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Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival

... only (n=629) within 70 days of regional lymph node dissection (intent-to-treat population). The ... with clinically non-palpable (microscopic) lymph node disease, the HR for RFS was 0.73 (99 percent CI, ... the HR in patients with one positive lymph node was 0.71 (99 percent CI, 0.53-0.97, P=0.004) as ...

Multiple Studies Presented at San Antonio Breast Cancer Symposium Reinforce Clinical Utility of Oncotype DX(R)

... trial that evaluated postmenopausal patients with node positive, hormone receptor-positive breast ... significantly predictive of recurrence in both node negative disease and node-positive disease, ... in some patients with hormone receptor positive, node positive breast cancer, the ability of Oncotype ...

Auxilium Pharmaceuticals, Inc. Announces XIAFLEX(TM) Meets Primary Endpoint With Statistical Significance (p<0.001) in CORD I Pivotal Phase III Study for Dupuytren's Contracture

... swelling, bruising and pruritis at the injection site and transient lymph node swelling and pain. In over 2,000 XIAFLEX injections administered in ... swelling, bruising and pruritis at the injection site and transient lymph node swelling and pain. These adverse events were consistent with previous ...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

... and was as high as 98%. Two patients with leukemia cutis had complete or partial clearance of skin lesions. One patient had a 36% reduction in lymph node size, a 28% decrease in spleen size and a significant increase (44%) in hemoglobin. Mild grade 1 or 2 infusion toxicity was observed and there were ...

Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy

... 23 cases were HER-2/neu positive. Scientists found that the increased expression of EZH-2 meant an increase in tumor size and an increase in lymph node metastasis. Dr. Nahleh said that increased identification of proteins in these aggressive forms of breast cancer is needed to develop better ...

Melanoma and Pregnancy: What Every Woman Needs to Know About the Risks, Prognosis

... the fetus during the procedure. However, if a melanoma is deeper than 1 mm, Dr. Driscoll advised that a procedure known as sentinel lymph node mapping and biopsy should be considered. This procedure has not been studied in a large number of pregnant women, and both when and how the procedure ...

Agendia's Breast Cancer Test MammaPrint(R) Identifies New Subset of Low Risk HER2+ Patients

... in HER2+ early breast cancer. These patients will be further studied in the ongoing MINDACT-trial (Microarray for Node-negative and 1-3 positive node Disease may Avoid ChemoTherapy) to determine the prospects of withholding chemotherapy and/or trastuzumab in HER2+, MammaPrint(R) low risk patients. ...

Young Women Diagnosed with Early-Stage Breast Cancer More Likely to Die than Older Women

... MD, assistant professor of surgery, Washington University School of Medicine, St. Louis, MO, "These are women with similar size tumor and lymph node status. The characteristics of the tumor itself, however, portend a poorer prognosis. "We think we should devote much of our future research to ...

News Media Advisory: World's Leading Surgical Oncologists to Gather at McLaren Regional Medical Center to Present Latest Work on Breast, Gastrointestinal Cancer Treatments

... symposium, hosted by McLaren and GLCI, was organized by McLaren's Sukamal Saha, M.D., an award-winning surgical oncologist whose work in sentinel node mapping for colorectal cancer has gained worldwide recognition and has evolved into international collaboration of multiple institutions from the ....

Radioactive Seed Therapy Shows Significant Reduction in Lung Cancer Recurrence

... for an estimated 85% of all cases. Stage I NSCLC is characterized by disease that is localized in the lung with no metastasis to the lymph node system. "The standard of care for patients with this particular disease is a lobectomy, or surgical removal of the entire lobe of the lung. ...

Agendia's MammaPrint(R) Included in 2008 Dutch Institute for Healthcare Improvement CBO Guidelines

... the new guidelines acknowledge the prognostic power of MammaPrint in general and highlight its ability to identify subgroups of untreated node negative patients as having a good or poor prognosis. The test also allows physicians and patients to determine with which therapy, if any, to ...

Bioimpedance Spectroscopy is More Accurate and Reliable Than Other Methods of Subclinical Assessment of Lymphedema in Breast Cancer Patients, According to Paper Published in Journal of Clinical Oncology

... Technology in Australia, is based on a study that involved 265 breast cancer patients. Approximately 87 percent of the patients had undergone lymph node dissection, 70 percent had received radiation therapy and 40 percent had received chemotherapy and/or hormone treatment. The study's investigators ...

The Leukemia & Lymphoma Society and Memgen Collaborate on CLL Clinical Trial

... Ph.D., at The University of Texas M. D. Anderson Cancer Center, a single infusion of ISF35 resulted in the rapid decline in circulating and lymph node bound leukemic cells, induced long-term immune based responses against these cells and sensitized them to standard chemotherapies, even in several ...

JDSU WaveReady Receives Brocade Data Center Ready Status for Brocade-Based Storage Area Network (SAN) Infrastructures

... and network monitoring solutions. The platform offers a robust "plug-and-play" solution that is very simple to operate and manage using the WaveReady node manager graphical interface. The flexibility, density and compact size of the WaveReady platform makes it an ideal optical transport solution. ...

TARGETED GENE DELIVERY SIGNALS CANCER VACCINATION IN VIVO: Intravenous Infusions of Rexin-G Followed by Reximmune-C Induce Tumor Necrosis and Recruitment of Tumor Infiltrating Lymphocytes in Cancerous Lesions (ASCO 2008)

... intervention. Immune-related reactions consisted of transient flu-like symptoms in two patients, redness and swelling of a tumor-infiltrated lymph node and one metastatic chest nodule, and acute flank pain in one patient with adrenal gland metastasis. Analysis of efficacy in biopsied tumor specimens ...

Researchers Train the Immune System to Deliver Virus That Destroys Cancer in Lab Models

... tumors often pose the most threat to patients, not the primary tumor. The prognosis for these patients often depends upon the degree of lymph node involvement and whether the cancer has spread. Dr. Vile and colleagues theorized that they could control the spread of cancer through the ...

Pilot Study Opens the Door for Avastin Use in Curative Setting for Women With Breast Cancer

... study included 226 women with lymph node positive breast cancer who have had already undergone surgical removal (mastectomy) of the lesion and lymph node dissection. The study was sponsored by the National Cancer Institute (NCI), part of the US National Institutes of Health, and conducted by a network ...

PET Scans Show Gene Therapy Normalizes Brain Function in Parkinson's Patients

... to be sure that the treatment doesn't make things worse." The gene makes an inhibitory chemical called GABA that turns down the activity in a key node of the Parkinson's motor network. The investigators were not expecting to see changes in cognition, and the scans confirmed that this did not occur. ...

Saving Lives of California Residents Who Develop Skin Cancer Each Year: The Key is Early Detection and Treatment

... including but not limited to melanoma, basal cell cancer, squamous cell cancer; diagnosis and treatment of moles and melanoma including sentinel node biopsy of lymph nodes; Mohs Surgery of skin cancer; evaluation and treatment of dysplastic nevus syndrome including use of episope evaluation of ...

New Study Shows Doxorubicin Plus Paclitaxel Followed by Weekly Paclitaxel as Adjuvant Therapy for High Risk Breast Cancer Warranted in Place of Doxorubicin Plus Cyclophosphamide Followed by Paclitaxel

... and trastuzumab-based regimens improve DFS and OS over AC-T in node positive and high risk node negative HER2 positive early breast cancer patients: Quality of ...

Newly Published Study Reveals Femara Improves Chances for Harder to Treat Early Breast Cancer Relapse in Postmenopausal Women

... positive nodes, positive oestrogen receptor status but negative progesterone status, grade three tumours and invasive disease. Notably, women with node positive disease, who are considered to be at a higher risk of recurrence, maintained this lower risk of relapse when treated with upfront Femara ...

Data to be Presented at ASCO 2007 Highlights sanofi-aventis Commitment to Cancer Care and Research

... included in two randomized trials. -- This presentation reviews the use of Taxotere(R) in trials involving patients with early stage node positive breast cancer, according to the hormonal receptor status of the tumor. -- Monday, June 4, 10:00 AM - 10:15 AM, E Hall D1, Oral ...

Ontak (denileukin diftitox) Achieves 49.1% Overall Response Rate in Phase III Trial of Cutaneous T-Cell Lymphoma (CTCL)

... can progress to the lymph nodes, spleen, liver and other organs. About 10% of CTCL sufferers will experience progressive disease with lymph node and/or internal involvement with serious complications. There is no known cure for CTCL. "The preliminary results of this study show that ONTAK ...

Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival

... (DMFS) (p-value 0.03). This group of patients constituted 43 percent of the trial population. At present, because of the increased use of sentinel node staging , this patient population largely constitutes the majority of patients diagnosed with stage III disease. In the study, participants reached ...

Santaris Pharma Presents Positive Clinical Data on SPC2996 in Chronic Lymphocytic Leukaemia

... at 2 mg/kg/infusion having a transient reduction in lymphocytes of up to 30% and doses of 1 mg/kg/infusion having no effect. Reductions in lymph node swelling was also observed in these patients, 2 out of 4 patients receiving drug at 4mg/kg/infusion and 1 out of 4 at 2 mg/kg/infusion showed a ...

Anastrozole (Arimidex) Improves Overall Survival in Postmenopausal Women with Early Breast Cancer Receiving Treatment with Tamoxifen

... of the study population. The result is particularly striking in that this was a substantial group of patients with a relatively good prognosis (74% node negative). The reason that this result is so important is that improvement in overall survival is the biggest prize of all," said Professor Jeffrey ...

First single breast cancer study to show significant survival benefit for women switching from tamoxifen to Arimidex

... the study population. The result is particularly striking in that this was a substantial group of patients with a relatively good prognosis (74% node negative). The reason that this result is so important is that improvement in overall survival is the biggest prize of all,” said Professor ...

Neoprobe Phase 2 Lymphoseek Trial Meets Primary Endpoint

... being developed for use with handheld gamma detection devices, such as Neoprobe's neo2000(R) system, in a surgical procedure known as Sentinel Lymph node Biopsy (SLNB). The primary endpoint of this multicenter, single-arm, open-label, within-patient, single-dose, multi-stage trial measured the rate ...
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