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Hybridization in Medical Technology

Quest Diagnostics ClariSure(TM) Postnatal Molecular Test Receives Clinical Laboratory Approval from New York State

... announced that its ClariSure(TM) microarray-based comparative genomic hybridization (aCGH) postnatal test is now available for testing on patients in the ... syndromes. A positive result may be confirmed using a fluorescence in situ hybridization (FISH) methodology. aCGH technologies compare and contrast a ...

Quest Diagnostics Introduces ClariSure(TM) Test for Identifying Chromosome Abnormalities Associated With 85 Developmental Disorders in Children

... services, developed its ClariSure(TM) microarray-based comparative genomic hybridization (CGH) test to enable physicians to use results obtained from a single ... who have already had extensive cytogenetic and/or fluorescence in situ hybridization testing.(2) CGH microarray technologies are also more efficient, as ...

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

... exceptional analytical performance in a proof-of-concept study is a significant step in designing an assay with great clinical performance. The hybridization techniques used today, simply cannot match the state-of-the-art analytical performance found with PCR-MS. "We are very excited about the ...

AdvanDx Launches Fast, 90 Minutes Protocol for All CE-IVD Marked PNA FISH(R) Tests in Europe

... PNA FISH(R) tests in Europe. The fast protocol reduces the PNA FISH turn-around time from the original 2.5 hours to 90 minutes by reducing PNA probe hybridization time from 90 minutes to 30 minutes. Clinical validation studies performed at hospitals in the United States and Europe show the two protocols to be ...

Study Demonstrates that AHCC(R) Enhances Immune System by Increasing the Production of Key Dendritic Cells

... Yale University and Columbia University Medical Center. What is AHCC (Active Hexose Correlated Compound)? AHCC is derived from the hybridization of several subspecies of medicinal mushroom, cultivated in Japan and then produced from a unique manufacturing process. AHCC is the leading ...

Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL

... patients (73 male, 65 female, with a median age of 64 years) stratified according to cytogenetic markers that were identified by fluorescent in situ hybridization (FISH) testing. The median number of two prior therapies in this group was two (range, 0 - 10), and of the patients who received prior treatment with ...

Ipsogen Launches a New Test to Determine Tumor HER2 Status and Guide Herceptin(R) Prescription in Breast Cancer

... for HER2 with 2 main complementary technologies: immunohistochemistry (IHC) which identifies HER2 protein expressed in the tumor cells and in situ hybridization (ISH), which quantifies HER2 DNA copy number in the cell chromosomes. Some RT-PCR assays, that quantify the amount of HER2 mRNA, have also been ...

Symposium Highlights Yale Study Indicating Role of AHCC(R) for Immune System Enhancement and as a Promising Cancer Preventative

... the immune system by increasing the activity of white blood cells. What is AHCC (Active Hexose Correlated Compound)? AHCC is derived from the hybridization of several subspecies of medicinal mushroom, cultivated in Japan and then produced from a specialized manufacturing process. AHCC is the leading ...

Study Demonstrates That AHCC(R) Provides Immune Enhancement Against the West Nile Virus

... number of diseases that include flu, cancer, and autoimmune diseases. What is AHCC (Active Hexose Correlated Compound)? AHCC is derived from the hybridization of several subspecies of medicinal mushroom, cultivated in Japan and then produced from a specialized manufacturing process. AHCC is the leading ...

Genomic Health Announces Data Supporting Use of Oncotype DX(R) to Accurately Assess HER2 Gene Expression in Breast Cancer Patients

... gene expression, as measured by the company's Oncotype DX(R) breast cancer assay, has a high degree of concordance with both fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) testing. HER2 is an important marker for therapeutic decision-making for patients with breast cancer, and ...

Study Shows Use of AdvanDx's PNA FISH(TM) Test was Associated with an 82% Reduction in Intensive Care Unit Mortality Rates from Staphylococcus aureus Bloodstream Infections

... appropriate therapy and save patient lives. About PNA FISH(TM) PNA FISH is an easy-to-use and highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. The unique ...

AdvanDx Submits Yeast Traffic Light PNA FISH(TM) for FDA 510(k) Clearance for Detection of Candida species in Positive Blood Cultures

... appropriate therapy and save patient lives. About PNA FISH(TM) PNA FISH is an easy-to-use and highly sensitive and specific fluorescence in situ hybridization (FISH) assay that uses PNA (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in bacteria and yeast. PNA FISH tests enable ...

ALS Therapy Development Institute Signs Collaboration Agreement with the Allen Institute for Brain Science

... Institute (ALS TDI) today announced it has entered into an agreement with the Allen Institute for Brain Science in Seattle, Wash. for in situ hybridization (ISH) services using diseased tissues from a preclinical animal model of amyotrophic lateral sclerosis -- ALS, or Lou Gehrig's disease. ALS is a ...

Abbott's m2000(TM) Molecular Diagnostic Instrument and RealTime HIV-1 Test Win Chicago Innovation Award

... information to help them predict if a particular type of cancer treatment may be effective for an individual patient. PathVysion fluorescence in situ hybridization (FISH) technology measures the number of copies of the HER-2 gene at the DNA level. Using fluorescent colors and a microscope, physicians count the ...

Researchers Develop New Procedure to Screen All 46 Human Chromosomes to Identify Abnormalities in Embryos

... most commonly used technology for chromosomal analysis of embryos (sometimes termed preimplantation genetic diagnosis or PGD), is florescent in situ hybridization (FISH). This technique assesses fewer than half of the 23 chromosome pairs found in the human karyotype and has a suboptimal error rate. This makes ...

American Fertility Association Calls for Expanded Research to Advance New Technology to Screen Embryos for Genetic Abnormalities

... most commonly used technology for chromosomal analysis of embryos (sometimes termed preimplantation genetic diagnosis or PGD), is florescent in situ hybridization (FISH). This technique assesses fewer than half of the 23 chromosome pairs found in the human karyotype and has a suboptimal error rate. This makes ...

Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy

... of IHC plus a reflex FISH assay (see below). Fluorescent in situ hybridization (FISH) involves the hybridization of specific DNA probes, which are visible on a fluorescent microscope. ...

Immunicon Will Exhibit CellCapture CTC Mouse/Rat Kit and EasyCount System for Automated Cell Counting at AACR

... development services for its CellTracks(R) System rare cell technology, including biomarker assays for protein markers or fluorescence in situ hybridization (FISH) targets and new assay kit development for analysis of other rare cells. Immunicon's clinical trial testing services include testing CTCs or ...

Testing for Human Papillomavirus

... (Tucson) offers Inform HPV, an analyte specific reagent assay that can be performed on both tissue specimens and LBPTs. The assay is an in situ hybridization test performed on histology or LBPT slides that are incubated with fluorescein-tagged DNA probes and counterstained. Microscopic observation of ...

The Past, Present and Future of HLA Typing

... are then incubated with unlabeled, sequence specific oligonucleotide probes immobilized on the membrane. After the incubation and wash steps, the hybridization products can be detected by streptavidin horseradish peroxidase and chromogenic substrate. Modifications such as this allow the HLA typing to be ...

Controlling the Spread of Healthcare Associated Methicillin Resistant Staphylococcus aureus Requires Active Surveillance

... on conventional media. IDI-MRSA (Infectio Diagnostic, Inc.), utilizes PCR for the amplification of MRSA DNA and fluorogenic target-specific hybridization probes for the detection of the amplicons. Nasal swab specimens are placed directly in sample preparation buffer, and after additional processing, ...
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