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Inflammatory in Medical Technology

VisEn Molecular Imaging Technology Enables Key Insights Into Newly Discovered Biologic Pathway Published in SCIENCE

... relates to monocyte deployment from the spleen to inflammatory sites, including myocardial infarction. The ... Reservoir Monocytes and Their Deployment to inflammatory Sites ," researchers at the Massachusetts General ... and demonstrate the monocyte deployment to inflammatory sites in vivo . In the in vivo data analysis, ...

SIMPONI(TM) (golimumab) Receives Positive Opinion From CHMP for Once-Monthly Subcutaneous Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

... for rheumatologists, and adults living with these inflammatory conditions who are seeking an effective and ... Arthritis Psoriatic arthritis is a chronic inflammatory arthropathy manifesting with joint pain and ... form of spinal arthritis, and symptoms of inflammatory back pain often first present in people under the ...

ALP Life Sciences, LLC Announces Nanoveson(TM) Patent Filing and Whitepaper Availability on Proposed Therapy for Non-Alcoholic Fatty Liver Disease (NAFLD) and Comorbid Diseases

... Arachidonic acid metabolism is implicated in many inflammatory diseases, including cardiovascular diseases, ... by reducing arachidonic acid availability for inflammatory metabolism. Orphan disease indication targets for inflammatory diseases may be pursed through clinical trials ...

School of Dentistry Studies Link Between Oral Health and Memory

... gum infection, you'll have an increased level of inflammatory byproducts," Crout explained. "We're looking for ... of the problems in the mouth and then see if the inflammatory markers go down." Researchers don't yet ... create health problems or whether the body's inflammatory response is to blame. It may be a combination of ...

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome

... Suggest Broad Implications for the Treatment of inflammatory and Autoimmune Disorders SOUTH SAN ... and long-lasting, lowering expression of multiple inflammatory mediators, including TNF-a and IL-6. Disease ... by the immunoproteasome in development of the inflammatory process. "Targeting protein degradation ...

Two-Year Data Show Patients Receiving SIMPONI(TM) (golimumab) Experienced Sustained Improvement in Signs and Symptoms of Psoriatic Arthritis and Ankylosing Spondylitis

... relief to patients living with the chronic inflammatory disease, ankylosing spondylitis," said Jurgen ... Arthritis Psoriatic arthritis is a chronic inflammatory arthropathy manifesting with joint pain and ... form of spinal arthritis, and symptoms of inflammatory back pain often first present in people under the ...

New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease

... weeks 30 and 54. Dr. William J. Sandborn, inflammatory Bowel Disease Clinic, Mayo Clinic, and principal ... response to conventional therapy, a related inflammatory bowel disease. REMICADE is also approved for the ... Crohn's Disease Crohn's disease, a chronic inflammatory disease of the gastrointestinal tract, affects ...

PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryx's Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference

... Affairs of ChemoCentryx. "No cure exists for inflammatory bowel diseases and many patients do not respond ... in CCR9-based therapeutics for the treatment of inflammatory bowel diseases." The randomized, ... as 'CCR9', which is selectively expressed by inflammatory T cells to migrate to the digestive tract in a ...

Medarex Announces Primary Endpoint Achieved in MDX-1100 Anti-IP-10 Antibody Phase 2 Trial for Rheumatoid Arthritis

... for rheumatoid arthritis and potentially other inflammatory indications." "Based on these positive ... the broader potential of MDX-1100 in a range of inflammatory diseases, including ulcerative colitis in an ... chemokine expressed in association with multiple inflammatory disease indications. The MDX-1100 Phase 2 study ...

Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies

... Antibodies Stimulate Dendritic Cell Maturation, inflammatory Cytokine and Chemokine Release and Recruitment of ... resulting in the mobilization of important inflammatory and other anti-tumor components of the immune ... to tumors and causes an increase in several inflammatory cytokines while decreasing an important ...

Cequent tkRNAi Technology to be Presented at the Centennial Meeting of the American Association for Cancer Research

... for other cancers, inflammatory diseases, and disorders Monday, April 20 ... and treat a wide range of human disorders - from inflammatory disease to cancer - based on the company's ... candidates targeting colon-cancer prevention and inflammatory bowel disease. The company designed its powerful ...

Osprey Pharmaceuticals U.S.A., Inc. Initiates Phase Ib Clinical Trial in IgA Nephropathy

... Trial to Evaluate Safety of CCL2-LPM for inflammatory Kidney Disease SAN FRANCISCO, April 14 ... for the treatment of IgA nephropathy, an inflammatory kidney disease. Osprey Pharmaceuticals U.S.A. is ... Modulators (LPMs), for the treatment of inflammatory and autoimmune diseases. CCL2-LPM selectively ...

Alba Therapeutics Corporation Announces the Next Clinical Trial of Its Lead Compound, Larazotide Acetate and Promotions

... with celiac disease and other autoimmune and inflammatory diseases," said Bruce Peacock. Francisco ... Dr. Leon was a Director of Clinical Development, inflammatory and Respiratory Diseases at MedImmune where he ... pharmaceutical products to treat autoimmune and inflammatory diseases and is based in Baltimore, Maryland. ...

Acanya(TM) Gel, a New Treatment for Moderate to Severe Acne, Launched by Coria Laboratories

... once-daily treatment of both non-inflammatory and inflammatory lesions of acne. In pivotal Phase III ... for treating patients with moderate to severe inflammatory and non-inflammatory acne. In addition, high ... Acanya Gel showed a 55% mean reduction in inflammatory lesions and a 43% mean reduction in ...

ESBATech's Antibody Fragment Enters Phase Ib/IIa in Ophthalmology

... in the development of novel treatments for inflammatory ocular conditions. We are very pleased to advance ... well known and well characterized drug target for inflammatory conditions. However, the spectrum of potential ... in ophthalmology lies way beyond classical inflammatory diseases. In our preclinical studies that we have ...

Takeda Initiates Two Phase III Studies with Vedolizumab (MLN0002) in Patients with Inflammatory Bowel Disease

... (MLN0002), an investigational compound for inflammatory bowel disease (IBD). The trials, known as the ... that vedolizumab works by blocking a key inflammatory marker on white blood cells, thereby preventing the migration of these inflammatory cells into the intestinal wall. The two ...

Roskamp Institute Identifies New Class of Drugs to Treat Alzheimer's Disease

... afflicted by Alzheimer's disease, also trigger an inflammatory response. This inflammatory response is thought to be detrimental to nerve ... and new amyloid production. As specific inflammatory molecules contact CXCR2, a signal is generated ...

Synvista Therapeutics Announces First Dosing of SYI-2074 in Clinical Trial for Psoriasis

... of mild to moderate plaque psoriasis, an inflammatory disease highly correlated with a molecular ... Psoriasis is an immune-mediated chronic inflammatory disease usually characterized by red lesions or ... can lead to psoriatic arthritis, another inflammatory disease affecting the joints. While the ...

Alba Therapeutics Presents New Data for Larazotide Acetate at the 2008 American College of Gastroenterology Annual Scientific Meeting

... Additional Data Indicates Potential in Treating inflammatory Bowel Disease ORLANDO, Fla., Oct. 7 ... acetate also inhibited the effect of inflammatory cytokines, including tumor necrosis factor ... offers potential as a future treatment for inflammatory bowel disease (IBD). Larazotide Acetate is a ...

Ardea Biosciences Presents Preclinical Anti-Inflammatory Data on its Lead MEK Inhibitor, RDEA119, at the ACG 2008 Annual Meeting

... appears to be a promising strategy for treating inflammatory disease, for which a significant unmet medical ... excellent progress with our programs addressing inflammatory disease and the data presented today ... MEK inhibitors for the treatment of cancer and inflammatory diseases, are two of the compounds from Ardea's ...

New Findings Show Efficacy of REMICADE(R) Compared With Azathioprine in Treatment of Crohn's Disease According to First-of-its Kind Study

... disease." Dr. William J. Sandborn, inflammatory Bowel Disease Clinic, Mayo Clinic, and principal ... Crohn's disease. Crohn's disease is a chronic inflammatory disease of the colon and large intestine that ... Crohn's Disease Crohn's disease, a chronic inflammatory disease of the gastrointestinal tract, affects ...

Athera Biotechnologies and Dyax Announce a Collaboration to Discover and Develop Antibodies for Cardiovascular Inflammation

... for the prevention or treatment of cardiovascular inflammatory diseases. The collaboration follows the recent ... disease. Atherosclerosis is a chronic inflammatory disease in which the walls of the blood vessels ... medical needs, with an emphasis on oncology and inflammatory indications. Dyax utilizes its proprietary drug ...

Ardea Biosciences to Present Data on Lead MEK Inhibitor, RDEA119, at American College of Gastroenterology Annual Scientific Meeting

... in Mice" Poster Number: P1050 Session Title: inflammatory Bowel Disease Location: Florida Exhibit Halls ... a precursor to trials in patients with inflammatory diseases. Lastly, we have evaluated our ... MEK inhibitor for the treatment of cancer and inflammatory diseases, RDEA436, in a human ...

SARcode and Sunesis Announce Start of Phase 1 Clinical Trial in Ocular Inflammatory Diseases

... on small molecule LFA-1 inhibitors to treat inflammatory diseases, and Sunesis Pharmaceuticals, Inc. ... has the potential to address immunological and inflammatory diseases, including dry eye syndrome. We look ... agents for the treatment of T-cell mediated inflammatory diseases. About Sunesis Pharmaceuticals ...

Isis Initiates Clinical Trial of CRP Drug

... benefit in cardiovascular, renal and inflammatory diseases CARLSBAD, Calif., Aug. 13 ... in cardiovascular disease but also in renal and inflammatory diseases. Based on our preclinical data, and the ... ISIS 353512 to treat cardiovascular, renal and inflammatory diseases. Any statement describing Isis' ...

Medarex Announces Initiation of Phase 2 Clinical Development Program for the Treatment of Lupus

... Phase 1 clinical trial for MEDI-545 in idiopathic inflammatory myositis, an immunological disease that ... excited about the role of the interferon alpha inflammatory pathway and look forward to exploring its ... United States are affected with lupus, a chronic inflammatory disease that causes the body to attack its own ...

Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City

... disease pathways in oncology and inflammatory diseases, including immune modulation by ... cause tissue damage in rheumatoid arthritis and inflammatory bowel diseases. MDX-1100 represents a ... the depletion and elimination of B-cells for inflammatory disease indications. Phase 1 trials in chronic ...

Micromet and Nycomed Begin Formal Preclinical Safety Studies for Antibody MT203 for Inflammatory and Autoimmune Diseases

... that may be useful for the treatment of various inflammatory and autoimmune diseases. Preclinical studies ... on MT203 related to the treatment of inflammatory and autoimmune diseases," said Anders Ullman, ... applications in the treatment of various inflammatory and autoimmune diseases, such as rheumatoid ...

Pilot Therapeutics Announces Relaunch as Gene Smart(TM) Health

... by dramatic increases in chronic inflammatory conditions, is a bold call for action for ... foods to prevent and treat chronic inflammatory conditions; Gene Smart(TM) Ingredients creates ... on the expression of genes that control the inflammatory process related to numerous chronic inflammatory ...

ChemoCentryx Completes Enrollment of PROTECT-1, a Phase II/III Clinical Trial of CCR9 Antagonist CCX282-B (Traficet-EN(TM)) in Crohn's Disease

... as 'CCR9', which is selectively expressed by inflammatory T cells to migrate to the digestive tract in ... inappropriate immune system response underlying inflammatory bowel disease (IBD) by blocking the CCR9 ... Crohn's Disease Crohn's disease is a chronic inflammatory condition of the gastrointestinal tract. It is ...

Targeted Genetics Announces Positive Phase 1/2 tgAAC94 Data Presented at Annual European Congress of Rheumatology

... tolerated and may improve disease symptoms in inflammatory arthritis patients refractory to other ... the data. Study Details 127 patients with inflammatory arthritis received a single intra-articular ... Genetics' product development efforts target inflammatory arthritis, AIDS prophylaxis, congestive heart ...

New Data Offers Insights Into the Potential Role for TYKERB(R) (Lapatinib) in Non-Cytotoxic Chemotherapy-Based Treatment Regimens

... TYKERB monotherapy as a treatment for relapsed inflammatory breast cancer (IBC) demonstrates activity in ... monotherapy in HER2+ relapsed/refractory inflammatory breast cancer (IBC): abstract 636(3) DATA ... results as a monotherapy in HER2-positive inflammatory breast cancer (IBC).(8) Although IBC is rare, it ...

Abbott Presents Long-Term Data From Extension Study Showing Adult Crohn's Patients Treated With HUMIRA(R) (Adalimumab) Maintained Remission

... Crohn's disease is a serious, chronic, inflammatory bowel disease that affects more than 500,000 ... M.D., Associate Professor, and Director of the inflammatory Bowel Disease Clinic at the University of Calgary ... tumor necrosis factor alpha (TNF-alpha), an inflammatory protein that, when produced in excess, plays a ...

Ardea Biosciences Presents Preclinical Data on RDEA119 Demonstrating Favorable Anti-Inflammatory Profile for Potential Use in Ulcerative Colitis

... are still significant unmet medical needs for inflammatory bowel disease. Blocking the MEK1/2 ... To support the development of RDEA119 in inflammatory diseases, a Phase 1 study in normal healthy ... of RDEA119, as well as its ability to inhibit inflammatory cytokines. Preliminary Phase 1 data have ...

New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease

... Among Employees with inflammatory Bowel Disease SAN DIEGO, May 20 /PRNewswire/ -- ... subgroup. Ulcerative colitis is a chronic inflammatory disease of the colon and large intestine that ... UC and Crohn's disease are known collectively as inflammatory bowel diseases, or IBD. Approved in 1998 by the ....

Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594

... from gout, which is the most common form of inflammatory arthritis in men over 40. Gout, also known as ... for the treatment of HIV, cancer and inflammatory diseases, including gout. We have four drug ... as a precursor to trials in patients with inflammatory diseases. Lastly, we have evaluated ...

ChemoCentryx Initiates Clinical Trial of CCR1 Inhibitor CCX354

... Potential New Approach for the Treatment of inflammatory Disease Milestone ... as rheumatoid arthritis (RA), as well as other inflammatory diseases. Significant levels of CCR1 ... receptors for the treatment of a variety of inflammatory disorders. Under the terms of the agreement, ...

Medarex Announces Initiation of Phase 2 Clinical Trials for the Treatment of Ulcerative Colitis and Rheumatoid Arthritis

... potentially treat UC and RA by suppressing the inflammatory process characteristic of these diseases. ... potential of MDX-1100 to address a range of inflammatory diseases." Patients in the Phase 2 randomized, ... "CXCL10 Expression and Biological Activities in inflammatory Bowel Disease" (Abstract #W1170) - Poster ...

Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results

... for the treatment of HIV, cancer and inflammatory diseases, including gout. We have four drug ... in normal healthy volunteers for the treatment of inflammatory diseases. We have evaluated our second generation ... RDEA436, for the treatment of cancer and inflammatory diseases in a human micro-dose ...

Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test

... in the Interleukin 1B (IL1B) gene with the inflammatory response. To view the Multimedia News ... then link them to biological events and risk of inflammatory disease. Dr. Kenneth Kornman, Chief Scientific ... nutritional compounds for their effects on inflammatory responses and other genetic variations, given ...
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