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Hypothesis in Medical Technology

Independent Analyses of the SEAS, SHARP and IMPROVE-IT Studies of Ezetimibe

... then this would have been clearly apparent in the hypothesis testing SHARP & IMPROVE-IT trials. Instead, there ... events Active Control hypothesis generator: SEAS 102 67 hypothesis test: SHARP & IMPROVE-IT* 313 326 * 216 ...

Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results

... in 19 European countries. The primary goal of the study is to test the hypothesis that treatment of T2DM patients with 40 mg of olmesartan medoxomil will ... agents that directly block the RAS. The secondary objective is to test the hypothesis that treatment with olmesartan medoxomil has a positive effect on ...

Imaging Results From the ADAGIO-LIPIDS Reveal That Effects of Rimonabant on Cardiometabolic Risk Profile Include Loss of Visceral Fat and Mobilization of Liver Fat

... using computed tomography was conducted to test, for the first time, the hypothesis that rimonabant could induce a loss of visceral fat and liver fat. "We ... tissue and the liver, results of ADAGIO-LIPIDS are consistent with the hypothesis that antagonism of the these peripheral CB1 receptors could slow ...

Prospective Microbial Analysis of Bronchoalveolar Lavage Fluids with Immune Function Testing Can Distinguish Between Fungal Colonization and Fungal Disease In Lung Transplant Recipients

... Society for Heart and Lung Transplantation (ISHLT) in Boston, MA. "Our hypothesis was that global immunoreactivity, as measured prospectively using the ... compared to patients with true fungal infections," said Dr. Husain. "This hypothesis appears to have been borne out by our preliminary results." "Our study ...

Kosan Presents Updated Data on Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma at Ash

... In addition, we are observing intriguing evidence supporting the hypothesis that in the tanespimycin/bortezomib combination, tanespimycin may be ... 13% Grade 3 neuropathy was observed. This observation supports the hypothesis that treatment with tanespimycin exerts a neuroprotective effect. ...

Regular Yoga Practice Is Associated With Mindful Eating

... found no association between other types of physical activity, such as walking or running, and mindful eating. "These findings fit with our hypothesis that yoga increases mindfulness in eating and leads to less weight gain over time, independent of the physical activity aspect of yoga practice," ...

Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis

... of osteoporosis and an area in which currently available osteoporosis treatments are weak." "These data are consistent with the clinical hypothesis for BA058--greater gains in BMD at the critical anatomic sites with less resorptive effect and less hypercalcemia compared to PTH and its analogs," ...

Diabetes Gene Raises Odds of Lower Birth Weight

... period may cause a baby to be born smaller. Low birth weight is already known to increase the risk of disease later in life, and the fetal insulin hypothesis proposes that the same gene that causes lower birth weight also increases the risk of developing type 2 diabetes. "The mechanisms by which ...

Wyeth Reports Publication of Phase 3 Data for Bazedoxifene/Conjugated Estrogens, an Investigational Compound Being Studied for the Treatment of Menopausal Symptoms

... Sterility , is from the S elective estrogens M enopause A nd R esponse to T herapy (SMART-1) clinical trial. SMART-1 was designed to explore the hypothesis that bazedoxifene, when paired with conjugated estrogens, may have the potential to eliminate the need for progestin in menopausal therapy in women ...

MJFF's Rapid Response Innovation Awards Hit Mid-2009 With Over $1 Million Funded in High-Risk/High-Reward Approaches to Parkinson's Disease

... whether phenylbutyrate may slow disease progression. Richard Smeyne, PhD, of Saint Jude Children's Research Hospital will test the hypothesis that the virulent H5N1 ("bird flu") strain of influenza virus can play a role in inducing parkinsonism. There is significant literature, mostly based ...

Alfacell Provides Shareholder Update

... with the drug. Striking decreases in all of these genes in the mesothelioma cell lines were seen after treatment with Onconase validating the hypothesis that one of the mechanisms of action of Onconase is to decrease resistance to chemotherapy. Moreover, these data in cell lines are complemented by ...

U.S. Naval Medical Research Center Proposed 'RESUS' Clinical Trial in Trauma Patients Remains on FDA Hold

... has also developed and submitted a protocol for a trial proposed to be conducted in the field, called Operation RESUS (OP RESUS). The proposed trial hypothesis is that for such casualties, Hemopure will improve survival and other clinical parameters, and will be relatively safe and well tolerated, in ...

New Study Shows Probiotic Strain Effective in Boosting Immune Response to Flu Virus

... through promoting a healthy bacterial ecosystem in the digestive tract, which comprises approximately 70 percent of the body's immune system, a hypothesis supported by the current study. Dr. Gary Huffnagle, a professor of microbiology and immunology at the University of Michigan , who has reviewed ...

Oasmia: FDA Grants Paclical(R) Orphan Drug Designation for Ovarian Cancer in the USA

... and FDA often provides technical and financial assistance to expedite and optimize drug development. The designation is based on the hypothesis that Paclitaxel is safer than Taxol(R). Oasmia Pharmaceutical is conducting a Phase III study comparing the use of Paclical to Taxol(R) in patients ...

New Study Shows Probiotic Strain Effective in Improving Irritable Bowel Syndrome Symptoms

... is beginning a placebo-controlled clinical trial to evaluate the efficacy of Ganeden's probiotic in patients with IBS and depression to test the hypothesis that there are common underlying factors beneath the two conditions that may be impacted by taking the Bacillus coagulans strain of probiotics. In ...

U.S. Naval Medical Research Center Resubmits IND Application for Proposed 'RESUS' Clinical Trial in Trauma Patients in the Out-of-Hospital Setting

... for resuscitation of operations casualties with severe traumatic hemorrhagic shock, when blood transfusion is not available. The proposed trial hypothesis is that for such casualties Hemopure will improve survival and other clinical parameters, and will be relatively safe and well tolerated, in ...

MultiCell Technologies Signs Liver Stem Cell R&D Agreement To Develop Products for the Study of Liver Cancer

... related to the isolation and differentiation of liver stem cells. The role of liver stem cells in the carcinogenic process has recently led to a new hypothesis that hepatocellular carcinoma arises by maturation arrest of liver stem cells. Primary liver cancer begins in the cells of the liver itself. ...

The Children's Hospital of Philadelphia: New Gene-Searching Method Uncovers Possible New Targets for Crohn's Disease Drugs

... the same biological pathway. "We applied our pathway-based approach to GWA data for Crohn's disease, but conducted the search without starting with a hypothesis focused on a specific suspected pathway," said Hakonarson. "Among hundreds of known biological pathways, the one that surfaced from the analysis as ...

Nerviano Medical Sciences Invited by EORTC-NCI-AACR to Present the State-of-the-Art of Aurora

... obtained from patient biopsies", explains Laffranchi. A decreased phosphorylation of Histone H3 in patients treated with PHA 739358 supports this hypothesis whereby the anti-cancer activity exerted by the compound is mediated through inhibition of Aurora kinases. "Results obtained to date in humans ...

Swedish in Seattle to Study Connections Between Preeclampsia and Migraine

... higher clotting levels have been reported in migraine sufferers and women with preeclampsia. "That suggests a connection, but we need to test that hypothesis thoroughly," Dr. Williams noted. "Only then can we develop conclusions that have medical value and can be acted on." The research will also ...

Cylex Announces Plan for Multi-Center Trial of ImmuKnow(R) Assay in South Korea

... demonstrated the potential of the ImmuKnow assay as a tool to monitor the immune status of patients following kidney transplantation. "The working hypothesis of the current trial is that the investigators will observe similar results in a Korean population," said Kyu Young Woo, President of Sun Woo ....

Cardiogenesis Announces Preliminary Clinical Results With the PHOENIX System Combining TMR + Stem Cells

... per month compared to 4 per month at follow up (p=0.03); -- and there were no perioperative adverse events including no arrhythmias. The hypothesis for the study is an enhanced cell uptake and angiogenic effect when delivering concentrated bone marrow derived stem cells to the stimulated tissue ...

US Oncology Affiliated Physicians Make a Strong Showing in ASCO Proceedings

... MBC patients, one that does not contain chemotherapy. This combination also has exciting potential as treatment for early stage breast cancer, a hypothesis that is being evaluated now in the global ALTTO trial." Dr. O'Shaughnessy serves as co-chair of the US Oncology Breast Cancer Research Committee and ...

TARGETED GENE DELIVERY SIGNALS CANCER VACCINATION IN VIVO: Intravenous Infusions of Rexin-G Followed by Reximmune-C Induce Tumor Necrosis and Recruitment of Tumor Infiltrating Lymphocytes in Cancerous Lesions (ASCO 2008)

... accumulate in cancerous lesions, thus increasing the effective local concentrations of the therapeutic nanoparticles within the tumors. The working hypothesis behind this two-stage approach to cancer management predicts that strategic and individualized vaccination of a patient against his/her own cancer ...

UPDATE: Infant Primates Given Vaccines on U.S. Children's Immunization Schedule Develop Behavioral Symptoms of Autism

... of Dr. Bernadine Healy, Former NIH Director in a CBS interview earlier this week. "I think public health officials have been too quick to dismiss the hypothesis as 'irrational,' without sufficient studies of ... without studying the population that got sick," Healy said. "I have not seen major ...

Biopure Announces Publication of Phase II Proof-of-Concept Coronary Trial

... study where subjects underwent coronary balloon occlusion, with and without oxygenated HBOC-201. The primary objective of the study was to test the hypothesis that intracoronary infusion of HBOC-201 during brief, total coronary artery occlusion would preserve left ventricular function. The primary endpoints ...

Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel Anticancer Agents, at AACR

... is directly linked to the induction of apoptosis. NEIs induce apoptosis in tumor derived cell lines but not in normal cells, further confirming the hypothesis of the novel, potent and selective anticancer activity of NEIs. Abstract 5688: "Anti-Tumor Activity of Novel Nuclear Export Inhibitors (NEIs) in ...

Use of PressureWire(R) Yields a More Accurate Assessment of Translesion Pressure Gradients in Peripheral Vasculature, Two New Studies Report

... and Catheter-Derived Measurements," this study, conducted at the Beth Israel Deaconess Medical Center in Boston, is the first to assess this hypothesis in patients with peripheral arterial occlusive disease. "We've long suspected that using a 4 or 5 French catheter for measuring pressure gradients ...

Revised: Challenging the Norm May Lead to New Therapy for Type 2 Diabetes

... disease that impacts millions of Americans. They saw the side effects caused by the current therapy like edema and weight gain, and went to work on a hypothesis that the current receptor was leading to these side effects associated with PPAR-based therapies. As non-conventional as the theory was, it's ...

Challenging the Norm May Lead to New Therapy for Type 2 Diabetes

... millions of Americans. They saw the side effects caused by the current therapy like high blood pressure and weight gain, and went to work on a hypothesis that the current receptor was leading to these side effects associated with PPAR-based therapies. As non-conventional as the theory was, it's ...

Novel Small Molecule Therapy Shows Benefit for Anemic Patients Via Hydration of Red Blood Cells

... we saw in this study provide further evidence that blocking the Gardos channel reduces dehydration of the sickle erythrocytes and thus supports the hypothesis that this type of approach may lead to an amelioration of the anemic state in patients with sickle cell anemia," said Dr. Ataga. "As noted in the ...

Children's Mental Focus Foundation Announces a Scientific Breakthrough for Children Who Have Been Diagnosed With Autism, ADD and ADHD

... the body to begin healing itself." This new approach in therapy is called "Information Therapy." As Dr. Hunt continues to describe his hypothesis it becomes apparent that this type of therapy USES NO DRUGS OR MEDICATION. This "Information Therapy" is classified as "complementary medicine," ...

Pharmion and MethylGene Start Phase 2 Combination Clinical Trial With MGCD0103 and Vidaza(R) in Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

... medical officer. "The biology of cancer suggests multiple epigenetic mechanisms cooperate to silence tumor suppressor genes, which raises the simple hypothesis that attacking these mechanisms with drug combinations may be superior to single-agent therapy. In this trial, we are combining Vidaza, our DNA ...

Avicena Announces Positive Phase II Data for a Combination Trial Involving AL-08 for the Treatment of Amyotrophic Lateral Sclerosis (ALS)

... trial's secondary objective was evaluation of futility, which showed that AL-08/celecoxib was non-futile compared to historical controls and the null hypothesis of at least a 25% reduction in the ALS-Functional Score could not be rejected. This combination was selected for a Phase III study. ABOUT AVICENA ...

New Data Confirms That a Selective, Fully Human Anti-VEGF Antibody Being Developed by Peregrine is as Effective as Avastin(R) in Preclinical Cancer Models

... driver in promoting the development and maintenance of the blood vessels needed by tumors to survive and grow. These new studies further tested the hypothesis that selectively inhibiting VEGFR2 is an equally effective anti-tumor strategy as blocking both VEGF receptors. Most of the anti-angiogenic agents ...

First High-Res 3-D Structures of Mammalian HSP90 Protein Solved, Key to Better Targets for AIDS, Sepsis, Cancer Drugs

... cancers. His work is being published today in a cover article in a top scientific journal -- Molecular Cell. Gewirth's study confirms his 2001 hypothesis that this protein -- GRP94 -- is from the same family as the better known HSP90 proteins. As ligand-regulated chaperones -- proteins that help other ...

Clinical Benefits Demonstrated with Low-Dose GATTEX(TM) in Phase 3 Short Bowel Syndrome Study

... appetite and it is possible that patients on the higher dose consumed fewer calories from food and thus did not decrease their PN regimens. A second hypothesis is that GLP-2 exerts various dose-dependent effects and may act by increasing nutrient absorption at low-doses while higher doses of GLP-2 may have a ...

MacuSight(TM) Announces Positive Initial Results From Phase 1 Study of Sirolimus in Diabetic Macular Edema

... pathway rather than simply reversing macular edema in a more non-specific way," said Dr. Blumenkranz. "Further studies to support or refute this hypothesis will be necessary. However, if so, then the potential clinical utilization of the drug may eventually extend beyond those patients with clinically ...

Experimental Drug Ketasyn(TM) Improves Memory in Age-Associated Memory Impairment Study

... into ketone bodies, which the brain can use for energy even when its ability to process glucose is impaired. "The results of this study support the hypothesis that providing additional energy reserves to the elderly brain improves a variety of cognitive activities. They also provide further evidence of the ...

Biopure Announces 2007 Third Quarter Financial Results

... coronary artery disease who are undergoing percutaneous coronary intervention (PCI), also continues to enroll patients. This trial is testing the hypothesis that Hemopure may improve oxygenation and heart function during times of coronary artery blockage. A revised protocol for the company's HEM-0125 ...
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(Date:10/14/2014)... the planet,s leading questions is how to produce enough ... climate. The Food and Agriculture Organization of the United ... the next 40 years to feed a growing global ... necessary rise in food production. Plants—grains, cereals, fruits, ... livestock. Current research must tap into our knowledge ...
(Date:10/14/2014)... of fish oil supplements, rich in omega-3 fatty acids, do ... in which the heart can beat as fast as 150 ... by the Montreal Heart Institute were published in the ... 7th. , For the trial, 337 patients with atrial fibrillation ... grams of fish oil a day or to placebo for ...
(Date:10/14/2014)... led by researchers at the University of Massachusetts ... Miller School of Medicine (UMMSM) have identified what ... (manic depressive) disorder, a breakthrough that could lead ... as well as depression and other related mood ... week in Nature Molecular Psychiatry , show ...
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