normalizes Brain Function in Parkinson's Patients
... Kaplitt, MD, of Weill
Cornell Medical Center in Manhattan and others to deliver genes for
glutamic acid decarboxylase (or GAD) into the subthalamic nucleus
brain in Parkinson's patients. The study was designed as a phase I safety
study, and the genes were delivered to only one side of the brain to ...
Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
... the very near future." About ZFPs ZFPs are the dominant class of naturally occurring proteins known as
transcription factors and are found in the nucleus
of every cell. They bind
to DNA to regulate gene expression. Though there are many kinds of
transcription factors, only ZFPs are amenable to ...
Benitec MOU With CalbaTech, Inc.
... is about controlling the flow of genetic information.
Our genome operates by sending instructions for the manufacture of proteins
from DNA in the nucleus
of the cell to the protein synthesizing machinery.
These instructions are conveyed by messenger RNA (mRNA). In 1998 it was
discovered that a certain ...
Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel
Anticancer Agents, at AACR
... protein that exports key regulatory proteins
("cargo" proteins) from the nucleus
to the cytoplasm. Many cargo
proteins that depend on CRM1 for nuclear ... accumulation of CRM1-dependent cargo proteins sequestered in the
is detected rapidly. Results also show that exposure to NEIs
Protein Found to Shield Pancreatic Cancer Cells from
mechanism that systematically destroys defective cells by forcing
them to kill themselves. In apoptosis, the cells die via damage to
and DNA, with other cellular organelles preserved.
Autophagy kills by degrading those other organelles while sparing
Mehta's lab ...
DNA Therapeutics Reports a Novel Mechanism of Action and a
Biomarker of its Lead Molecule Dbait That Open an Innovative
Pathway-Targeting in Molecular Cancer Therapy
persists more than 6 days as compared to 1 day for irradiation.
Cell imaging shows that the global distribution of gamma-H2AX in
of the cells transfected by Dbait was radically
different of the gamma-H2AX foci organization observed when H2AX
phosphorylation was triggered by ...
Ceregene Presents Interim Phase 1 Clinical Data of CERE-110 for the
Treatment of Alzheimer's Disease
... All six patients enrolled in the study underwent
stereotactic neurosurgery to deliver CERE-110 into a specific
region of the brain called the nucleus
Basalis of Meynert (NBM) --
an area that is a source for the production of cholinergic neurons,
which are known to undergo profound degeneration in ...
New Study Suggests no Significant Impairment in Middle-of-the-Night
Balance, Mobility or Memory in Older Adults Using Ramelteon
Ramelteon has a unique therapeutic mechanism of action that
selectively targets two receptors located in the brain's
(SCN). The SCN is known as the body's
"master clock" because it regulates the sleep- wake cycle.
* Ramelteon is not a controlled substance. A ...
Study Demonstrated Rozerem (ramelteon) Does Not Affect
Middle-of-the-Night Balance in Older Adults with Insomnia
... ROZEREM has a unique therapeutic mechanism of
action that selectively targets two receptors located in the
brain's suprachiasmatic nucleus
(SCN). The SCN is known as the
body's "master clock" because it regulates the sleep-wake
*ROZEREM is not a controlled substance. A clinical ...
Neurologix Announces Publication of Landmark Gene Therapy Study
Demonstrating Safety and Statistically Significant Improvement in
Patients With Advanced Parkinson's Disease
The study used an adeno-associated virus (AAV) vector to deliver
an inhibitory gene (glutamic acid decarboxylase or "GAD") to the
(STN) of the brain. In Parkinson's disease, STN
activity is abnormally increased, largely due to a deficit in GABA
(gamma-aminobutyric acid), the ...