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Acute Lymphoblastic Leukemia, the Most Common Childhood Cancer, Is Curable Without Preventive Cranial Radiation

... measurement of residual leukemia cells (so-called minimal residual disease) that were present after remission induction treatment. The measurement of minimal residual disease was used to modify therapy based ... study 100 percent of the patients for levels of minimal residual disease, an unprecedented rate of ...

Micromet's Blinatumomab Achieves Primary Endpoint in Phase 2 Study with Acute Lymphoblastic Leukemia Patients

... Showing High Response Rate in Patients with minimal Residual Disease BERLIN, June 8 ... acute lymphoblastic leukemia (ALL) patients with minimal residual disease (MRD)(1). Blinatumomab is a ... cancer cells in their bone marrow -- so called minimal residual disease (MRD). Various studies have ...

Gene Abnormality Found to Predict Childhood Leukemia Relapse

... IKAROS alterations was associated with levels of minimal residual disease, another measure of treatment response in ALL. "Measurement of levels of minimal residual disease is widely used to monitor ... added anything to just measuring levels of minimal residual disease. And, indeed, it did." The ...

Data To Be Presented at ASCO Supports Potential of Peregrine's Cotara(R) for the Treatment of Brain Cancer

... to brain tumors at high concentrations with minimal radiation exposure to other organs. Cotara is a ... of Cotara, showing it results in minimal radiation exposure to other organs, including the ... thereby destroying it "from the inside out," with minimal radiation exposure to healthy tissue. Cotara is ...

PEAK Surgical Announces Positive Results From Preclinical Study of PEAK PlasmaBlade(TM) for Obstetric and Gynecologic Surgery

... that cuts made with the PEAK PlasmaBlade produced minimal collateral damage compared with cuts made with ... precise soft-tissue cutting and coagulation with minimal thermal injury could change the way we operate." ... showed that the PEAK PlasmaBlade cuts produced minimal collateral damage compared to cuts made with the ...

Abbott's HUMIRA(R) (adalimumab) Receives FDA Approval For Moderate to Severe Chronic Plaque Psoriasis

... scale, a zero score means no signs, one means minimal and a five means signs of very severe psoriasis. ... patients achieved a PGA score of clear or minimal (0 or 1) compared to 4 percent of placebo-treated ... with HUMIRA achieved a PGA score of clear or minimal at 16 weeks of treatment, compared with only ...

PNH Patients With Lower Levels of Hemolysis, Mild Anemia and Minimal Transfusion Support Have Significant Disease Burden; Soliris(R) Therapy Provided Clinical Improvements in PNH Patients Regardless of Disease Severity

... with Lower Levels of Hemolysis, Mild Anemia and minimal Transfusion: Clinical Improvement with ... lower levels of hemolysis, mild anemia and minimal transfusion requirements. Data were analyzed by ... the lowest levels of hemolysis, mild anemia, or minimal transfusion requirements reported fatigue. ...

First Skin Cancer Patients Treated With Electronic Brachytherapy (eBx) At University of Wisconsin Riverview Cancer Center

... designed to deliver non-radioactive therapy directly to cancer sites with minimal radiation exposure to surrounding healthy tissue. Utilizing a proprietary ... a therapeutic dose of radiation directly to the region at risk with minimal radiation exposure to surrounding healthy tissue and without the complex ...

Pelleve Receives FDA Clearance for the Treatment of Mild to Moderate Facial Wrinkles

... non-invasive facial rejuvenation with no need for a local anesthetic and minimal discomfort -- a significant evolution from previous-generation ... The result is a noticeable improvement in skin quality and appearance with minimal side effects and healing time for patients. In a clinical trial ...

Cepheid Announces European Release of First On-Demand Molecular Test for Simultaneous Detection of Mycobacterium tuberculosis (TB) and Resistance to Rifampicin

... "We designed this test so that it could be used by someone with minimal training," said UMDNJ's David Alland, M.D. who collaborated closely with ... of molecular analysis, producing accurate results in a timely manner with minimal risk of contamination. The GeneXpert System is the only system to combine ...

American Lung Association Study to be Published in the 'New England Journal of Medicine' Finds Prescription Heartburn Medication Does Not Control Asthma Symptoms as Previously Thought

... inadequate asthma control despite inhaled corticosteroids and absent or minimal GER symptoms were randomly assigned to either esomeprazole 40 mg b.i.d. or ... GER documented by pH probe studies in 40% of participants with absent or minimal symptoms did not identify a subgroup benefiting from PPI treatment. ...

PEAK Surgical Announces Completion of First PRECISE Clinical Study, Receipt of Medical Design Excellence Award for PEAK(R) Surgery System and Achievement of Over 1,000 Surgeries Using PEAK PlasmaBlade(TM)

... to surgeons and patients, including improved surgical incision healing, minimal bruising, scarring and inflammation." "The PlasmaBlade technology has ... that the PlasmaBlade is associated with effective bleeding control, minimal thermal tissue injury, reduced scarring and inflammation, and improved ...

Freezing Kidney Cancer: Hot Treatment Should Be New Gold Standard for Destroying Small Tumors

... Most of our patients go home the same day they receive treatment with minimal limitation on regular activities. With laparoscopic kidney surgery, a ... nature of interventional cryoablation means that it can be performed with minimal blood loss and without an incision, just a tiny hole in the skin. The ...

Study Suggests New Treatment Approach May be Needed for Management of Depression in Some People With Bipolar Disorder

... or worsening depressive symptoms. "We found that people who had minimal manic symptoms or a "mixed depression" presentation were at greatest risk ... Medicine, reported that two-thirds of the depressed bipolar patients had minimal or mild manic symptoms "mixed" together. "We're learning that this ...

PEAK Surgical Receives 510(k) Clearance to Market PEAK(R) Surgery System for Use in Expanded Indications

... validate our preclinical results showing effective bleeding control, minimal thermal tissue injury, positive wound healing, minimal scarring and inflammation, and improved surgical incision healing and ...

Xoft Showcases Interim Clincal Results for Breast Cancer Product and New Indications for Electronic Brachytherapy(eBx) at Astro Meeting

... delivers non-radioactive, electronic therapy directly to cancer sites with minimal radiation exposure to surrounding healthy tissue, will showcase early ... a therapeutic dose of radiation directly to the region at risk with minimal radiation exposure to surrounding healthy tissue and without the complex ...

Access Pharmaceuticals Presents Favorable Ovarian Cancer Data and Clinical Update on ProLindac(TM) Development at Prestigious International Symposium

... multiple dosings in several patients. ProLindac was well-tolerated with minimal side-effects. "We continue to be impressed by clinical results that ... Jeffrey B. Davis, Access' President & CEO. "The sustained efficacy and minimal toxicity seen over multiple dosings provides further evidence that ...

Pivotal Study Shows Physician/Nurse Teams Using SEDASYS(TM) System Reduced Risk of Over Sedation With Propofol

... the trial, the system made it possible for gastroenterologists to maintain minimal to moderate sedation with propofol, and helped prevent patients from ... were a MOAA/S score of 2 -- 5, indicating minimal to moderate sedation. minimal to moderate propofol sedation with the SEDASYS(TM) System provided ...

R788 in TASKi3 Clinical Trial Does Not Meet Efficacy Endpoints in RA Patients Who Had Previously Failed Biologic Therapies - Results Incongruent

... options were pre-specified in the trial protocol and, in cases where doses were reduced, patients generally completed the clinical trial with minimal safety issues. The most common adverse events in the trial overall were related to infections, though these were generally evenly distributed among ...

Rigel's R788 Significantly Improves Rheumatoid Arthritis in Phase 2b Clinical Trial

... options were pre-specified in the trial protocol and in cases where doses were reduced, patients generally completed the clinical trial with minimal safety issues. The most common adverse events in the trial overall were related to infections, though these were generally evenly distributed among ...

Scottsdale Facility to Be First in U.S. to Showcase True REST Technology

... Flotation REST involves floating on top of a pool of saltwater - 10 inches of water and 800 pounds of Epsom salt - in a specially designed tank with minimal light and sound. Because of the high salt content of the water, which is heated to skin surface temperature, a person is able to float effortlessly. ...

Cepheid Receives Grant to Develop Ten-Color Real-Time PCR Detection Technology for Use in the GeneXpert(R) System

... and automated platform that represents a paradigm shift in the automation of molecular analysis, producing accurate results in a timely manner with minimal risk of contamination. The GeneXpert System is the only system to combine on-board sample preparation with real-time PCR (polymerase chain reaction) ...

Proteolix Presents Positive Clinical Data for Carfilzomib in Multiple Myeloma at the 2009 ASCO Annual Meeting

... proteasome inhibitors. Carfilzomib produces specific and sustained inhibition of the proteasome, leading to apoptosis in cancer cells with minimal off-target effects. In Phase 1 and Phase 2 clinical trials, carfilzomib has demonstrated single-agent activity in hematologic malignancies and solid ...

Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting

... proteasome inhibitors. Carfilzomib produces specific and sustained inhibition of the proteasome, leading to apoptosis in cancer cells with minimal off-target effects. In Phase 1 and Phase 2 clinical trials, carfilzomib has demonstrated single-agent activity in hematologic malignancies and solid ...

Optimer Pharmaceuticals Presents Results From Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection

... resulting in the death of Clostridium difficile . The narrow spectrum profile of fidaxomicin may eradicate Clostridium difficile selectively with minimal disruption to the normal intestinal flora. This may facilitate the return of the normal physiological conditions in the colon and reduce the ...

ISTA Pharmaceuticals Highlights Bepreve(TM) Clinical Data at the Association for Research in Vision and Ophthalmology (ARVO) 2009 Annual Meeting

... allergen challenge for at least 8 hours after dosing. In addition, ISTA demonstrated Bepreve 1.5%, dosed twice daily for six weeks, was safe with minimal adverse events in a healthy pediatric population from 10-17 years of age. Results were presented at the Association for Research in Vision and ...

Anthera's Varespladib Meets Primary Endpoint in Phase 2 FRANCIS Trial for the Treatment of Acute Coronary Syndrome

... protein. About Acute Coronary Syndrome Acute coronary syndrome is a heart condition characterized by chest pain occurring at rest or upon minimal exertion. This condition is also referred to as unstable angina. If the chest pain is associated with heart muscle damage and heart tracing ...

Video: ev3 Inc. Announces First Patient Enrollments in DEFINITIVE LE Post-Market Study

... the artery. As it is excised, the plaque collects in the tip of the device and then is removed from the patient, thereby restoring blood flow with minimal barotrauma and no permanent implant. Over 200,000 cases using the SilverHawk Plaque Excision System have been performed since the product first ...

AdvanDx Launches Fast, 90 Minutes Protocol for All CE-IVD Marked PNA FISH(R) Tests in Europe

... possible," Johansen concluded. PNA FISH Diagnostic Platform Features: Standard protocol with 90 min. Turn-around Time and minimal Hands-on Time Close to 100% sensitivity and specificity versus conventional, slower laboratory methods Molecular method requiring ...

Optimer Pharmaceuticals Receives Production Patent for Lead Product Candidate Fidaxomicin

... resulting in the death of Clostridium difficile . The narrow spectrum profile of fidaxomicin may eradicate Clostridium difficile selectively with minimal disruption to the normal intestinal flora. This may facilitate the return of the normal physiological conditions in the colon and reduce the ...

Watson Announces United States Availability of RAPAFLO(TM) (silodosin), a Novel New Treatment in Benign Prostatic Hyperplasia (BPH)

... urine flow rates) as early as two hours following first dose and at 12 weeks of treatment. In clinical trials, RAPAFLO(TM) also demonstrated minimal electro cardiac effects on the cardiovascular system, without any meaningful prolongation of the QT interval. The most common drug-related side ...

NHS National Innovation Centre Cites VNUS Closure(R) Procedure as Select Innovative Technology

... preferred technique to treat venous reflux because it requires no special modifications to operating areas, is well tolerated by patients, requires minimal post-procedure analgesia and is highly effective at permanently closing the vein," said Ian Franklin, Consultant Vascular Surgeon from Charing Cross ...

Interleukin Genetics Presents Research Linking Vertebral Fractures to Gene Variations in Asian Women With Osteoporosis

... 84 years and 400 Japanese women within 36 months post-menopause. "While studies exist that look at the genetics of osteoporosis, there has been minimal research into the genetic risk for vertebral fractures," commented Nazneen Aziz, Vice President of Research and Development. "Spinal or vertebral ...

Neurocrine Announces Top-Line Results From 702 Study (Lilac PETAL Study) of Elagolix for Treatment of Endometriosis Pain

... were typically mild and transient. Consistent with previous clinical studies, elagolix showed a dose dependent decrease in mean estradiol levels and minimal impact on bone mineral density and related serum n-telopeptide levels during the initial three months of treatment. Conference Call and ...

Following Encouraging Results Anthera to Continue IMPACTS Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease

... with acute coronary syndrome (ACS) for a reduction in secondary MACE. ACS is a heart condition characterized by chest pain occurring at rest or upon minimal exertion. This condition is also referred to as unstable angina. If the chest pain is associated with heart muscle damage and heart tracing ...

Micromet Has Started a New Phase 2 Trial with Adecatumumab in Colorectal Cancer Patients

... commented Carsten Reinhardt, MD, Chief Medical Officer of Micromet. "We look forward to exploring the promise of adecatumumab to eliminate minimal residual disease in colorectal cancer patients and thereby to potentially improve cure rates in these patients at high risk of relapse." ...

Research Shows VASER(R) Lipo Results in Excellent Skin Tightening

... preserving important tissue structures vital to natural skin tightening. By preserving nerves, blood vessels and collagen, patients also experience minimal to no pain and bruising postoperatively allowing for a fast return to normal activities. About Sound Surgical -- Founded in 1998, Sound ...

Freezing Prostate Cancer Does a Man's Body Good

... cancer usually grows slowly and initially remains confined to the prostate gland. While some types of prostate cancer grow slowly and may need minimal or no treatment, other types are aggressive and can spread quickly. A diagnosis of prostate cancer can be scary not only because it can be ...

New Study Published in the Journal of Drugs in Dermatology Finds DOT Microablative CO2 Laser Optimum for Skin Rejuvenation

... DOT (Dermal Optical Thermolysis), has become the optimal choice for active patients desiring significant effects from a single treatment with minimal downtime. Additionally, DOT Therapy is ideal in causing immediate contraction of wrinkles and loose skin, results that non-ablative lasers produce ...

Isolagen, Inc. Reports Positive Top-line Results from Phase II/III Study of Isolagen Therapy(TM) to Treat Moderate to Severe Acne Scars: Study Meets All Primary Efficacy Endpoints and is Statistically Significant

... California San Diego , and the study's other co-primary investigator further commented, "I am very pleased with the outcome of this study. There are minimal options currently available for the treatment of acne scars and the results of this study, coupled with my clinical experience with the Isolagen ...
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(Date:12/19/2014)... , Dec. 18, 2014  23andMe, Inc., the leading ... study that pinpoints fine-scale differences in genetic ancestry of ... . Since immigrants first arrived more than ... has served as a meeting place for ... history and the ongoing mixing of peoples with African, ...
(Date:12/17/2014)... FORT BELVOIR, Va. , Dec. 15, 2014 ... its efforts to make it easier to detect ... supply chain. Today the agency started ... marking. The capability will validate the authenticity of ... supply chain. The new quality control measures will ...
(Date:12/17/2014)... 2014 Research and Markets ( ... "Global Chemical Sensor Market 2015-2019" report ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend upcoming ... medical sensors in biomedical applications. Chemical sensors help ... correct diagnosis during surgical procedures. The Global Chemical ...
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(Date:12/24/2014)... 24, 2014 The federal court ... the blood thinner caused life-threatening episodes of internal ... structure for the proceeding, Bernstein Liebhard LLP reports. ... Court plans to select lawyers to serve as ... on appointing a Plaintiffs’ Steering Committee, which will ...
(Date:12/24/2014)... The report “Stivarga (Colorectal Cancer) – Forecast ... treatment landscape, unmet needs, current pipeline and commercial opportunities ... which is used in the treatment of colon or ... also prescribed to patients who suffer from advanced gastrointestinal ... a multi-kinase inhibitor and it blocks many enzymes which ...
(Date:12/24/2014)... Dennis Thompson HealthDay Reporter TUESDAY, ... have abstained from sex for one year will be allowed to ... that would reverse a 31-year ban on donations from men who ... announced Tuesday its intention to release a new draft guidance in ... from gay men. The FDA is changing its policy based ...
(Date:12/24/2014)... Dec. 24, 2014 (HealthDay News) -- A new, injectable ... and Drug Administration. The agency on Tuesday approved ... those who are overweight and have at least one ... 2 diabetes or high cholesterol. Patients taking the ... low-calorie diet and exercise regularly, the FDA noted. ...
(Date:12/24/2014)... Tara Haelle ... News) -- Teens are more likely to start smoking ... attention-deficit hyperactivity disorder (ADHD) or conduct disorder, new ... counsel families about the risk of substance use as ... Brinkman, research director at Cincinnati Pediatric Research Group, which ...
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