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Mitochondrial in Medical Technology

Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics

... instrument for the kinetic measurement of mitochondrial oxygen consumption and cytoplasmic glycolysis in ... us to quantify subtle changes in ATP turnover, mitochondrial uncoupling or respiratory chain inhibition that ... pathways." Martin Brand, a leading mitochondrial researcher from the Buck Institute, Novato, CA ...

New Research Shows One in 200 People Born with DNA Mutation That Can Lead to Devastating, Often Fatal Disease

... Mutation Causing mitochondrial Disease More Common Than Previously Believed ... disease in them or their offspring. mitochondrial disease is a devastating and often fatal disease, and mitochondrial disorders are at the core of many well known ...

Medivation Presents Positive New Data on Dimebon's Long-Term Efficacy and Novel Mechanism of Action at the International Conference on Alzheimer's Disease

... Medivation presented new data on Dimebon's novel mitochondrial mechanism of action. Mitochondria generate energy ... roles in mediating cell function and survival. mitochondrial dysfunction has been linked in the ... data presented showed that Dimebon improves mitochondrial function in the setting of cellular stress with ...

Edison Pharma Hits Milestone as A0001 Enters Phase 1 Clinical Development

... Targeting inherited mitochondrial diseases as an archetype for diseases of ... energy metabolism. Children with inherited mitochondrial defects clinically present with many conditions ... with aging. Edison believes that inherited mitochondrial diseases may be genetic roadmaps to deciphering ...

Transgenomic Establishes Collaboration With the National Cancer Institute to Investigate Mitochondrial Genome and Associated Nuclear Genes in Cancer Cell Lines

... mutational analysis and sequencing of the mitochondrial genes in the NCI 60 cancer cell line panel. mitochondrial damage is increasingly recognized as an early ... This is the first comprehensive evaluation of the mitochondrial genome in the NCI 60 panel. The data from this ...

Michael J. Fox Foundation Awards Up to $3 Million to Industry Teams to Jumpstart Promising PD Drug Development

... factories' of body cells. It is believed that mitochondrial function is decreased in people with Parkinson's disease and that mitochondrial toxins induce parkinsonian symptoms in ... are developing unique compounds that improve mitochondrial function and that are currently being evaluated ...

Cardax Pharmaceuticals Nominates Clinical Candidate Heptax for Liver Disease; Heptax Ameliorates Inflammation and Oxidative Stress Related to Liver Disease and Metabolic Syndrome

... Cellular studies have determined that this compound acts as a plasma and mitochondrial membrane stabilizer and a potent antioxidant. "Cardax has ... safe, small molecule compounds that impact inflammation driven by mitochondrial oxidative stress. The Company's first product localizes intracellularly in ...

Transgenomic and Power3 Medical Complete Agreement for Exclusive License of Neurodegenerative Biomarker Test

... and will add to Transgenomic's portfolio of molecular diagnostics used for mitochondrial disorders, oncology, hematology molecular pathology, and inherited ... disease fitting within Transgenomic's focus on disorders originating from mitochondrial damage. NuroPro will add significant depth to complement our array of ...

Medivation Announces Positive Top-Line Results From Phase 2 Dimebon Study in Huntington's Disease

... is exerting its benefits through a novel mechanism of action targeting mitochondrial dysfunction, a contributor to the loss of neuronal function in ... data generated to date suggest that Dimebon operates through a novel mitochondrial mechanism of action. Teleconference/Webcast Details Medivation will ...

UPDATE: Infant Primates Given Vaccines on U.S. Children's Immunization Schedule Develop Behavioral Symptoms of Autism

... the critical need for studies into vaccine safety and the immune and mitochondrial dysfunction of autistic children. The National Autism Association (NAA) ... that vaccines triggered her regression into autism by exacerbating mitochondrial dysfunction. "The recent Poling case and this new research provide further ...

Study Reports Successful Cloning of Human Embryo Using Adult DNA

... additional tests showed that the embryo had another type of DNA, called mitochondrial DNA, from both the female oocyte donor and the male DNA donor. mitochondrial DNA testing is viewed as an essential proof of successful human cloning -- ...

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

... first generation nucleoside polymerase inhibitor, RG7128 (formerly known as R7128). In vitro studies of PSI-7851 have not shown evidence of any mitochondrial or other cellular toxicities that may be associated with some nucleoside analogs. Like RG7128, PSI-7851 has demonstrated pan genotype activity in ...

Michael J. Fox Foundation Awards Over $2 Million for Validation of 10 Parkinson's Therapeutic Targets

... de Lausanne (Switzerland) and Deniz Kirik, MD, PhD, Lund University (Sweden) Validation of cyclophilin D, a protein involved in the mitochondrial permeability transi tion, as a target for Parkinson' s disease therapy Mathieu Lesort, PhD, University of Alabama at Birmingham The ...

Metabolic Solutions Development Company Announces Preliminary Results from Phase IIa Clinical Trial

... loss. "Our drug development program focuses on a different molecular target," said Colca. "We believe that selective activation of the novel mitochondrial target will produce a significantly improved safety profile for individuals with type 2 diabetes. If the results of this study can be successfully ...

Pfizer and Medivation Initiate Phase 3 Trial of Dimebon Added to Donepezil in Patients with Alzheimer's Disease

... In preclinical models of AD and HD explored thus far, Dimebon has been shown to inhibit brain cell death, potentially by stabilizing and improving mitochondrial function in a way that prevents neuron death and dysfunction. The Dimebon mechanism is thought to be distinct from currently available AD ...

Pharmasset Initiates First Time in Human Study of PSI-7851 for the Treatment of Hepatitis C (HCV)

... metabolite of Pharmasset's first generation nucleoside polymerase inhibitor, R7128. In vitro studies of PSI-7851 have not shown evidence of any mitochondrial or other cellular toxicities that may be associated with some nucleoside analogs. The half-life of the triphosphate in primary human hepatocytes is ...

Worldwide Cost Estimate for Alzheimer's and Dementia Is US$315.4 Billion

... discuss the progress of a number of drugs currently in the pipeline for Alzheimer's and dementia, including: A new approach targeting mitochondrial function that has very positive early results. Passive and active "vaccination" (immunotherapy) studies currently being performed. ...

Diverse Approaches to Alzheimer's Therapies Continue to Show Progress at ICAD

... marketed Alzheimer's drugs. Dimebon improves impaired mitochondrial function. Mitochondria are the central energy source of all cells and impaired mitochondrial function may play a significant role in the loss of brain cell function in Alzheimer's," Cummings added. First U.S. Double-Blind Phase II Clinical ...

Video: Resveratrol-based Nutriceutical (Longevinex(R)) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Prior Studies

... (Longevinex(R)) exhibited a much broader impact upon gene expression and more strikingly affected key genes, like Pdk4 and Pgc1 alpha, involved in mitochondrial energy metabolism. Only the nutriceutical matrix, and not resveratrol or a long-term calorie restricted diet, upregulated the Foxo1 gene which ...

Medivation Announces Publication in The Lancet of Dimebon Pivotal Trial Results in Alzheimer's Disease

... potential treatment for these and other neurodegenerative diseases. Preclinical data generated to date suggest that Dimebon operates through a novel mitochondrial mechanism of action. On July 7, 2008, Medivation announced positive safety and efficacy results from its Phase 2 trial of Dimebon for the treatment ...

Pressure BioSciences, Inc. Announces $850,000 NIH SBIR Phase II Award for the Development of a New PCT-dependent System for Improved Biomarker Discovery, Diagnostics, and Drug Discovery

... in energy production, but they also play critical roles in cellular response to signals, regulating gene expression, and controlling cell death. mitochondrial dysfunction has been implicated in diabetes, cancer, neurodegenerative disorders, stroke, head injury, and other disorders. As such, mitochondria are ...

Medivation Initiates Second Pivotal Phase 3 Trial of Dimebon(TM) in Patients With Alzheimer's Disease

... potential treatment for these and other neurodegenerative diseases. Preclinical data generated to date suggest that Dimebon operates through a novel mitochondrial mechanism of action. Medivation is also evaluating Dimebon in an ongoing Phase 2 clinical trial in Huntington's disease. About Medivation ...

Further Clinical Testing of BZL101 in Advanced Breast Cancer Demonstrates Favorable Efficacy and Toxicity Profiles

... an aqueous extract from herba Scutellaria Barbata D. Don of the Lamiaceae family. BZL101 is a compound that induces cell death due to attenuation of mitochondrial transmembrane potential (MTP) leading to the release of reactive oxygen species, causing inhibition of glycolysis and ending with induction of DNA ...

Pharmasset Nominates PSI-7851 as a Lead Development Candidate for the Treatment of Chronic Hepatitis C

... approximately 15- to 20-fold more potent than the active metabolite of R7128, PSI-6130. In vitro studies of PSI-7851 have not shown evidence of any mitochondrial or other cellular toxicities that may be associated with some nucleoside analogs. The half-life of the triphosphate in primary human hepatocytes is ...

Antipodean Pharmaceuticals Announces Completion of Phase 2 Study of Lead Compound MitoQ(R)

... Association for the Study of the Liver (EASL) Annual Meeting, being held April 23 - 27 in Milan, Italy. The poster, titled "Phase II Study of the mitochondrial Antioxidant Mitoquinone for Hepatitis C," will be presented April 24, 2008. The 28-day study enrolled 30 patients with Hepatitis C virus (HCV), who ...

AmpliMed Corporation Announces Promising 1-year Survival Data from Phase I/II Study of Amplimexon(R) in Metastatic Malignant Melanoma

... been no new treatments approved in the last decade." Amplimexon is a small molecule drug that increases oxidative stress in tumor cells leading to mitochondrial damage and apoptosis. In preclinical in vitro and animal model studies it shows activity against human tumors including melanoma and is synergistic ...

Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week

... to quickly and affordably sequencing the complete mitochondria from 10 individual mammoths. To put this new study in perspective, only seven mitochondrial genomes from extinct animals had been previously published, four from ancient birds, two mammoths and one of the mastodon, a distant relative of ...

Aeolus Pharmaceuticals' AEOL 10150 Highlighted in Nature Genetics Publication

... gene. These mutant flies had reduced mitochondrial function and increased production of reactive ... of California-Irvine concluded that the increased mitochondrial Reactive Oxygen Species (ROS) ... and Alzheimer's disease are often associated with mitochondrial dysfunction and the overproduction of reactive ...

AGI Dermatics Data Shows the 8 Oxo-Guanine Repair Enzyme OGG1 Encapsulated in Liposomes, Reduces MMP-1 and TNF-alpha in UV Irradiated Skin Cells

... guanine causes the most significant damage to mitochondrial DNA, which manifests as nearly all signs ... enzymatic peroxidation reactions and normal mitochondrial metabolism. Those mentioned account for nearly ... the rate of repair of 8-oxo-G, and reduces mitochondrial toxicity and analyzed mRNA content and protein ...

ZIOPHARM Presents Data Highlighting Oral ZIO-101 at AACR

... Exposure to ZIO-101 has a direct as well as indirect effect on mitochondrial functions, resulting in depletion of energy supply to the cell and ... Increase in intra-cellular Reactive Oxygen Species enhances this effect on mitochondrial functions and consequently the activation of the signal transduction ...

Trophos Publishes ALS Article in Journal of Pharmacology and Experimental Therapeutics

... Specialists Publish Details of a Novel Drug Candidate for ALS That Targets mitochondrial Proteins MARSEILLE, June 19th, 2007 - Trophos SA, a ... of additional commercially attractive therapeutic indications involving mitochondrial dysfunction, including painful neuropathies. The publication describes the ...

ZIO-101 (Darinaparsin) Interim Phase II and Preclinical Data Presented at International Myeloma Workshop

... Exposure to darinaparsin has a direct as well as indirect effect on mitochondrial functions, resulting in depletion of energy supply to the cell and ... Increase in intra-cellular Reactive Oxygen Species enhances this effect on mitochondrial functions and consequently the activation of the signal transduction ...

Callisto Pharmaceuticals Announces Publication of Research Article on Atiprimod Preclinical Studies in Mantle Cell Lymphoma

... and is titled: "Atiprimod inhibits the growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activating the mitochondrial pathways" by M. Wang, L. Zhang, X. Han, J. Yang, J. Qian, S. Hong, F. Samaniego, J. Romaguera and Q. Yi. Callisto is a biopharmaceutical company ...

Innovive Pharmaceuticals Announces Data from Oncology Drug Programs to be Presented at American Association for Cancer Research Annual Meeting

... ---------------------------------------------- Presentation Title: "Reduced chronic cardiotoxicity and mitochondrial damage of the (6- maleimidocaproyl) hydrazone derivative of doxorubicin (DOXO-EMCH) in a rat ...

Innovive Pharmaceuticals Announces Preclinical Data from INNO-206 Oncology Program

... American Association for Cancer Research 2007 Annual Meeting in Los Angles, CA. In a poster presentation titled "Reduced chronic cardiotoxicity and mitochondrial damage of the (6-maleimidocaproyl) hydrazone derivative of doxorubicin (DOXO-EMCH) in a rat model compared to doxorubicin" (Abstract # 5587), ...

Investigation Findings, Corroborated by Empirical Evidence of the Schisandra Berry as Cardio-Tonic in Traditional Chinese Medicine for Hundreds of Years, Support the Use of Schisandrin B in the Prevention and Treatment of IHD

... actions of MitoPharm's key Compound, demonstrating that it enhances the mitochondrial glutathione antioxidant status, a crucial factor in maintaining mitochondrial function and cell survival, and also induces the expression of heat shock proteins, another group of important molecules for cell protection. ...

Resveratrol Studies Suggest Broad Implications for SIRT1 Activation in Neurodegenerative Diseases of Aging Such as Alzheimer's Disease

... disorders including Alzheimer's Disease and Amyotrophic Lateral Sclerosis (ALS), neurodegenerative diseases which have been associated with reduced mitochondrial function. Sirtuins are a recently discovered class of enzymes that appear to affect the aging process in mammals and increase the number and function ...
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