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Levels in Medical Technology

Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009

... who cannot adequately control their cholesterol levels with current therapies and who need new treatment ... tissue and reduces survivin mRNA and protein levels in tumor cells. Isis and ... showing robust and sustained reduction in SGLT2 levels that resulted in a significant reduction in blood ...

Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA

... with metastatic carcinoid tumors. Elevated levels of serotonin contribute to the gastrointestinal ... currently available therapy. Up to four dose levels may be evaluated in a serial ascending fashion. ... enzyme in the synthesis of serotonin. Excessive levels of serotonin have been implicated in symptoms ...

Idenix Pharmaceuticals Successfully Completes Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)

... markers of liver injury, with mean AST and ALT levels decreasing to below the upper limit of normal. ... sustained for up to 6 days post-dosing, and most levels returned to baseline 14 days post-treatment. ... to the liver, leading to the formation of high levels of nucleoside triphosphate, potentially ...

Reliv International's GlucAffect(TM) Proven Effective in Clinical Study

... Shows GlucAffect Reduces Blood Glucose levels and Promotes Weight Loss CHESTERFIELD, ... RELV ), significantly reduced blood glucose levels and helped control weight in study participants. ... individuals who had pre-diabetic glucose levels prior to the study. Subjects taking GlucAffect, a ...

Analysis of Edoxaban Phase II Data Provides Insight Into Reduced Bleeding Events Seen in Once-Daily Dosing

... closely correlated with minimum concentration levels of the drug in the blood, and that these trough levels may best predict bleeding events, rather than ... overall bleeding rates when drug concentration levels reached the highest points (known as Cmax), ...

Results From Trials of DHA in Alzheimer's Disease and Age-Related Cognitive Decline

... treatment with DHA clearly increased blood levels of DHA, and also appeared to increase brain DHA ... + or - 0.76, p<0.03). Plasma phospholipid DHA levels doubled over the course of the study in those ... that was highly correlated with week 24 plasma levels (p<0.01). Blood pressure and body weight ...

When It Comes to Natural Remedies for Hormonal Balance, the Proof Is in the Clinical Research

... Femmenessence: Proven to Regulate Hormone levels in Women SAN FRANCISCO, June 12 /PRNewswire/ ... and exiting menopause are in a bind. As hormone levels fluctuate and decline, they experience a range of ... ability to balance (either increase or decrease) levels of its own hormones. Passing stringent ...

VIA Pharmaceuticals Meets With FDA to Discuss Next Steps For VIA-2291 and Phase 3 Outcome Trial in Cardiovascular Disease

... factors that may cause VIA's actual results, levels of activity, performance or achievements to be materially different from any future results, levels of activity, performance or achievements ... and which could materially affect actual results, levels of activity, performance or achievements. ...

FDA Advisory Committee Votes in Favor of Zyprexa for Two Adolescent Indications

... triglyceride, cholesterol and hepatic enzyme levels were greater in adolescents than adults. Sedation ... atypical antipsychotics and increases in glucose levels appears to fall on a continuum and Zyprexa ... sometimes very high, elevations in triglyceride levels and modest mean elevations in total cholesterol ...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... dependent glucose co-transporter type 2 (SGLT2) levels that resulted in a significant reduction in blood glucose levels in multiple animal species. Isis and its ... promising new targets demonstrating that reducing levels of these targets with antisense drugs can ...

SCAI Statement on the BARI 2D Trial (Bypass Angioplasty Revascularization Investigation With Diabetes Trial) Presented at the American Diabetes Association (ADA) Annual Scientific Sessions and Published in The New England Journal of Medicine

... diabetes patients works. When the blood sugar levels of diabetic patients are controlled to precise ... in a real-world setting, patients' blood sugar levels are not so closely monitored to maintain optimal levels as in this study," said Robert Chilton, DO, ...

Study Shows GSK's Novel Diabetes Treatment SYNCRIA(R) (albiglutide) Improves Glucose Control and Reduces Weight

... (albiglutide) significantly reduced blood glucose levels and provided weight loss across weekly, biweekly ... weight gain and fear of increased blood sugar levels can be major barriers to diabetes management." ... the body to help maintain normal blood sugar levels and to control appetite. Normally, ...

Studies Show AFRESA(R) Controls Post-Meal Sugar Levels With Less Weight Gain and Hypoglycemia Risk for Diabetes Patients

... 2 diabetes, as it controls post meal-time glucose levels with the added benefits of less weight gain and ... were proportion of subjects reaching specific A1C levels and treatment differences in postprandial plasma ... differences in LAA doses in either group. FPG levels (-35.5 +/- 3.3 vs. -20.6 +/- 3.2, p=0.0012) and ...

Boehringer Ingelheim Unveils Diabetes Pipeline

... metformin. The significant reduction in HbA1c levels seen in this trial is encouraging as it indicates ... blood sugar or fasting plasma glucose (FPG) levels (p-values of less than 0.05%):(1) ... significant reductions in mean HbA1c levels with linagliptin 5 mg and 10 mg compared with ...

AFRESA(R) Phase 3 Pulmonary Function Safety Data in Patients with Diabetes Presented at ADA

... by the body's inability to properly regulate levels of blood glucose, or blood sugar. Insulin, a ... levels, but in people with diabetes insufficient levels of insulin are produced (type 1 diabetes) or the ... insulin quickly to the blood stream. Peak insulin levels are achieved within 12 to 14 minutes of ...

Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting

... enzyme activity in heart muscle cells. The enzyme levels are decreased in late stages of heart failure, and extensive research shows loss of SERCA2a levels represents a common pathway resulting in a defect ... evaluate the use of MYDICAR at two or three dose levels compared to placebo in 37 patients. CUPID is ...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

... can control growth hormone and/or normalize IGF-1 levels in patients with acromegaly, a disease caused by ... pain on injection, high or low blood sugar levels and slow or irregular heart rate. Many patients ... compounds or products will achieve any particular levels of revenue in the future. In particular, ...

Scientific Data Relating to Cinryze(TM) Presented at 6th Annual C1 Inhibitor Deficiency Workshop

... (IV) Infusion of C1 Inhibitor (INH) on Blood levels in Swine'; In this study, 50 units/kg ... were infused either IV or SQ into swine. Blood levels of C1 inhibitor after IV infusion were compared ... perpetuate an attack by consuming the already low levels of endogenous C1 inhibitor in HAE patients. ...

RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment Delayed the Time to Relapse in Patients with Bipolar I Disorder

... and similar medications can raise the blood levels of a hormone known as prolactin, causing a condition known as hyperprolactinemia. Blood levels of prolactin remain elevated with continued use. ... RISPERDAL(R) CONSTA(R) elevates prolactin levels and the elevation persists during chronic ...

Metabolic Solutions Development Company Announces Preliminary Results from Phase IIa Clinical Trial

... improved insulin sensitivity and lower glucose levels without the side effects of current therapies ... insulin sensitivity and lower blood glucose levels in humans without the side effects of current ... Unlike Actos, MSDC-0160 did not decrease the levels of circulating blood cells and did not produce an ...

Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results

... are more closely related to their blood pressure levels than to their blood sugar levels," said Joseph L. ... to date, we have achieved some of the lowest BP levels ever in a clinical trial. About ROADMAP ... causes of kidney failure.(4) High blood sugar levels and high blood pressure (often present in ...

HIV/AIDS Research Network Recommends Use of Abbott RealTime Viral Load Test for NIH-Sponsored Clinical Trials

... allows physicians to confidently measure viral levels and provide optimal drug treatment," O'Kelly ... (PCR) to amplify, detect and measure minute levels of virus in blood samples as well as extremely high levels of these infectious agents. Real-time PCR ...

Arcion Therapeutics' Topical Pain Candidate, ARC-4558, Significantly Reduces Pain Caused by Diabetic Neuropathy

... dosing. Consistent with this, clonidine blood levels in the 0.2% group were the same as that in the ... to 29.3% in the placebo group (p=0.031). Blood levels of clonidine varied from non-detectable to levels several-fold below the threshold required to ...

Lack of Food Variety Puts Kids With Autism at Risk for Poor Nutrition

... red blood cells of children with autism have low levels of a fatty acid linked to cognitive function. ... further research into how the low fatty acid levels may trigger biochemical changes in the brain linked to autism. The team found that levels of docosahexanoic acid and total omega-3 fatty ...

Potentia Pharmaceuticals' POT-4 Drug Candidate for Age-Related Macular Degeneration Successfully Completes Phase I Clinical Trial - Prepares for Phase II

... well tolerated by all subjects and sustained levels of drug reported after one treatment ... reported. Additionally, significant sustained levels of POT-4 were consistently measured via serum ... expected to provide sustained therapeutic ocular levels of the drug for several months following a single ...

Alimera Sciences Announces Presentation of Data From the 12-Month Interim Readout of the Human PK Iluvien(TM) Study at ARVO 2009 Annual Meeting

... Group, which in addition to measuring systemic levels of FA, also assessed anterior chamber levels of FA, and assessed correlations between these levels and clinical outcomes. A total of 37 ...

Another Study Links Fluoride to Bone Cancer

... 29 /PRNewswire-USNewswire/ -- Blood fluoride levels were significantly higher in patients with ... Randhu and colleagues measured serum fluoride levels in three equal groups of age-matched and ... report proves a link between raised fluoride levels in serum and osteosarcoma," they write. This ...

Ferring Pharmaceuticals Launches Phase IIIB Trial of Degarelix as Intermittent Therapy

... prostate cancer who have rising serum PSA levels after previous curative therapies. The study ... Depot(R))(*)in reducing and sustaining castrate levels of testosterone.(1)(2) Suppression of testosterone to castrate levels occurred significantly faster in patients ...

Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen

... the 14 days of dosing, and the reductions in levels of HCV RNA were significant. Results of the ... -- experienced a median reduction in viral levels of -4.8 to -5.2 log(10) IU/mL in the highest ... of patients experiencing a decrease in viral levels below the quantification limit of the diagnostic ...

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

... who achieve an SVR, defined as undetectable levels of HCV (measured by Roche TaqMan assay) 24 weeks ... they have achieved RVR, defined as undetectable levels of HCV at week 4 (a strategy known as "RVR-guided" treatment), and maintain undetectable levels of HCV until week 22. Patients who do not achieve ...

Pistachios Offer Protective Benefits Against Heart Disease, Type II Diabetes and Obesity

... ability of pistachios to help control blood sugar levels and enhance satiety of meals and snacks. Fifteen ... response, delay gastric emptying and increase levels of the satiety hormone, ghrelin. The results ... significantly reduced LDL and total cholesterol levels compared to the full dose muffin group, as well ...

CRESTOR(R) Reduced CV Risk in Patients Achieving Low LDL and hsCRP Targets in New JUPITER Analysis

... show that patients with low to normal cholesterol levels and elevated high sensitivity C-reactive protein ... treated with rosuvastatin who achieved low levels of LDL-C and hsCRP had a greater reduction in ... elevated Total-C, LDL-C, ApoB, non-HDL-C, and TG levels and to increase HDL-C in adult patients with ...

Access Pharmaceuticals Announces Positive ProLindac(TM) Phase 2 Ovarian Cancer Clinical Trial Results

... was established as well as the recommended dose levels for future combination studies. "We are very ... and efficacy in patients at the highest dose levels which is very encouraging given that this study ... patient Phase 2 study explored 3 different dose levels and 2 dosing regimens of ProLindac as a ...

Nektar Announces Positive Results from Phase 2 Study of Oral NKTR-118 in Patients with Opioid-Induced Constipation (OIC)

... Significant Results Achieved at Two Dose levels with No Reversal of Analgesia SAN CARLOS, ... evidence of efficacy at two different dose levels of 25 mg once daily and 50 mg once daily. The ... orally once-daily at the 25 mg and 50 mg dose levels dramatically increased bowel movements within the ...

Diabetes Patients with High Triglycerides and Low HDL Cholesterol Get the Most Benefit From Fenofibrate Treatment: New Data From the FIELD Study

... cardiovascular risk, partly independent of levels of low-density lipoprotein (LDL) cholesterol. ... TIMI 22 Investigators. Impact of triglyceride levels beyond low-density lipoprotein cholesterol ... Targets Investigators. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. N ...

Statins Lower Stroke Severity, Improve Recovery

... on the drug -- even when their cholesterol levels were ideal. The finding is reported in the ... so we focused on the patients who had optimal LDL levels and found it still had quite significant value." ... 2005. Among that number, 207 had their lipid levels measured within 15 days either side of the stroke ...

Sequoia Pharmaceuticals Presents Proof of Clinical Concept of SPI-452, a Novel Pharmacokinetic Enhancer

... activity. Pharmacokinetic enhancers increase drug levels of co-administered agents through inhibition of ... metabolism. These increased drug levels can lead to improved efficacy, reduced pill ... and low- density lipoprotein (LDL) cholesterol levels in subjects receiving SPI-452 compared with ...

Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Announces FDA Filings for Paliperidone Palmitate and INVEGA(R)

... and similar medications can raise the blood levels of a hormone known as prolactin, causing a condition known as hyperprolactinemia. Blood levels of prolactin remain elevated with continued use. ... an erection. The connection between prolactin levels and side effects is unknown. People with ...

Medgenics Announces Positive Data From Phase I/II Clinical Trial of EPODURE Treatment of Anemia in Chronic Kidney Disease

... low dose does not result in sufficient hemoglobin levels in most patients. By having maintained hemoglobin levels in the target range for several months in more ... Even with the low dose, the hemoglobin levels of most of the patients have remained within ...

St. Jude Finds More Than 100 Gene Variations Linked With Response to Leukemia Treatment

... found a link between the IL15 SNPs, increased levels of IL15 in leukemia cells, and an increased ... and improve the outcome of patients with high levels of this interleukin." In addition, 21 of ... drugs from the body was associated with higher levels of MRD, suggesting that higher drug doses may be ...
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(Date:9/30/2014)... scientists and engineers, led by Clemson University associate ... million grant from the U.S. Department of Energy,s ... a direct positive impact on South Carolina in ... radioactive contaminants. , "Understanding the scientific and engineering ... aspects of nuclear technologies is imperative if South ...
(Date:9/30/2014)... England Journal of Medicine reports positive results of ... against the subset of lung cancer marked by rearrangement ... 50 patients with advanced non-small cell lung cancer testing ... 72 percent, with 3 complete responses and 33 partial ... for the disease to resume its growth after being ...
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Breaking Biology News(10 mins):Researchers get $5.25 million to advance nuclear technologies in South Carolina 2NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2On the trail of the truffle flavor 2
(Date:10/1/2014)... Between 23 million and 50 million people suffer ... from the National Institutes of Health (NIH) and the ... them have something else in common: They have a ... Gluten Free Therapeutics, makers of CeliVites nutritional supplements, ... publishing a series of blog posts aimed at educating ...
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Breaking Medicine News(10 mins):Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 4Health News:Anti Aging Clinic, the GTA’s Premier Provider of Anti Aging Treatments, Announces Deal on Units of Botox 2Health News:Chicago Coffee Start-up Makes a Big Impact, Earns National Recognition 2Health News:Nordic Naturals® Inspires Support for Paws for Veterans -- ‘Buy One Bottle. Help Two Heroes.’ Initiative Kicks Off October 1 2
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