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Monoclonal in Medical Technology

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... Sigma-Aldrich Corporation (Nasdaq: SIAL ), Open monoclonal Technology, Inc. (OMT) and INSERM today announced ... . About Open monoclonal Technology, Inc.: Open monoclonal Technology, Inc. ("OMT") is a private ...

Tolerx Presents Data at 69th Scientific Sessions of the American Diabetes Association

... with a surrogate of its Phase 3 anti-CD3 monoclonal antibody, otelixizumab, at the 69th Scientific ... of modified dosing regimens of the anti-CD3 monoclonal antibody in a commonly used non-obese diabetic ... result demonstrates that lower doses of anti-CD3 monoclonal antibody, causing partial TCR modulation, are ...

Micromet's Blinatumomab Achieves Primary Endpoint in Phase 2 Study with Acute Lymphoblastic Leukemia Patients

... antibody platform, as well as conventional monoclonal antibodies. BiTE antibodies represent a new class ... in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM ... with metastatic breast cancer. Micromet's monoclonal antibody MT293, also known as TRC093, is licensed ...

Micromet Presents Update on Blinatumomab's Response Rate and Duration in a Phase 1 Study in Non-Hodgkin's Lymphoma Patients

... antibody platform, as well as conventional monoclonal antibodies. BiTE antibodies represent a new class ... in many solid tumors. Micromet's human monoclonal antibody adecatumumab (MT201) also binds to EpCAM ... with metastatic breast cancer. Micromet's monoclonal antibody MT293, also known as TRC093, is licensed ...

Peregrine Pharmaceuticals Highlights Promising Early Data From Its Three Phase II Bavituximab Cancer Trials

... three separate cancer trials. Bavituximab is a monoclonal antibody with a unique mechanism that allows the ... for anti-cancer treatments. Bavituximab is a monoclonal antibody that binds specifically to these ... company with a portfolio of innovative monoclonal antibodies in clinical trials for the treatment ...

PharmAthene Submits Proposal to BARDA in Response to Broad Agency Announcement for Advanced Research and Development for Valortim(R)

... to further develop Valortim(R), a fully human monoclonal antibody, for the prevention and treatment of ... About Valortim(R) Valortim(R) is a fully human monoclonal antibody generated by Medarex, Inc's UltiMAb(R) ... vaccine Valortim(R) - a fully human monoclonal antibody for the prevention and treatment of ...

TRACON Pharmaceuticals' Small Molecule TRC102 and Antibody TRC105 to be Presented at ASCO 2009

... a wide variety of cancer types. TRC105 is a monoclonal antibody that binds CD105 (endoglin), a membrane ... three Phase 2-ready assets in 2009 including two monoclonal antibodies," commented Charles P. Theuer MD PhD, ... will complement existing therapies. TRC093 is a monoclonal antibody that binds to cleaved collagen to ...

Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells

... developed BiTE antibodies from the EGFR-specific monoclonal antibodies Erbitux(R) (cetuximab) and Vectibix(R) ... clinical studies have shown that the chimeric monoclonal antibodies cetuximab(2,3) and panitumumab(3,4) ... overcome significant limitations of conventional monoclonal antibodies," commented Patrick Baeuerle, Chief ...

Novel Valortim(R) Mechanism of Action Data Presented at the Keystone Symposia on Molecular and Cellular Biology

... s. Valortim(R) is a fully human anti-toxin monoclonal antibody being developed in conjunction with ... About Valortim(R) Valortim(R) is a fully human monoclonal antibody designed to protect against and treat ... vaccine Valortim(R) - a fully human monoclonal antibody for the prevention and treatment of ...

Intellect Neurosciences, Inc. Announces Independent Studies on Copper Binding Properties of its Lead Candidate OXIGON(TM)

... in Phase 1 clinical trials; IN-N01, a humanized monoclonal antibody designed to promote the clearance of ... royalty-bearing license to its ANTISENILIN(R) monoclonal antibody platform to Wyeth and Elan Pharma ... to the development and sale of Bapineuzumab, a monoclonal antibody intended to treat AD. Wyeth and Elan are ...

Access Pharmaceuticals Presents new Combination Data on the Company's Angiolix(R) Therapeutic Monoclonal Antibody

... new data this week on its proprietary humanized monoclonal antibody, Angiolix, which confirmed that ... Angiolix: Angiolix is a novel humanized monoclonal antibody which has considerable potential for the ... B12 uptake mechanism; Angiolix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis ...

Cephalon Signs Option Agreement to Acquire Ception Therapeutics

... Promising monoclonal Antibody In Late- Stage Clinical Trial for the ... product is reslizumab. Reslizumab is a humanized monoclonal antibody (mAb) against interleukin-5 (IL-5) ... Esophagitis Reslizumab is a humanized monoclonal antibody (mAb) against interleukin-5 (IL-5). ...

Micromet Key Events for 2009

... -- Adecatumumab, an EpCAM-targeting human monoclonal antibody in development with Merck-Serono is ... -- MT203, a GM-CSF neutralizing human monoclonal antibody in development with Nycomed for the ... trial in 2009; -- MT293, a humanized monoclonal antibody targeting denatured collagen, ...

Arzerra(TM) (ofatumumab) Demonstrates High Response Rates in Patients With Fludarabine Refractory Chronic Lymphocytic Leukemia (CLL)

... Ofatumumab is an investigational monoclonal antibody that targets a membrane-proximal (close ... et al. Ofatumumab (HuMax-CD20), a Novel CD20 monoclonal Antibody, Is An Active Treatment for Patients ... use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular ...

Access Pharmaceuticals Presents New Data on the Company's Angiolix(R) Therapeutic Monoclonal Antibody

... to be a more tumor selective anti-angiogenesis monoclonal antibody, with the benefit of ... About Angiolix: Angiolix is a novel humanized monoclonal antibody which has considerable potential for the ... uptake mechanism; Angiolix(R), a humanized monoclonal antibody which acts as an anti-angiogenesis ...

PharmAthene Presents Data for Protexia(R) and Valortim(R) at 2008 BARDA Industry Conference / PHEMCE Stakeholders Workshop

... Medarex, Inc., (Nasdaq: MEDX ) is a fully human monoclonal antibody designed to treat and protect ... of Intravenous Valortim(R), an Anti-toxin monoclonal Antibody, in the Treatment of Inhalation Anthrax ... anthrax vaccine -- Valortim(R) -- a fully human monoclonal antibody for the prevention and treatment of ...

Panacea Pharmaceuticals Announces Issuance of a U.S. Patent Covering Anti-HAAH Antibodies

... PAN-622, an all-human sequence anti-HAAH monoclonal antibody covered under this patent, as a cancer ... of PAN-622, an all-human sequence anti-HAAH monoclonal antibody, in animal models of cancer. In these ... and particularly PAN-622, our all-human sequence monoclonal antibody against HAAH," noted Hossein Ghanbari, ...

Clinical Data Published in 'Science' Show Tumor Regressions in Relapsed Lymphoma Patients Treated with T Cell Engaging BiTE Antibody Blinatumomab

... lower than serum levels needed by conventional monoclonal antibodies for achieving a tumor regression in ... anti-tumor approach than conventional monoclonal antibodies, which require much higher doses and ... is adecatumumab, also known as MT201, a human monoclonal antibody that targets epithelial cell adhesion ...

Tolerx Announces Achievement of Milestones upon anti-CD4 Antibody Program Advancement and Initiation of Phase 1 Clinical Trial

... modified version of TRX1, MTRX1011A, an anti-CD4 monoclonal antibody, into a phase 1 clinical trial that has ... in 2002 to develop and commercialize anti-CD4 monoclonal antibodies. Pursuant to this arrangement, ... and commercialize such anti-CD4 monoclonal antibodies. Tolerx will receive additional ...

Diverse Approaches to Alzheimer's Therapies Continue to Show Progress at ICAD

... -- Results of a Phase II study of a monoclonal antibody (LY2062430, Lilly) in mild to moderate ... and colleagues conducted a Phase II trial of a monoclonal antibody, known as LY2062430, that binds to the ... tolerability and biomarker effects of an Abeta monoclonal antibody administered to patients with ...

Abeome and Cato Research to Collaborate on Ovarian Cancer Therapeutic

... target. The company has developed novel monoclonal antibodies to four ovarian cancer cell lines and ... of novel antibodies to more cancer targets." monoclonal antibodies have become the centerpiece of many ... to accelerate and improve the development of monoclonal antibodies for life sciences. Abeome owns ...

FDA Advisory Committee Unanimously Recommends Approval of Ustekinumab for Treatment of Moderate to Severe Plaque Psoriasis

... plaque psoriasis. Ustekinumab is a new human monoclonal antibody with a novel mechanism of action that ... About Ustekinumab Ustekinumab is a new, human monoclonal antibody in Phase 3 development by Centocor, Inc. ... disease and psoriasis. The world leader in monoclonal antibody production and technology, Centocor has ...

Data From Two Phase 3 Studies Show Anti-TNF Golimumab Significantly Improved Signs and Symptoms of Rheumatoid Arthritis

... human anti-TNF-alpha monoclonal antibody, is being studied as an every four-week ... human anti-TNF-alpha monoclonal antibody, is currently in the most comprehensive ... disease and psoriasis. The world leader in monoclonal antibody production and technology, Centocor has ...

Eisai's Commitment to Oncology Demonstrated by Clinical Data to be Presented at ASCO Annual Meeting

... 2008 (farletuzumab) Study of MORAb-003, a monoclonal 4:30-4:45 p.m. Abstract No: 5500 Antibody ... May 31, 2008 (farletuzumab) a Humanized monoclonal Antibody 2:00-6:00 p.m. Abstract No: 5517 ... June 1, 2008 Abstract No: 3578 a monoclonal Antibody against 2:00-6:00 p.m. ...

Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis

... program of MDX-1100, a fully human monoclonal antibody that targets CXCL10 (also known as ... Study of MDX-1100, a Fully Human Anti-CXCL10 monoclonal Antibody, in Healthy Subjects" (Abstract ... Fully Human IgG1k Anti-CXCL10 (IP10) monoclonal Antibody, in Ulcerative Colitis" (Abstract #704) ...

Medarex Announces Presentations at Annual Meeting of the American Society of Clinical Oncology

... the example of ipilimumab, an anti-CTLA-4 monoclonal antibody" (Abstract #3008, Developmental ... and activity of MDX-1106 (ONO-4538), an anti-PD-1 monoclonal antibody, in patients with selected ... 31, 2008. -- "Antitumor activity of anti-CTLA-4 monoclonal antibody (mAb) in combination with ...

Micromet Demonstrates That the Antibodies in Commercial Products Herceptin, Erbitux, Vectibix and Xolair Can Be Converted Into Highly Potent, T Cell- Engaging BiTE Antibodies

... "Our data show that commercially successful monoclonal antibody therapeutics can be converted into the T ... BiTE antibody platform, we can teach conventional monoclonal antibodies how to recruit T cells for a ... is adecatumumab, also known as MT201, a human monoclonal antibody which targets epithelial cell adhesion ...

Tolerx Advancing Novel Type 1 Diabetes Agent into Phase III Clinical Trial Program Following End of Phase II FDA Meeting

... of otelixizumab, an investigational anti-CD3 monoclonal antibody, on preservation of endogenous insulin ... levels. About Otelixizumab Otelixizumab is a monoclonal antibody that binds to CD3, a T ... and TRX1. TRX1 is a humanized anti-CD4 monoclonal antibody being developed in collaboration with ...

Monogram Biosciences Provides Progenics Pharmaceuticals with HIV Assays for Use in Clinical Trials

... used to screen patients for clinical program of monoclonal antibody to CCR5 ... program of PRO 140, an investigational CCR5 monoclonal antibody being studied for the treatment of HIV. ... for PRO 140 in January 2008. PRO 140 is a novel monoclonal antibody that binds CCR5 and is designed to ...

Raven Announces Completion of Enrollment in the Phase 1/2a Clinical Trial of RAV12 Therapeutic Antibody for the Treatment of Adenocarcinomas

... held company focused on the development of monoclonal antibody therapeutics (MAbs) for cancer, today ... origin). RAV12, Raven's lead clinical monoclonal antibody drug candidate, targets the RAAG12 ... year. About RAV12 RAV12 is a novel, chimeric monoclonal antibody that is directed against a ...

Clinical Experience With Peregrine's Anti-Cancer Agent Bavituximab Presented at Leading Symposium on Anti-Angiogenic Agents

... U.S. Cancer Trial Presents Data on Novel Anti-PS monoclonal Antibody to Anti-Angiogenesis Experts - TUSTIN, ... stage biopharmaceutical company developing monoclonal antibodies for the treatment of cancer ... data on its anti-phosphatidylserine (anti-PS) monoclonal antibody bavituximab was discussed at the 10th ...

Tolerx Achieves Milestone with Completion of Phase Ib Clinical Study of TRX1 in Cutaneous Lupus Erythematosus

... study of TRX1, a novel humanized anti-CD4 monoclonal antibody (MAb), in subjects with ... to develop and commercialize certain anti-CD4 monoclonal antibodies, including TRX1. Pursuant to this ... About TRX1 TRX1 is a novel humanized monoclonal antibody (MAb) that binds to the CD4 receptor ...

Clinical Studies of OvaRex in Advanced Ovarian Cancer Fail to Meet Primary Endpoint

... is one of five investigational immunotherapeutic monoclonal antibodies which Unither Pharmaceuticals licensed ... triggering tumor-specific immunity using a murine monoclonal antibody has its challenges," said Christopher ... triggering tumor-specific immunity using a murine monoclonal antibody, and our expectation relating to the ...

Centocor and Janssen-Cilag Submit Applications Requesting Approval of Ustekinumab in the U.S. and Europe for Treatment of Moderate to Severe Plaque Psoriasis

... Agency (EMEA). Ustekinumab is a new, human monoclonal antibody with a novel mechanism of action that ... About Ustekinumab Ustekinumab is a new, human monoclonal antibody in Phase 3 development by Centocor, Inc. ... disease and psoriasis. The world leader in monoclonal antibody production and technology, Centocor has ...

Raven Announces Continued Enrollment of Phase 1/2a Clinical Trial of RAV12 Therapeutic Antibody for Treatment of Adenocarcinomas

... held company focused on the development of monoclonal antibody therapeutics (MAbs) for cancer, today ... origin). RAV12, Raven's lead clinical monoclonal antibody drug candidate, targets the RAAG12 ... FL. About RAV12 RAV12 is a novel, chimeric monoclonal antibody that is directed against a ...

Promising Phase 3 Trial Results Show Novel Biologic Therapy Ustekinumab (CNTO 1275) Significantly Improved Psoriasis

... placebo. Ustekinumab is a new, fully-human monoclonal antibody with a novel mechanism of action ... Ustekinumab Ustekinumab is a new, fully-human monoclonal antibody in Phase 3 development by Centocor, Inc. ... disease and psoriasis. The world leader in monoclonal antibody production and technology, Centocor has ...

Peregrine Pharmaceuticals Doses First Patient in Cotara(R) Phase II Brain Cancer Trial In India

... biopharmaceutical company developing targeted monoclonal antibodies for the treatment of cancer and ... uses--a radioactive isotope--to a targeted monoclonal antibody. This monoclonal antibody is designed to bind to a type of DNA ...

MacroGenics and Lilly Achieve Targeted Patient Enrollment in PROTEGE, a Global Phase 2/3 Clinical Trial of Teplizumab in Type 1 Diabetes

... treatment of individuals with recent-onset type 1 diabetes, is a humanized monoclonal antibody engineered to alter the function of the T lymphocytes that ... in 2000, the company has built a fully-integrated set of capabilities in monoclonal antibody product development. The company's product development efforts ...

New Analysis Shows Efficacy of SIMPONI(TM) (golimumab) in Anti-TNF Experienced Rheumatoid Arthritis Patients

... the impact of TNF inhibitor types (P75 receptor-fusion protein versus monoclonal antibody) on SIMPONI response. The occurrence of adverse events (AEs) ... may contribute to the disease. About SIMPONI SIMPONI is a human monoclonal antibody that targets and neutralizes excess TNF-alpha, a protein that ...

DSM Announces Yield Boosts of 5-10 Fold With XD(R) Technology for Mammalian Manufacturing Platforms

... ingredients (API's), fermentation, mammalian cell production of monoclonal antibodies and proteins, formulation development, clinical trial ... human cell line as a production platform for recombinant proteins and monoclonal antibodies. The combination of the PER.C6(R) human cell line and DSM's ...
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