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Mouse in Medical Technology

Novel Valortim(R) Mechanism of Action Data Presented at the Keystone Symposia on Molecular and Cellular Biology

... to kill anthrax bacilli. In an in vitro mouse macrophage model, Valortim(R) enhanced the ... and Basu build on this initial information in the mouse model by demonstrating that Valortim(R) can ... Dr. Cross continued, "As is the case with mouse macrophages, our in vitro data suggest that ...

Why Wait for an Anti-Aging Drug? Researchers Interviewed on CBS-TV's 60 MINUTES Discover Longevinex(R) Nutriceutical Matrix Activates 9-Fold More Longevity Genes than Plain Resveratrol

... Longevinex(R) nutriceutical matrix 1711 genes, in mouse heart tissue.* The notion that mega-dose ... of life-prolonging strategies. The mouse has about the same number of genes as humans ... expression of long-term caloric restriction in mouse heart. Barger JL, Kayo T, Pugh TD, Prolla TA, ...

Gene Therapy Corrects Sickle Cell Disease in Laboratory Study

... a harmless virus to insert a corrective gene into mouse blood cells, scientists at St. Jude Children's ... Therapy , the researchers used a strain of mouse with basically the same genetic defect and ... While Persons believes that the mouse experiments will lead to treatments in humans, he ...

Local Research Foundation Achieves Milestone in Fight Against Cancer

... potent anticancer activity against a type of mouse leukemia. The Stehlin Foundation has ... the use of nude mice in cancer research. Nude mouse tests are now the final, non-human studies ... scientists around the world consider the nude mouse one of the 20th century's most ...

Vical Expands Applications of Vaxfectin(R) Adjuvant for Infectious Disease and Cancer Vaccines; 80% to 100% of High-Dose Responders in H5N1 Clinical Trials Still Responding at 6 Months

... Vaxfectin(R)-formulated Cancer Vaccines In a mouse study, a Vaxfectin(R)-formulated vaccine ... 1 clinical trial, the results of nonclinical mouse studies of Vaxfectin(R)-formulated protein-based ... vaccines, and the results of a nonclinical mouse study of a Vaxfectin(R)-formulated TRP-2 ...

Resveratrol Longevity Science Makes Dramatic U-Turn, But Resveratrol Supplements Remain Unchanged

... of long-term caloric restriction in mouse heart. Experimental Gerontology 2008 ... treatment reduces breast tumor growth in a nude mouse model. Translational Oncology 2008 March; ... dietary supplement activity. In the Longevinex(R) mouse study, the Sirtuin1 gene was down-regulated, ...

Video: Resveratrol-based Nutriceutical (Longevinex(R)) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Prior Studies

... in mouse heart tissue. The results of the mouse study were unexpected and surprising, pointing to ... the dose employed in a prior widely acclaimed mouse study (Nature Magazine Nov. 1, 2006) the ... exerted 9-fold greater effect over the mouse genome at the equivalent daily human dose of ...

Additive Anti-Tumor Activity of NKTR-102 in Combination With Bevacizumab Highlighted in Positive Preclinical Data Presented at AACR Meeting

... demonstrated enhanced anti-tumor activity in a mouse xenograft model of colorectal cancer when ... by up to 97% in an irinotecan-resistant mouse xenograft model of colorectal cancer (HT29), ... in combination with bevacizumab in a mouse model of human colorectal tumors" #5741: ...

New Data Confirms That a Selective, Fully Human Anti-VEGF Antibody Being Developed by Peregrine is as Effective as Avastin(R) in Preclinical Cancer Models

... showing that Peregrine's selective anti-VEGF mouse antibody 2C3 and its fully human counterpart ... on 2C3, our selective anti-VEGF mouse antibody, along with the current study results ... but not limited to, the risk that pre-clinical mouse model results for breast cancer will not ...

Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells

... or the site specific manipulation of the mouse genome, which has revolutionized biology and ... the generation of mouse cell-lines and transgenic mouse models of human disease. However, until now and ... cell lines and transgenic animals bedsides the mouse that may be valuable models of human disease ...

NKTR-102 (PEG-Irinotecan) Demonstrates Significant Tumor Growth Inhibition In Multiple Preclinical Tumor Models

... inhibited tumor growth by greater than 90% in mouse xenograft models of colorectal (HT29), lung ... Preclinical Studies Preclinical studies in mouse xenograft tumor models evaluated comparative ... Anti-Tumor Activity of NKTR-102 in mouse Xenograft Models of Human Colorectal, Lung and ...

Seal Shield Launches World's First Antibacterial, Dishwasher Safe Keyboard and Mouse for Infection Control

... to the company, the SILVER SEAL(TM) Keyboard and mouse are the first ever antibacterial keyboard and mouse to be fully submersible and dishwasher safe. It ... studies have shown the computer keyboard and mouse to be a major source of cross contamination ...

Tumor Growth Inhibition and Pharmacokinetic Profile of NKTR-102 (PEG-Irinotecan) in Multiple Solid Tumors To Be Presented at Upcoming AACR-NCI-EORTC International Conference

... results from preclinical trials of NKTR-102 in mouse models of colorectal, lung and breast cancers. ... on tumor growth inhibition of NKTR-102 in mouse xenograft models of colorectal, lung and breast ... following administration of NKTR-102 in mouse xenograft models of lung and colorectal cancer. ...

Senesco Announces H1N1 Influenza Survival Test Results in Mice

... or the "Company") (NYSE Amex: SNT ) today reported results of H1N1 mouse influenza survival studies that were conducted in Dr. William Scheld's lab ... of 73 mice were infected with a lethal dose of nasally administered H1N1 mouse influenza. The treated mice (n=31 mice) were administered Senesco's siRNA ...

Affitech-Discovered Anti-PS Antibodies in Development by Peregrine Pharmaceuticals Show Excellent Functionality in Preclinical Studies

... in vitro and in a number of animal cancer models. Specifically, in a mouse model of prostate cancer, treatment with a mouse equivalent of PGN635 significantly retarded the growth of tumors by more ...

Data Presented at AACR Annual Meeting Show Anti-Tumor Activity of Peregrine's Fully Human Anti-PS Antibody in Prostate Cancer Model

... and Expand the Company's PS-Targeting Platform- -Treatment with mouse Equivalent to the Human Antibody Inhibited Tumor Growth in a Prostate ... vessels with PGN635 binding. The researchers also reported that in a mouse model of prostate cancer, treatment with a mouse-equivalent antibody of ...

Longevity Seekers Advised to Consume Modest Doses of Red Wine Molecules in Dietary Supplements (Longevinex(R)) Rather than Mega-Dose Resveratrol Alone

... 1, advice concerning dosage has been confusing at times. A 2006 mouse study suggested consumers would have to drink about 750 to 1500 bottles of ... small molecules may be superior to resveratrol alone. According to a mouse study conducted by Longevinex(R), published in the September 2008 issue of ...

Vical Pandemic Influenza Vaccines Achieve T-Cell Responses and Cross-Clade Reactivity in Humans

... DNA vaccine Phase 1 clinical trial and the results of nonclinical mouse studies of Vaxfectin(R)-formulated influenza vaccines produced by the ... will be confirmed in larger studies; whether nonclinical results from mouse studies will advance to human clinical testing, and if so, whether such ...

Trius Antibiotics to be Highlighted in 18 Presentations at ICAAC/IDSA

... 92, 11:15 am - 12:15 pm) -- A-985: Pharmacodynamics of TR-701 in a mouse Thigh Infection Model Against S. aureus ATCC 33591, a ... cfr Strain CM/05 -- F1-2066: Demonstration of TR-701 Efficacy in a mouse Inhalation Anthrax Model -- F1-2067: Absence of a Pressor Response ...

Data from In Vivo Disease Models on Taligen Therapeutics' Pipeline Candidates to be Presented at the XXII International Complement Workshop

... Session 2, Poster 174 Alternative complement pathway signaling in a mouse model of choroidal neovascularisation Barbel Rohrer*, Qin Long, Brooks ... ischemia/reperfusion injury and antibody-mediated rejection in a mouse heterotopic heart transplant model Carl Atkinson*, Yongquan Gong, ...

St. Jude Study Finds Treatment With New Drug Might Make Tumor Cells More Sensitive to Therapy

... and move studies from isolated cells to mouse models. "Results of those mouse model studies would help us to determine if and how to proceed with ... the team reported. The researchers also showed that CP466722 sensitized mouse cells to irradiation, an important finding since the team plans to study ...

Enobia Pharma Initiates Clinical Testing of Enzyme Replacement Therapy to Treat Hypophosphatasia

... of the disease. "In preclinical studies using a mouse model, ENB-0040 consistently improved survival as well as bone and dental ... the enzyme to bone. Preclinical studies of ENB-0040 in the "knockout" mouse model of severe hypophosphatasia were recently published in the Journal of ...

ALS Therapy Development Institute Partners with Clinical Centers to Establish Pathological Mechanisms of Lou Gehrig's Disease

... and will be compared with the ALS TDI transcriptome database for the SOD1 mouse collected last year. To date, the Institute has cataloged and analyzed the ... largest collection of information on the molecular changes in the leading mouse model in the effort to establish the fundamental pathological mechanisms ...

Ardea Biosciences Presents Preclinical Data on RDEA119 Demonstrating Favorable Anti-Inflammatory Profile for Potential Use in Ulcerative Colitis

... ERK kinase (MEK) inhibitor, RDEA119, demonstrating potent activity in mouse models of colitis. An oral presentation of the data was given at Digestive ... RDEA119 was shown to reduce damage to colonic tissue in two different mouse models of colitis, murine trinitrobenzene sulfonic acid (TNBS) colitis ...

Continued Funding to Help Advance 'Exciting Moment' in Diabetes Research

... are lead researchers for the grant projects. Dr. Rosen's study Humanized mouse Models of Type 2 Diabetes will focus on whether mouse models with human diabetes genes will have beneficial effects on glucose ...

Cequent Pharmaceuticals' Johannes Fruehauf, MD, Ph.D., to be Featured Speaker at RNAi World Congress in Boston - May 2, 2008

... program for the therapeutic, presenting efficacy data in mouse models and data on a major monkey toxicology study currently under way. ... programs on the way to clinical trials. In April, Dr. Fruehauf presented mouse data from Cequent's colon cancer prevention program at the American ...

Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting

... Glioblastoma Killing in the Presence of Dexamethasone in mouse Tumor Model SAN DIEGO, April 15 /PRNewswire-FirstCall/ -- Sangamo ... glioblastoma cells in vitro. In addition, data were presented from a mouse model of GBM demonstrating that the T-cells were capable of killing tumor ...

Data Presented at AACR Annual Meeting Shows Bavituximab Equivalent Plus Docetaxel Reduces Tumor Growth By Up to 95% and Halts Metastasis in a Model of Hormone-Refractory Prostate Cancer

... of the American Association for Cancer Research (AACR) shows that a mouse equivalent of Peregrine's anti-phosphatidylserine (anti-PS) vascular ... of Texas Southwestern Medical Center at Dallas, reported that in a mouse model of hormone-refractory prostate cancer, the combination of the ...

ALS Therapy Development Institute Signs Collaboration Agreement with the Allen Institute for Brain Science

... completed an enormous database of transcriptome information for the SOD1 mouse model, the leading mouse model used internationally by ALS researchers. ALS TDI, a leader in ...

Recent siRNA Research Publications Support Silence Therapeutics Combined Development Approach

... et. al., Gene Therapy(3) 2006 Sep;13(18):1360-70. "RNA interference in the mouse vascular endothelium by systemic administration of siRNA- lipoplexes for ... "A novel siRNA- lipoplex technology for RNA interference in the mouse vascular endothelium." New York Times(5), April 2, 2008. "Study is a ...

Novel Mechanism for Long-Term Learning Identified by Carnegie Mellon Researchers

... researchers tracked the changes in the neurons by using a transgenic mouse model that Barth created. In the model, a mild sensory imbalance is created by allowing the mouse to sense its surrounding through only one whisker. Whiskers are useful in ...

Mayo Clinic Study Shows Drug Could Effectively Treat, Prevent the Spread of Breast Cancer

... in particular the spread of breast cancer. The study, which was done in mouse models, is featured on the cover of the November issue of Cancer Research. ... to self-destruct. Dr. Cicek and colleagues conducted experiments in mouse models to determine whether 2ME2 would be an effective drug against breast ...

Nobel Prize Awarded to Foundation for Biomedical Research Board Member

... of embryonic stem cells." Their studies resulted in genetically altered mouse models, innovating the way researchers work to combat such diseases as ... of animal research. My scientific life has been devoted to the use of mouse models for the understanding of the development of therapies of human ...

ALS TDI Completes Gene Expression Profile of Lou Gehrig's Disease in Mice

... gene-expression database for ALS with the profiling of the SOD1 mouse model of amyotrophic lateral sclerosis -- ALS, or Lou Gehrig's disease. ... "Additional gene expression profiling and proteomics analysis from other mouse models of neurodegeneration, as well as human samples collected at ALS ...

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome

... in an article published today in Nature Medicine, Proteolix's selective immunoproteasome inhibitor PR-957 was shown to block disease progression in mouse models of rheumatoid arthritis in a dose-dependent manner and to completely eliminate visible signs of disease at the highest dose. The ...

Merz Pharmaceuticals Announce Three Studies of NT-201 - (Botulinum neurotoxin type A Free From Complexing Proteins)

... During the 1-year trial period, adverse events were observed in 56.6% of patients. None of the patients had positive antibody titer tested in the mouse diaphragm assay. About Merz Merz (KGAa) is known worldwide for its development of original compounds and formulations for medical ...

Tolerx Presents Data at 69th Scientific Sessions of the American Diabetes Association

... presented data demonstrating the effects of modified dosing regimens of the anti-CD3 monoclonal antibody in a commonly used non-obese diabetic (NOD) mouse model of autoimmune diabetes. Tolerx researchers conducted dose-ranging studies to establish the minimum effective dose and to investigate ...

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

... indicator for protection against herpes simplex as well. Dr. Borthakur, of the University of Hawaii , reported at the Microbiology Conference that mouse blood cells taken from L.E.A.P.S. TB immunized mice made detectable amounts of gamma interferon within one day of treatment. Dr. Daniel ...

Neurobiological Technologies' Partner, Celtic Pharma, Announces Results of XERECEPT(R) Phase 3 Clinical Program

... Center, both in North Carolina. The tumor assessment studies were conducted using both pediatric and adult human brain tumor xenografts. The mouse tumor models demonstrated statistically significant tumor regression and prolongation of survival following treatment with XERECEPT(R). XERECEPT(R) ...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

... an up regulation/increase of HSP70. The change in HSP70 observed at the highest dose of AUY922 exceeded the level needed to inhibit tumor growth in a mouse model for breast cancer(14). About the Novartis Oncology pipeline The Novartis Oncology pipeline features 18 ...
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(Date:12/17/2014)... December 17, 2014 A group of 127 ... Longevity, today, in reaction to a recent statement by the ... brain training and derogated the efficacy of all brain exercises. ... with the parts of the center’s statement critical of brain ... center had also overstated its case, in a document it ...
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(Date:12/17/2014)... December 17, 2014 Project Veritas is ... brought videos of MIT economist and Obamacare architect Jonathan ... James O’Keefe conducted the interview, which is being distributed ... there was intentional mislabeling in the Affordable Care Act ... bill: A two-hundred-and-fifty billion dollar per year tax grab. ...
(Date:12/17/2014)... Alan Mozes HealthDay Reporter , ... of infectious diseases, one worrisome phenomenon is when an illness ... process -- known as zoonosis -- is not uncommon and ... that an animal-borne disease might make inroads into the human ... development -- and the culprits in this case were guinea ...
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