Navigation Links
Nucleotide in Medical Technology

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

... C (HCV). PSI-7851 is a second generation nucleotide polymerase inhibitor of HCV. PSI-7851 ... safety data with PSI-7851, our second generation nucleotide analog," said Michelle Berrey, MD, MPH, ... that we have achieved our goal of identifying a nucleotide analog with good efficacy that can be ...

Idenix Pharmaceuticals Advances HCV Discovery Program to Clinic

... application. IDX184 is a once-daily, oral nucleotide prodrug polymerase inhibitor for the treatment of ... for the treatment of hepatitis C." IDX184 nucleotide Prodrug Polymerase Inhibitor IDX184 is a once-daily, oral nucleotide prodrug candidate based on Idenix's proprietary ...

Pharmasset Initiates First Time in Human Study of PSI-7851 for the Treatment of Hepatitis C (HCV)

... dose (SAD) study in healthy volunteers with PSI-7851, a second generation nucleotide analog polymerase inhibitor of hepatitis C virus (HCV). Pharmasset filed ... milestone for Pharmasset. PSI-7851 is a wholly owned, second generation nucleotide analog that was discovered by Pharmasset scientists" stated Dr. Michelle ...

Idenix Pharmaceuticals Initiates Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)

... that it has initiated a proof-of-concept study of IDX184, a liver-targeted nucleotide prodrug candidate for the treatment of HCV under an Investigational New ... and two to placebo. About IDX184 IDX184 is a once-daily, oral nucleotide prodrug candidate based on Idenix's proprietary liver-targeting ....

Isis Highlights Robust Drug Portfolio for Diabetes and Obesity at ADA Conference

... drug for a kidney target, ISIS 388626 is also unique due to its 12 nucleotide length rather than the more typical 18 - 21 nucleotide sequences that comprise Isis' other drugs. This attribute simplifies ...

Idenix Pharmaceuticals Reports First Quarter 2008 Financial Results

... programs, having presented data from preclinical studies of its lead nucleotide prodrug candidate, IDX184, and potential clinical candidates from its ... the EASL presentations.) -- The lead clinical candidate from the nucleotide prodrug program, IDX184, is on track for an investigational new ...

Preclinical Studies Show Potential Progress Toward Identifying Specific Tumor Types With Higher Likelihood of Demonstrating Response to Anti-Cancer Compounds Early in Clinical Development

... DNA damage measured by histone H2AX phosphorylation independently of the nucleotide excision repair pathways. (Abstract #B77) Yves Pommier, M.D., Ph.D., ... 743. In addition, the study showed brostallicin is less dependent on the nucleotide excision repair (NER) gene than ecteinascidin 743 and that cells selected ...

Researchers Develop New Procedure to Screen All 46 Human Chromosomes to Identify Abnormalities in Embryos

... 23 chromosome aneuploidy screening in human blastomeres using single nucleotide polymorphisms (SNP)," provides fertility specialists for the first time ... amplified, approximately 250,000 different areas of the DNA, called single nucleotide polymorphisms (SNPs, or "snips") are individually examined and assigned a ...

Idenix Pharmaceuticals Successfully Completes Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)

... data set from this study at a scientific meeting later this year. About IDX184 IDX184 is a novel, liver-targeted 2'-methyl guanosine nucleotide prodrug, which includes Idenix's proprietary liver-targeting technology. This technology enables the delivery of nucleoside monophosphate to the ...

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

... a rapid, accurate, and cost efficient manner. SEQUENOM's MassARRAY system facilitates a number of nucleic acid analysis applications including single nucleotide polymorphism (SNP) genotyping and allelotyping, copy number variation analysis, quantitative gene expression analysis, quantitative methylation ...

Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug

... for the in vitro treatment of human and animal sperm, in which the active ingredient is adenosine 5'-triphosphate (ATP). ATP is a ubiquitous purine nucleotide found in every cell of the human body where it plays a critical role in cellular metabolism and constitutes the source of energy for all bodily ...

Pharmasset to Present at Goldman Sachs and Needham Healthcare Conferences

... clinical trial in combination with Pegasys plus Copegus through a strategic collaboration with Roche; PSI-7851, an unpartnered, next generation HCV nucleotide analog, which recently began Phase 1 clinical studies and Racivir, for the treatment of HIV that has completed a Phase 2 clinical trial. ...

Creighton Medical Laboratories First to Offer New Cancer Test

... genomics at Creighton Medical Laboratories. "We can detect genetic abnormalities that previously would have been missed." The SNP (single nucleotide polymorphism) array used by Creighton allows the detection of a very common genetic abnormality or lesion in cancer cells - called copy neutral ...

TriLink Launches CleanAmp(TM) dNTPs for Hot Start PCR

... to improved hot start PCR results. Using CleanAmp(TM) dNTPs allows precise control at the start of PCR thermal cycling by blocking DNA polymerase nucleotide incorporation until heat activated. The temperature dependent control of DNA polymerase extension vastly reduces mis-priming, primer dimer formation ...

Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen

... of HIV in combination with other approved HIV drugs, has completed a Phase II clinical trial. PSI-7851, an unpartnered second generation HCV nucleotide analogue recently entered Phase I studies. Additional information is available on the Internet at http://www.pharmasset.com ...

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

... of HIV in combination with other approved HIV drugs, has completed a Phase II clinical trial. PSI-7851, an unpartnered second generation HCV nucleotide analogue recently entered Phase I studies. Pharmasset Forward-Looking Statements Pharmasset "Safe Harbor" Statement under the Private ...

Pharmasset Voluntarily Halts Clinical Studies with Clevudine in Hepatitis B Infected Patients

... treatment of HIV in combination with other approved HIV drugs, has completed a Phase 2 clinical trial. PSI-7851, an unpartnered second generation HCV nucleotide analogue recently entered phase 1 studies. Pegasys(R) and Copegus(R) are registered trademarks of Roche. Contact Richard E. T. ...

Interleukin Genetics Presents Research Linking Vertebral Fractures to Gene Variations in Asian Women With Osteoporosis

... found Korean women in the study were seventy percent more likely to get vertebral fracture if they carried a genetic variation, also called single nucleotide polymorphism (SNP), in the IL-10 gene, while those who carried a SNP in the IL1-RN gene were fifty percent more predisposed to vertebral fracture. ...

The Children's Hospital of Philadelphia: New Gene-Searching Method Uncovers Possible New Targets for Crohn's Disease Drugs

... and detect the most significant gene variants associated with a given disease. Those variants, each a change in a single DNA base, are called single nucleotide polymorphisms (SNPs). However, individual GWA studies often do not have the statistical power to detect subtle but important variants that are ...

Scientists Unmask Genetic Markers Associated With Psoriasis

... the first time by this study, and two more have since been confirmed by these researchers. Research details The team looked for single nucleotide polymorphisms (SNPs), or DNA changes, at 438,670 sites in 1,359 psoriasis cases and 1,400 healthy controls. Initial scans signaled differences in at ...

Michael J. Fox Foundation Awards $2.7 Million to Four Industry Teams for Pre-Clinical Parkinson's Disease Research

... Progression and Therapeutics Interventions in Parkinson's Disease Patrizia Fanara, Ph.D., KineMed, Inc. Selective Inhibition of Cyclic nucleotide Phosphodiesterase Type 7 (PDE7): A Novel and Efficacious Approach to Treating Parkinson's Disease Vincent Allen Florio, Ph.D., Omeros Corporation ...

Pharmasset Reports Fiscal Year End 2008 Financial Results

... regimen for HCV, which we believe would be the future of treatment. These efforts provide the groundwork for our next generation of nucleoside and nucleotide inhibitors, such as PSI-7851, that hold the potential for us to explore fixed dosed combinations." Financial Results For the fiscal ...

St. Jude Identifies Genomic Causes of a Certain Type of Leukemia Relapse

... diagnosed and after they had relapsed. The investigators used millions of genetic markers -- characteristic genetic variations called single nucleotide polymorphisms -- as guideposts to pinpoint genetic changes characteristic of relapsed cells. Using these genetic markers, the researchers analyzed ...

Pharmasset Reports Financial Results for Quarter Ended June 30, 2008

... and 3 treatment-experienced HCV patients. -- Nominated PSI-7851 as a lead product candidate for the treatment of HCV. PSI-7851 is a proprietary nucleotide analogue polymerase inhibitor of HCV that is being advanced into Good Laboratory Practice (GLP) toxicology studies. -- Announced receipt of ...

Exiqon Forms Research Collaboration With M. D. Anderson Cancer Center

... at the Kleberg Center for Molecular Markers," said Rahul Mitra, Ph.D., associate director of the Kleberg Center. About LNATM LNAs are a class of nucleotide analogues that bind very strongly to RNA and DNA targets. By including LNAs in detection probes, it is possible to design very specific high-affinity ...

Pharmasset Nominates PSI-7851 as a Lead Development Candidate for the Treatment of Chronic Hepatitis C

... of active drug in the liver. We anticipate completing the required animal toxicity studies and filing an IND in the first quarter of 2009." nucleotide analogs have shown the ability to deliver higher levels of the active triphosphate form of the drug into infected cells. PSI-7851 has demonstrated in ...

Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test

... in the U.S. and Canada under the Gensona(R) brand and marketed by Alticor Inc. The Gensona(R) Heart Health Genetic Test employs a number of single nucleotide polymorphisms (genetic sequence variations called SNPs) to identify specific genetic patterns in the Interleukin 1 genes. These genetic patterns are ...

Idenix Pharmaceuticals Presents Positive Preclinical Data on HCV Programs at The Annual Meeting of The European Association for the Study of the Liver (EASL)

... for the Study of the Liver (EASL) being held this week in Milan, Italy. Second-Generation Nucleoside Polymerase Inhibitor Program IDX184 is a nucleotide prodrug derived from Idenix's proprietary liver- targeting technology. Results from in vitro and in vivo preclinical studies confirm that this ...

Karmanos Cancer Institute Research Supports Role of Inflammation to Determine Lung Cancer Risk, Particularly in African-American Women

... to Karmanos Principal Investigator Alison L. Van Dyke, MD/PhD Candidate, Class of 2011. Genetic variation was evaluated by looking at single nucleotide polymorphisms (SNPs) in cytokine genes. Population-based cases included 95 African-American and 365 Caucasian women, aged 18-74. Each had been ...

Idenix Pharmaceuticals Provides Update on Hepatitis C Pipeline at JP Morgan Healthcare Conference

... Second-Generation Nucleoside Polymerase Inhibitor Program Idenix's preclinical HCV nucleoside polymerase inhibitor program comprises two novel nucleotide prodrugs, IDX184 and IDX102. This program is based on Idenix's proprietary liver-targeting technology, which delivers high levels of nucleoside ...

American Fertility Association Calls for Expanded Research to Advance New Technology to Screen Embryos for Genetic Abnormalities

... to patients as quickly as possible." The procedure, known as "Accurate 23 chromosome aneuploidy screening in human blastomeres using single nucleotide polymorphisms (SNP)," makes it possible for the first time to fully evaluate the genetic make up of human embryos quickly and accurately enough to ...

Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week

... reads, including paired reads, characteristic of 454 Sequencing. Previous studies of human genomic variation tended to look at changes called single nucleotide polymorphism (SNP), variations that involve just one nucleotide. However, the study, "Paired-End Mapping Reveals Extensive Genomic Structural ...

Major Gene Study Uncovers Secrets of Leukemia

... more than 350,000 markers called single nucleotide polymorphisms. Single nucleotide polymorphisms are individual variations in the DNA that are spaced across the human chromosomes. Single nucleotide polymorphisms function as flags for researchers, allowing them to detect ...

Data from Preclinical Studies of Gilead Nucleotide Compound GS 9219 to be Presented at AACR

... today announced that the company will present data on a novel nucleotide analog, GS 9219, which has shown evidence of anti-cancer activity in ... in the United States. About GS 9219 GS 9219 is a prodrug of the nucleotide analog PMEG (9-(2-phosphonylmethoxyethyl)guanine). It is selectively ...

Researchers Discover a Common Variation in a Gene Segment that Increases the Risk for Prostate Cancer

... DNA in cells, and contains an estimated 700 to 1,100 genes. The region the CGEMS study identified on chromosome 8 is marked by a number of single nucleotide polymorphisms (SNPs), including rs6983267. SNPs are the most common type of gene variant in which a single unit of DNA may vary from one person to ...

Somanta Announces the Presentation of Alchemix Data at The American Association for Cancer Research Annual Meeting

... Research Annual Meeting in Los Angeles. The poster presentation is entitled "Cytotoxicity of novel alkylating anthraquinones in cells with DNA nucleotide Excision Repair and DNA Mismatch Repair defects," and focuses on structure-activity studies on the company's novel technology for targeting and ...

Phase III Study Evaluating Gilead's Viread for the Treatment of Chronic Hepatitis B Virus Meets Primary Endpoint

... (IOCB) in Prague and Dr. Erik DeClercq, Rega Institute for Medical Research, Katholic University in Leuven, Belgium. About Hepsera Hepsera, a nucleotide analogue for the treatment of chronic hepatitis B, works by inhibiting HBV DNA polymerase, an enzyme involved in the replication of the virus in the ...

Second Phase III Study Evaluating Gilead's Viread for the Treatment of Chronic Hepatitis B Virus Meets Primary Endpoint

... (IOCB) in Prague and Dr. Erik DeClercq, Rega Institute for Medical Research, Katholic University in Leuven, Belgium. About Hepsera Hepsera, a nucleotide analogue for the treatment of chronic hepatitis B, works by inhibiting HBV DNA polymerase, an enzyme involved in the replication of the virus in the ...

Second Phase III Study Evaluating Gilead's Viread for the Treatment of Chronic Hepatitis B Virus Meets Primary Endpoint

... (IOCB) in Prague and Dr. Erik DeClercq, Rega Institute for Medical Research, Katholic University in Leuven, Belgium. About Hepsera Hepsera, a nucleotide analogue for the treatment of chronic hepatitis B, works by inhibiting HBV DNA polymerase, an enzyme involved in the replication of the virus in the ...
Other Contents
(Date:10/15/2014)... an unexpected extent. The outbreak does not follow the ... a new disease dynamic in regions, where it has ... National Academy of Sciences Leopoldina, acatech – the German ... the German Academies of Sciences and Humanities have presented ... the statement the academies call for the following consequences ...
(Date:10/15/2014)... Oct. 15, 2014   Neurotechnology , a ... the availability of the VeriLook Surveillance 3.0 ... provides real-time biometric face identification using live video ... cameras. The new version not only identifies faces ... from objects while they are moving through the ...
(Date:10/14/2014)... fly genome for the first time, revealing robust immune ... thrives in pathogen-rich dung piles and garbage heaps. , ... Genome Biology , will increase understanding of house fly ... to resist insecticides, which could lead to novel control ... transmit more than 100 human and animal diseases, including ...
Breaking Biology News(10 mins):Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3House fly genome reveals expanded immune system 2
(Date:10/20/2014)... 20, 2014 With a mere 19 ... Crist made a brief fundraising stop at the ... , Fresh from a debate last night with his ... stage for the first seven minutes because Crist had ... described the incident in one word: "weird." , Before ...
(Date:10/20/2014)... The Advocator Group, LLC is proud ... for Suicide Prevention’s (AFSP) Out of the Darkness walk ... that hosts hundreds of community walks throughout the country ... to help understand and prevent suicide through not only ... , The Advocator Group shares this passion for ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Women’s health ... in Obstetrics & Gynecology of Columbus, Inc., A Division ... healthcare services to more than 100,000 patients annually. Dr. ... all ages and stages of a women’s life. She ... locations in Westerville and Dublin. , Dr. Murphy ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 hc1.com ... a secure cloud solution that enables healthcare organizations ... the ultimate healthcare-specific customer relationship management (“CRM”) solution. ... the unique needs of the healthcare industry, the ... for providers and patients by combining healthcare CRM, ...
(Date:10/20/2014)... Angeles, CA (PRWEB) October 20, 2014 ... fitness expertise, nutritional coaching, corporate wellness programming, authorship, international ... CPT, is excited to announce the release of the ... , After many years of coaching thousands of individuals ... nutrition tracking app that does not require calorie counting ...
Breaking Medicine News(10 mins):Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 2Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 3Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3Health News:Healthcare Relationship Management (HRM) Leader hc1.com® Launches hc1® Quick Start™ 2Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3
Other TagsOther Tags