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Immunity in Medical Technology

An Independent Study Reports on the Utility of ImmuKnow(R), the Cylex(TM) Immune Cell Function Assay, for Monitoring Heart Transplant Recipients

... as an in vitro assessment of cell-mediated immunity in immunosuppressed patient populations, numerous ... cellular immune status by detecting cell-mediated immunity (CMI) in adult immunosuppressed patients. It ... diagnostic utilized to detect cell-mediated immunity (CMI) in an immunosuppressed population, and is ...

New Data Support Role for Monitoring of Cell-Mediated Immunity in Adult Patients Following Renal Transplantation

... to examine the association between cell-mediated immunity and risk for organ rejection (in under- ... closely to the three categories of cell-mediated immunity defined for adult transplant patients in ... standards for use of cell-mediated immunity to monitor risk for infection and rejection in ...

New Data Support Earlier Suggested Guidance for Levels of Cell-Mediated Immunity in Pediatric Liver Transplant Patients

... clinical potential of monitoring cell- mediated immunity in pediatric liver-transplant ... In adult transplant patients, cell-mediated immunity as measured using the ImmuKnow assay is ... support these lower categories for cell-mediated immunity in pediatric transplant patients, and in ...

Genetic Immunity to Present at 2008 BIO International Convention

... (PT): Dr. Lisziewicz will represent Genetic immunity in an international case study, "Biotechnology in ... . While at the conference Genetic immunity will discuss three partnering opportunities. The ... antigens. About Genetic Immunity(R) Genetic immunity is a US/Hungarian clinical stage ...

Genetic Immunity Presents Clinical Data on DermaVir Patch Immune Therapy at 15th Annual Conference on Retroviruses and Opportunistic Infections

... who are currently on drug therapy. Genetic immunity studied nine HIV infected individuals on ... induced by DermaVir Patch treatment. The Genetic immunity team is encouraged by this data, which suggests ... therapy." About Genetic Immunity(R) Genetic immunity is a US/Hungarian development stage ...

Researchers Train the Immune System to Deliver Virus That Destroys Cancer in Lab Models

... directly in the tumor itself, you can get a weak immunity against the tumor, but if you use this virus ... tumor cells in the lymph nodes, you get a higher immunity against the tumor," Dr. Vile says. RESULTS ... spleens of mice that had lung cancer developed immunity to the cancer after the treatment. The ...

Three Independent Studies Include the ImmuKnow(R) Assay to Manage and Optimize Immunosuppression Therapy in Transplant Patients

... function that assesses cellular immune status by detecting cell-mediated immunity (CMI) in adult immunosuppressed patients. It measures the concentration ... ImmuKnow is the in vitro diagnostic utilized to detect cell-mediated immunity (CMI) in an immunosuppressed population, and is increasingly being adopted ...

Living Donor Kidney Transplants Using Alemtuzumab Pre-Conditioning and Tacrolimus Monotherapy: Long-Term Safety and Efficacy

... function that assesses cellular immune status by detecting cell-mediated immunity (CMI) in adult immunosuppressed patients. It measures the concentration of ... ImmuKnow is the in vitro diagnostic utilized to detect cell-mediated immunity (CMI) in an immunosuppressed population, and is increasingly being adopted ...

Vical Completes Enrollment and Reports Positive Interim Data in CMV Vaccine Phase 2 Trial

... codes. The results indicated significant enhancement of CMV-specific immunity in the recipient-only arm as measured by T-cell responses to the two CMV ... al. Impact on the cytomegalovirus (CMV) viral load by CMV-specific T-cell immunity in recipients of allogeneic stem cell transplantation. Bone Marrow ...

Cylex Announces Plan for Multi-Center Trial of ImmuKnow(R) Assay in South Korea

... for a major, multi-center trial of the ImmuKnow assay for cell-mediated immunity at seven highly respected medical institutions in the Republic of Korea," ... the immune cell function assay cleared by the FDA to detect cell-mediated immunity (CMI) in adult patient populations undergoing immunosuppressive therapy ...

Promise of Vical's CMV Vaccine Noted by Independent Experts

... CMV infection continues to be a problem in the transplant setting. CMV immunity appears to play a critical role in controlling viral load and disease in these patients. The ability to stimulate CMV immunity with vaccination may have an important role in the management of CMV ...

Penn State Hershey Transplant Program Uses Assay to Monitor Cell-Mediated Immunity

... with post-transplant de novo malignancy, assessing the cell-mediated immunity of patients by taking advantage of the ability of the Cylex immune cell ... Medical Center. The ImmuKnow cell function test measures cell-mediated immunity (CMI) by assaying the concentration of adenosine triphosphate (ATP) from ...

Genetic Immunity Announces Data Related to the DermaVir Nanomedicine Patch in the Journal of Immunology

... has been scientifically sound. About Genetic Immunity(R) Genetic immunity is a US/Hungarian development stage biopharmaceutical company establishing ... its proprietary immune amplification platform technology, Genetic immunity aims to create new markets for infectious diseases, cancer and allergies ...

Prospective Microbial Analysis of Bronchoalveolar Lavage Fluids with Immune Function Testing Can Distinguish Between Fungal Colonization and Fungal Disease In Lung Transplant Recipients

... Center (UPMC) has suggested that the ImmuKnow(R) assay of cell-mediated immunity (CMI), when combined with microbial analysis of bronchoalveolar (BAL) ... ImmuKnow(R) is the in vitro diagnostic utilized to detect cell-mediated immunity (CMI) in an immunosuppressed population, and is increasingly being adopted ...

Independent Studies Report on Possible Roles for Cylex's Immune Cell Function Assay in Monitoring of Heart and Lung Transplant Recipients

... cleared as an in vitro diagnostic technique to detect cell-mediated immunity (CMI) in immune-suppressed adult patients, understanding of the ... ImmuKnow(R) is the in vitro diagnostic utilized to detect cell-mediated immunity (CMI) in an immunosuppressed population, and is increasingly being adopted ...

New Patent Awarded for Antigen-Sparing Vaccines that Elicit Robust Immunity

... point of most respiratory infections -- development of rapid mucosal immunity followed by systemic immunity -- antigen-sparing capability -- thermally stable, requires no ...

Arrayit to Mass Produce Rapid H1N1 Swine Flu Test Chip

... human influenza viruses, allowing direct human-to-human transmission without the need for agricultural contact. The dangerous 2009 strain has little immunity in the human population, resistance to several common anti-viral drugs, and has caused serious illness and death. Department of Health and Human ...

Phase 1 Trial of Whole-Parasite Malaria Vaccine to Begin

... include the assessment of the vaccine candidate, expectations for the number and timing of the inoculation of study subjects, the expectations for immunity of the vaccine, and belief concerning the measure of success. These forward-looking statements are further qualified by important factors that could ...

ViroPharma Submits Comments on Vancocin(R) Draft Bioequivalence Guidance

... Advanced age, gastrointestinal surgery/manipulation, long length of stay in healthcare settings, a serious underlying illness and compromised immunity are conditions associated with increased risk of disease. According to the U.S. Centers for Disease Control and Prevention (CDC), there are an ...

Alba Therapeutics Corporation Announces the Next Clinical Trial of Its Lead Compound, Larazotide Acetate and Promotions

... Resident of the Year in Spain in 2001 (Sanities Prize). Dr. Leon was a postdoctoral fellow in the Laboratory of Clinical Investigation (Mucosal immunity Section) and in the Laboratory of Molecular Immunology (Mucosal Biology Section) of the National Institutes of Allergy and Infectious Diseases, ...

Nobilon Advances First Vaccine Into Human Trials - Intranasal Influenza Vaccine Begins Phase I Clinical Development

... by intranasal application. Moreover, Live Attenuated Influenza Vaccine (LAIV) is expected to be more effective in inducing local and cellular immunity and as such may be more efficacious in eliciting protection. About SCH 900795 Nobilon acquired in 2004 the majority of rights to develop, ...

IBT Laboratories to Launch New Pneumococcal Antibody Avidity Test at AAAAI Meeting, Booth 729

... a delayed drug reaction. IBT will present two scientific posters at the conference: Saturday, 9:45-10:45 am - # 41: T Cell immunity Assessed by Intracellular Cytokine Analysis Following Stimulation of Whole Blood or PBMCs with Microbial Antigens of Mitogens Sunday, ...

Cancer Research 'David' Hopes to Slay 'Cancer Goliath'

... strain of mice that has naturally occurring breast cancer. (The injected pre-treated serum into the large animal appears to give the animal lifetime immunity to cancer). Protein-B(LPN) has shown effectiveness on a number of organ sites in both man and animals toward the conquest of cancer without ...

Human Genome Sciences Begins Delivery of First-in-Class Anthrax Treatment to U.S. Strategic National Stockpile

... Both are essential to dealing with anthrax, but both have limitations. The anthrax vaccine takes several weeks following the initial doses before immunity is detectable, and requires multiple injections over a period of eighteen months, in addition to annual booster vaccination, to maintain protective ...

IBT Laboratories Expands its Menu of Tests for Immune Deficiency

... need a complete assessment of the capabilities of the patient's immune system to respond to challenge by microorganisms. Both innate and adaptive immunity need to be evaluated. Previously, these kinds of tests were only used by the research community, and were not available in the clinical-diagnostics ...

U.S. Navy and U.S. Army to Develop Dengue DNA Vaccine Formulated With Vical's Vaxfectin(R) Adjuvant

... subtropical regions. Dengue does not spread directly from person to person. An individual infected by one serotype of dengue virus develops lifelong immunity against that serotype, but not against other serotypes. Symptoms of classic dengue fever include high fever (up to 105 degrees F), severe headache ...

ImmunoVaccine Technologies' DepoVax(TM) Shows Positive Results for Cancer and Infectious Diseases

... induced by the depot vaccine were 10-15 times higher than a single dose of the control alum vaccine. The vaccine induced quick and strong specific immunity against the avian influenza antigen. In the longer term, the antibody responses generated were superior or equal to the two-dose alum vaccine. ...

Symposium Highlights Yale Study Indicating Role of AHCC(R) for Immune System Enhancement and as a Promising Cancer Preventative

... Staphylococcus aureus (MRSA), the Klebsiella pnuemoniae and the Candida albicans viruses. It was reported that supplementation with AHCC modulated immunity and delivered positive results in response to acute infections. "AHCC continues to demonstrate its essential role for healthy immune function," ...

VIRxSYS to Host a Web Conference to Announce Clinical Trial Update

... the impact of the first stages of infection by preventing the massive destruction of CD4 T cells that ensues. Activation of both cellular and humoral immunity can also halt the slow destruction of the immune system by the latently dormant virus. The results from these studies of VRX1023 have led to the ...

The New England Journal of Medicine Publishes Study Investigating the Safety and Efficacy of Baxter's Cell-Based Pandemic, Avian Flu Vaccine

... using the H5N1 Vietnam strain. About Pandemic Flu A pandemic is a global disease outbreak of a virus for which there is little or no immunity in the human population, causing serious illness and spreading easily person-to-person worldwide. Most cases of avian flu infection in humans have ...

University of Miami Team Confirms Value of Monitoring Cell-Mediated Immunity Pre- and Post-Transplant in Management of Kidney Transplant Recipients

... of Surgery and Pathology at the University of Miami - Lawrence Miller School of Medicine have corroborated the value of monitoring cell- mediated immunity (CMI) post transplant in recipients of kidney transplants using a regular laboratory assay of cell function (ImmuKnow(R)/Cylex). Their paper, ...

Preclinical Study Presented at AACR Annual Meeting Shows Peregrine's Anti-PS Immunocytokines Can Generate Protective Immune Responses in a Highly Aggressive Breast Cancer Model

... a study in mice assessing the efficacy of a tumor vaccine approach that uses these anti-PS immunocytokines in combination with radiation to achieve immunity to a lethal form of breast cancer. Dr. Huang commented, "A likely contributor to the lack of immunogenicity of tumors is the fact that ...

Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa

... an adenovirus, such as the virus that causes the common cold. The AdVac(R) technology is specifically designed to manage the problem of pre-existing immunity in humans against the most commonly used recombinant vaccine vector, adenovirus serotype 5 (Ad5), without compromising large-scale production ...

Cancer Pioneer Reaches Key Agreement on Colon Cancer Drug OncoVAX(R)

... prevent colon cancer from recurring in many patients. "This agreement represents a major step forward in defeating cancer by increasing the body's immunity to it," said Dr. Hanna, who has been working on cancer vaccines for more than 30 years. In the agreement, Vaccinogen obtained exclusive license to ...

Steps Toward Stopping Autoimmune Disease: International Consortium Identifies Genes Linked to Lupus

... lead to new therapies and earlier diagnosis. "The SLEGEN study is a model for collaborative genetic research," said Mary Kuntz Crow, M.D., an immunity and inflammation specialist at the Hospital for Special Surgery in New York and 2008 chair of the ALR Scientific Advisory Board. "The ALR approach of ...

Juvaris BioTherapeutics Announces Cooperative Research and Development Agreement With The Centers for Disease Control and Prevention

... "In preclinical studies using seasonal influenza vaccine our adjuvant can decrease the amount of vaccine necessary to induce protective antibody immunity up to fifty-fold, which would be beneficial in case of limited vaccine supply during an influenza pandemic. Furthermore, preclinical experiments with ...

New Approach to Treating Anthrax Significantly Improves Survival Rates in Pivotal Efficacy Studies

... Both are essential to dealing with anthrax, but both have limitations. The anthrax vaccine takes several weeks following the initial doses before immunity is detectable, and requires multiple injections over a period of eighteen months, in addition to annual booster vaccination, to maintain protective ...

Clinical Studies of OvaRex in Advanced Ovarian Cancer Fail to Meet Primary Endpoint

... these findings. The IMPACT trials, which were well designed and rigorously conducted, indicate that the approach of triggering tumor-specific immunity using a murine monoclonal antibody has its challenges," said Christopher Nicodemus, MD, Unither Pharmaceuticals' Senior Vice President Clinical ...

Video: Actress and New Mom Keri Russell Joins PKIDs to Launch 'Silence the Sounds of Pertussis' Campaign

... as well as educational materials about preventing and managing pertussis are available on PKIDs' website at http://www.pkids.org . "Because immunity from early childhood vaccination decreases over time, adults and teens can become infected with pertussis repeatedly and transmit the disease ...

Actress and New Mom Keri Russell Joins PKIDs to launch 'Silence the Sounds of Pertussis' Campaign

... as well as educational materials about preventing and managing pertussis are available on PKIDs' website at http://www.pkids.org . "Because immunity from early childhood vaccination decreases over time, adults and teens can become infected with pertussis repeatedly and transmit the disease ...
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