CHMP Recommends Approval of New Indication for Enbrel(R) as Treatment for Severe Psoriasis in Paediatric Patients

... (RA) in adults, and polyarticular juvenile idiopathic arthritis (JIA) in children.(1) ... physical function. Polyarticular juvenile idiopathic arthritis Treatment of active polyarticular juvenile idiopathic arthritis in children and adolescents ...

Pediatric Researchers Find Possible 'Master Switch' Gene in Juvenile Arthritis

... reported on the link between the gene region and juvenile idiopathic arthritis (JIA), formerly called juvenile rheumatoid arthritis. The genetic variant is ... genes and environmental triggers, a child may get juvenile arthritis." The study compared 67 Caucasian ...

U.S. Food and Drug Administration Approves ORENCIA(R) (abatacept) for the Treatment of Moderate-to-Severe Polyarticular Juvenile Idiopathic Arthritis (JIA) in Patients Six Years and Older

... with moderately to severely active polyarticular juvenile idiopathic arthritis (JIA). ORENCIA may be used ... to Assess efficacy and safety in Key Endpoints in juvenile idiopathic arthritis Not responding to current ... sclerosis while on open-label treatment. About juvenile Idiopathic Arthritis (JIA) JIA -- also commonly ...

Rigel's R788 Shows Preclinical Activity in Type 1 Diabetes Model

... Type 1 Diabetes and R788 According to the juvenile Diabetes Research Foundation, type 1 diabetes, also called juvenile diabetes or insulin-dependent diabetes, occurs ... This work was supported by funds provided by the juvenile Diabetes Research Foundation and the Naomi Berrie ...

Keppra XR(TM) Extended-Release Tablets Filed with the FDA

... and adolescents 12 years of age and older with juvenile myoclonic epilepsy, and primary generalized ... In patients 12 years of age and older with juvenile myoclonic epilepsy, the most common adverse ... Keppra(R) injection use for myoclonic seizures in juvenile myoclonic epilepsy and partial onset seizures in ...

UCB Announces Positive Phase III Trial Results for Keppra XR(TM) (levetiracetam) Extended-Release Tablets

... and adolescents 12 years of age and older with juvenile myoclonic epilepsy, and primary generalized ... In patients 12 years of age and older with juvenile myoclonic epilepsy, the most common adverse ... Keppra(R) injection use for myoclonic seizures in juvenile myoclonic epilepsy and partial onset seizures in ...

ORENCIA(R) (abatacept) Supplemental Biologics License Application for Juvenile Idiopathic Arthritis Accepted by FDA for Filing and Review

... for the treatment of pediatric patients with juvenile idiopathic arthritis (JIA) who have had ... required for full T-cell activation. About juvenile Idiopathic Arthritis JIA -- also commonly known as juvenile rheumatoid arthritis (JRA) -- is a chronic, ...

Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression of Structural Joint Damage in Rheumatoid Arthritis Patients

... disease; in April 2008, additional indications for rheumatoid arthritis, juvenile idiopathic arthritis and systemic-onset juvenile idiopathic arthritis were also approved in Japan. ACTEMRA (known as ...

Two-Year Data Reinforce Effect of ACTEMRA(R) (tocilizumab) in Inhibiting Progression of Joint Damage and Improving Physical Function in Rheumatoid Arthritis Patients

... disease; in April 2008, additional indications for rheumatoid arthritis, juvenile idiopathic arthritis and systemic-onset juvenile idiopathic arthritis were also approved in Japan. ACTEMRA (known as ...

Roche and FDA Agree on Pathway Towards U.S. Approval of ACTEMRA(R) (tocilizumab)

... disease; in April 2008, additional indications for rheumatoid arthritis, juvenile idiopathic arthritis and systemic-onset juvenile idiopathic arthritis were also approved in Japan. The serious ...

Abbott Presents Long-Term Data From Extension Study Showing Adult Crohn's Patients Treated With HUMIRA(R) (Adalimumab) Maintained Remission

... adult patients. Severe adverse reactions reported in the clinical trial of juvenile idiopathic arthritis (JIA) included neutropenia, streptococcal ... reduce signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in patients four years of age and older. ...

New Study Demonstrates ACTEMRA(R) (tocilizumab) Inhibits Progression of Joint Damage in Rheumatoid Arthritis Patients

... 2008, ACTEMRA was approved for the treatment of rheumatoid arthritis, juvenile idiopathic arthritis and systemic-onset juvenile idiopathic arthritis in Japan. The serious adverse events reported in ...

Abbott's HUMIRA(R) (adalimumab) Receives FDA Approval For Moderate to Severe Chronic Plaque Psoriasis

... it had also submitted an FDA regulatory application for HUMIRA to treat juvenile rheumatoid arthritis and an EMEA regulatory application for HUMIRA to treat juvenile idiopathic arthritis. Clinical trials are currently underway evaluating ...

Vical Demonstrates Dose-sparing of Protein-based H5N1 Influenza Vaccine With Vaxfectin(TM) Adjuvant

... virus after challenge. In May, the company announced similar results in juvenile (1 - 2 year old) nonhuman primates. Both measles studies were conducted in ... of influenza; whether the measles vaccine will be effective in protecting juvenile or infant humans against infection or disease; whether the influenza or ...

Juvenile Diabetes Research Foundation, The Genomics Institute of the Novartis Research Foundation Announce Innovative Diabetes Drug Discovery and Development Partnership

... - Program Focuses on Expanding Pipeline of Drugs For People with Type 1 Diabetes - NEW YORK, Aug. 5 /PRNewswire-USNewswire/ -- The juvenile Diabetes Research Foundation said today that it has entered into a novel collaborative research agreement with the Genomics Institute of the Novartis ...

Spherix Announces Positive Phase 2 Study Results

... increase as an epidemic. Customarily considered a disease of adults, T2DM is increasingly being diagnosed in children in correlation to increasing juvenile obesity rates. About Naturlose Spherix holds patents on the use of Naturlose as a drug to treat diabetes. Naturlose is D-tagatose, which ...

Tolerx Presents Data at 69th Scientific Sessions of the American Diabetes Association

... has difficulty regulating its blood glucose (sugar) level. There are two major types of diabetes: type 1 and type 2. Type 1, previously known as juvenile diabetes or insulin-dependent diabetes, is a disorder of the body's immune system. In type 1 diabetes, the immune system attacks and destroys the ...

Juvenile Diabetes Research Foundation to Honor Duane DeSisto of Insulet Corporation and Senator Edward M. Kennedy at 27th Annual Hearts & Heroes Gala

... WELLESLEY, Mass., May 15 /PRNewswire/ -- The New England Chapter - Bay State Branch of the juvenile Diabetes Research Foundation (JDRF), the leader in setting the agenda for diabetes research worldwide and the largest charitable funder and advocate ...

Raptor Pharmaceuticals Appoints Dr. Patrice P. Rioux as Chief Medical Officer

... announced the completion of patient enrollment in its Phase 2a open-label clinical trial to evaluate a prototype formulation of DR Cysteamine in juvenile patients diagnosed with NASH. Results from that study are expected later this year. In November, 2008, Raptor entered into an agreement with ...

Wayne County Partners With TechTown to Launch Global Stem Cell 'Innovation and Commercialization Lab'

... which scientists can transfigure into a replica of any cell in the body. Stem cells are the raw material for drugs that can treat everything from juvenile diabetes to traumatic brain injury. "We are looking to collaborate with scientists and research universities internationally," Charlton said. ...

New Study Demonstrated ACTEMRA(R) (tocilizumab) Inhibited Progression of Joint Damage in Rheumatoid Arthritis Patients

... 2005, ACTEMRA was launched by Chugai in Japan as a therapy for Castleman's disease; in April 2008, additional indications for rheumatoid arthritis, juvenile idiopathic arthritis and systemic-onset juvenile idiopathic arthritis were also approved in Japan. The serious adverse reactions reported in ...

ACTEMRA (R) (tocilizumab) Significantly Reduced Signs and Symptoms of Rheumatoid Arthritis in Patients Who Failed Prior Treatments

... 2005, ACTEMRA was launched by Chugai in Japan as a therapy for Castleman's disease; in April 2008, additional indications for rheumatoid arthritis, juvenile idiopathic arthritis and systemic-onset juvenile idiopathic arthritis were also approved in Japan. The serious adverse reactions reported in ...

Continuous Treatment With Abbott's HUMIRA(R) Achieves Superior Long-Term Efficacy for Psoriasis Patients Compared to Interrupting Treatment

... including cyclosporine, methotrexate or PUVA. HUMIRA in combination with methotrexate is indicated for the treatment of active polyarticular juvenile idiopathic arthritis, in adolescents aged 13 to 17 years who have had an inadequate response to one or more DMARDs. HUMIRA can be given as ...

Tolerx Initiates Dosing of Otelixizumab, a Novel Type 1 Diabetes Agent, in DEFEND, a Phase 3 Clinical Trial

... body has difficulty regulating its blood glucose (sugar) level. There are two major types of diabetes: type 1 and type 2. Type 1, previously known as juvenile diabetes or insulin-dependent diabetes, is a disorder of the body's immune system. In type 1 diabetes, the immune system attacks and destroys the ...

ACTEMRA(R) (tocilizumab) Significantly Reduces Rheumatoid Arthritis Signs and Symptoms Regardless of Previous Therapy in Two New Global Studies

... 2005, ACTEMRA was launched by Chugai in Japan as a therapy for Castleman's disease; in April 2008, additional indications for rheumatoid arthritis, juvenile idiopathic arthritis and systemic-onset juvenile idiopathic arthritis were also approved in Japan. The serious adverse events reported in ACTEMRA ...

Shire Enhances its Orphan Drug Pipeline With the Acquisition of a New Clinical Candidate for Metachromatic Leukodystrophy

... the first few years of life. During the final stages all patients reach a decerebrate, vegetative state. The majority of cases are late infantile or juvenile patients. The number of adult patients exhibiting mild forms of MLD is unknown, as adult onset MLD can present with symptoms similar to psychosis. ...

Discovery Leads to Earlier Diagnosis of Type 1 Diabetes

... The Journal of Immunology recently published this research. This research was accomplished through the Max McGee National Research Center for juvenile Diabetes, established by football legend Max McGee. Diabetes is prevalent in the McGee family. Max's brother fought diabetes in his lifetime, and ...

Tolerx Advancing Novel Type 1 Diabetes Agent into Phase III Clinical Trial Program Following End of Phase II FDA Meeting

... has difficulty regulating its blood glucose (sugar) levels. There are two major types of diabetes: type 1 and type 2. Type 1, previously known as juvenile diabetes or insulin-dependent diabetes, is a disorder of the body's immune system. In type 1 diabetes, the immune system attacks and destroys the ...

International ACTEMRA Rheumatoid Arthritis Study Highlighted in The Lancet

... launched by Chugai in Japan as a therapy for Castleman's disease; in April 2006, additional indications for rheumatoid arthritis and systemic-onset juvenile idiopathic arthritis were also filed in Japan and are currently under review. The serious adverse events reported in ACTEMRA clinical trials ...

Arthritis Foundation Announces Amgen and Wyeth to Be Presenting Sponsor of the 2008 Arthritis Walk (R)

... is most prevalent in people over 60 years of age, while rheumatoid arthritis appears primarily in women in their young- to mid-adult years. juvenile rheumatoid arthritis is the most common form of arthritis in children. About the Arthritis Foundation The Arthritis Foundation is the leading ...

Sangamo BioSciences Announces Completion of Enrollment of Phase 2 Clinical Trial of ZFP Therapeutic for Diabetic Neuropathy

... and expand these findings and to evaluate repeat dosing with SB-509. The trial has been partially funded by a $3.0 million commitment from the juvenile Diabetes Research Foundation International (JDRF) pursuant to a research agreement between Sangamo and JDRF. Completion of enrollment of the trial ...

Neptune Industries Reports Favorable Phase II Trial Results on Ento- Protein(TM)

... first quarter of 2008, constructing its first pilot production facility, and bringing product to market by year end. The Phase II trials compared juvenile hybrid striped bass fed on a typical fishmeal-based diet, with those fed with Neptune's Ento-Protein(TM), consisting of 100% of the fishmeal portion ...

JDRF and Lilly Partner to Fund Research to Identify Beta Cell Biomarkers

... Three Years from Lilly Foundation Could 'Fill a Major Gap' in Diabetes Science - NEW YORK, Nov. 14 /PRNewswire-FirstCall/ -- The juvenile Diabetes Research Foundation and Eli Lilly and Company announced today that they are joining together to create a $3 million research effort to ...

Two Pivotal Phase III Studies for Roche's ACTEMRA(TM) (tocilizumab) Demonstrate Significant Improvement in Rheumatoid Arthritis Symptoms

... by Chugai in June 2005 as a therapy for Castleman's disease; in April 2006, additional indications for rheumatoid arthritis and systemic-onset juvenile idiopathic arthritis were also filed in Japan. The most common adverse events reported in ACTEMRA global clinical studies are upper respiratory ...

Obesity-Related Hormone is Higher in Children with Down Syndrome

... obesity often occurs in Down syndrome." The National Institutes of Health, the Penn-Cheyney Export Center, the National Down Syndrome Society, the juvenile Diabetes Research Foundation, and the Lawson Wilkins Pediatric Endocrinology Society all provided support for this study. Dr. Stettler and Dr. ...

Abbott's ABT-874 Shows Positive Results for Maintenance of Response in Phase II Psoriasis Study

... monoclonal antibody, the world's first, is now approved in four indications around the world and has been submitted for approval in psoriasis and juvenile rheumatoid arthritis. Our scientists are developing additional biologics including ABT-874, which takes a new approach by targeting interleukin-12 ...

Vaxfectin-formulated Measles DNA Vaccine Elicits Long-term Protection and Sterilizing Immunity in Nonhuman Primates

... protective levels of neutralizing antibodies in juvenile (1 - 2 year old) nonhuman primates confirmed by ... disease and death rates." The study in juvenile rhesus macaques tested the protective efficacy of ... of vaccine at the same 0.5 mg dose used in the juvenile animals. Neutralizing antibody levels ...

Newest Adult Stem Therapy Treats Diabetes

... Leaves Individuals With juvenile Diabetes Insulin-Free WASHINGTON, April 10, 2007 /PRNewswire-USNewswire/ ... Medical Association (JAMA) today released a study in which 14 of 15 juvenile Diabetes patients demonstrated significant improvement as a result of an ...

UCB Announces Positive Top-Line Phase III Results for Keppra as Adjunctive Therapy for Partial Onset Seizures in Paediatric Patients from One Month to Less than Four Years of Age

... seizures in adults and adolescents 12 years of age and older with juvenile myoclonic epilepsy, and as adjunctive therapy in the treatment of primary ... nervousness and asthenia. In patients 12 years of age and older with juvenile myoclonic epilepsy, the most common adverse events associated with ...