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Metabolism in Medical Technology

ALP Life Sciences, LLC Announces Nanoveson(TM) Patent Filing and Whitepaper Availability on Proposed Therapy for Non-Alcoholic Fatty Liver Disease (NAFLD) and Comorbid Diseases

... to the life sciences industry in the area of drug metabolism testing. Research has demonstrated that ... research focused on blocking arachidonic acid metabolism along cytochrome P450, leukotriene, ... thromboxane eicosanoid pathways. Arachidonic acid metabolism is implicated in many inflammatory diseases, ...

Bionovo Reports on Metabolic Studies Related to Its Menopausal Hot Flash Drug Candidate

... and Disposition, entitled "Oxidative In Vitro metabolism of Liquiritigenin, a Bioactive Compound Isolated ... clinical testing. The paper describes in vitro metabolism of Liquiritigenin which is almost exclusively ... . "Most adverse drug reactions are linked to metabolism of the drug in the human body. Many women of ...

Embryo Viability Studies Support Utility of Novel, Metabolomic Profiling Technology

... of the same morphology. This indicates that the metabolism of the embryo -- and therefore, its reproductive ... small molecular compounds produced by cellular metabolism which, when evaluated as a whole, represent ... disease), maternal fetal medicine, pulmonary metabolism and edema, and lactate metabolism. ...

New Discovery of Key Difference in Bile Acid Metabolism in Patients with Type 2 Diabetes May Suggest Underlying Disorder

... have discovered a key difference in bile acid metabolism in people with type 2 diabetes which may suggest ... important signaling molecules that regulate the metabolism of glucose, fat, and energy. And until now, there ... data suggesting alterations in bile acid metabolism in people with type 2 diabetes. Now new data ...

Amylin Pharmaceuticals Initiates Phase 2B Dose-Ranging Clinical Study of Pramlintide/Metreleptin Combination Treatment in Obesity

... is a fundamentally important hormone in energy metabolism with a unique role in inducing fat-specific ... a fundamental role in the regulation of energy metabolism and body weight. Amylin acquired exclusive rights ... activities leverage the company's expertise in metabolism to develop potential therapies to treat diabetes ...

Study Results of GAMMAGARD S/D and GAMMAGARD LIQUID in Patients with Mild-to-Moderate Alzheimer's Disease Announced

... of baseline within three to six months). Brain metabolism (Additional, Observational Finding) Dr. Lisa ... S/D and GAMMAGARD LIQUID treatment. "Brain metabolism usually decreases progressively in patients ... The Phase II study also evaluated brain metabolism in patients treated with GAMMAGARD S/D and ...

Isis Reports Preclinical Data Supporting Liver Safety of ISIS 301012

... of ISIS 301012 - Favorable changes in liver fat metabolism associated with apoB inhibition ... led to compensatory changes in liver fat metabolism including reduced fat production and increased ... metabolites are relevant indicators of liver fat metabolism in preclinical studies, Isis plans to incorporate ...

Experimental Drug Ketasyn(TM) Improves Memory in Age-Associated Memory Impairment Study

... symptoms may be related to declines in glucose metabolism in the brain that are also associated with aging. ... source, so aging brains with impaired glucose metabolism require an alternative source of energy. Ketasyn ... evidence of the roles that glucose and insulin metabolism plays in cognition and memory," said Dr. Lauren ...

Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug

... in every cell of the human body where it plays a critical role in cellular metabolism and constitutes the source of energy for all bodily functions. ATP is ... and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of which constitute novel ...

Newly Published Phase III Study Shows Arzoxifene Significantly Increased Bone Mineral Density

... published online this week in the Journal of Clinical Endocrinology & metabolism , showed that arzoxifene, an investigational selective estrogen receptor ... statements. (1) Journal of Clinical Endocrinology and metabolism Web site. April 7, 2009. (2) Cooper C. Epidemiology of Osteoporosis. ...

Sequoia Pharmaceuticals Presents Proof of Clinical Concept of SPI-452, a Novel Pharmacokinetic Enhancer

... Evaluation The ability of SPI-452 to inhibit CYP3A and the metabolism of HIV PIs was assessed using liver microsomes or cryopreserved hepatocytes. In these in vitro studies, SPI-452 inhibited the metabolism of all HIV PIs and one investigational HCV PI tested in human liver ...

Genomas Clinical Study Finds Increased Prevalence of Drug Metabolism Deficiencies in Patients With Serious Psychotropic Side Effects

... were carriers of multiple gene variations associated with no or poor drug metabolism capacity on 2 or 3 genes compared to 36 percent of individuals in the ... "We found clear evidence that there were significantly more innate drug metabolism deficiencies based on the gene variants predominantly observed in the ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... and monitor periodically during therapy. Hepatic impairment metabolism of Tasigna is mainly hepatic. Tasigna has not been investigated in ... a protein that acts as a central regulator of tumor cell division, cell metabolism and blood vessel growth. The safety and efficacy profile of ...

Raptor Pharmaceuticals Corp. Announces Positive Phase IIa Clinical Study Results for Convivia(TM) Program

... of Japanese descent with a history of symptoms of inborn altered ethanol metabolism with concomitant ethanol exposure. At the time of enrollment, study ... is an accumulation of acetaldehyde, a carcinogenic intermediate in the metabolism of ethanol, in blood and tissues. Published retrospective studies have ...

Amylin Pharmaceuticals to Present Novel Data on Promising Obesity Pipeline at 2008 Annual Scientific Meeting of The Obesity Society

... by fat cells that plays a fundamental role in the regulation of energy metabolism and body weight. To date, more than 1,200 overweight or obese individuals ... research and development activities leverage the company's expertise in metabolism to develop potential therapies to treat diabetes and obesity. Amylin is ...

Stem Cell Sciences Announces the Creation of the World's First Authentic Rat Embryonic Stem Cells from its Exclusively Licensed Technology

... Alternatively, the insertion of genes such as those involved in drug metabolism in the human liver means that knock-in models can provide information on ... drug targets. The ability to knock-in human genes should also enable drug metabolism studies to be undertaken with higher predictability in rats than ...

Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling

... systemic endocrine functions, acting as important mediators of glucose metabolism and insulin signaling. The featured article in the current issue of Nature ... receptors (GPCRs) such as TGR5. -- Bile acids play a major role in lipid metabolism and homeostasis. For example, bile acid activation of FXR results in a ...

'Snapshots' of Eyes Could Serve as Early Warning of Diabetes or Diabetic Eye Disease, U-M Researchers Report

... in performing this study was to determine whether we could detect abnormal metabolism in the retina of patients who might otherwise remain undiagnosed based on ... at the U-M Medical School. "FA serves as a 'spectral-biomarker' for metabolism gone awry, and we can use the results to detect and monitor disease." ...

Molecular Biometrics Hires Denny Sakkas, PhD Renowned Yale Embryologist and International Thought-Leader, as Chief Scientific Officer; Opening U.S. Research Facility

... signals from many small molecular compounds produced by cellular metabolism which, when evaluated as a whole, represent unique biomarkers of normal ... disease and Parkinson's disease), maternal fetal medicine, pulmonary metabolism and edema, and lactate metabolism. For more information, please visit ...

Feeling Anxious or Distracted? New Research Shows a Cup of Tea Could Help

... that is involved in cancer cells; -- Tea may play a role in shifting metabolism to favor weight loss and better manage blood sugar levels; -- Tea is ... and fat oxidation. "A few studies have found modest benefits on metabolism from Green Tea extract, but more research is needed before recommending ...

TWO NEW KLRI PEER-REVIEWED PUBLICATIONS: Hormone Therapy May Reduce Atherosclerosis in Women Close to Menopause; Growth Hormone May Increase Risk of Diabetes, Improve Lipid Profile in Men

... Results from this study are not expected for several more years. Another KLRI study, appearing in the Journal of Clinical Endocrinology and metabolism and led by Marc Blackman of the Washington DC VA Medical Center, tests the effects of growth hormone (GH) therapy, both combined with sex steroids ...

Shire Reports Positive Results From First of Three Phase III Trials of velaglucerase alfa for Type 1 Gaucher Disease and Provides Important Updates on Interactions With FDA

... of 1 in 10 (Dr. John Barranger and Dr. Ed Ginns 1989). This panethnic disease involves many organ systems, such as liver, spleen, lungs, brain, metabolism and bone marrow. Gaucher Disease results from a specific enzyme deficiency in the body, caused by a genetic mutation received from both ...

OPAXIO(TM) Combined with Alimta(R) Well Tolerated in Dose-Ranging Study of Patients with Advanced Non-Small Cell Lung Cancer

... the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer cells may be influenced by estrogen, which could lead to enhanced release of paclitaxel and efficacy in women with lung cancer ...

Exenatide Once Weekly Provided Superior Glucose Control Compared to Lantus(R) in Head-to-Head DURATION-3 Study

... development and commercialization of innovative medicines. Amylin's research and development activities leverage the Company's expertise in metabolism to develop potential therapies to treat diabetes and obesity. Amylin is headquartered in San Diego, California. Through a long-standing ...

Shire Receives Fast Track Designation for velaglucerase alfa for Gaucher Disease

... of 1 in 10 (Dr. John Barranger and Dr. Ed Ginns 1989). This panethnic disease involves many organ systems, such as liver, spleen, lungs, brain, metabolism and bone marrow. Gaucher Disease results from a specific enzyme deficiency in the body, caused by a genetic mutation received from both ...

Mayo Clinic Proceedings: A Comprehensive Review of Addiction to Prescription Painkillers Among Patients and Physicians

... and a continual appraisal of the patient's adherence to the treatment. Their colleague, Dr. Smith, stresses the importance of understanding the metabolism of opioids in individual patients. Keen awareness by family and friends of potential addiction is crucial for physicians and other health care ...

Why Do African-Americans Fare Worse With Cancer? Access and Economics Are Only Part of the Story

... M.D., of the Columbia University College of Physicians and Surgeons . "There may be differences in genetic factors by race that alter the metabolism of chemotherapy drugs or that make cancers more resistant or more aggressive," she adds. Hershman published a smaller study last month that ...

Shire has Filed a Treatment Protocol for Velaglucerase Alfa for Gaucher Disease

... of 1 in 10 (Dr. John Barranger and Dr. Ed Ginns 1989). This panethnic disease involves many organ systems, such as liver, spleen, lungs, brain, metabolism and bone marrow. Gaucher Disease results from a specific enzyme deficiency in the body, caused by a genetic mutation received from both ...

Spherix Announces Positive Phase 2 Study Results

... rise of plasma glucose (Yongming Lu, Gilbert Levin, Thomas Donner. Tagatose, a New Anti-Diabetic and Obesity-Control Drug. Diabetes, Obesity and metabolism . 10 , 2008, 109-134.) About Type 2 Diabetes Type 2 diabetes mellitus (T2DM) is a disease that is characterized by elevated blood ...

Covance Announces Integrated Radiolabeled Clinical Pharmacology Studies

... with Food and Drug Administration (FDA) guidance on Metabolites in Safety Testing (MIST). Recent MIST guidance requires earlier human absorption, metabolism and excretion (AME) testing in support of Investigative New Drug/Clinical Trial Application (IND/CTA) submissions. "Integrated human AME ...

Meta-Analysis of Clinical Data Showed No Increased Risk of Cardiovascular Events Associated With Exenatide Use: Data Presented at ADA 2009

... (pramlintide acetate) injection and BYETTA(R) (exenatide) injection. Amylin's research and development activities leverage the Company's expertise in metabolism to develop potential therapies to treat diabetes and obesity. Amylin is headquartered in San Diego, California. Further information about Amylin ...

Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years: DURATION-1 Interim Long-Term Data Presented at ADA 2009

... development and commercialization of innovative medicines. Amylin's research and development activities leverage the Company's expertise in metabolism to develop potential therapies to treat diabetes and obesity. Amylin is headquartered in San Diego, California. Through a long-standing ...

Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer

... the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer cells may be influenced by estrogen, which could lead to enhanced release of paclitaxel and efficacy in women with lung cancer ...

Encouraging First Data on New Targeted Treatment for Patients With Melanoma - the Deadliest Form of Skin Cancer

... and diagnostics. Roche is the world's largest biotech company with truly differentiated medicines in oncology, virology, inflammation, metabolism and CNS. Roche is also the world leader in in-vitro diagnostics, tissue-based cancer diagnostics and a pioneer in diabetes management. Roche's ...

New Phase 3 Study of Tapentadol Immediate Release Tablets Published in Current Medical Research and Opinion Journal

... NUCYNTA(TM), particularly with concomitant use of serotonergic drugs such as SSRIs, SNRIs, TCAs, MAOIs and triptans, and with drugs which impair metabolism of serotonin (including MAOIs). Serotonin syndrome may include mental-status changes (e.g., agitation, hallucinations, coma), autonomic instability ...

RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment Delayed the Time to Relapse in Patients with Bipolar I Disorder

... and features are consistent with NMS. Use Risperdal Consta with caution in patients with conditions and medical conditions that could affect metabolism or hemodynamic responses. (e.g. Recent Myocardial infarction or unstable cardiac disease) Extrapyramidal Symptoms (EPS): The overall incidence ...

Lack of Food Variety Puts Kids With Autism at Risk for Poor Nutrition

... fatty acids are nutritionally important substances considered vital to the normal development of children. Evidence of abnormal fatty acid metabolism in children with autism runs counter to at least one previous study that suggested no difference between normally developing and autistic children. ...

Hyperion Therapeutics Receives Orphan Drug Designation for HPN-100 for the Treatment of Urea Cycle Disorders

... previously granted the designation for the same indication. About Urea Cycle Disorders Urea cycle disorders are inherited, inborn errors of metabolism present in an estimated 1 in 10,000 births in the United States. Patients with urea cycle disorders are deficient in one of the key enzymes that ...

Amylin and Lilly Announce Plans to Develop Pen Device for Exenatide Once Weekly

... (pramlintide acetate) injection and BYETTA(R) (exenatide) injection. Amylin's research and development activities leverage the company's expertise in metabolism to develop potential therapies to treat diabetes and obesity. Amylin is headquartered in San Diego, California. Further information about Amylin ...

Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia

... converts testosterone to DHT, D-3263 is not an inhibitor of this enzyme suggesting that the two agents may act by different means to affect androgen metabolism and prostate hyperplasia. "BPH is a condition that affects a significant number of men, and based on the preclinical data announced today ...
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(Date:7/11/2014)... Mineral Research awarded Michael F. Holick, PhD, MD, of ... Louis V. Avioli Award. Holick, a professor of medicine, ... revolutionizing the understanding of vitamin D and its role ... member of the American Society for Bone and Mineral ... basic research. It is named for ASBMR,s first president ...
(Date:7/11/2014)... 10, 2014---A team of researchers from The Chinese University ... a gene of wild soybean linked to salt tolerance, ... in saline soil. This study published online in ... novel genomic information for crop improvement. , Soybean is ... and human selection, cultivated soybeans have less genetic diversities ...
(Date:7/11/2014)... July 11, 2014 Researchers have pioneered ... images. The new technology, called Virtual Finger, allows ... structures like neurons and synapses using the flat ... technology makes 3D imaging studies orders of magnitude ... an unprecedented level across many areas of experimental ...
Breaking Biology News(10 mins):BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2BGI reports a novel gene for salt tolerance found in wild soybean 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
(Date:7/13/2014)... 2014 Epidemiologists forecast an increase in ... from 8,062 diagnosed incident cases in 2013 to 11,568 ... Rate (AGR) of 4.35%, during the forecast period. In ... diagnosed incident cases of aGVHD in the 6MM, with ... lowest number of diagnosed incident cases of aGVHD, with ...
(Date:7/13/2014)... ability to identify odors might indicate the development ... of the eye could indicate the build-up of ... brain, according to the results of four research ... Conference 2014 (AAIC 2014) in Copenhagen. , In ... identify odors was significantly associated with loss of ...
(Date:7/13/2014)... Wright & Schulte LLC has learned that ... July of 2015, in U.S. District Court, District of ... discovery process in the South Carolina federal court ... the multidistrict litigation (MDL). The complaints pending in the ... allege that they took the statin medication to lower ...
(Date:7/13/2014)... Celebrity fitness trainer and former World ... partnership with Aqua Health Labs for their flagship product ... . The collaboration was recently announced live on ESPN ... , actor, model, and a two time World Super ... he has prepared stars including Demi Moore, Hilary Swank ...
(Date:7/13/2014)... Hope Palliative & Hospice Care announced today that ... the Tamarack Senior Living Community in Palatine, IL. The group, ... the 3rd Wednesdays of every month. This group will ... located at 55 S. Greeley St. Palatine, IL 60067. ... no cost for the group. , “A grief support ...
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