Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009
... who cannot adequately control their cholesterol levels
with current therapies and who need new treatment ... tissue and reduces survivin mRNA and protein levels
in tumor cells.
Isis and ... showing robust and sustained reduction in SGLT2 levels
that resulted in a significant reduction in blood ...
Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA
... with metastatic carcinoid tumors. Elevated levels
of serotonin contribute to the gastrointestinal ... currently available therapy. Up to four dose levels
may be evaluated in a serial ascending fashion. ... enzyme in the synthesis of serotonin. Excessive levels
of serotonin have been implicated in symptoms ...
Idenix Pharmaceuticals Successfully Completes Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)
... markers of liver injury, with mean AST and ALT levels
decreasing to below the upper limit of normal. ... sustained for up to 6 days post-dosing, and most levels
returned to baseline 14 days post-treatment.
... to the liver, leading to the formation of high levels
of nucleoside triphosphate, potentially ...
Reliv International's GlucAffect(TM) Proven Effective in Clinical Study
... Shows GlucAffect Reduces Blood Glucose levels
and Promotes Weight Loss
CHESTERFIELD, ... RELV ), significantly reduced blood glucose levels
and helped control weight in study participants. ... individuals who had pre-diabetic glucose levels
prior to the study. Subjects taking GlucAffect, a ...
Analysis of Edoxaban Phase II Data Provides Insight Into Reduced Bleeding Events Seen in Once-Daily Dosing
... closely correlated with minimum concentration levels
of the drug in the blood, and that these trough levels
may best predict bleeding events, rather than ... overall bleeding rates when drug concentration levels
reached the highest points (known as Cmax), ...
Results From Trials of DHA in Alzheimer's Disease and Age-Related Cognitive Decline
... treatment with DHA clearly increased blood levels
of DHA, and also appeared to increase brain DHA ... + or - 0.76, p<0.03). Plasma phospholipid DHA levels
doubled over the course of the study in those ... that was highly correlated with week 24 plasma levels
(p<0.01). Blood pressure and body weight ...
When It Comes to Natural Remedies for Hormonal Balance, the Proof Is in the Clinical Research
... Femmenessence: Proven to Regulate Hormone levels
SAN FRANCISCO, June 12 /PRNewswire/ ... and exiting menopause are in a bind. As hormone levels
fluctuate and decline, they experience a range of ... ability to balance (either increase or decrease) levels
of its own hormones. Passing stringent ...
VIA Pharmaceuticals Meets With FDA to Discuss Next Steps For VIA-2291 and Phase 3 Outcome Trial in Cardiovascular Disease
... factors that may cause VIA's actual results, levels
of activity, performance or achievements to be materially different from any future results, levels
of activity, performance or achievements ... and which could materially affect actual results, levels
of activity, performance or achievements.
FDA Advisory Committee Votes in Favor of Zyprexa for Two Adolescent Indications
... triglyceride, cholesterol and hepatic enzyme levels
were greater in adolescents than adults. Sedation ... atypical antipsychotics and increases in glucose levels
appears to fall on a continuum and Zyprexa ... sometimes very high, elevations in triglyceride levels
and modest mean elevations in total cholesterol ...
Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions
... dependent glucose co-transporter type 2 (SGLT2) levels
that resulted in a significant reduction in blood glucose levels
in multiple animal species. Isis and its ... promising new targets demonstrating that reducing levels
of these targets with antisense drugs can ...
SCAI Statement on the BARI 2D Trial (Bypass Angioplasty Revascularization Investigation With Diabetes Trial) Presented at the American Diabetes Association (ADA) Annual Scientific Sessions and Published in The New England Journal of Medicine
... diabetes patients works. When the blood sugar levels
of diabetic patients are controlled to precise ... in a real-world setting, patients' blood sugar levels
are not so closely monitored to maintain optimal levels
as in this study," said Robert Chilton, DO, ...
Study Shows GSK's Novel Diabetes Treatment SYNCRIA(R) (albiglutide) Improves Glucose Control and Reduces Weight
... (albiglutide) significantly reduced blood glucose levels
and provided weight loss across weekly, biweekly ... weight gain and fear of increased blood sugar levels
can be major barriers to diabetes management."
... the body to help maintain normal blood sugar levels
and to control appetite. Normally, ...
Studies Show AFRESA(R) Controls Post-Meal Sugar Levels With Less Weight Gain and Hypoglycemia Risk for Diabetes Patients
... 2 diabetes, as it controls post meal-time glucose levels
with the added benefits of less weight gain and ... were proportion of subjects reaching specific A1C levels
and treatment differences in postprandial plasma ... differences in LAA doses in either group. FPG levels
(-35.5 +/- 3.3 vs. -20.6 +/- 3.2, p=0.0012) and ...
Boehringer Ingelheim Unveils Diabetes Pipeline
... metformin. The significant reduction in HbA1c levels
seen in this trial is encouraging as it indicates ... blood sugar or fasting plasma glucose (FPG) levels
(p-values of less than 0.05%):(1)
... significant reductions in mean HbA1c levels
with linagliptin 5 mg and 10 mg compared with ...
AFRESA(R) Phase 3 Pulmonary Function Safety Data in Patients with Diabetes Presented at ADA
... by the body's inability to properly regulate levels
of blood glucose, or blood sugar. Insulin, a ... levels, but in people with diabetes insufficient levels
of insulin are produced (type 1 diabetes) or the ... insulin quickly to the blood stream. Peak insulin levels
are achieved within 12 to 14 minutes of ...
Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting
... enzyme activity in heart muscle cells. The enzyme levels
are decreased in late stages of heart failure, and extensive research shows loss of SERCA2a levels
represents a common pathway resulting in a defect ... evaluate the use of MYDICAR at two or three dose levels
compared to placebo in 37 patients. CUPID is ...
Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types
... can control growth hormone and/or normalize IGF-1 levels
in patients with acromegaly, a disease caused by ... pain on injection, high or low blood sugar levels
and slow or irregular heart rate. Many patients ... compounds or products will achieve any particular levels
of revenue in the future. In particular, ...
Scientific Data Relating to Cinryze(TM) Presented at 6th Annual C1 Inhibitor Deficiency Workshop
... (IV) Infusion of C1 Inhibitor (INH) on Blood levels
In this study, 50 units/kg ... were infused either IV or SQ into swine. Blood levels
of C1 inhibitor after IV infusion were compared ... perpetuate an attack by consuming the already low levels
of endogenous C1 inhibitor in HAE patients. ...
RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment Delayed the Time to Relapse in Patients with Bipolar I Disorder
... and similar medications can raise the blood levels
of a hormone known as prolactin, causing a condition known as hyperprolactinemia. Blood levels
of prolactin remain elevated with continued use. ... RISPERDAL(R) CONSTA(R) elevates prolactin levels
and the elevation persists during chronic ...
Metabolic Solutions Development Company Announces Preliminary Results from Phase IIa Clinical Trial
... improved insulin sensitivity and lower glucose levels
without the side effects of current therapies ... insulin sensitivity and lower blood glucose levels
in humans without the side effects of current ... Unlike Actos, MSDC-0160 did not decrease the levels
of circulating blood cells and did not produce an ...
Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results
... are more closely related to their blood pressure levels
than to their blood sugar levels," said Joseph L. ... to date, we have achieved some of the lowest BP levels
ever in a clinical trial.
... causes of kidney failure.(4) High blood sugar levels
and high blood pressure (often present in ...
HIV/AIDS Research Network Recommends Use of Abbott RealTime Viral Load Test for NIH-Sponsored Clinical Trials
... allows physicians to confidently measure viral levels
and provide optimal drug treatment," O'Kelly ... (PCR) to amplify, detect and measure minute levels
of virus in blood samples as well as extremely high levels
of these infectious agents. Real-time PCR ...
Arcion Therapeutics' Topical Pain Candidate, ARC-4558, Significantly Reduces Pain Caused by Diabetic Neuropathy
... dosing. Consistent with this, clonidine blood levels
in the 0.2% group were the same as that in the ... to 29.3% in the placebo group (p=0.031). Blood levels
of clonidine varied from non-detectable to levels
several-fold below the threshold required to ...
Lack of Food Variety Puts Kids With Autism at Risk for Poor Nutrition
... red blood cells of children with autism have low levels
of a fatty acid linked to cognitive function. ... further research into how the low fatty acid levels
may trigger biochemical changes in the brain linked to autism.
The team found that levels
of docosahexanoic acid and total omega-3 fatty ...
Potentia Pharmaceuticals' POT-4 Drug Candidate for Age-Related Macular Degeneration Successfully Completes Phase I Clinical Trial - Prepares for Phase II
... well tolerated by all subjects and sustained levels
of drug reported after one treatment
... reported. Additionally, significant sustained levels
of POT-4 were consistently measured via serum ... expected to provide sustained therapeutic ocular levels
of the drug for several months following a single ...
Alimera Sciences Announces Presentation of Data From the 12-Month Interim Readout of the Human PK Iluvien(TM) Study at ARVO 2009 Annual Meeting
... Group, which in addition to measuring systemic levels
of FA, also assessed anterior chamber levels
of FA, and assessed correlations between these levels
and clinical outcomes.
A total of 37 ...
Another Study Links Fluoride to Bone Cancer
... 29 /PRNewswire-USNewswire/ -- Blood fluoride levels
were significantly higher in patients with ...
Randhu and colleagues measured serum fluoride levels
in three equal groups of age-matched and ... report proves a link between raised fluoride levels
in serum and osteosarcoma," they write.
Ferring Pharmaceuticals Launches Phase IIIB Trial of Degarelix as Intermittent Therapy
... prostate cancer who have rising serum PSA levels
after previous curative therapies. The study ... Depot(R))(*)in reducing and sustaining castrate levels
of testosterone.(1)(2) Suppression of testosterone to castrate levels
occurred significantly faster in patients ...
Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen
... the 14 days of dosing, and the reductions in levels
of HCV RNA were significant.
Results of the ... -- experienced a median reduction in viral levels
of -4.8 to -5.2 log(10) IU/mL in the highest ... of patients experiencing a decrease in viral levels
below the quantification limit of the diagnostic ...
Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C
... who achieve an SVR, defined as undetectable levels
of HCV (measured by Roche TaqMan assay) 24 weeks ... they have achieved RVR, defined as undetectable levels
of HCV at week 4 (a strategy known as "RVR-guided" treatment), and maintain undetectable levels
of HCV until week 22. Patients who do not achieve ...
Pistachios Offer Protective Benefits Against Heart Disease, Type II Diabetes and Obesity
... ability of pistachios to help control blood sugar levels
and enhance satiety of meals and snacks. Fifteen ... response, delay gastric emptying and increase levels
of the satiety hormone, ghrelin. The results ... significantly reduced LDL and total cholesterol levels
compared to the full dose muffin group, as well ...
CRESTOR(R) Reduced CV Risk in Patients Achieving Low LDL and hsCRP Targets in New JUPITER Analysis
... show that patients with low to normal
and elevated high sensitivity C-reactive protein ... treated with
rosuvastatin who achieved low levels
of LDL-C and hsCRP had a greater
reduction in ... elevated Total-C,
LDL-C, ApoB, non-HDL-C, and TG levels
and to increase HDL-C in adult patients
Access Pharmaceuticals Announces Positive ProLindac(TM) Phase 2 Ovarian Cancer Clinical Trial Results
... was established as well as the recommended dose levels
for future combination studies.
"We are very ... and efficacy in patients at the highest dose levels
which is very encouraging given that this study ... patient Phase 2 study explored 3 different dose levels
and 2 dosing regimens of ProLindac as a ...
Nektar Announces Positive Results from Phase 2 Study of Oral NKTR-118 in Patients with Opioid-Induced Constipation (OIC)
... Significant Results Achieved at Two Dose levels
with No Reversal of Analgesia
SAN CARLOS, ... evidence of efficacy at two different dose levels
of 25 mg once daily and 50 mg once daily. The ... orally once-daily at the 25 mg and 50 mg dose levels
dramatically increased bowel movements within the ...
Diabetes Patients with High Triglycerides and Low HDL Cholesterol Get the Most Benefit From Fenofibrate Treatment: New Data From the FIELD Study
... cardiovascular risk, partly independent
of low-density lipoprotein (LDL) cholesterol.
... TIMI 22 Investigators.
Impact of triglyceride levels
beyond low-density lipoprotein cholesterol ... Targets
Investigators. HDL cholesterol, very low levels
of LDL cholesterol, and
cardiovascular events. N ...
Statins Lower Stroke Severity, Improve Recovery
... on the drug -- even when their cholesterol levels
were ideal. The finding is reported in the ... so we focused on the patients who had optimal LDL levels
and found it still had quite significant value." ... 2005. Among that number, 207 had their lipid levels
measured within 15 days either side of the stroke ...
Sequoia Pharmaceuticals Presents Proof of Clinical Concept of SPI-452, a Novel Pharmacokinetic Enhancer
... activity. Pharmacokinetic enhancers increase drug levels
co-administered agents through inhibition of ... metabolism. These increased drug levels
can lead to improved efficacy,
reduced pill ... and low-
density lipoprotein (LDL) cholesterol levels
in subjects receiving SPI-452
compared with ...
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Announces FDA Filings for Paliperidone Palmitate and INVEGA(R)
... and similar medications can raise the blood levels
of a hormone known as prolactin, causing a condition known as hyperprolactinemia. Blood levels
of prolactin remain elevated with continued use. ... an erection. The connection between prolactin levels
and side effects is unknown.
People with ...
Medgenics Announces Positive Data From Phase I/II Clinical Trial of EPODURE Treatment of Anemia in Chronic Kidney Disease
... low dose does not result in sufficient hemoglobin levels
in most patients.
By having maintained hemoglobin levels
in the target range for several months in more ...
Even with the low dose, the hemoglobin levels
of most of the patients have remained within ...
St. Jude Finds More Than 100 Gene Variations Linked With Response to Leukemia Treatment
... found a link between the IL15 SNPs, increased levels
of IL15 in leukemia cells, and an increased ... and improve the outcome of patients with high levels
of this interleukin."
In addition, 21 of ... drugs from the body was associated with higher levels
of MRD, suggesting that higher drug doses may be ...