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Neurons in Medical Technology

Neuroscience Researcher Has Positive Message for International Alzheimer's Awareness Week, July 6 - 12: 'Even Though World Economy is Declining, Alzheimer's Research is Advancing'

... unregulated, excessive calcium levels within the neurons and the occurrence of Alzheimer's disease. ... now know that it is 'calcium overload' within the neurons that causes those neurons to stop functioning and brings about cognitive ...

Astrocytes Help Separate Man From Mouse

... simply to support flashier brain cells known as neurons that send electrical signals, are bigger, faster, ... moving on to their flashy counterparts, the neurons that fire the electrical signals crucial to ... everything we do. It's the electrical activity of neurons that constitutes what most scientists have ...

Neuralstem's Human Stem Cells Integrate into Nervous System of Rats with Animal Model of ALS

... Make Synaptic Contact with Host Motor neurons ROCKVILLE, Md., March 9 ... US: CUR) made synaptic contacts with the motor neurons of rats with ALS-like symptoms, a paper published ... is the first demonstration of transplanted human neurons synapsing, or making mature structural ...

Groundbreaking Paper Publishes Long Term Results of a Successful Phase I Clinical Trial Using Autologous Neural Stem Cells to Treat Parkinson's Disease

... ultimately differentiate them to produce mature neurons before they are reintroduced into the brain's ... neurogenesis to regenerate millions of mature neurons characterized before transplantation. These ... the combination of dopaminergic and GABA-ergic neurons that produced the long- lasting motor ....

Insmed Provides Update on IPLEX(TM) Expanded Access Program in Italy for the Treatment of Amyotrophic Lateral Sclerosis

... nerve cells in the brain and spinal cord. Motor neurons reach from the brain to the spinal cord and from ... body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate ...

Five Clinical Studies to Receive $2.5 Million Under Foundation's 2007 Clinical Discovery Program

... Dr. Albin will investigate the role of serotonin neurons in PD-related sleep-disordered breathing. He will visualize serotonin neurons using an advanced medical imaging technique, then ... in London hypothesizes that serotonin neurons are responsible for levodopa-induced dyskinesias. ...

St. Jude Identifies the Specific Cell That Causes Eye Cancer, Disproving Long-Held Theory

... of mouse models, fully differentiated horizontal neurons could multiply and yet retain all of the differentiated features of normal horizontal neurons including neurites and synapses. "For the past ... multiply temporarily and replace the neighboring neurons that were lost as a result of ...

Diamyd Updates Gene Therapy Program and Outlines Plans for Phase I Clinical Trial for Treatment of Cancer Pain

... locally in the targeted sensory neurons to block pain signals before they are transmitted ... to deliver and express gene products directly in neurons that project into the spinal cord is extremely ... Pain is transmitted through a series of neurons that run from the skin to the brain. Pain ...

Michael J. Fox Foundation Funds $1.1 Million for Cutting-Edge Approaches to Parkinson's Disease Under Rapid Response Innovation Awards 2008

... cells, then using these engineered stem cells to generate human dopamine neurons with or without mutations in the respective genes. Both projects seek ... hope to elucidate the mechanisms by which nicotine may protect dopamine neurons through development and validation of a screening test for small molecules ...

Headache Specialists Convene in Boston For 50th Annual American Headache Society Meeting

... ease the throbbing of a headache? Think again. Researchers discovered neurons are not the only carrier of pain signals to the brain. Glial cells, which outnumber neurons 20:1, have been shown to prompt chronic pain in a variety of ways, ...

Brain Stem Cells Can Be Awakened, Say Schepens Scientists

... to sleep brain stem cells, which, when activated, can transform into neurons (nerve cells) and repair damaged brain tissue. Their findings are ... When they compared the chemical makeup of the areas known to generate new neurons in the hippocampus with other parts of the brain, the team discovered that ...

Michael J. Fox Foundation Awards Up to $3 Million to Industry Teams to Jumpstart Promising PD Drug Development

... Chronic inflammation plays a role in the death of the dopamine-producing neurons that are lost in Parkinson's disease. Patrick Flood, PhD, of TheraLogics, ... demonstrated that the compound can increase the number of dopaminergic neurons in a mouse model of PD. The goal now is to gain greater understanding of ...

Ceregene Presents Long-term Follow-up From Phase 1 Trial of CERE-120 in Parkinson's Disease

... their putamen -- a region of the brain affected by the degeneration of neurons in Parkinson's disease. Several validated secondary motor endpoints, i.e., ... properties, and both have been shown to benefit the midbrain dopamine neurons that degenerate in Parkinson's disease and are responsible for the major ...

Survival Data for Avicena's Amyotrophic Lateral Sclerosis Drug Candidate, AL-02, to be Presented at 18th International Symposium on ALS/MND

... ABOUT ALS ALS is a neurodegenerative disease that attacks the motor neurons of the brain and spinal cord that are responsible for voluntary muscle movement. As these motor neurons degenerate, their ability to send impulses to the muscle fibers is ...

Orexigen(R) Therapeutics Schedules July 20, 2009 Teleconference and Webcast Discussion of Contrave(R) Phase 3 Results

... as well as the mechanisms that come into play to limit weight loss over time. Each product candidate is designed to act on a specific group of neurons in the central nervous system with the goal of achieving appetite suppression and sustained weight loss. Further information about the Company can be ...

Cognition Therapeutics Closes Series A Financing to Advance Drug Candidates for Alzheimer's Disease

... of proteins in Alzheimer's disease and other neurodegenerative diseases. These assays emphasize phenotypic or functional responses of mature primary neurons to the toxic proteins. Cognition's proprietary chemistry platform converts natural products into low molecular weight chemically stable druglike ...

Michael J. Fox Foundation Awards Over $2 Million for Validation of 10 Parkinson's Therapeutic Targets

... therapy Mathieu Lesort, PhD, University of Alabama at Birmingham The therapeutic role of CMA-MEF2D in the survival of dopamine neurons Zixu Mao, PhD, Emory University SHP-2 phosphatase: A new pharmacological target for Parkinson ' s disease? Maria-Cristina ...

Neuralstem's ALS Trial on Clinical Hold

... and spinal cord in commercial quantities, and the ability to control the differentiation of these cells into mature, physiologically relevant human neurons and glia. Major Central Nervous System diseases targeted by the Company with research programs currently underway include: Ischemic Spastic ...

Parkinson's Disease Foundation Awards $300,000 in Bridge Funding for Innovative Research Projects

... slow its progression. Dr. Sulzer will investigate the role that inflammation, caused by an immune response, plays in causing the death of neurons in Parkinson's. Scientists already know that inflammation occurs in areas of the brain affected by Parkinson's disease and suspect that it may ...

Endo Pharmaceuticals Announces Research Collaborations to Develop Novel Pain Treatments and Discover Potential Cancer Treatments

... Research at Massachusetts General Hospital, and Bruce Bean, Ph.D., Harvard Medical School Professor of Neurobiology, that targets pain-sensing neurons without affecting motor neurons. Under the terms of the agreement, Endo will receive exclusive world-wide rights to the technology and be ...

Merck Serono's Safinamide Significantly Improved Motor Function in Patients With Advanced Parkinson's Disease in a Phase III Pivotal Trial

... of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Secondary symptoms may include high-level cognitive dysfunction and subtle language problems. Parkinson's disease is both chronic and ...

Michael J. Fox Foundation Awards $2.9 Million for Two New Parkinson's Disease Clinical Trials

... 2 study to determine whether isradipine (marketed under the trade name Dynacirc), an approved high blood pressure medication, can rescue dopamine neurons from the degeneration seen in Parkinson's. Although the drugs' current uses for cholesterol and blood pressure management might not seem ...

Orexigen(R) Therapeutics Announces Changes to Its Clinical Programs and Management Team

... trials, and Empatic, which is in the later stages of Phase 2 clinical development. Each product candidate is designed to act on a specific group of neurons in the central nervous system with the goal of achieving appetite suppression and sustained weight loss. Further information about the company can be ...

Neuralstem Licenses Cleveland Clinic Spinal Cord Injection Technology

... and spinal cord in commercial quantities, and the ability to control the differentiation of these cells into mature, physiologically relevant human neurons and glia. Major Central Nervous System diseases targeted by the Company with research programs currently underway include: Ischemic ...

Neuronascent, Inc. Receives Multiple Fundings for Its Neurogenesis Therapeutic Programs

... from the Challenge Investment Program. The company's lead compounds, currently in preclinical testing, aim to replace damaged neurons, restore neurons critical to cognition and memory and enhance neuroprotection against neurodegenerative diseases. Results from recent animal studies show a reversal ...

Protein Shown to Play a Key Role in Normal Development of Nervous System

... that carry signals into the cell. The most vigorous dendrite growth occurs shortly after birth, when GluR1 is present on the surface of the cell. As neurons mature, GluR1 is lost from the cell surface of some neurons, and dendrites stop growing. Kalb and colleagues showed that suppressing GluR1 activity ...

Orexigen(R) Therapeutics Presents Data on Its Proprietary Formulation of Naltrexone Sustained Release (SR) Used in Contrave(R)

... and Empatic(TM), which is in the later stages of Phase 2 clinical development. Each product candidate is designed to act on a specific group of neurons in the central nervous system with the goal of achieving appetite suppression and sustained weight loss. Beyond obesity, Orexigen is developing ...

deCODE Files IND for DG071, a Novel PDE4 Modulator Being Developed for Alzheimer's and Other Cognitive Disorders

... to slow or stop progression of the disease but will not reverse the destruction of neurons. Our expectation is that DG071 will allow the remaining neurons to store and retrieve memories more efficiently. DG071 could be useful in the treatment not only of Alzheimer's disease, but might also have benefit ...

Quark Pharmaceuticals Announces First RNAi Drug Candidate Having a Novel, Proprietary Structure Covered by Quark Intellectual Property

... of RGC death induced by axotomy of the optic nerve. QPI-1007 displayed neuroprotective activity towards RGCs. It significantly protected retinal neurons against delayed degeneration and reduced injury induced RGC death in vivo, the hallmarks of glaucoma and acute injuries such as ischemic optic ...

Novel Photoconductive Life Science Research Innovation Enables Rapid, Reproducible, and Non-Invasive Cellular Excitation

... From neurons to Beyond; Advancing the Frontiers of Life Science Research Toward Realizing Healthcare Solutions in Areas of Clinical Need Such as Parkinson's, ...

Neurosciences Institute Discovers Drug Extends Stroke Treatment Time to 24 Hours, Repairs Brain Tissue

... rapidly -- within seconds to minutes -- and as oxygen becomes depleted in the brain tissue, cells die. This means that hundreds of thousands of neurons -- each linked to thousands of connections -- die. In animal testing, Bryostatin completely rescues these dying neurons, stimulates the growth of new ...

Sound Pharmaceuticals Files Second IND with the FDA for the Prevention of Chemotherapy Induced Hearing Loss in Advanced Stage Cancer

... GPx is the dominant catalytic antioxidant enzyme within the inner ear, and a loss of its activity results in irreparable damage to hair cells, neurons and non-sensory tissues that are critical for hearing and balance. "A dose limiting side effect of platinum based chemotherapies are their ...

'Hibernation-On-Demand' Drug Hydrogen Sulfide Significantly Improves Survival After Extreme Blood Loss

... death from profound and sustained blood loss? One possibility is that in reducing metabolism, H2S also reduces oxygen demand, which allows crucial neurons in the hippocampus, the part of the brain that controls autonomic functions such as breathing and heartbeat, to withstand low oxygen levels due ...

Bionovo's Drug Candidate for Menopausal Symptoms Shows Effect on Neural Pathways Related to Temperature Regulation

... FRANCISCO and EMERYVILLE, Calif., June 16 /PRNewswire-FirstCall/ -- Bionovo Inc. (Nasdaq: BNVI ) today announced results from in vitro studies in neurons of its drug candidate, MF101. The data were presented at the Endocrine Society 90th Annual Meeting. Bionovo showed that, in neurons differentiated ...

Neuralstem Announces Issuance of Core Technology Patent in Europe

... and spinal cord in commercial quantities, and the ability to control the differentiation of these cells into mature, physiologically relevant human neurons and glia. Major Central Nervous System diseases targeted by the Company with research programs currently underway include: Ischemic ...

BrainCells Inc. Initiates Phase 2 Clinical Trial with BCI-540 for Depression with Anxiety

... BrainCells Inc. (BCI), a biopharmaceutical company utilizing its platform technology to identify and develop compounds that promote the growth of new neurons for the treatment of central nervous system (CNS) diseases, announced today that it has initiated a Phase 2a clinical trial with its lead product ...

FTY720, a novel oral therapy in development for MS, shows sustained benefits for the majority of patients after three years of treatment

... the following toll-free number: 866-788-3930, or visit http://www.MSClinicalTrials.com . MS is caused by the destruction of myelin, which helps neurons carry electrical signals in the brain. The disease causes problems with muscle control and strength, vision, balance, sensation and mental function. ...

St. Jude Finds Signaling System That Halts the Growth of a Childhood Brain Cancer

... the intricate signaling mechanisms that govern the proliferation of cells called granule neuron progenitors (GNPs). These cells go on to develop into neurons in the cerebellum during the first year of life. But the disruption of this differentiation process can trigger medulloblastoma. Previous ...

NeurogesX Announces Preliminary Results from Second Phase 3 Clinical Trial in HIV-DSP

... 500,000 people in the United States living with PHN. HIV-DSP is caused primarily by three factors: direct activation of cells known as sensory neurons by the HIV virus, the immune system's fight against the infection, and the drugs administered to treat HIV. Painful HIV-DSP is characterized by ...

Novel Mechanism for Long-Term Learning Identified by Carnegie Mellon Researchers

... synaptic strengthening, while blocking mGlu receptors caused strengthening to stop. The Carnegie Mellon researchers tracked the changes in the neurons by using a transgenic mouse model that Barth created. In the model, a mild sensory imbalance is created by allowing the mouse to sense its ...
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(Date:7/9/2014)... As climate change shifts the geographic ranges in which ... it has on their parasites. Does an increased range ... as well? , Not necessarily, says a team of ... Armand Kuris. In a study published in the ... that for some species, the opposite may happen: Hosts ...
(Date:7/9/2014)... Emerging fungal pathogens pose a greater threat ... population declines of amphibians, bats, corals, bees and ... Florida published in the prestigious journal Nature ... immunological resistance to a deadly chytrid fungus implicated ... resistance is important because it is the basis ...
(Date:7/9/2014)... with traumatic injuries have identified an immune marker ... a hospital-acquired infection. The study, led by clinician-scientists ... June in the journal Shock , is ... to the clinical implementation of quick-turnaround immune function ... system damage following critical illness or injury in ...
Breaking Biology News(10 mins):Not at home on the range 2Not at home on the range 3Not at home on the range 4USF study: Amphibians can acquire resistance to deadly fungus 2Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3
(Date:7/9/2014)... Researchers at the Perelman School of Medicine at the ... Cancer Institute have received an $8 million grant from ... of photodynamic light therapy (PDT) in patients with malignant ... most often manifests itself in the lining of the ... asbestos. The grant will fund a clinical trial and ...
(Date:7/9/2014)... into the metabolism of stromal support cells and immune ... these cell types in the development of diseases ... and cancer. That was the conclusion of a review ... the leading journal Nature . , Prof. Peter ... call. The metabolism of cancer cells has been examined ...
(Date:7/9/2014)... N.Y. Although feelings are personal and subjective, ... code that objectively represents emotions across different senses, ... by Cornell University neuroscientist Adam Anderson. , "We ... the orbitofrontal cortex, an area of the brain ... code which captures an individual,s subjective feeling," says ...
(Date:7/9/2014)... World Cup highlights, Brian Williams refreshing old school rap ... on railings. A University of Colorado Cancer Center study ... that YouTube also allows researchers, journals, and health advocates ... skin cancer and prevention. , "No matter what field ... we communicate around the world," says Chante Karimkhani, MD ...
(Date:7/9/2014)... print and poor printing on prescription labels handed ... lead to errors in taking medication, according to ... CNIB (Canadian National Institute for the Blind)., The ... Journal , found that labels on prescription medications ... recommended guidelines for legibility. , By simply following ...
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