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Nucleic in Medical Technology

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

... (MALDI-TOF) mass spectrometry-based nucleic acid analysis platform that quantitatively ... MassARRAY system facilitates a number of nucleic acid analysis applications including single ... system allows a direct mass measurement of nucleic acids, providing unparalleled precision and ...

Another LNA-based RNA Inhibitor Enters Clinical Trials

... "Androgen receptor (AR) down regulation by locked nucleic acid antisense oligonucleotides specifically ... antagonist" "EZN-3042, a novel locked nucleic acid oligonucleotide against survivin, inhibits ... PEGylation technology platform and the Locked nucleic Acid (LNA) technology. Enzon's PEGylation ...

Novel PCT Method Unveiled by Pressure BioSciences, Inc. and Collaborators at the Harvard School of Public Health

... extraction, isolation, and fractionation of nucleic acids (DNA and RNA), proteins, and lipids ... studies. This method also yields high recovery of nucleic acids and proteins, shows ... extraction, isolation, and fractionation of nucleic acids, proteins, and lipids from a wide variety ...

Xenomics Announces Issuance of a US Patent That Covers Use of Transrenal Nucleic Acid Technology for Infectious Disease Diagnostics and Monitoring

... of its US patent "Methods for detection of nucleic acid sequences in urine," RE39,920 that covers use of its proprietary transrenal nucleic acid technology in the area of infectious disease diagnostics and monitoring. Transrenal nucleic acids (Tr-DNA and Tr-RNA) are fragments of DNA ...

Cepheid Receives Grant to Develop Ten-Color Real-Time PCR Detection Technology for Use in the GeneXpert(R) System

... amplification and detection functions for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect, and identify targeted nucleic acid sequences thereby delivering answers directly from unprocessed ...

Cepheid Announces European Release of First On-Demand Molecular Test for Simultaneous Detection of Mycobacterium tuberculosis (TB) and Resistance to Rifampicin

... amplification and detection functions for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect and identify targeted nucleic acid sequences thereby delivering answers directly from unprocessed ...

DSM Obtains Exclusive World-Wide License for Innovative Drug Delivery Technology

... used with a diverse group of drug candidates, from proteins, peptides and nucleic acids to small molecule drugs, thus expanding the possible application ... based therapies in oncology, immunology and on the delivery of nucleic acids. " Through this deal we bring in the first biodegradable ...

Verification Studies of IntelligentMDx's Proprietary Molecular Diagnostic Assay Process Have Been Completed

... /PRNewswire/ --IntelligentMDx a developer and manufacturer of proprietary nucleic acid assays, today announced that verification studies of the ... test functionality. IntelligentMDx's current pipeline includes proprietary nucleic acid (DNA or RNA) tests for Real Time PCR. These tests cover a range of ...

Cepheid Molecular Diagnostic Test for Positive Blood Culture Bottles Categorized 'Moderate Complexity' by FDA

... amplification and detection functions for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect and identify targeted nucleic acid sequences thereby delivering answers directly from unprocessed ...

Cepheid Announces CE IVD Release of First On-Demand Test for van A/van B Genes Most Associated With Hospital-Acquired VRE Infection

... amplification and detection functions for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect and identify targeted nucleic acid sequences thereby delivering answers directly from unprocessed ...

Regado Biosciences Reports Clinical Results for REG1 Anticoagulation System at European Society of Cardiology Congress 2008

... agent. The REG1 anticoagulant component, RB006, is a single-stranded, nucleic acid aptamer. RB006 selectively and potently binds to and inhibits factor ... to blood coagulation. The reversal agent, RB007, is a complementary nucleic acid that binds to and neutralizes RB006. The amount of RB007 administered ...

Cepheid GeneXpert(R) System and Xpert(TM) MRSA Selected for up to 11 Victoria, Australia Hospitals in Rollout of 'Start Clean' Strategy

... amplification and detection functions for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect and identify targeted nucleic acid sequences thereby delivering answers directly from unprocessed ...

QIAGEN and Center for Molecular Medicine Create Research Collaboration for Molecular Diagnostic Markers for Breast Cancer, Other Women's Health Issues

... consumable products and automated solutions for sample collection, nucleic acid and protein handling, separation, and purification and open and ... applied testing markets, clinical research markets and proteomics markets, nucleic acid-based molecular diagnostics market, and genetic vaccination and gene ...

Cepheid Launches New GeneXpert(R) Tests in Europe for Simultaneous, Rapid Detection of Staphylococcus Aureus and Methicillin Resistant Staphylococcus Aureus

... amplification and detection functions for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect and identify targeted nucleic acid sequences thereby delivering answers directly from unprocessed ...

Abbott Receives Supplemental FDA Approval for its Best-in-Class in Sensitivity RealTime HIV-1 Viral Load Test

... with Abbott for the development and commercialization of molecular, or nucleic acid-based, diagnostic products, and is also developing new diagnostic ... consumables, software, and services. Customers use these tools to analyze nucleic acids (DNA and RNA), small molecules, and proteins to make scientific ...

New Small and Medium Sized Enterprises Join TI Pharma by Signing Two New Projects

... on angiostatic miRNAs. miRNA is utilized as a therapeutic modality and advanced nanoparticle delivery systems accomplish intracellular delivery of nucleic acid agents. These will be combined with the identification of surface receptor targets on tumor blood vessels to allow for therapeutic intervention. ...

TriLink Launches CleanAmp(TM) dNTPs for Hot Start PCR

... SAN DIEGO, May 6 /PRNewswire/ -- TriLink BioTechnologies, Inc. (TriLink), a leading provider of custom nucleic acid-based compounds, has launched a new Hot Start PCR reagent - CleanAmp(TM) dNTPs. CleanAmp(TM) dNTPs offer a less expensive solution to ...

Investigational Genetic Test May Help Address Common Problems in Prostate Cancer Diagnosis

... About Gen-Probe Gen-Probe Incorporated is a global leader in the development, manufacture and marketing of rapid, accurate and cost-effective nucleic acid tests (NATs) that are used primarily to diagnose human diseases and screen donated human blood. Gen-Probe has more than 25 years of NAT ...

Gen-Probe and DiagnoCure Amend Collaboration Agreement Surrounding PCA3-Based Prostate Cancer Tests

... About Gen-Probe Gen-Probe Incorporated is a global leader in the development, manufacture and marketing of rapid, accurate and cost-effective nucleic acid tests (NATs) that are used primarily to diagnose human diseases and screen donated human blood. Gen-Probe has more than 25 years of NAT ...

Data Suggests New Antigen-Antibody Combo Test Useful for High Volume Public Health Screening

... from the Global HIV Surveillance Program at Abbott. "The current method for detection of acute infections is expensive and labor- intensive pooled nucleic acid testing (NAAT). The combination assay represents a reliable and cost-effective alternative with important benefits for HIV prevention ...

Breakthrough in Prenatal Screening for Down Syndrome

... medical director Dr. Stephen A. Brown at the University of Vermont incorporates the use of methylation-sensitive amplification (MSA) of fetal nucleic acid markers. In the preliminary studies, more than ten clinical plasma specimens of various ethnicities provided by clinical partners were tested ...

Regado Biosciences Completes Patient Enrollment for Phase IIa Study of REG1 Anticoagulation System

... system, consisting of an aptamer-based anticoagulant and its matched reversal agent. The anticoagulant component, RB006, is a single-stranded, nucleic acid aptamer. RB006 selectively and potently binds to and inhibits factor IXa, a protein that is critical to blood coagulation. The reversal agent, ...

Nuvelo Announces Positive Phase 1b Proof-of-Concept Data With Anticoagulant NU172

... be reversed with protamine once the procedure has been completed. About Aptamers and NU172 Aptamers are chemically synthesized single-stranded nucleic acids that form well-defined three-dimensional shapes, allowing them to bind target molecules in a manner that is conceptually similar to ...

Regado Biosciences Announces Publication in Circulation of Clinical Trial Results of REG1 Anticoagulation System

... system, consisting of an aptamer-based anticoagulant and its matched antidote. The REG1 anticoagulant component (RB006) is a single-stranded, nucleic acid aptamer. RB006 selectively and potently binds to and inhibits Factor IXa, a protein that is critical to blood coagulation. The antidote ...

Nuvelo Initiates Phase 1B Clinical Trial of Anticoagulant NU172

... 10 minutes. No serious adverse events occurred in the trial. About Aptamers and NU172 Aptamers are chemically synthesized single-stranded nucleic acids that form well-defined three-dimensional shapes, allowing them to bind target molecules in a manner that is conceptually similar to ...

TriLink Awarded a Phase II Grant for a Second Hot Start PCR Project

... SAN DIEGO, May 6 /PRNewswire/ -- TriLink BioTechnologies (TriLink), a leading provider of custom nucleic acid-based compounds, has been awarded a Phase II Small Business Innovation Research (SBIR) grant of approximately $750,000 to continue its ...

Nuvelo Announces Positive Proof-of-Concept Data With Anticogulant NU172

... standard of care for anticoagulation in CABG surgeries and PCI. About Aptamers and NU172 Aptamers are chemically synthesized single-stranded nucleic acids that form well-defined three-dimensional shapes, allowing them to bind target molecules in a manner that is conceptually similar to ...

Columbia University Medical Center and Rosetta Genomics Announce Columbia University's Submission of the First Cancer Diagnostic Test Based on Rosetta Genomics Proprietary MicroRNA Technology for Approval to the New York State Department of Health Clinica

... Laboratory: The Columbia University Medical Center Molecular Pathology Laboratory is a high complexity molecular pathology laboratory that provides nucleic acid-based testing in the fields of molecular oncology and molecular genetics, with New York state permits in the categories of genetic testing, ...

Gen-Probe Begins U.S. Clinical Study of Molecular Test for Human Papillomavirus, Which Causes Cervical Cancer

... accurate APTIMA HPV assay that improves the detection and treatment of cervical cancer." The investigational APTIMA HPV assay is an amplified nucleic acid test that detects 14 high-risk HPV types that are associated with cervical cancer. More specifically, the assay detects two messenger RNAs ...

Nuvelo Initiates Phase 1 Clinical Trial of Thrombin Inhibitor, NU172

... onset and offset of action, and avoidance of heparin-induced thrombocytopenia. About Aptamers Aptamers are chemically synthesized single-stranded nucleic acids that form well-defined three-dimensional shapes, allowing them to bind target molecules in a manner that is conceptually similar to ...

Beckman Coulter Announces Licensing Agreements for Molecular Tests with National University of Ireland, Galway

... about 50 percent of the $2 billion molecular diagnostics market in the United States. The assay development research relies on NUI Galway nucleic acid detection technology for both bacterial and fungal targets along with SPRI(R) (Solid Phase Reversible Immobilization) and other technologies ...

Interim Safety Analysis Supports Continuation of Allos Therapeutics' Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-cell Lymphoma

... molecule chemotherapeutic agent that inhibits dihydrofolate reductase, or DHFR, a folic acid (folate)-dependent enzyme involved in the building of nucleic acid, or DNA, and other processes. PDX was rationally designed for efficient transport into tumor cells via the reduced folate carrier, or RFC-1, and ...

Regado Biosciences Presents Early Stage Clinical Data for REG1 Anticoagulation System at American Heart Association 2007 Scientific Sessions

... system, consisting of an aptamer-based anticoagulant and its matched antidote. The REG1 anticoagulant component (RB006) is a single-stranded, nucleic acid aptamer. RB006 selectively and potently binds to and inhibits Factor IXa, a protein that is critical to blood coagulation. The antidote ...

Regado Biosciences Presents Positive Data From REG1 Anticoagulation System Phase Ic Study at American Heart Association 2007 Scientific Sessions

... system, consisting of an aptamer-based anticoagulant and its matched antidote. The REG1 anticoagulant component (RB006) is a single-stranded, nucleic acid aptamer. RB006 selectively and potently binds to and inhibits Factor IXa, a protein that is critical to blood coagulation. The antidote ...

Regado Biosciences Initiates Phase IIa Clinical Study of REG1 Anticoagulation System

... system, consisting of an aptamer-based anticoagulant and its matched antidote. The REG1 anticoagulant component (RB006) is a single-stranded, nucleic acid aptamer. RB006 selectively and potently binds to and inhibits Factor IXa, a protein that is critical to blood coagulation. The antidote ...

QIAGEN N.V. (Nasdaq: QGEN) Invites You to Join Its Third Quarter 2007 Earnings Conference Call on the Web

... QIAGEN has developed a comprehensive portfolio of more than 500 proprietary, consumable products and automated solutions for sample collection, and nucleic acid and protein handling, separation, and purification. QIAGEN also supplies diagnostic kits, tests, and assays for human and veterinary molecular ...

Interim Response and Safety Analyses Support Continuation of Allos Therapeutics' Pivotal Phase 2 PROPEL Trial of PDX in Patients with Peripheral T-Cell Lymphoma

... molecule chemotherapeutic agent that inhibits dihydrofolate reductase, or DHFR, a folic acid (folate)-dependent enzyme involved in the building of nucleic acid, or DNA, and other processes. PDX was rationally designed for efficient transport into tumor cells via the reduced folate carrier, or RFC-1, and ...

Furamidine Found to Inhibit a Key Enzyme Involved in Cancer Cell DNA Repair Mechanisms

... for identification of human tyrosyl- DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC305831) as an inhibitor of Tdp1," nucleic Acids Research, http://nar.oxfordjournals.org/, Copyright (C) 2007 Oxford University Press. About Immtech Pharmaceuticals, Inc. Immtech ...

Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma

... molecule chemotherapeutic agent that inhibits dihydrofolate reductase, or DHFR, a folic acid (folate)-dependent enzyme involved in the building of nucleic acid, or DNA, and other processes. PDX was rationally designed for efficient transport into tumor cells via the reduced folate carrier, or RFC-1, and ...
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