Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival
... only (n=629) within 70 days of regional lymph node
(intent-to-treat population). The ... with clinically non-palpable (microscopic) lymph node
the HR for RFS was 0.73 (99 percent CI, ... the HR in patients with one positive lymph node
was 0.71 (99
percent CI, 0.53-0.97, P=0.004) as ...
Multiple Studies Presented at San Antonio Breast Cancer Symposium Reinforce Clinical Utility of Oncotype DX(R)
... trial that evaluated postmenopausal patients with node
positive, hormone receptor-positive breast ... significantly predictive of recurrence in both node
negative disease and node-positive disease, ... in some patients with hormone receptor
positive breast cancer, the ability of Oncotype ...
Auxilium Pharmaceuticals, Inc. Announces XIAFLEX(TM) Meets Primary Endpoint With Statistical Significance (p<0.001) in CORD I Pivotal Phase III Study for Dupuytren's Contracture
... swelling, bruising and pruritis at the injection site and
transient lymph node
swelling and pain. In over 2,000 XIAFLEX injections
administered in ... swelling, bruising and pruritis at the injection site
and transient lymph node
swelling and pain. These adverse events were
consistent with previous ...
Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)
... and was as high as 98%. Two patients with leukemia cutis had complete or partial clearance of skin lesions. One patient had a 36% reduction in lymph node
size, a 28% decrease in spleen size and a significant increase (44%) in hemoglobin. Mild grade 1 or 2 infusion toxicity was observed and there were ...
Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy
... 23 cases were HER-2/neu positive. Scientists found that the increased expression of EZH-2 meant an increase in tumor size and an increase in lymph node
Dr. Nahleh said that increased identification of proteins in these aggressive forms of breast cancer is needed to develop better ...
Melanoma and Pregnancy: What Every Woman Needs to Know About the Risks, Prognosis
... the fetus during the procedure.
However, if a melanoma is deeper than 1 mm, Dr. Driscoll advised that a procedure known as sentinel lymph node
mapping and biopsy should be considered. This procedure has not been studied in a large number of pregnant women, and both when and how the procedure ...
Agendia's Breast Cancer Test MammaPrint(R) Identifies New Subset of Low Risk HER2+ Patients
... in HER2+ early breast cancer. These patients will be further
studied in the ongoing MINDACT-trial (Microarray for Node-negative and 1-3
Disease may Avoid ChemoTherapy) to determine the prospects of
withholding chemotherapy and/or trastuzumab in HER2+, MammaPrint(R) low risk
Young Women Diagnosed with Early-Stage Breast Cancer More Likely to Die than Older Women
... MD, assistant professor
of surgery, Washington University School of Medicine, St. Louis, MO, "These
are women with similar size tumor and lymph node
characteristics of the tumor itself, however, portend a poorer prognosis.
"We think we should devote much of our future research to ...
News Media Advisory: World's Leading Surgical Oncologists to Gather at McLaren Regional Medical Center to Present Latest Work on Breast, Gastrointestinal Cancer Treatments
... symposium, hosted by
McLaren and GLCI, was organized by McLaren's Sukamal Saha, M.D., an
award-winning surgical oncologist whose work in sentinel node
colorectal cancer has gained worldwide recognition and has evolved into
international collaboration of multiple institutions from the ....
Radioactive Seed Therapy Shows Significant Reduction in Lung Cancer Recurrence
... for an estimated 85% of all cases. Stage I NSCLC is
characterized by disease that is localized in the lung with no metastasis
to the lymph node
"The standard of care for patients with this particular disease is a
lobectomy, or surgical removal of the entire lobe of the lung. ...
Agendia's MammaPrint(R) Included in 2008 Dutch Institute for Healthcare Improvement CBO Guidelines
... the new
guidelines acknowledge the prognostic power of MammaPrint in general and
highlight its ability to identify subgroups of untreated node
patients as having a good or poor prognosis. The test also allows
physicians and patients to determine with which therapy, if any, to ...
Bioimpedance Spectroscopy is More Accurate and Reliable Than Other Methods of Subclinical Assessment of Lymphedema in Breast Cancer Patients, According to Paper Published in Journal of Clinical Oncology
... Technology in Australia, is
based on a study that involved 265 breast cancer patients. Approximately 87
percent of the patients had undergone lymph node
dissection, 70 percent had
received radiation therapy and 40 percent had received chemotherapy and/or
hormone treatment. The study's investigators ...
The Leukemia & Lymphoma Society and Memgen Collaborate on CLL Clinical Trial
... Ph.D., at The University of Texas
M. D. Anderson Cancer Center, a single infusion of ISF35 resulted in the
rapid decline in circulating and lymph node
bound leukemic cells, induced
long-term immune based responses against these cells and sensitized them to
standard chemotherapies, even in several ...
JDSU WaveReady Receives Brocade Data Center Ready Status for Brocade-Based Storage Area Network (SAN) Infrastructures
... and network
monitoring solutions. The platform offers a robust "plug-and-play" solution
that is very simple to operate and manage using the WaveReady node
graphical interface. The flexibility, density and compact size of the
WaveReady platform makes it an ideal optical transport solution. ...
TARGETED GENE DELIVERY SIGNALS CANCER VACCINATION IN VIVO: Intravenous Infusions of Rexin-G Followed by Reximmune-C Induce Tumor Necrosis and Recruitment of Tumor Infiltrating Lymphocytes in Cancerous Lesions (ASCO 2008)
Immune-related reactions consisted of transient flu-like symptoms in two
patients, redness and swelling of a tumor-infiltrated lymph node
metastatic chest nodule, and acute flank pain in one patient with adrenal
gland metastasis. Analysis of efficacy in biopsied tumor specimens ...
Researchers Train the Immune System to Deliver Virus That Destroys Cancer in Lab Models
... tumors often pose the most threat to
patients, not the primary tumor. The prognosis for these patients often
depends upon the degree of lymph node
involvement and whether the cancer
Dr. Vile and colleagues theorized that they could control the spread of
cancer through the ...
Pilot Study Opens the Door for Avastin Use in Curative Setting for Women With Breast Cancer
... study included 226 women with lymph node
positive breast cancer who have had already undergone surgical removal
(mastectomy) of the lesion and lymph node
dissection. The study was
sponsored by the National Cancer Institute (NCI), part of the US National
Institutes of Health, and conducted by a network ...
PET Scans Show Gene Therapy Normalizes Brain Function in Parkinson's Patients
... to be sure that
the treatment doesn't make things worse." The gene makes an inhibitory
chemical called GABA that turns down the activity in a key node
Parkinson's motor network. The investigators were not expecting to see
changes in cognition, and the scans confirmed that this did not occur.
Saving Lives of California Residents Who Develop Skin Cancer Each Year: The Key is Early Detection and Treatment
... including but not limited to melanoma, basal cell cancer,
squamous cell cancer; diagnosis and treatment of moles and melanoma
including sentinel node
biopsy of lymph nodes; Mohs Surgery of skin cancer;
evaluation and treatment of dysplastic nevus syndrome including use of
episope evaluation of ...
New Study Shows Doxorubicin Plus Paclitaxel Followed by Weekly
Paclitaxel as Adjuvant Therapy for High Risk Breast Cancer
Warranted in Place of Doxorubicin Plus Cyclophosphamide Followed by
... and trastuzumab-based regimens improve DFS and OS over
AC-T in node
positive and high risk node
negative HER2 positive early
breast cancer patients: Quality of ...
Newly Published Study Reveals Femara Improves Chances for Harder to
Treat Early Breast Cancer Relapse in Postmenopausal Women
... positive nodes, positive oestrogen receptor status but
negative progesterone status, grade three tumours and invasive
disease. Notably, women with node
positive disease, who are
considered to be at a higher risk of recurrence, maintained this
lower risk of relapse when treated with upfront Femara ...
Data to be Presented at ASCO 2007 Highlights sanofi-aventis
Commitment to Cancer Care and Research
... included in two randomized trials.
-- This presentation reviews the use of Taxotere(R) in trials involving
patients with early stage node
positive breast cancer, according to the
hormonal receptor status of the tumor.
-- Monday, June 4, 10:00 AM - 10:15 AM, E Hall D1, Oral ...
Ontak (denileukin diftitox) Achieves 49.1% Overall Response Rate in
Phase III Trial of Cutaneous T-Cell Lymphoma (CTCL)
... can progress to the lymph nodes, spleen, liver and other
organs. About 10% of CTCL sufferers will experience progressive
disease with lymph node
and/or internal involvement with serious
complications. There is no known cure for CTCL.
"The preliminary results of this study show that ONTAK ...
Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III
Melanoma Demonstrated Significant and Sustained Impact on
... (DMFS) (p-value 0.03). This group of
43 percent of the trial population. At present, because of the
increased use of sentinel node
staging , this patient population
largely constitutes the majority of patients diagnosed with stage
In the study, participants reached ...
Santaris Pharma Presents Positive Clinical Data on SPC2996 in
Chronic Lymphocytic Leukaemia
... at 2 mg/kg/infusion having a transient reduction in
lymphocytes of up to 30% and doses of 1 mg/kg/infusion having no
Reductions in lymph node
swelling was also observed in these
patients, 2 out of 4 patients receiving drug at 4mg/kg/infusion and
1 out of 4 at 2 mg/kg/infusion showed a ...
Anastrozole (Arimidex) Improves Overall Survival in Postmenopausal
Women with Early Breast Cancer Receiving Treatment with Tamoxifen
... of the
study population. The result is particularly striking in that this
was a substantial group of patients with a relatively good
prognosis (74% node
negative). The reason that this result is so
important is that improvement in overall survival is the biggest
prize of all," said Professor Jeffrey ...
First single breast cancer study to show significant survival
benefit for women switching from tamoxifen to Arimidex
... the study population. The result is particularly striking in
that this was a substantial group of patients with a relatively
good prognosis (74% node
negative). The reason that this result is
so important is that improvement in overall survival is the biggest
prize of all,” said Professor ...
Neoprobe Phase 2 Lymphoseek Trial Meets Primary Endpoint
... being developed for use with handheld
gamma detection devices, such as Neoprobe's neo2000(R) system, in a
surgical procedure known as Sentinel Lymph node
Biopsy (SLNB). The
primary endpoint of this multicenter, single-arm, open-label,
within-patient, single-dose, multi-stage trial measured the rate ...