Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics
... instrument for the
kinetic measurement of mitochondrial
oxygen consumption and cytoplasmic
glycolysis in ... us to quantify
subtle changes in ATP turnover, mitochondrial
uncoupling or respiratory
chain inhibition that ... pathways."
Martin Brand, a leading mitochondrial
researcher from the Buck
Institute, Novato, CA ...
New Research Shows One in 200 People Born with DNA Mutation That Can Lead to Devastating, Often Fatal Disease
... Mutation Causing mitochondrial
Disease More Common Than Previously
... disease in them or their offspring. mitochondrial
a devastating and often fatal disease, and mitochondrial
disorders are at
the core of many well known ...
Medivation Presents Positive New Data on Dimebon's Long-Term Efficacy and Novel Mechanism of Action at the International Conference on Alzheimer's Disease
... Medivation presented new data on
Dimebon's novel mitochondrial
mechanism of action. Mitochondria generate
energy ... roles in mediating cell function and
dysfunction has been linked in the ... data
presented showed that Dimebon improves mitochondrial
function in the
setting of cellular stress with ...
Edison Pharma Hits Milestone as A0001 Enters Phase 1 Clinical Development
... Targeting inherited mitochondrial
diseases as an archetype for diseases of ... energy metabolism. Children with inherited mitochondrial
clinically present with many conditions ... with aging.
Edison believes that inherited mitochondrial
diseases may be genetic
roadmaps to deciphering ...
Transgenomic Establishes Collaboration With the National Cancer Institute to Investigate Mitochondrial Genome and Associated Nuclear Genes in Cancer Cell Lines
... mutational analysis and sequencing of the mitochondrial
the NCI 60 cancer cell line panel.
damage is increasingly recognized as an early ... This is the first
comprehensive evaluation of the mitochondrial
genome in the NCI 60 panel.
The data from this ...
Michael J. Fox Foundation Awards Up to $3 Million to Industry Teams to Jumpstart Promising PD Drug Development
... factories' of body cells. It is believed
function is decreased in people with Parkinson's disease
and that mitochondrial
toxins induce parkinsonian symptoms in ... are developing
unique compounds that improve mitochondrial
function and that are currently
being evaluated ...
Cardax Pharmaceuticals Nominates Clinical Candidate Heptax for Liver Disease; Heptax Ameliorates Inflammation and Oxidative Stress Related to Liver Disease and Metabolic Syndrome
... Cellular studies have determined that this compound acts as a plasma and mitochondrial
membrane stabilizer and a potent antioxidant.
"Cardax has ... safe, small molecule compounds that impact inflammation driven by mitochondrial
oxidative stress. The Company's first product localizes intracellularly in ...
Transgenomic and Power3 Medical Complete Agreement for Exclusive License of Neurodegenerative Biomarker Test
... and will add to Transgenomic's portfolio of molecular diagnostics used for mitochondrial
disorders, oncology, hematology molecular pathology, and inherited ... disease fitting within Transgenomic's focus on disorders originating from mitochondrial
damage. NuroPro will add significant depth to complement our array of ...
Medivation Announces Positive Top-Line Results From Phase 2 Dimebon Study in Huntington's Disease
... is exerting its benefits through a
novel mechanism of action targeting mitochondrial
contributor to the loss of neuronal function in ... data generated to date suggest that
Dimebon operates through a novel mitochondrial
mechanism of action.
Medivation will ...
UPDATE: Infant Primates Given Vaccines on U.S. Children's Immunization Schedule Develop Behavioral Symptoms of Autism
... the critical need for studies into vaccine safety and
the immune and mitochondrial
dysfunction of autistic children. The National
Autism Association (NAA) ... that vaccines triggered her regression into autism by
dysfunction. "The recent Poling case and this
new research provide further ...
Study Reports Successful Cloning of Human Embryo Using Adult DNA
... additional tests showed that the embryo had
another type of DNA, called mitochondrial
DNA, from both the female oocyte
donor and the male DNA donor.
DNA testing is viewed as an essential proof of successful
human cloning -- ...
Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C
... first generation nucleoside polymerase inhibitor, RG7128 (formerly known as R7128). In vitro studies of PSI-7851 have not shown evidence of any mitochondrial
or other cellular toxicities that may be associated with some nucleoside analogs. Like RG7128, PSI-7851 has demonstrated pan genotype activity in ...
Michael J. Fox Foundation Awards Over $2 Million for Validation of 10 Parkinson's Therapeutic Targets
... de Lausanne (Switzerland) and Deniz Kirik, MD, PhD, Lund University (Sweden)
Validation of cyclophilin D, a protein involved in the mitochondrial
permeability transi tion, as a target for Parkinson' s disease therapy
Mathieu Lesort, PhD, University of Alabama at Birmingham
Metabolic Solutions Development Company Announces Preliminary Results from Phase IIa Clinical Trial
"Our drug development program focuses on a different molecular target," said Colca. "We believe that selective activation of the novel mitochondrial
target will produce a significantly improved safety profile for individuals with type 2 diabetes. If the results of this study can be successfully ...
Pfizer and Medivation Initiate Phase 3 Trial of Dimebon Added to Donepezil in Patients with Alzheimer's Disease
... In preclinical models of AD and HD explored thus far, Dimebon has been shown to inhibit brain cell death, potentially by stabilizing and improving mitochondrial
function in a way that prevents neuron death and dysfunction. The Dimebon mechanism is thought to be distinct from currently available AD ...
Pharmasset Initiates First Time in Human Study of PSI-7851 for the Treatment of Hepatitis C (HCV)
... metabolite of Pharmasset's first generation nucleoside polymerase inhibitor, R7128. In vitro studies of PSI-7851 have not shown evidence of any mitochondrial
or other cellular toxicities that may be associated with some nucleoside analogs. The half-life of the triphosphate in primary human hepatocytes is ...
Worldwide Cost Estimate for Alzheimer's and Dementia Is US$315.4 Billion
... discuss the progress of a number of drugs currently in the pipeline for Alzheimer's and dementia, including:
A new approach targeting mitochondrial
function that has very positive early results.
Passive and active "vaccination" (immunotherapy) studies currently being performed.
Diverse Approaches to Alzheimer's Therapies Continue to Show Progress at ICAD
... marketed Alzheimer's drugs. Dimebon improves impaired
mitochondrial function. Mitochondria are the central energy source of all
cells and impaired mitochondrial
function may play a significant role in
the loss of brain cell function in Alzheimer's," Cummings added.
First U.S. Double-Blind Phase II Clinical ...
Video: Resveratrol-based Nutriceutical (Longevinex(R)) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Prior Studies
... (Longevinex(R)) exhibited
a much broader impact upon gene expression and more strikingly affected key
genes, like Pdk4 and Pgc1 alpha, involved in mitochondrial
Only the nutriceutical matrix, and not resveratrol or a long-term
calorie restricted diet, upregulated the Foxo1 gene which ...
Medivation Announces Publication in The Lancet of Dimebon Pivotal Trial Results in Alzheimer's Disease
... potential treatment for these and other
neurodegenerative diseases. Preclinical data generated to date suggest that
Dimebon operates through a novel mitochondrial
mechanism of action.
On July 7, 2008, Medivation announced positive safety and efficacy
results from its Phase 2 trial of Dimebon for the treatment ...
Pressure BioSciences, Inc. Announces $850,000 NIH SBIR Phase II Award for the Development of a New PCT-dependent System for Improved Biomarker Discovery, Diagnostics, and Drug Discovery
... in energy production, but they also play critical roles in cellular
response to signals, regulating gene expression, and controlling cell
dysfunction has been implicated in diabetes, cancer,
neurodegenerative disorders, stroke, head injury, and other disorders. As
such, mitochondria are ...
Medivation Initiates Second Pivotal Phase 3 Trial of Dimebon(TM) in Patients With Alzheimer's Disease
... potential treatment for these
and other neurodegenerative diseases. Preclinical data generated to date
suggest that Dimebon operates through a novel mitochondrial
Medivation is also evaluating Dimebon in an ongoing Phase 2 clinical
trial in Huntington's disease.
Further Clinical Testing of BZL101 in Advanced Breast Cancer Demonstrates Favorable Efficacy and Toxicity Profiles
... an aqueous extract from herba Scutellaria Barbata D. Don of the
Lamiaceae family. BZL101 is a compound that induces cell death due to
attenuation of mitochondrial
transmembrane potential (MTP) leading to the
release of reactive oxygen species, causing inhibition of glycolysis and
ending with induction of DNA ...
Pharmasset Nominates PSI-7851 as a Lead Development Candidate for the Treatment of Chronic Hepatitis C
... approximately 15- to 20-fold more potent than the active
metabolite of R7128, PSI-6130. In vitro studies of PSI-7851 have not shown
evidence of any mitochondrial
or other cellular toxicities that may be
associated with some nucleoside analogs. The half-life of the triphosphate
in primary human hepatocytes is ...
Antipodean Pharmaceuticals Announces Completion of Phase 2 Study of Lead Compound MitoQ(R)
... Association for the Study of the Liver
(EASL) Annual Meeting, being held April 23 - 27 in Milan, Italy.
The poster, titled "Phase II Study of the mitochondrial
Mitoquinone for Hepatitis C," will be presented April 24, 2008. The 28-day
study enrolled 30 patients with Hepatitis C virus (HCV), who ...
AmpliMed Corporation Announces Promising 1-year Survival Data from Phase I/II Study of Amplimexon(R) in Metastatic Malignant Melanoma
... been no new treatments approved in the last
Amplimexon is a small molecule drug that increases oxidative stress in
tumor cells leading to mitochondrial
damage and apoptosis. In preclinical
in vitro and animal model studies it shows activity against human tumors
including melanoma and is synergistic ...
Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week
... to quickly and affordably sequencing the complete
mitochondria from 10 individual mammoths. To put this new study in
perspective, only seven mitochondrial
genomes from extinct animals had been
previously published, four from ancient birds, two mammoths and one of the
mastodon, a distant relative of ...
Aeolus Pharmaceuticals' AEOL 10150 Highlighted in Nature Genetics
... gene. These mutant flies had reduced mitochondrial
and increased production of reactive ... of California-Irvine concluded that the
Reactive Oxygen Species (ROS) ... and Alzheimer's
disease are often associated with mitochondrial
dysfunction and the
overproduction of reactive ...
AGI Dermatics Data Shows the 8 Oxo-Guanine Repair Enzyme OGG1
Encapsulated in Liposomes, Reduces MMP-1 and TNF-alpha in UV
Irradiated Skin Cells
... guanine causes the most significant
damage to mitochondrial
DNA, which manifests as nearly all signs ... enzymatic
peroxidation reactions and normal mitochondrial
mentioned account for nearly ... the rate of repair of 8-oxo-G, and
toxicity and analyzed mRNA content and
ZIOPHARM Presents Data Highlighting Oral ZIO-101 at AACR
... Exposure to ZIO-101 has a direct as well as indirect
effect on mitochondrial
functions, resulting in depletion of energy
supply to the cell and ... Increase in intra-cellular Reactive Oxygen Species enhances
this effect on mitochondrial
functions and consequently the
activation of the signal transduction ...
Trophos Publishes ALS Article in Journal of Pharmacology and
... Specialists Publish Details of a Novel
Drug Candidate for ALS That Targets mitochondrial
MARSEILLE, June 19th, 2007 - Trophos SA, a ... of additional commercially attractive therapeutic
indications involving mitochondrial
dysfunction, including painful
neuropathies. The publication describes the ...
ZIO-101 (Darinaparsin) Interim Phase II and Preclinical Data
Presented at International Myeloma Workshop
... Exposure to darinaparsin has a direct
as well as indirect effect on mitochondrial
functions, resulting in
depletion of energy supply to the cell and ... Increase in intra-cellular Reactive Oxygen
Species enhances this effect on mitochondrial
consequently the activation of the signal transduction ...
Callisto Pharmaceuticals Announces Publication of Research Article
on Atiprimod Preclinical Studies in Mantle Cell Lymphoma
... and is titled: "Atiprimod inhibits the
growth of mantle cell lymphoma in vitro and in vivo and induces
apoptosis via activating the mitochondrial
pathways" by M. Wang, L.
Zhang, X. Han, J. Yang, J. Qian, S. Hong, F. Samaniego, J.
Romaguera and Q. Yi.
Callisto is a biopharmaceutical company ...
Innovive Pharmaceuticals Announces Data from Oncology Drug Programs
to be Presented at American Association for Cancer Research Annual
Presentation Title: "Reduced chronic cardiotoxicity and
damage of the (6-
maleimidocaproyl) hydrazone derivative of
doxorubicin (DOXO-EMCH) in a rat ...
Innovive Pharmaceuticals Announces Preclinical Data from INNO-206
... American Association for Cancer Research 2007 Annual
Meeting in Los Angles, CA.
In a poster presentation titled "Reduced chronic cardiotoxicity
damage of the (6-maleimidocaproyl) hydrazone
derivative of doxorubicin (DOXO-EMCH) in a rat model compared to
doxorubicin" (Abstract # 5587), ...
Investigation Findings, Corroborated by Empirical Evidence of the
Schisandra Berry as Cardio-Tonic in Traditional Chinese Medicine
for Hundreds of Years, Support the Use of Schisandrin B in the
Prevention and Treatment of IHD
of MitoPharm's key Compound, demonstrating that it enhances the
mitochondrial glutathione antioxidant status, a crucial factor in
function and cell survival, and also
induces the expression of heat shock proteins, another group of
important molecules for cell protection. ...
Resveratrol Studies Suggest Broad Implications for SIRT1 Activation
in Neurodegenerative Diseases of Aging Such as Alzheimer's Disease
including Alzheimer's Disease and Amyotrophic Lateral Sclerosis
(ALS), neurodegenerative diseases which have been associated with
function. Sirtuins are a recently discovered
class of enzymes that appear to affect the aging process in mammals
and increase the number and function ...