Got Pain?

... the 27 bones, cartilage, joints, tendons and nerves in the hand do not work as they should, ... ) nerves in the hand can be damaged by pressure, stretching or cutting. Injury to the nerves can stop the transmission of signals to and from ...

Sangamo BioSciences Initiates Phase 2 Clinical Trial of Treatment for Amyotrophic Lateral Sclerosis (ALS)

... vessel and muscle growth. In ALS, the motor nerves comprised of nerve cells in the brain and spinal ... and muscle composition. Similar effects on motor nerves and muscles in these patients may slow the ... role in the growth and health of blood vessels, nerves and muscle and we believe that our approach of ...

Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting

... velocity (NCV) in both sensory and motor nerves is a method of assessing the integrity or ... pattern that targets the major peripheral nerves in the legs and feet. As announced on June 6, ... pattern that targets the major peripheral nerves in the legs and feet. Peripheral blood samples ...

St. Jude Identifies the Specific Cell That Causes Eye Cancer, Disproving Long-Held Theory

... scientific principle that fully formed, mature nerves cannot multiply like young, immature cells, Dyer ... disease can occur when differentiated nerves in the brain try to multiply, and in the process, ... among scientists that differentiated mature nerves are so elaborate that they can't divide, and if ...

VA Studies Advanced Prosthetic Arm

... will be wireless. The arm can also be adapted to work with other control systems, including myoelectric switches, which are wired to residual nerves and muscles in the upper body and respond to movement impulses from the brain, shoulder joysticks or other conventional inputs. Frederick Downs ...

Video: UCB Launches Vimpat(R) in the U.S. for Add-On Treatment of Epilepsy in Adults

... studies also suggest that Vimpat(R) binds to the collapsin response mediator protein-2 (CRMP-2), an important target that affects the way that nerves differentiate and grow. The precise nature of the interaction between Vimpat(R) and CRMP-2 and between CRMP-2 and seizure control is not known. ...

Arcion Therapeutics' Topical Pain Candidate, ARC-4558, Significantly Reduces Pain Caused by Diabetic Neuropathy

... PDN. PDN is thought to result from chronic hyperglycemia, which can lead to diabetic microvascular injury involving small blood vessels that supply nerves (vasa nervorum), particularly the sensory, motor and autonomic nerve fibers. Patients with PDN often experience debilitating pain symptoms that ...

Cardium's InnerCool Announces Positive Benefits of Cooling During Robotic-Assisted Prostate Surgery Published in Urology

... tissue. It is a complex procedure because the prostate gland is located deep inside the pelvis and is intimately associated with delicate nerves that control erections and bladder control. Historically, radical prostatectomy has been performed as an open procedure requiring surgical precision ...

Fifth U.S. Hand Transplant Patient Heads Home to NY

... laboratory tests." A hand transplant, unlike a solid organ transplant, involves multiple tissues (skin, muscle, tendon, bone, cartilage, fat, nerves and blood vessels) and is called composite tissue allotransplantation. A partnership of physicians and researchers at Jewish Hospital Hand Care ...

Kleinert Kutz Hand Surgeons Perform Fifth U.S. Hand Transplant in Record Time at Jewish Hospital Hand Care Center

... Jewish Hospital. A hand transplant, unlike a solid organ transplant, involves multiple tissues (skin, muscle, tendon, bone, cartilage, fat, nerves and blood vessels) and is called composite tissue allotransplantation. "The fifth hand transplant went faster and smoother than any of the ...

Raptor Pharmaceuticals to Collaborate with Centre Hospitalier Universitaire d'Angers for Phase II Clinical Trial in Huntington's Disease

... the "national reference center for neurodegenerative diseases." Patients suffering from genetic damages to the brain, spinal cord or periphery nerves are diagnosed and cared for by a multidisciplinary team coordinated by Dr. Christophe Verny, neurologist, and Professor Dominique Bonneau, ....

Texas Back Institute Leads Way in New Facet Joint Clinical Trial

... devices intended to stabilize affected spinal joints while preserving the natural motion of the spine. "It's a great device because it frees up the nerves and spinal cord, eliminates the excess bone growth and maintains natural motion," said Dr. Sachs. "Patients are recovering quickly and we've seen ...

PharmAthene Initiates Phase I Clinical Trial of Nerve Agent Bioscavenger Protexia(R)

... blood stream via inhalation or absorption through the skin. The nerve agents travel in the circulatory system to the brain and muscles causing the nerves to become over-stimulated which lead to massive convulsions and death in severe cases. About PharmAthene, Inc. PharmAthene was formed to meet the ...

Ironwood and Collaborators Present Preclinical Data Demonstrating That Cyclic GMP Alleviates Intestinal Pain

... These studies demonstrate that cGMP inhibits intestinal pain in a preclinical model of intestinal hyperalgesia and desensitizes colonic afferent nerves in a similar model of experimental colitis. These results are from separate, ongoing collaborations with Dr. Michael Pezzone of the University ...

Mayo Clinic Discovery May Help Diabetic Gastric Problem

... stomach spasms and weight loss due to inadequate absorption of nutrients. The abnormally high blood glucose levels cause chemical changes in nerves and in pacemaker cells which regulate digestive processes in the gut, and damage blood vessels that carry oxygen and nutrients to cells. "If these ...

PharmAthene Presents Data for Protexia(R) and Valortim(R) at 2008 BARDA Industry Conference / PHEMCE Stakeholders Workshop

... blood stream via inhalation or absorption through the skin. The nerve agents travel in the circulatory system to the brain and muscles causing the nerves to become over-stimulated which leads to massive convulsions and death in severe cases. About PharmAthene, Inc. PharmAthene was formed to meet ...

Coapt Systems Launches FDA Cleared Novielle Voice (TM) for Restoration of Voice Loss

... Medical Director for Coapt Systems, "Examples of patients who can be helped by Novielle Voice injections are patients who have experienced damage to nerves in the voice box, stroke, or surgery of the esophagus. We believe many other patient populations, such as those with Parkinson's disease or ...

Gene That Causes Childhood Cancer Neuroblastoma Is Found

... of all childhood cancers, but due to its often aggressive nature, causes 15 percent of all childhood cancer deaths. It arises in the developing nerves of a child, often appearing as a tumor in the chest or abdomen. Because only about 600 new cases of all forms of neuroblastoma occur annually in ...

Focal Cryoablation Highlighted in Urology Times Best of AUA Orlando 2008

... is a minimally-invasive method of freezing and destroying only the cancerous portion of the prostate gland while leaving the healthy tissue and the nerves intact, resulting in low overall morbidity and a high rate of sexual potency. Focal cryoablation represents an important new option for prostate ...

New Minimally Invasive Surgical Procedure Restores Quality of Life in Patients With Potentially Debilitating Spinal Condition

... in the lower back, known as the lumbar area. This narrowing occurs when bone and/or ligament growth restricts the canal, squeezing and irritating the nerves that branch out from the spinal cord. This compression causes patients to experience low back pain, leg fatigue and pain, and, in severe cases, a ...

Device Blocking Stomach Nerve Signals Shows Promise in Obesity

... and food is digested following a meal. The lead wires are implanted in the abdomen laparoscopically, with electrodes attached to the vagal nerves and the neuroregulator, a pacemaker-sized device, is implanted just under the skin. While gastric bypass involves removing portions of the digestive ...

Synapse Biomedical Receives FDA Approval of NeuRx Diaphragm Pacing System (DPS)(TM) For Spinal Cord Injury Breathing Applications

... ) The device implanted through minimally invasive laparoscopic surgery, provides electrical stimulation to muscle and nerves that run through the diaphragm. When stimulated by the NeuRx DPS(TM), the diaphragm contracts, mimicking natural breathing, and allows air to fill ...

Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs

... will receive a total of two treatments (Day 0 and 90). Subjects receive injections in a distribution pattern that targets the major peripheral nerves in the legs and feet. The expansion protocol will enroll approximately 45 additional subjects in the trial. Subjects will again be randomized to ...

Cryoablation Is Focus of 17 Clinical Studies at American Urological Association Annual Meeting

... more than 74 percent resumed potency within 36 months. Focal cryoablation is designed to destroy the tumors in the prostate while sparing the nerves to retain potency. These patients are also part of the COLD Registry. -- An 88-patient Cleveland Clinic study of the long term disease-free ...

Eribulin Mesylate Demonstrated Anti-Tumor Activity in Heavily Pretreated Patients with Advanced Breast Cancer

... white blood cell count, 14%), and weakness/fatigue (10%; no Grade 4 events). Grade 3 peripheral neuropathy (a functional disturbance or damage to nerves outside the brain and spinal cord) was reported in 5.5% of patients. No Grade 4 peripheral neuropathy events were reported. No correlation was seen ...

Shire Enhances its Orphan Drug Pipeline With the Acquisition of a New Clinical Candidate for Metachromatic Leukodystrophy

... the kidneys and gallbladder. When these sulfated glycolipids accumulate in the brain, they cause a breakdown of myelin, a substance that protects the nerves in the brains and in the rest of the body. This breakdown is what makes MLD a progressive, neurodegenerative disease. Symptoms and Patient Outlook ...

First Human Implant of New Archus Orthopedics Facet Replacement System

... company's product line for treating spinal stenosis, a condition in which degenerative changes in the facet joints result in compression of spinal nerves producing neurological symptoms in the legs. Traditionally, patients with moderate to severe spinal stenosis undergo decompressive laminectomy ...

New York-Presbyterian/Weill Cornell is First New York Medical Center to Offer Tantalus Clinical Trial to Diabetes Patients

... diagnosed with the disease annually. The most common form of diabetes, type-2 diabetes, left untreated, may result in damage to the eyes, kidneys, nerves or heart and lead to major health complications later in life, or to death. For more information on and to be considered for the study, please ...

NPS Reports Successful GATTEX(TM) Extension Study

... may include an increased risk of systemic infections due to the presence of an intravenous feeding line, degenerative changes in the bones and nerves due to vitamin and mineral deficiencies, and liver failure. Potential benefits derived from reduced dependence on intravenous feeding may include ...

Study Finds Starion Instruments' Tissue Welding Technology Safe and Effective in Parotidectomy Procedures

... facial nerve and that no current passes through the patient, enabling continuous monitoring of the facial nerve. The ability to continuously monitor nerves during the procedure helps minimize the risk for inadvertent injury and subsequent facial nerve palsy." About Starion Instruments Starion ...

EpiCept Provides Update on Clinical and Regulatory Progress with Ceplene(TM) and EpiCept(TM) NP-1 Cream

... neuropathies are medical conditions caused by damage to the nerves in the peripheral nervous system. The peripheral nervous system includes nerves that run from the brain and spinal cord to the rest of the body. It is estimated that these conditions affect more than 15 million people in the U.S. ...

Sangamo BioSciences Announces Completion of Enrollment of Phase 2 Clinical Trial of ZFP Therapeutic for Diabetic Neuropathy

... (Day 0, 60 and 120). Subjects will receive injections in a distribution pattern that targets the skeletal muscle adjacent to the major peripheral nerves in the legs and feet. The symptoms of diabetic peripheral neuropathy and any changes that occur during the trial will be evaluated based on ...

New Study: Pine Bark Extract Boosts Nitric Oxide (NO) Production

... by satisfying the enhanced muscle oxygen demand and increasing the blood flow to active muscles. When people are performing heavy physical activity, nerves release neurotransmitter acetylcholine to arteries supplying muscles, which makes them expand, a process that requires enhanced production of NO." A ...

Clinical Benefits Demonstrated with Low-Dose GATTEX(TM) in Phase 3 Short Bowel Syndrome Study

... may include an increased risk of systemic infections due to the presence of an intravenous feeding line, degenerative changes in the bones and nerves due to vitamin and mineral deficiencies, and liver failure. Potential benefits derived from reduced dependence on intravenous feeding may include ...

September is National Pain Awareness Month

... the spinal cord. Animal research suggests that the mechanism of action for PRIALT works by targeting and blocking N-type calcium channels on nerves in the spinal cord that ordinarily transmit pain signals. Dr. McDowell explains, "It's a very innovative form of therapy that's very exciting. ...

Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes

... starting at 0 and rising to the severity of stage IV. NSCLC can spread through the lymphatic system, penetrating the chest lining, ribs, and the nerves and blood vessels that lead to the arm. The liver, bones and brain are potential targets if the cancerous cells enter the blood stream. About Lilly ...

Lilly Files for European Approval of ALIMTA(R) (pemetrexed for injection) for First-Line Treatment of Non-Small Cell Lung Cancer

... starting at 0 and rising to the severity of stage IV.(ii) NSCLC can spread through the lymphatic system, penetrating the chest lining, ribs and the nerves and blood vessels that lead to the arm. The liver, bones and brain are potential targets if the cancerous cells enter the blood stream. According to ...

'Use it or Lose it': A New Theory About Preserving Erectile Function After Prostate Surgery

... has traditionally been attributed to nerve damage that theoretically should heal over time. But it can take as long as two years for the nerves to recover enough for a man to have an erection without the aid of drugs or devices. By that time, other damage may have occurred, according to an ...

Sangamo BioSciences Announces Presentation of ZFP Therapeutic Data From Nerve Regeneration Program at American Society for Neural Therapy and Repair Meeting

... of VEGF expression has regenerative effects on nerves and a positive effect on the health of nerves injured by both mechanical means such as in ... adults. The spinal cord is the major bundle of nerves that carries nerve impulses to and from the brain ...