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OPAXIO(TM) Combined with Alimta(R) Well Tolerated in Dose-Ranging Study of Patients with Advanced Non-Small Cell Lung Cancer

... (pemetrexed) was well tolerated and resulted in median progression-free survival of 3.3 months. ... grade 3 or greater nonhematologic toxicities. A median of 4.5 cycles was delivered in each cohort. ... patients were alive at time of data presentation. median progression free survival was 3.3 months. ...

Afinitor(R) Phase II Data Show Positive Results for Patients With Multiple Types of Lymphoma, Leading to Phase III Trial

... shrinkage (95% confidence interval: 26-41%). The median time to disease progression for all 145 patients was 4.3 months (95% CI; 3.6-5.9 months) and the median duration of response for the 48 responders was ... despite prior treatment. Patients had received a median of four prior therapies (between one and 15 ...

Medivation Announces Positive New Efficacy Data From Phase 1-2 Trial of MDV3100 in Advanced Prostate Cancer Patients

... cell (CTC) counts. New findings include the median time to PSA progression, which was 6.1 months for post-chemotherapy patients, with the median time not yet reached for chemotherapy-naive patients. In addition, the median time to radiographic progression was 6.6 months ...

CuraGen Updates CR011-vcMMAE Data at ASCO

... on expression of GPNMB in patients' tumors. The median number of prior chemotherapy regimens for ... observed in 34 evaluable patients, and median duration of response of 5.3 months. The median overall progression-free survival (PFS) was 4.4 ...

Pixantrone Produces High Rates of Complete and Partial Remissions Even Among Aggressive NHL Patients With Extensive Prior Doxorubicin Treatment or Prior Rituximab Treatment

... vincristine and prednisone) therapy. The median prior exposure of these patients, most of whom ... median mg/m2 median mg/m2 1 68 ...

Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

... due to a new malignancy on day 6. The median prior treatment regimens was two, with prior ... grade 3/4 adverse events. Best response and median time to progression of capecitabine + perifosine ... N CR PR ORR Wks CBR median TTP N(%) N(%) N(%) ...

Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

... due to a new malignancy on day 6. The median prior treatment regimens was two, with prior ... grade 3/4 adverse events. Best response and median time to progression of capecitabine + perifosine ... CR PR ORR SD > 12 CBR median TTP N(%) N(%) N(%) ...

Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer

... N PR SD > 12 wks CBR* median PFS N (%) N (%) ... with Stable Disease or Partial Response The median PFS for all 46 patients was 12.5 weeks [95% CI (11.9, 19)]. The median overall survival has not been reached with 33 of ...

New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)

... OTC(R) 40 mg (20 mg X 2), did not alter the median time it took for maximum plasma concentration of ... resulted in a nearly 45 percent reduction in the median time to reach maximum plasma concentrations of ... When ADDERALL XR was administered alone, the median time to maximum plasma amphetamine concentration ...

TYRX Presents Early Clinical Results from AIGISRX(TM) Antibacterial Envelope Retrospective Registry

... with a mean follow-up period of 59 days and a median follow-up of 32 days. Noting that De Oliveira et al.(1) report the median time to CRMD infection as 14 days, and Klug et al.(2) reported a median time to infection of 52 days, the preliminary ...

Men Treated for Localized Prostate Cancer Could Benefit From Pomegranate Juice Consumption

... active patients who remain on the study have a median total follow-up of 56 months. These participants ... at baseline to 60 months post-treatment, with a median PSA slope decrease of 60 percent, 0.06 to 0.024. ... PSA doubling time prolongation and the decline in median PSA slope were greater in active patients when ...

ANA598 Demonstrates Potent Antiviral Activity at all Dose Levels in Completed Phase Ib Study in Hepatitis C Patients

... in rapid and sustained reductions in HCV RNA with median reductions at end of treatment (Day 4) exceeding ... dose levels. At 200 mg bid (twice-daily), the median viral load reduction was 2.4 log10 (range of 0.4 ... 2.2 to 3.4). Genotype 1a patients demonstrated median reductions of 1.4 log10, 1.8 log10, and 2.5 log10 ...

Hana Biosciences Announces New Positive Interim Efficacy Results in Pivotal rALLy Clinical Trial of Marqibo in Acute Lymphoblastic Leukemia

... - 31% COMPLETE RESPONSE RATE - median SURVIVAL OF 10.5 MONTHS IN COMPLETE RESPONDERS ... full blood count recovery (CRi). The estimated median overall survival (OS) in responders was 10.5 ... the nine CRs were still alive at that time, the median OS in this group may prove to be longer. ...

Keryx Biopharmaceuticals, Inc. Reports Updated Phase 1/2 Data on KRX-0401 (Perifosine) in Combination with Bortezomib (+/- Dexamethasone) at the 12th International Multiple Myeloma Meeting

... 73 patients were evaluable for response. median prior lines of therapy was 5 (range 1 - 13), ... relapsed on a bortezomib-based treatment had a median time to progression (TTP) of 8.5 months. The median TTP for all 73 evaluable study patients (both ...

Data from Phase 2 Study of Peramivir in Patients Hospitalized with Influenza Presented at the XI International Symposium on Respiratory Viral Infections

... stability, the primary endpoint, showed a median of 23.7 hours for peramivir 200 mg, 37.0 hours ... from baseline in viral titer) was reduced by a median of -2.0 logs for peramivir 200 mg, -2.1 logs for ... Patients were discharged from hospital after a median of 4.0 days for peramivir 200 mg, 3.8 days for ...

Update of Long-Term Data on Brain Cancer Patients Receiving DCVax(R)-Brain Continues to Show Striking Improvements in Delay of Disease and Survival

... and chemotherapy) without DCVax(R)-Brain have a median survival of only 14.6 months, and less than 5% of ... patients have lived longer than the median survival of 14.6 months with existing standard of ... progression (recurrence) for longer than the median progression free survival of 6.9 months ...

ANA598 Demonstrates Potent Antiviral Activity in an Early Clinical Study in HCV-Infected Patients

... ongoing Phase Ib trial demonstrated a 2.5 log10 median viral load decline after three days ... days. At the end of the treatment period, the median viral load decline was 2.5 log10 (>99%), with ... ANA598 were genotype 1a and demonstrated a median viral load decline of 1.6 log10, while five ...

Keryx Biopharmaceuticals, Inc. Reports Phase 1/2 Data on KRX-0401 (Perifosine) at 50th Annual Meeting of American Society of Hematology

... and 66 patients in the Phase II component). median prior lines of therapy was 5 (range 1 - 13), ... to 4 cycles median TTP for all study patients was 6.3 months. median TTP for responding patients has not yet been ...

Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL

... doses of Campath three times per week. After a median follow-up time of 37.9 months, the study found an ... of 30 percent among the total patient population. median PFS time was 7.7 months, and median OS time was 19.1 months. "These ...

Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma

... analysis was presented at ASH 2007. Data with a median follow up of 25.9 months were presented at this ... with the MP arm (hazard ratio =0.644, p=0.0032; median survival not yet reached in either arm). ... VcMP arm. Patients remained on VcMP therapy for a median of 46 weeks (eight cycles) out of the planned ...

Alexion Reports Positive Results from AEGIS Registration Study of Soliris in Japanese Patients With PNH

... dehydrogenase (LDH), decreased 86 percent from a median of 1,814 U/L at baseline to a median of 244 U/L following 12 weeks of treatment ... treatment (P<0.001 for the pre-specified median change). Transfusion independence was ...

Sunesis Pharmaceuticals Announces Presentation of Voreloxin Clinical Data in Patients with Acute Myeloid Leukemia at the 50th Annual Meeting of the American Society of Hematology

... chemotherapy. In Schedule A, 29 patients with a median age of 75 were enrolled and treated with 72 ... blast reductions to less than 5 percent. The median duration of response for patients achieving a CR ... is generally a disease of older adults and the median age of a patient diagnosed with AML is about 67 ...

Novel Therapeutic Approaches May Transform Treatment and Improve Patient Outcomes in Several Platelet Disorders

... and high-dose arms, respectively. The median number of red blood cell transfusions (usually ... with those in the placebo arm. While baseline median platelet counts were 16,000 microliters in both ... in the placebo group. This is in contrast to median platelet counts rising to 36,000 microliters in ...

GSK Reports PROMACTA(R) (eltrombopag) Significantly Increased Platelet Counts and Reduced Bleeding in Long-Term Study of Patients With Chronic ITP

... Throughout the study, the median platelet count in the placebo group ... in the PROMACTA arm experienced a rise in their median platelet count to 36,000/microliters, with median platelet levels subsequently ranging from 52,000 ...

Isis Announces That OGX-011 Has Shown Overall Survival Advantage in Prostate Cancer Compared to Standard Therapy in a Randomized Phase 2 Study

... prostate cancer. The current 10.6 month median overall survival advantage observed in the OGX-011 arm represents an increase over the median survival observed in the control arm. OGX-011 ... cancer refractory to hormone therapy showed a median survival of 27.5 months for the patients in the ...

Dramatic JUPITER Findings Fail to Sway Prescribing Behavior, Poll Shows

... taken daily for just under two years reduced median LDL cholesterol to 55 mg/dL, down from a median of 108 mg/dL, and median hs-CRP (high-sensitivity C-reactive protein), a ...

New Findings Show Efficacy of REMICADE(R) Compared With Azathioprine in Treatment of Crohn's Disease According to First-of-its Kind Study

... enrolled in SONIC were male and patients had a median age of 34-years-old, median weight of 70 kg, median disease duration of 2.3 ...

RAD001 Combined with Sandostatin LAR(R) Depot and as Monotherapy Controls Growth of Rare Pancreatic Neuroendocrine Tumors

... unknown response. Responses were maintained for a median of 10.6 months (8.3-N/A). Further, the results demonstrate PFS of 9.3 months. median overall survival had not been reached at the time ... the results demonstrate PFS of 12.9 months. median overall survival had not been reached at the time ...

Long-Term Phase I and Phase I/II Trial Data Continue to Show Striking Improvement in Survival of Brain Cancer Patients Who Receive DCVax(R)-Brain

... surviving as long as 8 years to date. The median survival in the patients from these trials is now ... defining this standard of care achieved a median time to progression of 6.9 months and a median overall survival of 14.6 months (Stupp, et. al., ...

New Data Shows Prescription Omega-3 Acid Ethyl Esters Reduced the Incidence of Death in Heart Failure Patients

... (3,494 patients) or placebo (3,481 patients). median age of study participants was 67 years and 42 ... reasons. Patients were followed for a median of 3.9 years. Results from the study showed that ... LOVAZA also resulted in an increase in LDL-C by a median of 45%, from ...

BRIDION(R) (sugammadex) Injection - First and Only Selective Relaxant Binding Agent - Approved in European Union

... is needed. In BRIDION clinical studies, the median time to reversal of rocuronium was about three ... reversal regimen. In the SIGNAL trial, the median time to reversal of muscle relaxation to ... plus glycopyrrolate. In the AURORA trial, the median time to reversal of muscle relaxation to a TOF ...

CryoCath Arctic Front(R) Results Published in JACC

... only one procedure with Arctic Front upon a median follow-up time of 12 months. "As we continue to ... applicability of Arctic Front cryoablation. The median number of applications per vein was 2.8 and the median total procedure time was 170 minutes confirming ...

BioNumerik Pharmaceuticals Observes Evidence of a Survival Increase in Lung Cancer Patients Participating in Tavocept(TM) Clinical Trial

... chemotherapy - median survival increase of 6.5 months seen for patients ... patients in the chemotherapy only group. The median survival time for all non-small cell lung cancer ... participating in the Japan Tavocept Trial, the median survival time observed for patients receiving ...

Study Shows Use of AdvanDx's PNA FISH(TM) Test was Associated with an 82% Reduction in Intensive Care Unit Mortality Rates from Staphylococcus aureus Bloodstream Infections

... group vs. 56% for UC group -- 67% reduction in median antibiotic use after notification of results; median of 1 day for NPF group vs. 3 days for UC group -- 100% reduction in median antibiotic use for CoNS patients ...

Results Published in the Journal 'Cancer' Demonstrate that Oral Talactoferrin Alfa is Active as Monotherapy in Previously Treated Patients with Metastatic Renal Cell Carcinoma

... of partial responses and an apparent increase in median PFS and median overall survival (OS) relative to ... rate was 75%. The median PFS was 6.4 months. The median overall survival (OS) was 21.1 months, and the 1 ... RCC is metastatic, it is difficult to treat, and median survival is between one and two years. A number ...

Journal of Clinical Oncology Publishes Leukine(R) Study Demonstrating Positive Survival Outcomes in Patients with High-Risk Melanoma

... that Leukine(R) (sargramostim) demonstrated a median overall survival of 65 months and increased ... cell analysis. Results showed that the median overall survival was 65 months (95 percent, CI 43-67 months). median recurrence-free survival was 5.6 months (95 ...

Vion Pharmaceuticals Announces Presentation of Data of Cloretazine(R) (VNP40101M) in Elderly Patients with High-Risk Myelodysplastic Syndromes at the EHA Annual Meeting

... (FAB) Group criteria. The median age of the patients in the subset was 71 years ... of the 10 responders received consolidation. The median (range) of overall survival for the entire patient group was 3.4 months (0.6-28.6) and the median (range) of overall survival for responders was ...

Phase 1/2 Trial of Motexafin Gadolinium Plus Antibody Targeted Radiation Therapy Demonstrates High Complete Response Rate in Patients With Non-Hodgkin's Lymphoma

... with a 64 percent complete response rate and a median time to progression of 14 months. Adverse events ... whole brain radiation therapy (WBRT) improved the median time to neurologic progression from 10.0 months ... alone produces a 15% complete response rate with median time to tumor progression of about seven months ...

Ipilimumab Plus Chemotherapy is Associated with Prolonged Survival and Increased Disease Control Rates in Patients with Advanced Melanoma

... defined progressive disease (4.4 years). The median OS for patients treated with ipilimumab ... with data in medical literature, in which median OS ranges from 6 to 9 months for patients with ... was 21.6%, or 8 of the 37 patients, with median OS of 12 months. Ipilimumab is being developed ...

New Data Show TORISEL Improves Progression-Free Survival for Patients With Relapsed/Refractory Mantle Cell Lymphoma

... a statistically significant improvement in median progression-free survival (PFS), compared ... is the only renal cancer therapy proven to extend median overall survival compared with interferon-alpha ... objective response rate and overall survival. median PFS for patients treated with TORISEL 175 mg/75 ...
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