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Metabolic in Medical Technology

FDA Advisory Committee Votes in Favor of SAPHRIS(R) (asenapine) for Acute Bipolar I Disorder and Acute Schizophrenia

... demonstrated efficacy combined with an attractive metabolic safety profile. SAPHRIS has the potential to ... either poor tolerability or incomplete efficacy. metabolic safety, including weight gain, elevation of lipid ... to lack of efficacy or side effects, including metabolic side effects. Poor tolerability frequently leads ...

Cardax Pharmaceuticals Nominates Clinical Candidate Heptax for Liver Disease; Heptax Ameliorates Inflammation and Oxidative Stress Related to Liver Disease and Metabolic Syndrome

... stress are the mechanistic underpinnings of metabolic syndrome. The Cardax lead compound is a ... dietary carotenoid astaxanthin that addresses metabolic syndrome, including liver and cardiovascular ... of liver and cardiovascular disease as well as metabolic syndrome." "Our novel derivative of the ...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... Sanjay Bhanot, M.D., Ph.D., Vice President of metabolic Disorders and Head of Translational Medicine at ... approach for the treatment of obesity and related metabolic disorders. "We are looking forward to expanding our metabolic disease pipeline by adding antisense drugs to ...

Essentialis Meets Primary Endpoint in Phase 2b Trial of DCCR for Treatment of Hypertriglyceridemia and is Granted Extensive Patent Coverage in the US

... potential utility in several cardiovascular and metabolic diseases. Extensive Phase 1 testing and ... medicines for the treatment of cardiovascular and metabolic diseases. The company's portfolio of products is ... to impact a wide range of cardiovascular and metabolic diseases. The company's lead product has ...

Metabolic Solutions Development Company Announces Preliminary Results from Phase IIa Clinical Trial

... KALAMAZOO, Mich., May 14 /PRNewswire/ -- metabolic Solutions Development Company (MSDC) announced ... that this compound can deliver significant metabolic benefit without some of the complications ... health care professionals as an epidemic. metabolic Solutions Development Company ( ...

Isis and Collaborators Present New Research at the ATVB Annual Conference

... of apolipoproteinC-III mitigated features of metabolic syndrome and reduced atherosclerosis in LDL ... that inactivates steroids and may contribute to metabolic disease, suggesting the potential therapeutic ... disease, including severe neurodegenerative and metabolic diseases, and cancer." ABOUT ISIS ...

Diabetes Patients with High Triglycerides and Low HDL Cholesterol Get the Most Benefit From Fenofibrate Treatment: New Data From the FIELD Study

... to 1.7 mmol/L-150mg/dL ) are key criteria of the metabolic syndrome according to the old definition of the ... in type 2 diabetes patients with and without the metabolic syndrome. It also examined the effect of more ... 31%, P=0.0002).(6, 7) What is the metabolic syndrome? ...

Cerenis Therapeutics In-Licenses Intellectual Property for New Treatment of Aortic Valve Stenosis

... compounds for the treatment of cardiovascular and metabolic diseases, today announced that it has in-licensed ... therapies for the treatment of cardiovascular and metabolic diseases. Based on pioneering research conducted ... in the treatment of cardiovascular and metabolic diseases. Cerenis has operations in Ann Arbor, ...

Genaera Presents Promising Preclinical Data for Trodusquemine (MSI-1436) at Keystone Symposia

... of MSI-1436 (Trodusquemine) on Body Weight and metabolic Profile in Diet-Induced Obese Rats" concluded ... reductions across a wide range of clinical and metabolic outcomes associated with both obesity and ... demonstrated significant weight loss without metabolic rebound, which often limits sustained weight loss ...

Epidemics of Both Type 1 Diabetes (Insulin Dependent) and Type 2 Diabetes (Obesity Related) Are Linked to Immunization

... Classen published this week in Diabetes & metabolic Syndrome: Clinical Research & Reviews ... there is a global epidemic of type 2 diabetes and metabolic syndrome. "The picture is becoming ... 1 diabetes but they are causing an epidemic of metabolic syndrome as the immune system acts to suppress ...

Genomas Clinical Study Finds Increased Prevalence of Drug Metabolism Deficiencies in Patients With Serious Psychotropic Side Effects

... because their common variants result in deficient metabolic capacity for many psychotropic drugs. ... Individuals that are multiply deficient in CYP450 metabolic routes are at risk for developing serious side ... for DNA-guided diagnosis and prevention of metabolic disorders induced by drugs in cardiovascular and ...

Concord Grape Juice Has No Significant Impact on Body Weight

... on body weight, diet quality, and markers of metabolic syndrome. The study included 76 men and women ... a beneficial effect on one of the markers of metabolic syndrome. There were no changes in other markers of metabolic syndrome, including cholesterol, triglyceride, ...

Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling

... with Potential Applications in Treating metabolic Diseases NEW YORK, Aug. 7 /PRNewswire/ -- ... 2 diabetes, atherosclerosis and other chronic metabolic disorders such as nonalcoholic steatohepatitis. ... Schoonjans, include: -- Bile acids serve as metabolic integrators, activating major signaling pathways ...

Genaera Releases Phase 1 Data and New Preclinical Data on the CNS Function of Trodusquemine (MSI-1436) at CBI Obesity Summit

... Values for a wide range of endocrine and metabolic biomarkers as well as evaluations of mood and ... variety of animal models and appears to overcome metabolic readjustment, which often limits sustained weight ... focused on advancing the science and treatment of metabolic diseases. The Company has significant market ...

'Snapshots' of Eyes Could Serve as Early Warning of Diabetes or Diabetic Eye Disease, U-M Researchers Report

... FA imaging, invented at U-M, measures metabolic stress in retina ANN ARBOR, Mich., July 14 ... and Visual Sciences at U-M Medical School. metabolic stress, and therefore disease, can be detected by ... company, OcuSciences, Inc., to commercialize the metabolic imaging instrument. Reference: "Rapid, ...

Metabolex Completes Patient Enrollment in Phase 2 Trial of MBX-8025 for Treatment of Dyslipidemia

... of proprietary new medicines for the treatment of metabolic diseases, announced today that it has completed ... and body weight and composition. metabolic parameters, including glucose and insulin levels ... treating the constellation of symptoms known as metabolic syndrome. About Metabolex Metabolex is a ...

Isis Highlights Robust Drug Portfolio for Diabetes and Obesity at ADA Conference

... significant activity in eight new metabolic disease targets utilizing antisense SAN ... targets that offer new mechanisms to treat metabolic diseases. The nine presentations (including two ... Sanjay Bhanot, M.D., Ph.D., Vice President of metabolic Diseases Research & Development of Isis ...

New Discovery of Key Difference in Bile Acid Metabolism in Patients with Type 2 Diabetes May Suggest Underlying Disorder

... 2 diabetes which may contribute to the observed metabolic behavior, and further, that treatment with a bile ... are "on mechanism" or are acting upon specific metabolic pathways that are the basis for ... that mediate disease: cardiovascular disease, metabolic disease, neurodegenerative diseases and disease ...

NAFLD AND NASH Linked to Metabolic Syndrome and Cardiovascular Disease

... steatohepatitis (NASH), are associated with the metabolic syndrome and pose an increased risk ... for liver transplantation. In turn, the metabolic syndrome is a combination of risk ... association between NAFLD, NASH, and the metabolic syndrome is a great cause for concern because ...

Lotrel, a Single-Pill Combination for Treating High Blood Pressure, Reduced Cardiovascular Events by 20% in High-Risk Patients

... Novartis: strength in cardiovascular and metabolic diseases Novartis is focused on improving the ... people with diseases of the cardiovascular and metabolic systems. As a global leader and innovator in cardiovascular and metabolic health, Novartis provides novel therapies and ...

Update on Progression of Phosphagenics and Nestle Nutrition's Phospha E(R) Trial

... Phosphagenics' Phospha E(R) in the management of metabolic syndrome is advancing at three sites in ... many of the key biomarkers associated with metabolic syndrome. metabolic syndrome is characterized by a group of risk ...

Joslin Study Identifies Key Factor That Links Metabolic Syndrome; Finding May Help Millions at High Risk of Cardiovascular Disease

... in the liver as a key factor in the cause of metabolic syndrome and its associated atherosclerosis, ... not only an understanding of how metabolic syndrome occurs, but also pinpoint a target for ... true insights into the role of the liver in the metabolic syndrome and provides guidance for future ...

DiObex, Inc. Awarded Patent for the Prevention of Insulin-Induced Hypoglycemia

... company developing treatments for metabolic diseases, announced today that it has secured a ... portfolio protecting its product candidates for metabolic diseases. In addition to the recently issued U.S. ... developing novel products for diabetes and metabolic diseases. DiObex has two product candidates in ...

Medpace Opens Clinical Pharmacology Unit in Cincinnati, Ohio

... CPU will uniquely focus on studies in defined metabolic patient populations. The company's ... with a strategic partnership with the renowned metabolic and Atherosclerosis Research Center (MARC) led ... diabetics (Types I and II), patients with metabolic syndromes and cardiovascular diseases. The ...

Ambrx Enters FGF-21 Type 2 Diabetes Drug Discovery Collaboration with Merck and Co. Inc.

... for the treatment of type 2 diabetes and related metabolic disorders such as obesity. The collaboration ... this agreement with Merck, a world leader in the metabolic diseases field with a proven track record in the ... our portfolio of products for people with metabolic disorders." The transaction includes an initial ...

Vital Therapies Announces Presentation of ELAD(R) 'Artificial Liver' Data at American Association for the Study of Liver Diseases 2007 Annual Meeting

... was a poster presentation detailing the metabolic characteristics of the ELAD(R) cartridges in ... Device) The ELAD(R) system provides important metabolic support for patients with liver failure, enabling ... liver cell-based system which provides important metabolic support for patients with severe liver failure. ...

Genaera Corporation Provides Highlights of Positive Phase 1 Trodusquemine (MSI-1436) Data from the North American Association for the Study of Obesity Annual Meeting

... Values for a wide range of endocrine and metabolic biomarkers as well as evaluations of mood and ... bridge the treatment for two of the most serious metabolic diseases, type 2 diabetes and obesity. ... of animal models and appears to overcome metabolic readjustment, which often limits sustained weight ...

The Quigley Corporation Reports Third Quarter Results, Increases Investment in Pharmaceutical R&D for Diabetic Neuropathy

... on patients suffering from metabolic Syndrome, a condition which inhibits normal metabolic processes. metabolic Syndrome sufferers are vulnerable to dangerous ...

Genaera Corporation Presents Phase 1 Data for Trodusquemine (MSI-1436) at the North American Association for the Study of Obesity Annual Meeting

... bridge the treatment for two of the most serious metabolic diseases, type 2 diabetes and obesity. ... of animal models and appears to overcome metabolic readjustment, which often limits sustained weight ... focused on advancing the science and treatment of metabolic diseases. The Company has significant market ...

Genaera Corporation Presents Preclinical Trodusquemine (MSI-1436) Data at the North American Association for the Study of Obesity Annual Meeting

... bridge the treatment for two of the most serious metabolic diseases, type 2 diabetes and obesity. ... of animal models and appears to overcome metabolic readjustment, which often limits sustained weight ... focused on advancing the science and treatment of metabolic diseases. The Company has significant market ...

Nestle Nutrition and Phosphagenics to Commence Phospha E(R) Phase 2 Clinical Trial

... Phosphagenics' Phospha E(R) in the management of metabolic syndrome. Ethics approval has been obtained to ... 2 clinical trial, which will commence shortly. metabolic syndrome is characterized by a group of risk ... of the key biomarkers associated with metabolic syndrome, inflammation and cardiovascular ....

Isis Earns $5 Million Milestone Payment From Ortho-McNeil, Inc. for Initiation of Phase 1 Study of ISIS 325568

... represent novel approaches for the treatment of metabolic disease. ISIS 325568 was designed to ... are focused on treating cardiovascular and metabolic diseases. Isis' partners are developing drugs for ... and development of drugs for diabetes and metabolic diseases, and the therapeutic potential of ISIS ...

Metabolex Begins Phase 2 Trial of MBX-8025 for Treatment of Dyslipidemia

... of novel therapeutics for diabetes and related metabolic disorders, announced today that it has begun a ... triglycerides and body weight and composition. metabolic parameters, including glucose and insulin levels, ... transform the treatment of diabetes and related metabolic disorders. Metabolex has drawn on its deep ...

Isis Initiates Phase 1 Study of ISIS 325568 Targeting Glucagon Receptor to Treat Type 2 Diabetes

... *Isis Now Has Two Drugs From Its metabolic Disease Program In Clinical ... Sanjay Bhanot, M.D., Ph.D., Vice President of metabolic Diseases Research & Development, Isis ... are focused on treating cardiovascular and metabolic diseases. Isis' partners are developing drugs for ...

The Heart, Diabetes, And Weight Loss Centers of New York Introduce the New Science of Metabolic Diagnosis and Weight Management

... weight management, and diabetes, introduces his metabolic diagnosis and weight management system. The first phase of the metabolic diagnosis and weight management system (MD/WM) ... (2) The calorimetry determines the body's basal metabolic rate or resting energy expenditure and ...

Sarasota's Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes

... mechanism for the development of obesity and the metabolic syndrome, which are the forerunners of type 2 ... the study, this can then lead to obesity and the metabolic syndrome, the precursors of type 2 diabetes. ... study and devise treatments for obesity and the metabolic syndrome. "We are particularly excited about ...

Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference

... for the Treatment of Obesity and Related metabolic Disorders," during the IBC 12th Annual World ... bridge the treatment for two of the most serious metabolic diseases, obesity and type 2 diabetes. In ... variety of animal models and appears to overcome metabolic readjustment, which often limits sustained weight ...

Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009

... highlighted new antisense therapeutic programs and targets to treat metabolic diseases, including obesity, at the American Diabetes Association (ADA) ... Isis' drug development programs are focused on treating cardiovascular, metabolic and severe neurodegenerative diseases and cancer. Isis' partners are ...

Debiopharm Group and Mercury Therapeutics, Inc. Sign an Exclusive License Agreement for the Development and Commercialisation of Debio 0930

... monophosphate activated protein kinase) for the treatment of diabetes and metabolic diseases. Activation of AMPK has been shown to lower fasting blood glucose ... and of the growing appreciation of AMPK as a novel drug target for metabolic diseases. The development of an orally available direct activator of AMPK ...

Reliv International's GlucAffect(TM) Proven Effective in Clinical Study

... Elevated weight and blood glucose levels are key factors in metabolic syndrome, which dramatically increases the likelihood of developing ... to the American Heart Association, nearly 1 in 4 American adults have the metabolic syndrome. The participants consumed GlucAffect or a placebo ...
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