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Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

... treatment of patients with KRAS wild-type metastatic colorectal cancer (mCRC). "We believe ... document an important advance for patients with metastatic colorectal cancer," said Roger M. Perlmutter, ... agent for the treatment of EGFR-expressing, metastatic colorectal carcinoma is based on progression-free ...

Study Shows Cancer Vaccines Led to Long-Term Survival for Patients with Metastatic Melanoma and to Long Periods of Disease Control After Completion of Therapy

... long-term survival rates in patients with metastatic melanoma whose disease had been minimized by ... Anti-Tumor Vaccines in Patients with metastatic Melanoma," was published in the June 2009 issue ... for melanoma patients with recurrent or distant metastatic disease at the time of diagnosis because there ...

UPDATE: US Oncology Research Network Participates in Phase III Follow-up Study to BiPar's Investigational Cancer Drug BSI-201

... Progesterone Receptor (PR), and HER2-negative metastatic breast cancer. Joyce O'Shaughnessy, ... which is a very promising new treatment for metastatic triple negative breast cancer," says Dr. ... include adults with histologically documented metastatic breast cancer with measurable disease that is ...

CuraGen Announces Expansion of CR011-vcMMAE Phase II Trial in Advanced Breast Cancer

... treatment of melanoma and for the treatment of metastatic breast cancer, and in a Phase I trial to evaluate ... in therapy, the median survival of patients with metastatic breast cancer is 2 to 3 years, while patients ... approaches for patients with locally advanced and metastatic breast cancer who have failed other therapies. ...

Investigational Cancer Drug BSI-201 Showed Clinical Benefit in 62% of Patients with Triple-Negative Metastatic Breast Cancer and Significantly Prolonged Survival

... carboplatin (GC) chemotherapy, in patients with metastatic triple-negative breast cancer (TNBC). BSI-201 is ... damage. In this study, 116 women with metastatic TNBC, defined as tumors lacking expression of ... expect to begin a Phase 3 trial with BSI-201 in metastatic TNBC this summer. About ASCO ASCO ...

CuraGen Updates CR011-vcMMAE Data at ASCO

... median number of prior chemotherapy regimens for metastatic disease was 4 (range 2-11). Triple negative ... expand the activity of CR011 into patients with metastatic breast cancer and open this area up as an ... in addition to the opportunity in patients with metastatic melanoma," commented Dr. Timothy Shannon, ...

Neurobiological Technologies' Partner, Celtic Pharma, Announces Results of XERECEPT(R) Phase 3 Clinical Program

... XERECEPT(R) in Patients with Primary and metastatic Brain Tumors Administration of XERECEPT(R) ... cerebral edema associated with both primary and metastatic brain tumors. The Company also announced the ... use over the longer-term and the impact seen in metastatic patients, a large group with limited treatment ...

Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

... + Placebo in Patients with 2nd or 3rd Line metastatic Colon Cancer NEW YORK, June 1 ... alone in patients with second- or third-line metastatic colon cancer," was presented yesterday in a ... the United States, patients with 2nd or 3rd line metastatic colon cancer were randomized to receive ...

Encouraging First Data on New Targeted Treatment for Patients With Melanoma - the Deadliest Form of Skin Cancer

... to the liver, lung and bone[i]. Historically, metastatic melanoma patients live less than two months ... if caught early but patients who develop metastatic disease are rarely cured with available ... been observed - Regression of metastatic lesions in every site to which melanoma ...

Study Showed Lilly's GEMZAR(R) (gemcitabine HCl for injection) Improved Progression-Free Survival in Cervical Cancer Patients

... locally advanced (Stage IIIA or Stage IIIB) or metastatic (Stage IV or cancer that has spread) non-small ... II or Stage III when surgery is not an option) or metastatic (Stage IV) adenocarcinoma of the pancreas. GEMZAR ... FDA for the first-line treatment of patients with metastatic breast cancer after they have received another ...

Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

... + Placebo in Patients with 2nd or 3rd Line metastatic Colon Cancer NEW YORK, May 31 ... alone in patients with second- or third-line metastatic colon cancer," is being presented today in a ... the United States, patients with 2nd or 3rd line metastatic colon cancer were randomized to receive ...

Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer

... #5034, entitled, "Phase II study of perifosine in metastatic renal cell carcinoma (RCC) progressing after ... clinical benefit to patients with 2nd or 3rd line metastatic renal cell cancer. We are grateful to Dr. ... therapies for the treatment of advanced metastatic RCC (VEGF inhibitors, sunitinib and sorafenib, ...

New Preliminary Data from Two Studies Show Clinical Activity of Neratinib in Combination with Trastuzumab and in Combination with Paclitaxel in Advanced HER-2 Positive Breast Cancer

... medical need for more therapies for patients with metastatic breast cancer. These data warrant ongoing and ... phase 1 portion (part 1), and only patients with metastatic ErbB-2 positive breast cancer were enrolled in ... investigated in patients with ErbB-2 positive metastatic breast cancer. A total of 102 patients ...

Poniard Pharmaceuticals Announces Progression-Free Survival Data From Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer

... Phase 2 trial of picoplatin in patients with metastatic colorectal cancer (CRC). The new data ... activity in the treatment of first-line metastatic CRC, as assessed by progression-free survival ... regimen is the current standard of care for metastatic colorectal cancer, but is associated with severe ...

CuraGen to Present CR011-vcMMAE Data at ASCO

... conjugate, in patients with locally advanced or metastatic breast cancer. Monday, June 1, 2009, poster ... treatment of melanoma and for the treatment of metastatic breast cancer, and in a Phase I trial to evaluate ... in therapy, the median survival of patients with metastatic breast cancer is 2 to 3 years, while patients ...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

... need of new treatments." Sandostatin LAR in metastatic neuroendocrine midgut tumors Data from the ... a significant antitumor effect in patients with metastatic neuroendocrine tumors (NET) of the midgut(1). ... efficacy of O ctreotide LAR in patients with metastatic neuroendocrine MID gut tumors), is a Phase IIIb ...

BioVex to Report Phase I/II Clinical Trial Results for the Front Line Treatment of Head and Neck Cancer With OncoVEX GM-CSF at the 2009 American Society of Clinical Oncology Meeting

... abstract submission. Three patients had distant metastatic disease. Two of these were in the low dose group. ... the immune system to destroy un-injected metastatic deposits. Both modes of action have been clearly ... in the clinic, where multiple patients with metastatic disease progressing at enrollment have been ...

Poniard Pharmaceuticals Reports First Quarter 2009 Financial Results and Provides a Corporate Update

... study of picoplatin in patients with metastatic colorectal cancer (CRC) was presented at the ... to oxaliplatin for the first-line treatment of metastatic CRC. Patient enrollment was completed in May ... trials of picoplatin as first-line treatment for metastatic colorectal and castration-resistant prostate ...

Poniard Pharmaceuticals to Present New Data from Phase 2 Clinical Trials of Picoplatin in Multiple Tumor Types at the 45th Annual Meeting of the American Society of Clinical Oncology

... plus docetaxel/prednisone in patients with metastatic castration-resistant (hormone-refractory) ... picoplatin plus 5-FU/leucovorin in patients with metastatic colorectal cancer (CRC). Both presentations ... in small cell lung cancer and Phase 2 trials in metastatic colorectal and castration-resistant (hormone ...

Delcath Continues Expansion of Clinical Trial Centers Offering PHP(TM)

... CANCER CENTER JOINS PHASE III TRIAL FOR metastatic MELANOMA NEW YORK, April 9 ... Phase III clinical trial for the treatment of metastatic melanoma in the liver. Ohio State is the ... look forward to treating patients in this trial. metastatic melanoma, once it reaches the liver, has few ...

Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update

... with docetaxel and prednisone in patients with metastatic castration-resistant (hormone-refractory) ... and prednisone, the standard treatment for metastatic CRPC, supporting the use of this combination in ... and leucovorin (FOLPI) in patients with metastatic colorectal cancer (CRC) at the ASCO 2009 ...

Video: Provectus PV-10 Interim Phase 2 Safety and Efficacy Results are as Good as or Better than Phase 1 Results

... its Phase 2 clinical trial for the treatment of metastatic melanoma are as good as or better than Phase 1 ... for Provectus' Phase 2 study of PV-10 for metastatic melanoma, Professor John F Thompson, MD, ... 120,000 patients in the U.S. alone have metastatic melanoma, and the World Health Organization ...

New Hope to Beat Cancer

... of this trial at NCI. Capstran had stage-four metastatic melanoma, a diagnosis that few survive, but with ... the NCI are exciting for patients with stage-four metastatic melanoma. Published reports for the trial show a ... all patients must be diagnosed with stage-four metastatic melanoma. During the trial blood is drawn from ...

Metastatic Bone Disease Patients Can Walk in Lazarus' Footsteps

... procedure to treat the painful effects of metastatic bone disease by injecting bone cement to support ... of life can be severely affected when they have metastatic bone disease. Normal daily activities can become ... of their primary cancers," added Anselmetti. metastatic bone disease is a painful condition that can ...

A First-Line Therapy for Renal Cell Carcinoma that can Increase Overall Survival when Compared with Sutent Would Earn a Higher Patient Share in the United States Than in Europe

... issues, finds that a first-line therapy for metastatic renal cell carcinoma that can increase overall ... surveyed oncologists' prescribing decisions in metastatic renal cell carcinoma. Clinical data and the ... proprietary clinical gold standard in 2008 for metastatic renal cell carcinoma. Based on available ...

Oncolytics Biotech Inc. Announces Start of Patient Enrolment in Translational Clinical Trial Investigating REOLYSIN(R) in Patients with Metastatic Colorectal Cancer

... administration of REOLYSIN(R) in patients with metastatic colorectal cancer prior to surgical resection of ... operations to remove colorectal cancer deposits metastatic to the liver. Patients will comprise two groups ... to the U.K. translational study for patients with metastatic colorectal cancer with liver metastases, and the ...

Algeta Completes Comprehensive Phase II Clinical Program With Alpharadin for Treating Bone Metastases in Patients With Advanced Prostate Cancer

... as a new, safe and effective treatment for metastatic prostate cancer. The program has demonstrated ... generated so far for Alpharadin in treating metastatic prostate cancer are highly encouraging and offer ... nature of Alpharadin. ALP is a severity marker of metastatic bone disease and of prognostic importance. Again, ...

RAD001 Phase II Trial Results Positive in Patients with Advanced Gastric Cancer After Failure of One or More Prior Treatments

... advanced gastric cancer (inoperable, recurrent or metastatic gastric cancer) whose disease progressed despite ... phase II study of RAD001 for previously treated metastatic gastric cancer. Presented at the American Society ... 23, 2008. (3) Ohtsu, A. Chemotherapy for metastatic gastric cancer: past, present, and future. J ...

New Study First to Confirm Sandostatin LAR(R) Depot Controls Tumor Growth in Patients With Rare Gastrointestinal Tumors

... demonstrated antitumor benefit in patients with metastatic neuroendocrine tumors (NETs) of the midgut, ... efficacy of O ctreotide LAR in patients with metastatic neuroendocrine MID gut tumors). ... also helps control tumor growth in patients with metastatic neuroendocrine tumors of the midgut," said PROMID ...

Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer

... from a Phase 3 study show that patients with metastatic breast cancer who were treated previously with an ... "Anthracyclines are active drugs for metastatic breast cancer, but concerns about cardiac ... be an effective treatment for patients with metastatic breast cancer who have relapsed after prior ...

RAD001 Shows Potential to Reverse Resistance to Herceptin(R)* in Metastatic Breast Cancer Patients, Leading to Phase III Trial

... (trastuzumab)* in women with HER2-positive metastatic breast cancer. These results support the ... growth in 77% of patients with HER2-positive metastatic breast cancer with documented resistance to ... Herceptin-resistant patients with HER2-positive metastatic breast cancer. In the study, RAD001 in ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... and trastuzumab in HER-2-overexpressing metastatic breast cancer with prior resistance to ... trastuzumab in patients with HER-2-overexpressing metastatic breast cancer with prior resistance to ... arthritis and bone fracture. In the metastatic cancer setting, commonly reported side effects ...

Isis Announces That OGX-011 Has Shown Overall Survival Advantage in Prostate Cancer Compared to Standard Therapy in a Randomized Phase 2 Study

... ("the control arm") for first-line treatment of metastatic castrate resistant prostate cancer. The current ... the Phase 2 randomized study in 82 patients with metastatic or locally recurring prostate cancer refractory ... in combination with docetaxel for progressive metastatic prostate cancer. Recently, the FDA confirmed the ...

Vical Signs Binding Letter of Intent for Sales and Marketing of Allovectin-7(R) in Turkey

... of Allovectin-7(R) in patients with advanced metastatic melanoma, we are also looking ahead to ... an immune response against both local and distant metastatic tumors. Vical conducted a large Phase 2 ... a single agent for patients with Stage III or IV metastatic melanoma. Based on advice from clinical experts ...

CuraGen Announces Preliminary Data from Ongoing Phase II Study Showing Clinical Activity of CR011-vcMMAE in Patients with Metastatic Melanoma

... in an ongoing Phase II trial in patients with metastatic breast cancer who have received previous ... data from more frequent dosing in patients with metastatic melanoma and from the Phase II study in patients ... treatment of melanoma and for the treatment of metastatic breast cancer, and in a Phase I trial to ...

BN ImmunoTherapeutics Announces Positive Mature Phase II Results From Newly Acquired Prostate Cancer Vaccine

... a specific, targeted immune response that attacks metastatic cells in the prostate. Conventional chemotherapy ... continuously improved. However, the treatment for metastatic prostate cancer has not been improved in ... agent approved for the treatment of metastatic prostate cancer that extends survival by ~ 2 ...

Bavarian Nordic Announces Positive Mature Phase II Results From Newly Acquired Prostate Cancer Vaccine

... a specific, targeted immune response that attacks metastatic cells in the prostate. Conventional chemotherapy ... continuously improved. However, the treatment for metastatic prostate cancer has not been improved in ... agent approved for the treatment of metastatic prostate cancer that extends survival by - 2 ...

Algeta Reports Positive Headline Phase II Data on Pain Palliation With Alpharadin

... is an important quality of life benefit in metastatic cancer patients. The trial also confirmed ... dose levels of Alpharadin in patients with bony metastatic HRPC. The drug was given by i.v. injection mainly ... dose groups. ALP is a severity marker of bony metastatic disease and of prognostic importance. The study ...

U.S. NCI Starts Enrolment in Phase 2 Systemic Melanoma Clinical Trial with REOLYSIN(R)

... of REOLYSIN(R) in patients with metastatic malignant melanoma, as well as the safety profile ... is expected to enroll up to 47 patients with metastatic melanoma. Approximately 60,000 people are ... administration clinical trial for patients with metastatic melanoma, and the Company's belief as to the ...

Journal of Clinical Oncology Article Highlights CellSearch(TM) Circulating Tumor Cell Test in Treatment of Metastatic Colorectal Cancer

... Netherlands, and the United Kingdom, found that metastatic colorectal cancer patients with fewer than three ... "Obtaining measurements of CTCs for patients with metastatic colorectal cancer beginning a new therapy ... Survival, and Overall Survival in Patients with metastatic Colorectal Cancer," which summarizes data from a ...
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