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Innate in Medical Technology

CMC ICOS Biologics and Implicit Bioscience Ltd Announce IC14 Antibody Manufacturing Agreement and Patent License

... of human CD14, an essential component of the innate inflammatory response to bacterial infection. CD14 triggers activation of the innate immune response to bacterial components including ... (TLR) pathway. Lung inflammation in response to innate immune activation through the TLR pathway is a ...

IBT Laboratories Expands its Menu of Tests for Immune Deficiency

... to respond to challenge by microorganisms. Both innate and adaptive immunity need to be evaluated. ... is one of the most important components of the innate immune system. IBT has developed a unique and ... recurrent infections to determine whether their innate immune system is compromised. It will also help ...

Agennix Receives Fast Track Designation From FDA for Talactoferrin in Combination With Sunitinib for Renal Cell Carcinoma

... by targeting dendritic cells which play an important role in activating innate and adaptive immunity. After being transported into the gut associated ... activate Natural Killer (NK) and Natural Killer T-cells (NK-T) of the innate immune pathway and CD8+ lymphocytes of the adaptive immune pathway. ...

VentiRx Pharmaceuticals Commences Phase I Clinical Trial of VTX-2337, a Novel TLR8 Agonist for the Treatment of Oncology

... of VTX-2337 suggests that it may play a key role in augmenting the innate arm of the immune system and provide a valuable addition to various ... compound to reach the clinic and we are hopeful that modulation of the innate immune response will provide a benefit to patients in a number of oncology ...

CorMatrix(R) Announces Intramyocardial Injection of Emulsified ECM Technology(TM) Demonstrates Enhanced Angiogenesis and Improved Cardiac Function in a Preclinical Model

... matrix (ECM(TM)) biomaterial technologies that harness the body's innate ability to repair damaged cardiovascular tissue, presented data on its ECM ... and delivering innovative biomaterial devices that harness the body's innate ability to repair damaged cardiovascular structures. For more information ...

CEL-SCI Presents Data for CEL-1000 as a Vaccine Adjuvant with Recombinant Hepatitis B Virus Protein

... virus, viral encephalitis and malaria. CEL-1000 appears to activate innate (very early stage) and Th1 type (cellular) immune responses to induce a broad-spectrum protection against infection in animal models. The innate immune system is generally accepted to be the first line of defense ...

St. Francis Surgeon Uses Tissue Regeneration Technology to Rebuild Patients' Heart Structures

... heart tissue to re-grow inside the beating hearts of heart surgery patients. The CorMatrix ECM is a unique biomaterial that harnesses the body's innate ability to repair damaged heart tissue. Over time, it is replaced by the patients' own tissue. "The use of this biomaterial is a major ...

VentiRx Pharmaceuticals Initiates Phase I Clinical Trial of VTX-1463, a Novel TLR8 Agonist for the Treatment of Allergic Rhinitis

... "Allergic diseases affect approximately twenty percent of the overall population. Based on strong preclinical data, we expect that modulation of the innate immune response will provide a benefit to people that suffer from these diseases." About VentiRx Pharmaceuticals VentiRx Pharmaceuticals ....

Drug Development Program Started Based on CAP(R) Human Cell Line

... of our partners." On the scientific importance Alloksys' COO, Dr Ruud Brands commented: "rhuALP, based on the proposed mechanism of action in innate immune modulation, may enable the application in a wide array of disabling chronic inflammatory conditions, thereby eliminating the potentially ...

Genomas Clinical Study Finds Increased Prevalence of Drug Metabolism Deficiencies in Patients With Serious Psychotropic Side Effects

... for developing serious side effects to a variety of psychotropic medications. "We found clear evidence that there were significantly more innate drug metabolism deficiencies based on the gene variants predominantly observed in the population experiencing side effects," said Gualberto Ruano, ...

Previous Claims of siRNA Therapeutic Effects Called into Question by Report in 'Human Gene Therapy'

... design siRNA studies that incorporate suitable controls to differentiate the disease-modulating effect of an siRNA from its ability to stimulate an innate immune response. siRNAs have been highly touted for their ability to target very specifically and selectively the disease-causing factors in a ...

Results Published in the Journal 'Cancer' Demonstrate that Oral Talactoferrin Alfa is Active as Monotherapy in Previously Treated Patients with Metastatic Renal Cell Carcinoma

... to the GALT and induces their maturation. DC maturation in the presence of tumor antigens and lymphoid effector cells induces a strong systemic innate and adaptive immune response mediated by anti-cancer Natural Killer (NK) cells, CD8+ lymphocytes and NK-T cells. This results in the activation ...

Tengion Scientists Publish Key Preclinical Findings Demonstrating the Benefits of Organ Regeneration Vs. Repair

... uses biocompatible materials and a patient's own (autologous) cells to create neo-organs or neo-tissues that are designed to catalyze the body's innate ability to regenerate. Tengion's product candidates may ultimately address the most critical problems facing organ and tissue failure patients, ...

Romark Laboratories Completes Enrollment in U.S. Phase II Study of Nitazoxanide for Chronic Hepatitis C Genotype 1 Non-Responders

... small molecule kinase activators called the thiazolides. Like interferons, thiazolides modulate cell signaling pathways involved in the host cell's innate defense against viruses. Thiazolides can be administered orally and are not associated with side effects commonly associated with use of interferon. ...

Preclinical Data Demonstrate Ability to Regenerate an Entire Bladder With Tengion Neo-Bladder Replacement(TM)

... uses biocompatible materials and a patient's own (autologous) cells to create neo-organs or neo- tissues that are designed to catalyze the body's innate ability to regenerate. Tengion's product candidates may ultimately address the most critical problems facing organ and tissue failure patients, ...

ChemoCentryx Initiates Clinical Trial of CCR1 Inhibitor CCX354

... agents and analgesics, addressing a $10 billion market. During the development and progression of RA, the recruitment of immune cells, both innate and adaptive, into affected joints plays a key role in the inflammatory process and the ensuing joint destruction. There is strong evidence ...

Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008

... cell signaling modulators (CSMs) called the thiazolides. Like interferons, thiazolides modulate cell signaling pathways involved in the host cell's innate defense against viruses. Thiazolides can be administered orally and are not associated with side effects commonly associated with use of ...

Oral Talactoferrin Alfa Improves Overall Survival in Patients With Refractory Non-Small Cell Lung Cancer: Final Phase 2 Study Results Presented at the 8th Annual Targeted Therapies for the Treatment Of Lung Cancer Meeting

... to the GALT and induces their maturation. DC maturation in the presence of tumor antigens and lymphoid effector cells induces a strong systemic innate and adaptive immune response mediated by anti-cancer Natural Killer (NK) cells, CD8+ lymphocytes and NK-T cells. This results in the activation ...

Juvaris BioTherapeutics Announces Cooperative Research and Development Agreement With The Centers for Disease Control and Prevention

... in multiple infectious disease and cancer applications. The JuvImmune product has been shown to be at least 50-times more potent at triggering innate immune activation and interferon release than current immune stimulants. When combined with disease-specific antigens, the technology ...

Tumor Eradication Article Published by Cancer Research

... viral colonization enables the immune system to recognize tumors as foreign elements and activate defense mechanisms to fight them. These increased innate and adaptive immune responses further contribute to the regression and eventual eradication of the tumor. This research was conducted in ...

Pharmaceutical Companies Lead Fight Against Staph and Other Infectious Diseases

... strains of Staphylococcus aureus. --A medicine for the treatment of hepatitis C that is part of a new class of drugs to regulate innate immunity. --A medicine that stops the life cycle of the bacterium that causes tuberculosis. Other medicines are in development for treatment of ...

Dynavax's HEPLISAV(TM) Hepatitis B Vaccine Maintains Full Immunogenicity at 50 Weeks in Phase 3 Trial

... HBV vaccine is based on its proprietary immunostimulatory sequence (ISS) that specifically targets Toll-Like Receptor 9 (TLR9) to stimulate an innate immune response. Dynavax's HBV vaccine combines ISS with HBV surface antigen (HBsAg) and is designed to significantly enhance the level, speed and ...

Drug in New Hepatitis C Clinical Trial

... ongoing phase Ib study of subcutaneously administered drug at the Princess Alexandra Hospital in Brisbane. Oglufanide disodium regulates the body's innate immune response to defeat invading germs and cancer cells. The drug is also under development by Implicit as a biodefense therapy and for ovarian ...

Inimex Product Candidate is First Immune Defense Regulator to Cure Infections Without Causing Harmful Inflammation

... therapeutics that utilize this powerful innate response without the threat of a cytokine ... peptide that selectively modulates the innate immune response" in Nature Biotechnology (April ... on the development and commercialization of innate Defense Regulators (IDRs), novel first-in-class ...

New Report Illuminates Ampligen's Unique Mechanism of Action

... if TLR-3 is essential for the activities of dsRNAs for the induction of innate immunity. Unlike the toxic Poly I:Poly C, Ampligen is directed towards the activation of TLR-3 in the induction of innate immune responses. The closely allied compound, Poly I : Poly C, has been ...

CEL-SCI's Cel-1000 Shown to Significantly Enhance Immune Response Against Hepatitis B Antigen in Animals

... virus, viral encephalitis and malaria. CEL-1000 appears to activate innate (very early stage) and Th1 type (cellular) immune responses to induce a broad- spectrum protection against infection in animal models. The innate immune system is generally accepted to be the first line of defense ...

CEL-SCI'S CEL-1000 Shown to Significantly Enhance Immune Response Against Avian Flu Antigen in Animals

... virus, viral encephalitis and malaria. CEL-1000 appears to activate innate (very early stage) and Th1 type (cellular) immune responses to induce a broad-spectrum protection against infection in animal models. The innate immune system is generally accepted to be the first line of ...

Biothera's Imprime PGG Enhanced Effectiveness of Avastin in Cancer Study

... Imprime PGG is a biological response modifier that enhances specific innate immune cell responses. Biothera has completed two Phase I clinical trials ... The company's primary focus is developing pharmaceuticals that engage the innate immune system to fight cancer. Other applications include hematopoiesis ...

Hollis-Eden Announces Cancellation of Acute Radiation Syndrome RFP by Department of Health and Human Services

... disrupted by disease and aging, have been demonstrated in humans to possess several properties with potential therapeutic benefit -- they regulate innate and adaptive immunity, reduce nonproductive inflammation and stimulate cell proliferation. The Company's lead product candidate, NEUMUNE(R) (HE2100), ...

ImmuneRegen BioSciences Announces Promising Data on Homspera Suggesting Potential as a Co-Therapeutic Agent

... and platelets, which could be of value in radiation-treated cancer patients. Studies in cell culture have revealed elevations in components of the innate immune system that are consistent with Toll-like Receptor activation, a postulated mechanism by which vaccine adjuvants accomplish their ...

The Sturdier Sex?: Study by Pittsburgh Scientists Finds Female Stem Cells Work Better

... and 60 percent of the female populations of stem cells had an RI higher than the mean RI of the male cells (95). This difference may arise from innate sex-related differences in the cells' stress responses, according to Dr. Deasy, an assistant professor in the Departments of Orthopaedic Surgery ...

Near-Patient Testing: The Advantages of C-Reactive Protein in Hematological Testing

... CBC forms an integral part of hematology and guides numerous therapeutic interventions. CRP, an acute phase plasma protein, is involved in the innate inflammatory response and is a well known marker of systemic inflammation. CRP is secreted rapidly, within a few hours of the immunological insult, ...
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