Discovery of Marker for Colon Stem Cells Could Shed Light on What Drives Tumor Growth

... that aldehyde dehydrogenase 1 (ALDH1) is a marker for identifying and isolating colon stem cells is ... because it had previously been identified as a marker for leukemias, brain cancers, and breast cancer. ... researchers found that ALDH1 is a more specific marker for colon cancer stem cells than are other ...

Panacea Pharmaceuticals Announces Issuance of a U.S. Patent Covering Anti-HAAH Antibodies

... in early 2009. HAAH is a cancer molecular marker that has been detected by immunohistochemical staining in a broad range of cancers; this marker was originally discovered at the Rhode Island ... drug target for cancer therapy as well as a marker for cancer diagnosis. HAAH over-expression has ...

Markers in Blood and Spinal Fluid, and a New Imaging Agent, Show Promise for Early Detection of Alzheimer's

... test for Alzheimer's disease." Spinal Fluid marker Tracks Brain Amyloid, May Identify ... AB42 in cerebrospinal fluid (CSF) is an effective marker for determining the presence of amyloid in the brain as assessed by PET scans using a marker called Pittsburgh Compound B (PIB). In a new ...

New Data Showed ACTOS(R) (pioglitazone HCl) Prevented Progression of Atherosclerotic Plaque Volume in Patients With Type 2 Diabetes

... population using IVUS, a unique marker for coronary atherosclerosis CHICAGO, March 31 ... of plaque build-up in the coronary arteries, a marker of coronary atherosclerosis. The data are ... neck arteries. CIMT is an established surrogate marker of atherosclerosis. The CHICAGO ...

Prometheus Announces New Findings Regarding Patients at Risk for Celiac Disease at DDW

... new findings regarding a correlation between an important serologic marker used in the detection of Crohn's disease and particular genetic markers in ... the sensitivity of the test by more than 25% when compared to single marker sensitivity values. About Celiac Celiac disease is an ...

Pistachios Offer Protective Benefits Against Heart Disease, Type II Diabetes and Obesity

... suggest that nut consumption is linked to a lower body mass index - a marker for overweight and obesity, and pistachios are thought to provide a high ... on each diet intervention, researchers measured the subjects' HbA1c (a marker of blood sugar control over the previous three months) as well as blood ...

Newly Published Phase III Study Shows Arzoxifene Significantly Increased Bone Mineral Density

... -1.1%, p<1.001). Arzoxifene significantly decreased biochemical marker of bone resorption C-terminal cross-linking telopeptide of type I collagen ... -30.01 percent, placebo 3.79 percent; p<0.001); and biochemical marker of bone formation serum N-terminal propeptide of type I collagen (PINP, ...

Phase III Trial Showed Investigational Compound Arzoxifene Was Superior to Evista(R) (raloxifene HCl) in Increasing BMD in Postmenopausal Women with Osteoporosis

... (p<0.05 for all comparisons): CTX (biochemical marker of bone resorption); -40.6 percent vs. -29.8 percent PINP (biochemical marker of bone formation) : -41.5 percent vs. -30.8 percent ...

FDA Submission of B-R-A-H-M-S MR-proANP Kryptor

... emergency rooms the study demonstrated MR-proANP to be a highly useful marker for diagnosing congestive heart failure. Furthermore it provides ... of B-R-A-H-M-S AG, markets Procalcitonin(R), the company's FDA-cleared marker for sepsis. The B-R-A-H-M-S PCT sensitive Kryptor(R) test enables ...

Gene Marker May Improve Odds of Stem Cell Therapies for Disease

... -- A single tumor-suppressor gene may provide a unique marker for senescence in Mesenchymal stem cells (MSCs) in vitro, while also ... of Rb2 during senescence raises the possibility it may provide an early marker of the process," said co-author Umberto Galderisi, a Professor at the ...

Gene Abnormality Found to Predict Childhood Leukemia Relapse

... of treatment failure. By using a molecular test to identify this genetic marker in ALL patients, physicians should be better able to assign patients to ... treatment intensity appropriately, but until now there has been no good marker for predicting outcome. "Great progress has been made in recent years ...

Insmed Announces First Human Bioequivalence Data for a Follow-on Biologic by a U.S. Company

... were identical. Absolute neutrophil count, the primary pharmacodynamic marker for G-CSF products, exhibited the same response profile to dosing with ... indistinguishable. Absolute neutrophil count, the primary pharmacodynamic marker for G-CSF products, exhibited the same response profile to dosing with ...

Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting

... effect of SB-509 on nerve regrowth. This test is a very sensitive marker of DN severity and may provide an important mechanistic marker for efficacy. Phase 2 study of SB-509 for moderate to severe DN ...

The Largest Ever Study of Diabetes Shows Intensive Glucose Control Reduces Serious Complications

... evidence as we have now shown that reducing the haemoglobin A1c level (a marker of blood glucose control) to 6.5% is a safe and effective way to reduce ... and 30% reduction in the development of proteinuria, a well established marker of increased cardiovascular risk. - Achieved a positive trend towards ...

Vermillion Receives Award From the Society of Gynecologic Oncologists

... Poster Award for its abstract, "Prospective independent validation of a marker panel for distinguishing benign from malignant pelvic masses." The ... University of Texas M.D. Anderson Cancer Center -- Validation of a marker Panel for Distinguishing between Benign and Malignant Pelvic Masses ...

Exelixis Initiates Phase 1/2 Trial of XL184 in Patients With Non-Small Cell Lung Cancer

... with MTC experienced a rapid decrease in plasma levels of calcitonin, a marker frequently elevated in MTC, and six of the seven patients had a decrease in the tumor marker carcinoembryonic antigen. All seven MTC patients remain on study. In ...

Interim Phase 2 Data for Exelixis' XL880 Show Anti-Tumor Activity in Papillary Renal Cell Cancer

... activity, following administration of XL880. A potential plasma marker of MET inhibition, sMET, was statistically significantly increased in all ... clinical trial, statistically significant anti-angiogenic pharmacodynamic marker changes have been detected, consistent with effects observed with ...

Kosan Presents Phase 1 Data Showing Antitumor Activity and Safety Profile of Epothilone KOS-1584 at AACR/NCI/EORTC Meeting

... active on study at Cycle 5) experienced a 40% reduction in tumor marker CA-15.3, 42.5% reduction in CA27,29 and 30% reduction in CEA; -- 1 patient with advanced ovarian cancer (4 prior regimens) had 40% tumor marker CA125 decrease and 20% shrinkage of nodal disease (on study for 6 ...

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

... polymorphism (SNP) genotyping and allelotyping, copy number variation analysis, quantitative gene expression analysis, quantitative methylation marker analysis, comparative sequence analysis of haploid organisms, SNP discovery, and oligonucleotide quality control. About SEQUENOM ...

Landmark Study for GSK's Cervical Cancer Vaccine Published in The Lancet

... the abnormal cells will become cancer cells. CIN 1, 2 and 3 refers to mild, moderate or severe cell changes respectively. CIN 2+ is the surrogate marker for cervical cancer. Worldwide, more than 500,000 women will be newly diagnosed with cervical cancer and 280,000 women will die from it each year. ...

Urologist and Allergist Explore Link Between Allergies and Interstitial Cystitis

... ear infections, or chronic urticaria (hives). Hubbard and Smith are collaborating on a more formal study of the link. One goal is to find a marker that will help urologists decide which patients may benefit from allergy testing and treatment. Like many urologists, Hubbard uses cystoscopy and ...

Entremed Presents Results of ENMD-2076 Phase 1 Study in Advanced Cancer Patients

... renal cell, ovarian and colorectal cancer. ENMD-2076 was well-tolerated when administered daily. In addition, plasma soluble KDR (VEGFR2), a marker of effect against the VEGF receptor, was reduced in all patients when compared to baseline. Side effects included hypertension and low blood counts, ...

Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy

... The research appears at www.ASCO.org and www.jco.org and is entitled "Enhancer of Zeste Homologue 2 (EZH-2) expression in breast cancer: a novel marker and potential target." Karmanos scientists tested 84 cases of hormone receptor negative human breast carcinomas and discovered that the protein ...

First Jatropha Genome Completed by Synthetic Genomics Inc. and Asiatic Centre for Genome Technology

... genome. The teams are now working on annotating the genome to identify particular genes of interest and to discover genetic variations for use in marker assisted breeding. The teams are also applying traditional breeding tools, as well as modern plant molecular biology tools, to improve plant yield, ...

Lack of Food Variety Puts Kids With Autism at Risk for Poor Nutrition

... presenting their findings on May 4, the researchers said screening children for the amount of variety of food in their diets may be a good clinical marker to predict which children might be at risk for nutrition problems. Kids with low food variety scores who are at risk could then be referred to ...

New Study Shows Probiotic Strain Effective in Boosting Immune Response to Flu Virus

... Bacillus coagulans boosts a key immune marker in healthy people CLEVELAND, May 5 /PRNewswire/ -- A new study in the current issue of Postgraduate Medicine suggests that a specific strain ...

Gen-Probe and DiagnoCure Amend Collaboration Agreement Surrounding PCA3-Based Prostate Cancer Tests

... PCA3 assay that could lead to regulatory approval by the U.S. Food and Drug Administration (FDA). About PCA3 PCA3 is a molecular marker that studies indicate is more specific for prostate cancer than the commonly used diagnostic test, PSA (prostate specific antigen). PCA3 has been ...

Cepheid Announces European Release of First On-Demand Molecular Test for Simultaneous Detection of Mycobacterium tuberculosis (TB) and Resistance to Rifampicin

... Mycobacterium tuberculosis (MTB) and resistance to rifampicin (RIF), a common first-line drug for treatment of the disease and a reliable surrogate marker of strains that are multidrug-resistant (MDR-TB). Xpert MTB/RIF is expected to enable clinicians to dramatically improve patient outcomes -- a ...

CRESTOR(R) Reduced CV Risk in Patients Achieving Low LDL and hsCRP Targets in New JUPITER Analysis

... one other risk factor including hypertension, low HDL-C, family history of premature coronary heart disease (CHD) or smoking. hsCRP is a recognized marker of inflammation which is associated with an increased risk of atherosclerotic cardiovascular events. JUPITER is a part of AstraZeneca's ...

CRESTOR(R) Reduced Risk of Blood Clots in the Veins

... one other risk factor including hypertension, low HDL-C, family history of premature coronary heart disease (CHD) or smoking. hsCRP is a recognized marker of inflammation which is associated with an increased risk of atherosclerotic cardiovascular events. JUPITER is a part of AstraZeneca's ...

PSA Screening Cuts Deaths by 20%, Says World's Largest Prostate Cancer Study

... at the annual European Urology Congress in Stockholm, Sweden (17 - 21 March 2009). By initially screening men 55 to 69 years with the PSA marker and offering regular follow up, this led to an increase in early detection. Deaths due to metastasized disease were then reduced. Exact data showed ...

YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB PRESENTATIONS TO BE MADE AT THE 100TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AND EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY

... combined with rash being reported independent of the KRAS status of patients, are in sharp contrast to the dated speculation that toxicity is a marker for efficacy of EGFR-targeting agents," said David Allan, Chairman and CEO of YM BioSciences. "The data we present show the monovalent binding to ...

Access Pharmaceuticals Announces Positive ProLindac(TM) Phase 2 Ovarian Cancer Clinical Trial Results

... of all patients, and 66% of all patients in the higher dose groups. Sustained and significant reductions in Ca-125, the established specific serum marker for ovarian cancer, were also observed in several patients. "We are delighted that the results from this study support our belief that ...

Researchers Discover Metabolite Linked to Aggressive Prostate Cancer

... end up overtreating our patients because physicians don't know which tumors will be slow-growing. With this research, we have identified a potential marker for the aggressive tumors," says senior study author Arul Chinnaiyan, M.D., Ph.D., director of the Michigan Center for Translational Pathology and ...

St. Jude Finds More Than 100 Gene Variations Linked With Response to Leukemia Treatment

... end of induction therapy. "Our finding that IL15 plays such an important role in the failure of chemotherapy suggests that this gene may be a marker we could use to predict outcome of therapy," Relling said. " IL15 might also represent a new target for novel drugs that knock out its activity and ...

Why Wait for an Anti-Aging Drug? Researchers Interviewed on CBS-TV's 60 MINUTES Discover Longevinex(R) Nutriceutical Matrix Activates 9-Fold More Longevity Genes than Plain Resveratrol

... MIT come to realize the Sirtuin1 gene is not activated in all tissues and organs in calorie restricted animals, so it may not serve as a universal marker of calorie restriction. A growing number of recent research studies indicate resveratrol actually down-regulates the Sirtuin1 gene. Resveratrol ...

Takeda Initiates Two Phase III Studies with Vedolizumab (MLN0002) in Patients with Inflammatory Bowel Disease

... studied for its effect on inducing and maintaining mucosal healing. Studies have demonstrated that vedolizumab works by blocking a key inflammatory marker on white blood cells, thereby preventing the migration of these inflammatory cells into the intestinal wall. The two randomized, ...

Molecular Marker Identifies Normal Stem Cells as Intestinal Tumor Source

... compounds that will affect the malignant stem cell but not the normal stem cell." More broadly, Prominin1 might prove to be a useful marker to trace cancer stem cells in the kidney, brain, pancreas and other tissues. The researchers are also exploring the use of stem cell markers in ...

Ipsogen Launches a New Test to Determine Tumor HER2 Status and Guide Herceptin(R) Prescription in Breast Cancer

... of the HER2 oncogene protein and fuels uncontroled tumor growth in approximately 15 to 30% of breast tumors. HER2 is considered today as a predictive marker for clinical benefit from trastuzumab, or Herceptin(R), a monoclonal antibody directed against the HER2 protein, in both primary and metastatic ...

Seniors Can Be Heartened by New Study on Statins

... would not normally be treated for heart disease. Patients in the study had normal cholesterol. But they had higher levels of C-reactive protein, a marker of inflammation that indicates a risk of heart disease. "This study shows that even if you have low cholesterol levels, you aren't safe from heart ...