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Interactions in Medical Technology

42 Top U.S. Scientists and Specialists Explore Cutting-Edge Innovations to Defend America From Dangerous Zoonotic Diseases

... said. "Our goal was to keep the forum small enough to encourage dynamic interactions between the speakers, panelists and participants. Such interactions often result in the long-term, professional relationships that are ...

Sequella Presents Data on Synergy Between Investigational New TB Drugs SQ109 and TMC207

... between Sequella and Tibotec was designed to investigate in vitro interactions of SQ109 for synergistic, additive, or antagonistic activity in the ... of both drug sensitive and drug resistant M. tuberculosis (MTB). In vitro interactions investigated included synergy studies, rate of killing, post antibiotic ...

Ardea Biosciences Presents Phase 2a Antiviral Activity Data for Lead HIV Candidate, RDEA806 at XVII International AIDS Conference

... interaction study with RDEA806 and Truvada confirmed the lack of drug-drug interactions between these agents, paving the way for initiation of the Phase 2b ... in a patient-friendly, oral dosing regimen; limited pharmacokinetic interactions with other drugs; and the ability to be co-formulated with other HIV ...

Shire Reports Positive Results From First of Three Phase III Trials of velaglucerase alfa for Type 1 Gaucher Disease and Provides Important Updates on Interactions With FDA

... therapeutic goals is very important and is welcomed by both the physicians and patients." Regulatory Updates With regard to ongoing interactions with the FDA, Shire provided the following important updates: - The FDA has accepted Shire's treatment protocol for velaglucerase alfa. ...

BioCryst Pharmaceuticals Reports Positive Results of Shionogi & Co. Sponsored Phase 3 Studies of i.v. Peramivir for Influenza

... receive a manufacturing approval as soon as possible in Japan. About Peramivir Peramivir is an anti-viral agent that inhibits the interactions of influenza neuraminidase, an enzyme which is critical to the spread of influenza within a host. Peramivir has demonstrated clinical activity and ...

UNT Health Science Center's Groundbreaking Research Applied to Protecting Brain After Traumatic Injury

... injury in animals, estrogens can protect nerve cells and reduce neurological deficits. Application of these discoveries to human subjects awaited the interactions of Simpkins with the pioneering clinical research of Wigginton, who is now the first to take estrogens into clinical trials for acute brain injury ...

Amicus Therapeutics Commences Phase 3 Trial Evaluating Amigal(TM) for the Treatment of Fabry Disease

... for Amicus and highlights our transition into a late-stage development company." Crowley continued, "We are very pleased with the outcome of our interactions with FDA around the design of this pivotal study and are confident we have set the stage for a successful Phase 3 study. We continue to believe that ...

Study Results Present Efficacy and Safety Findings from the PHIRST-1 Study of Patients with Pulmonary Arterial Hypertension Taking Tadalafil Tablets Once Daily

... pressure. CIALIS for once daily use provides continuous plasma tadalafil levels which should be considered when evaluating the potential for interactions with certain medications (e.g., nitrates, alpha-blockers, anti-hypertensives and potent inhibitors of CYP3A4) and with substantial amounts of ....

Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections

... of therapy Possibility for expanded indications including bacteremia, severe CAP and osteomyelitis Lower potential for drug-drug interactions including those with dietary tyramine, SSRIs and vasoconstrictors About Trius Therapeutics Trius Therapeutics is discovering ...

SCAI Statement on the BARI 2D Trial (Bypass Angioplasty Revascularization Investigation With Diabetes Trial) Presented at the American Diabetes Association (ADA) Annual Scientific Sessions and Published in The New England Journal of Medicine

... failure, or could have faced complications from combining insulin with other medicines. Knowing a patient's full medical profile and possible drug interactions is imperative to all physicians to achieve the best possible outcomes for our patients." ...

Heaviest Smokers Face Greatest Risk of Death After Lung Cancer Diagnosis

... compared with females' average of 112. Patients with stage 3 tumors smoked an average of 198 packs a year. The study is titled "Impact and interactions between smoking and traditional prognostic factors in lung cancer progression." In addition to the Mary Babb Randolph Cancer Center, the study ...

Video: UCB Launches Vimpat(R) in the U.S. for Add-On Treatment of Epilepsy in Adults

... has been studied in combination with multiple AEDs as well as several commonly used medications with no clinically significant pharmacokinetic drug interactions observed in clinical trials. This demonstrates the importance and potential utility of including Vimpat(R) in partial onset epilepsy treatment ...

New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)

... immediately and the other type to be released approximately four hours later in the lower intestine where pH levels are higher. The drug interactions section of the ADDERALL XR product labeling states that coadministration of ADDERALL XR and proton pump inhibitors should be avoided, as these ...

Study Reported Tadalafil Taken Once Daily Improved Erectile Function in Men with ED and Sexual Quality of Life in Couples

... in blood pressure. Cialis for once daily use provides continuous plasma tadalafil levels which should be considered when evaluating the potential for interactions with certain medications (e.g., nitrates, alpha-blockers, anti-hypertensives and potent inhibitors of CYP3A4) and with substantial amounts of ....

Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2009 First Quarter Results

... in March 2009. Top line results from the trial indicated that LX2931 was well tolerated in combination with methotrexate, and no drug-drug interactions were observed. In addition, Lexicon will present Phase 1 data for LX2931 at the European League Against Rheumatism (EULAR) annual meeting on June ...

Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen

... (SAEs), no dose reductions and no discontinuations were reported in the study. Pharmacokinetic analysis confirmed that there were no drug-drug interactions between the compounds. Next Steps in the Development Program The companies are now exploring twice-daily dosing of R7227 and higher total ...

Trubion Pharmaceuticals, Inc. Announces Upcoming Presentation at the 2009 American Association of Cancer Research Annual Meeting

... simultaneously. Trubion's SCORPION format provides the basis for development of single therapies that simultaneously inhibit multiple ligand/receptor interactions or that manipulate cellular signaling pathways by cross-linking multiple cell surface receptors. About Trubion Trubion is a ...

Edifecs, CAQH and Harvard Pilgrim Health Care Will Examine CORE Phase II Testing Outcomes and Lessons Learned at HIMSS09 Interoperability Showcase

... healthcare administration, resulting in a better care experience for patients and caregivers. CAQH solutions - like CORE - help promote quality interactions between plans, providers and other stakeholders, reduce costs and frustrations associated with healthcare administration and encourage ...

DURECT Reports Positive Phase IIb Data from TRANSDU(TM)-Sufentanil Clinical Program

... 300 patient exposures. These studies include evaluating wearing, pharmacokinetics, specialty populations, repeat applications, skin abrasions, drug interactions and dose conversions. In addition, a non-clinical package comprising multiple animal safety studies has been developed, including carcinogenicity ...

Beating Blood Clots after Joint Replacement

... "is the fact it is hard to manage the dosage and requires monitoring and dose adjustment on a regular basis. There are also many food and drug interactions that can alter the effectiveness of the drug." "Nothing is 100 percent preventable, but we can certainly cut the risk significantly and improve ...

Data from Phase 2 Study of Peramivir in Patients Hospitalized with Influenza Presented at the XI International Symposium on Respiratory Viral Infections

... Singapore, Australia, New Zealand, and South Africa, in 2007 and 2008. About Peramivir Peramivir is an antiviral agent that inhibits the interactions of influenza neuraminidase, an enzyme which is critical to the spread of influenza within a host. In laboratory tests, peramivir has shown activity ...

Atritech to Participate in Late-Breaking Clinical Trial Presentation at American College of Cardiology Meeting

... medications to prevent these clots from forming in the heart. Current medical therapy requires frequent monitoring and has diet and other drug interactions and increases the risk of bleeding. The WATCHMAN device may be an effective alternative to warfarin for these patients. About Atritech ...

New PRO2000 HIV-Prevention Findings Important Milestone on Path Toward Development of Effective Vaginal Microbicide

... to women during sex. BufferGel's primary action is to lower vaginal pH while PRO2000 is a large charged polymer designed to interfere with HIV's interactions with its target cells. Results from the four-year trial (HPTN 035), conducted in Malawi, South Africa, the United States, Zambia and Zimbabwe, ...

Oridion Announces Significant Medical Studies Presented at STA

... Pulmonary Index from Israel. The new index is described in these reports as providing a simple and clinically useful approach to assessing the interactions of heart rate, oxygen saturation, respiratory rate and adequacy of ventilation." Oridion is the global leader of innovative capnography ...

Amicus Therapeutics Announces Positive Progress of Three Lead Clinical Programs and General Outlook for 2009

... clinical milestones and financial guidance for 2009 at the 27th Annual J.P. Morgan Healthcare Conference. The Company also provided an update on its interactions with U.S. and European regulatory agencies that are expected to lead to the commencement of Phase 3 clinical development for Amigal(TM) (migalastat ...

Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia

... in patients with hepatic impairment. Caution is recommended in these patients and QT interval should be monitored closely. Drug interactions The concomitant use of QT prolonging drugs and strong inhibitors or inducers of CYP3A4 should be avoided as they may affect serum ...

RHEI Pharmaceuticals Announces the Initiation of the Final Clinical Study for Approval of Tibozole in China

... Chief Executive Officer and Chairman of RHEI Pharmaceuticals. "Although very effective, systemic drugs can have systemic side effects and drug interactions in certain patients, like those with cancer or AIDS, who are often on multiple other therapies. Tibozole, a locally active azole derivative in a ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... in patients with hepatic impairment. Caution is recommended in these patients and QT interval should be monitored closely. Drug interactions The concomitant use of QT prolonging drugs and strong inhibitors or inducers of CYP3A4 should be avoided as they may affect serum concentration ...

Colesevelam HCl Lowered LDL Cholesterol in Pediatric Patients With Heterozygous Familial Hypercholesterolemia

... tract surgery, or if you have trouble swallowing. Tell your doctor if you have vitamin A, D, E, or K deficiencies. Welchol has known interactions with glyburide (a drug for diabetes), levothyroxine (a drug used to treat an underactive thyroid) and certain oral contraceptives. Welchol has not ...

NanoBio Demonstrates New Topical Approach to Treating Nail Fungus That Circumvents Problems with Current Therapy

... the treatment of onychomycosis," Ciotti said. "And because there is no systemic absorption, NB-002 does not pose the risk of adverse events or drug interactions that systemic antifungal agents present." NB-002 kills both active spores and developing hyphae, an additive effect that lessens the fungi's ...

Pivotal Phase III Data Confirm the Efficacy and Safety of Arpida's Intravenous Iclaprim in Treating Patients With Complicated Skin and Skin Structure Infections

... frequent among patients treated with iclaprim as compared to linezolid. In earlier Phase I trials, iclaprim was shown to have a low propensity for interactions with other drugs. "These data further support the safety and efficacy of iclaprim as a potential treatment against complicated skin and skin ...

Sequoia Pharmaceuticals Presents In Vitro and First-in-Human Data Supporting Further Development of SPI-256, a Novel Investigational Protease Inhibitor

... we designed our protease inhibitor using a structure-based approach that targets highly conserved regions of the protease enzyme while minimizing interactions with regions of the enzyme that are highly malleable and thus susceptible to mutations." First-in-human data with SPI-256 The primary objective ...

F.D.A. Approves SANCUSO(R), the First and Only Patch for Preventing Nausea and Vomiting in Cancer Patients Undergoing Chemotherapy

... clothing while wearing the patch and for 10 days after removing it. The most common adverse reaction is constipation. No clinically relevant drug interactions have been reported in clinical studies with Sancuso. About ProStrakan ProStrakan is one of Europe's fastest growing pharmaceutical ...

Bionovo Reports on Metabolic Studies Related to Its Menopausal Hot Flash Drug Candidate

... the parent compound towards selective activation of the estrogen receptor beta. Enzyme kinetic experiments suggest that clinically relevant drug-drug interactions are highly unlikely, which is a positive safety feature of MF101, applicable if the drug is taken in combination with other drugs. The paper is ...

Data Suggest CEL-SCI's CEL-2000 Vaccine Prevents or Retards Permanent Damage of Rheumatoid Arthritis

... preventive sites for the application of L.E.A.P.S.(TM) technology. The concept behind the L.E.A.P.S.(TM) technology is to directly mimic cell/cell interactions on the T-cell surface with synthetic peptides. The L.E.A.P.S.(TM) constructs containing the antigenic disease epitope linked to a T-cell binding ...

New Genes Found for Inflammatory Bowel Disease in Children

... to a type of TNF involved in the disease (Among those drugs are infliximab, adalimumab and certolizumab). "As we better understand the complex gene interactions in IBD, we may be able to diagnose patients by their genetic profile to predict who will better respond to anti-TNF drugs," said Hakonarson. Anti-TNF ...

Shingles Pain Treatment Will Benefit More Patients

... with caution in patients with severe cardiac impairment, severe renal impairment or severe hepatic impairment. Interactions: No clinically relevant interactions have been observed in clinical studies. Absorption of lidocaine from the skin is low. Use with caution in patients receiving Class I antiarrhythmic ...

Ardea Biosciences Advances Lead Product Candidate for the Treatment of Gout, RDEA594, Into Phase 1 Clinical Trial

... that are resistant to efavirenz (Sustiva(R)) and other currently available NNRTIs; a high genetic barrier to resistance; limited pharmacokinetic interactions with other drugs; no reproductive toxicity based on animal studies; and the potential to be readily co-formulated in a single pill with other HIV ...

Amicus Therapeutics Announces Second Quarter 2008 Financial Results

... (EMEA) regarding plans for a global Phase 3 clinical development program for Amigal. In line with previous guidance, Amicus expects to complete these interactions in the second half of 2008, and subject to the outcome of the discussions, the Company plans to initiate Phase 3 development of Amigal in the first ...

Abbott's Kaletra(R) Tablet Dosed Once-Daily or Twice-Daily Demonstrated Similar Clinical Results Across Race and Gender Lines

... Rifater(R), or Rifamate(R); St. John's Wort (hypericum perforatum); Mevacor(R) (lovastatin), or Zocor(R) (simvastatin). There are drug-drug interactions with the potential for risk of serious or life-threatening side effects. Alterations in dose, increased monitoring of drug levels in the blood, or ...
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