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Lipoprotein in Medical Technology

Diabetes Patients with High Triglycerides and Low HDL Cholesterol Get the Most Benefit From Fenofibrate Treatment: New Data From the FIELD Study

... or higher) and low high-density lipoprotein (HDL) cholesterol (<1.03 mmol/L-40mg/dL in men ... risk, partly independent of levels of low-density lipoprotein (LDL) cholesterol. In people with ... of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the ...

Ion Mobility Diagnostic Test from Quest Diagnostics is First to Provide Direct Physical Measurement of Lipoprotein Particles, Cardiovascular Disease Indicators, Study Finds

... offers advantages over other procedures for lipoprotein particle analysis because it both measures ... provides the only direct physical measurement of lipoprotein particle size and concentration for each lipoprotein subclass, from small HDL to large VLDL," said ...

July 2009 Mayo Clinic Women's HealthSource Highlights Food Storage Safety, Energy Therapies and Vitamins and Minerals

... Researchers have found that, in high doses, niacin can reduce low-density lipoprotein (LDL or "bad" cholesterol) and triglycerides and raise high-density lipoprotein (HDL or "good") cholesterol. However, the doses needed for these effects, ...

Glybera(TM) Shows Long-Term Health Benefits

... significant and clinically important reduction in acute pancreatitis in lipoprotein lipase deficient patients. Recurrent acute pancreatitis is the most ... developed Glybera as a treatment for patients with the genetic disorder lipoprotein lipase deficiency. LPLD is an orphan disease for which no treatment exists ...

February 2009 Mayo Clinic Women's HealthSource Highlights Diabetes and Heart Disease, Going Vegetarian and Tinnitus

... target is less than 100 milligrams per deciliter (mg/dL) for low-density lipoprotein (LDL) cholesterol. For high-density lipoprotein (HDL) cholesterol, the recommended level is more than 50 mg/dL for women ...

AMT: Glybera(R) Lowers Pancreatitis Incidence Significantly

... clinically important lowering of the incidence of acute pancreatitis in lipoprotein Lipase Deficient patients. Recurrent acute pancreatitis is the most debilitating complication of lipoprotein Lipase Deficiency (LPLD) and is associated with significant morbidity and ...

Colesevelam HCl Lowered LDL Cholesterol in Pediatric Patients With Heterozygous Familial Hypercholesterolemia

... HCl was well-tolerated and produced a significant reduction in low density lipoprotein (LDL) or "bad" cholesterol when used as monotherapy or in combination with ... significant, placebo-adjusted mean six percent increase in high density lipoprotein (HDL) or "good" cholesterol (p<0.01). These study arm findings also ...

Anthera Announces Preliminary Positive Results From Once-Daily A-002 Phase II Cardiovascular Trial

... reductions in blood levels of total cholesterol, Non-High Density lipoprotein Cholesterol (non HDL-C), and Low Density lipoprotein Cholesterol (LDL-C), known as "bad" cholesterol, oxidized LDL, and ...

Video: Quest Diagnostics Health Trends(TM) Report Shows Significant Gap in Care for Patients With Chronic Kidney Disease

... The tests used in this analysis were for diabetes (HbA1c), low-density lipoprotein cholesterol (LDL) and kidney disease (eGFR and microalbumin). "More ... on approximately 13 million test results for diabetes (HbA1c), low-density lipoprotein cholesterol (LDL) and kidney disease (eGFR and microalbumin) performed in ...

Anthera Announces Positive Phase II Clinical Results From A-002 Cardiovascular Disease Trial

... reductions in blood levels of total cholesterol, Non- High Density lipoprotein Cholesterol (non HDL-C), and Low Density Lipoprotein Cholesterol (LDL-C), ... patients treated with statins," said Dr. Robert Rosenson, Director of lipoprotein Disorders and Clinical Atherosclerosis Research at the University of ...

Heart Disease Treatment Breakthrough

... to produce a much smaller, and more bio-available molecule. The early studies have shown that Ateronon can inhibit the oxidation of low density lipoprotein (LDL) cholesterol, which can put people at risk of suffereing heart attacks and stroke, to almost zero within eight weeks. An estimated 17.5 ...

Anthera's Varespladib Meets Primary Endpoint in Phase 2 FRANCIS Trial for the Treatment of Acute Coronary Syndrome

... when administered to patients within 96 hours of an Acute Coronary Syndrome (ACS) event, met its primary endpoint of a reduction in Low Density lipoprotein Cholesterol (LDL-C). All patients in the FRANCIS trial received once daily doses of 80mg of Lipitor (atorvastatin calcium), plus 500mg of varespladib ...

Sequoia Pharmaceuticals Presents Proof of Clinical Concept of SPI-452, a Novel Pharmacokinetic Enhancer

... safe and well tolerated, with few side effects. Furthermore, there were no statistically significant changes in triglyceride and low- density lipoprotein (LDL) cholesterol levels in subjects receiving SPI-452 compared with placebo, which may indicate that SPI-452 has a favorable lipid profile, an ...

New Analysis Estimates Numbers of Older U.S. Adults Who May Benefit From Statin Therapy

... would be candidates for statin therapy under the strictest JUPITER trial criteria -- hsCRP at or above 2 milligrams per liter (mg/L) and low-density lipoprotein cholesterol (LDL) under 130 milligrams per deciliter (mg/dL), Spatz said. She estimated that another 3 million people, or 5.3 percent of the ...

Anthera Completes Special Protocol Assessment With FDA and Receives EMEA Scientific Advice on Development Path Toward Varespladib Approval

... validation of the anatomical importance of reducing PLA2 activity in a cardiovascular population," said Dr. Robert S. Rosenson, Director of lipoprotein Disorders and Clinical Atherosclerosis Research at the University of Michigan. "The on-going FRANCIS trial with varespladib, which is designed to ...

August 2008 Mayo Clinic Women's HealthSource Highlights Avoiding Blood Pressure Increase at Menopause, Healthful Benefits of Dark Chocolate and Scheduling a Colorectal Exam

... dark chocolate a day, about one square, lowered systolic and diastolic blood pressure by 2 points each. Dark chocolate also may lower low-density lipoprotein (LDL) cholesterol levels by about 5 points. While not a huge affect, it's sending that "bad" cholesterol in the right direction. Also, flavonoids ...

Metabolex Completes Patient Enrollment in Phase 2 Trial of MBX-8025 for Treatment of Dyslipidemia

... an 8-week period, both alone and in combination with Lipitor(R) (atorvastatin). The primary endpoint is the reduction in Apo B-100, the atherogenic lipoprotein in LDL (low-density lipoprotein), compared to placebo. Secondary endpoints include measurements of the effect of treatment on LDL, HDL (high-density ...

New Discovery of Key Difference in Bile Acid Metabolism in Patients with Type 2 Diabetes May Suggest Underlying Disorder

... changes in patients. IMPORTANT INFORMATION ABOUT WELCHOL Welchol is indicated as an adjunct to diet and exercise to reduce elevated low-density lipoprotein cholesterol (LDL-C) in patients with primary hyperlipidemia (Fredrickson Type IIa) as monotherapy or in combination with an ...

Heart Patients More Likely to Adopt Healthy Habits in 3-Year Program Led by Cardiac Rehabilitation Experts, Mayo Clinic Research Shows

... The goals of heart attack prevention for patients with coronary heart disease in the Minnesota survey included: -- Achieving a low-density lipoprotein (LDL) cholesterol of less than 100 milligrams per deciliter -- Lowering blood pressure to less than 140 systolic and 90 diastolic -- Taking a ...

Welchol(TM) Lowered A1C by a Mean 1 Percent or Greater When Added to Metformin-, Insulin-, or Sulfonylurea-Based Therapy in 47 Percent of Patients Evaluated

... of 11.31 (P<0.0001). IMPORTANT INFORMATION ABOUT WELCHOL Welchol is indicated as an adjunct to diet and exercise to reduce elevated low-density lipoprotein cholesterol (LDL-C) in patients with primary hyperlipidemia (Fredrickson Type IIa) as monotherapy or in combination with an ...

Synvista Therapeutics Presents New Preclinical Data Demonstrating the Value of Haptoglobin Genotype Testing In Diabetes at ACC Scientific Sessions

... 2-2 genotype that show impairment in the clearance of the Haptoglobin (Hp)-Hemoglobin (Hb) complex may result in a modification of high-density lipoprotein (HDL) structure and defective reverse cholesterol transport. These findings, which were presented today at the 57th Annual Scientific Sessions of the ...

Photo: Welchol(TM) (colesevelam HCl) Receives FDA Approval to Reduce Blood Glucose in Adults with Type 2 Diabetes

... type 2 diabetes.(8) IMPORTANT INFORMATION ABOUT WELCHOL Welchol is indicated as an adjunct to diet and exercise to reduce elevated low-density lipoprotein cholesterol (LDL-C) in patients with primary hyperlipidemia (Fredrickson Type IIa) as monotherapy or in combination with an ...

Surgeons Find That Laparoscopic Banding Procedure Helps Overweight Adolescents Lose Weight and Improve Health

... all significantly decreased. Prior to the operation, there were a total of 43 comorbidities in all 14 participants, back pain, dyslipidemia (a lipoprotein metabolism disorder) depression, osteoarthritis, and sleep disorders. At one-year follow-up, 34 of these factors were reassessed and the vast ...

Surface Logix Presents Positive Phase 1 Repeat-Dose Trial Data on SLx-4090 at The 16th International Symposium on Drugs Affecting Lipid Metabolism

... that there are more than 240 million people with abnormal lipoprotein levels. Of these, more than 55 million are estimated to have low high density lipoprotein (HDL) and/or high triglyceride levels. About Surface Logix, Inc. Surface Logix, Inc. uses its expertise in biophysical chemistry to create and ...

Anthera Announces Completion of Enrollment and Dosing in Phase II Trial of A-002 for the Treatment of Cardiovascular Disease

... safety and the efficacy of A-002 (a potent inhibitor of the human enzymes known as secretory phospholipase A2) on dyslipidemia (primarily Low Density lipoprotein Cholesterol "LDL-C") and systemic inflammation (as measured by levels of C-Reactive Protein "CRP") in patients with stable coronary heart disease. ...

Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation

... may be developed to prevent inappropriate platelet activation and reduce the risk of adverse cardiovascular events," Dr Podrez said. Low-density lipoprotein (LDL) cholesterol is often called "bad" cholesterol because it can accumulate in blood vessel walls, narrowing vessels and reducing blood supply to ...

Researchers at Cleveland Clinic Identify Site of 'Dysfunction' in HDL, Carrier of Good Cholesterol

... Online on Aug. 5 in Nature Journal CLEVELAND, Aug. 7 /PRNewswire/ -- Researchers at Cleveland Clinic have identified the region within high density lipoprotein (HDL), the major carrier of "good" cholesterol, that can become dysfunctional within the artery wall, inhibiting the body's ability to fight ...

Low-Density Cholesterol Subfractions: Not all LDL-C Particles are Created Equal

... been measured by a simple panel of high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C); good and bad cholesterol. In ... from the total cholesterol test to a fasting lipoprotein profilecomprised of total cholesterol, HDL-C, ...

Liponex Inc. Reports Phase I/II Clinical Trial Data for CRD5

... specializing in developing advanced products related to High Density lipoprotein (HDL), often called “good cholesterol,” today announced ... company specializing in developing products related to High Density lipoprotein (HDL), often called "good cholesterol." Its drug candidates relate to the ...

Isis Pharmaceuticals Announces Its Participation at the Upcoming ACC 56th Annual Scientific Session in New Orleans and Its Live Analyst/Investor Webcast Presentation

... Dr. Evan A. Stein Title: High Low-Density lipoprotein Cholesterol on Three Drugs* *to include preliminary ... Significant Additional Reduction of Low-Density lipoprotein Cholesterol and Apolipoprotein B in ...

Isis Pharmaceuticals Reports Positive Phase 2 Data for ISIS 301012 in Familial Hypercholesterolemia Patients Presented at ACC

... B Presentation: 603-8 Time: 8:15 - 8:30 a.m. Speaker: Dr. Evan A. Stein Title: High Low-Density lipoprotein Cholesterol on Three Drugs More about Phase 2 Trials for ISIS 301012 Additional data from two ongoing studies in ...

Diobex Announces Successful Completion of Phase 2a Trial Of DIO-902, a Novel Cortisol Synthesis Inhibitor for Type 2 Diabetes

... insulin resistance. In the growing number of patients with type 2 diabetes and metabolic syndrome, co-morbidities such as hypertension and abnormal lipoprotein levels dramatically increase the risk of cardiovascular disease. DIO-902 is one of two enantiomers contained within racemic ketoconazole, a ...

Cholesterol Drug Fails to Slow Progression of Coronary Disease, Cleveland Clinic Study Reports

... NEW ORLEANS, March 26, 2007 /PRNewswire/ -- Cleveland Clinic researchers today report that the drug torcetrapib, despite raising high density lipoprotein cholesterol (HDL) or the "good" cholesterol by more than 60%, did not slow the progression of plaque buildup in the coronary arteries as measured ...

Study Presented at ACC Shows Treatment With ISIS 301012 Added to Statins for Only 5 Weeks Results in 75% of Patients Achieving LDL-C Levels Less Than 100 mg/dL and 50% of Patients Achieving LDL-C Levels of Less Than 70 mg/dL

... an Antisense Inhibitor of Apolipoprotein B, Produces Significant Additional Reduction of Low-Density lipoprotein Cholesterol and Apolipoprotein B in Hypercholesterolemic Subjects on Statins Not Meeting Target More ...

ACC Presentation Indicates Interleukin-1 Gene Variants Determine Increased Risk for Coronary Artery Disease from Oxidized Phospholipids

... on pro-inflammatory variants of the interleukin-1 (IL-1) genes. In a presentation titled "The Influence of Oxidized Phospholipids and Lp(a) lipoprotein on Coronary Artery Disease Is Conditional Upon Genotype at the Interleukin-1 Region," the investigators reported that in patients with the ...

Safety Analyses of Clinical Data for Bifeprunox in Patients with Schizophrenia Showed a Favorable Weight and Lipid Profile, Similar to Placebo

... active-referenced studies: * Bifeprunox had favorable effects on total cholesterol, triglycerides (TG), very low-density lipoprotein and low-density lipoprotein, similar to placebo. * Bifeprunox patients experienced decreases in body weight, body mass ...

Liponex Inc. Reports Further Analysis of CRD5 Phase I/II Clinical Trial Data

... OTTAWA, April 11 /CNW/ - Liponex Inc. (TSX:LPX), a biopharmaceutical company specializing in developing advanced products related to High Density lipoprotein (HDL), often called "good cholesterol," today announced information from further analysis of the Phase I/II Clinical Trial of its lead product, CRD5. ...

Amsterdam Molecular Therapeutics BV to present preclinical proof-of-concept data on its gene therapy AMT-020 to treat acute intermittent porphyria

... and validated a unique, stable and scalable GMP production platform. Its lead product, AMT-011, is in phase II for the first indication: treatment of lipoprotein lipase deficiency type I. The company's Management, Supervisory and Scientific Advisory Board bring together an extensive know-how from both gene ...

KineMed Presents Data Measuring Changes in Reverse Cholesterol Transport for the First Time

... Tissues in Vivo". This poster showed that infusion of CSL-111 (provided by CSL Behring AG), which is reconstituted high density lipoprotein (rHDL) particles, into animals increased efflux of cholesterol out of tissues into the bloodstream. In addition, data were ...
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(Date:4/23/2014)... conclusive evidence that the source of a unique rhythmic ... called the "bio-duck," is the Antarctic minke whale ( ... personnel in the 1960s who thought it sounded like ... various locations in the Southern Ocean, but its source ... 2013, an international team of researchers deployed acoustic tags ...
(Date:4/23/2014)... that the likelihood of an accurate group decision increases ... up when a collective faces a variety of factors ... Princeton University researchers report that smaller groups actually tend ... become excessively focused on only certain pieces of information. ... is known about collective intelligence, or the "wisdom of ...
(Date:4/23/2014)... boom has transformed the energy landscape in the ... cause conflict among the energy industry, residents and ... They add that degraded water quality is a ... feature article appears in the ACS journal ... Mauter and colleagues point out that a major ...
Breaking Biology News(10 mins):Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3Too many chefs: Smaller groups exhibit more accurate decision-making 2Too many chefs: Smaller groups exhibit more accurate decision-making 3How to avoid water wars between 'fracking' industry and residents 2
(Date:4/24/2014)... and irrelevant, could offer an alternative to heart transplants ... Furtado, and her team from the Australian Regenerative Medicine ... fibroblast is a close relative to a cardiomyocyte, the ... research published today in Circulation Research , Dr ... due to their genetic program, and will aid in ...
(Date:4/24/2014)... national response to the epidemic of prescription opioid overdose ... Journal of Medicine by leaders of agencies in ... The commentary calls upon health care providers to expand ... reduce overdose deaths, and describes a number of misperceptions ... The commentary also discusses how medications can be used ...
(Date:4/24/2014)... It is better to give than to receive ... a new study suggests. , The study found that 15- ... giving their money to family members, are less likely to ... taking risks or keeping the money for themselves. , The ... National Academy of Sciences . , The study focused on ...
(Date:4/24/2014)... NH, 4/24/14) Dartmouth has been awarded one of ... serve as a Lead Academic Participating Site in its ... Award recipients are a select groups of investigators charged ... fewer cooperative groups., The NCTN grant system reflects recommendations ... It streamlines operations to achieve four goals:, ...
(Date:4/24/2014)... The National Science Foundation has awarded LSU ... for Undergraduates (REU) Site grant in the amount ... of undergraduates from diverse social and educational backgrounds, ... Orleans area. The project will provide students ... of 2014-16. It will be led by ...
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