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Herpes in Medical Technology

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

... In prior tests involving L.E.A.P.S. herpes simplex vaccines, CEL-SCI and other researchers ... was a good indicator for protection against herpes simplex as well. Dr. Borthakur, of the ... peptide from a disease-related protein, such as a herpes simplex virus (HSV) glycoprotein to make a ...

ViroPharma Announces Discontinuation of Maribavir Phase 3 Study in Liver Transplant Patients

... About Cytomegalovirus CMV is a member of the herpes virus group, which includes the viruses that cause chicken pox, mononucleosis, herpes labialis (cold sores), and herpes genitalis (genital herpes). Like ...

Topical Treatment for Cold Sores Achieves Efficacy of Oral Drugs; Represents Paradigm Shift in the Treatment of Skin Infections

... and epidermis, where it surrounds and fuses with herpes simplex virus and disrupts the outer envelope of ... not absorbed into the bloodstream." Because the herpes simplex virus causes both cold sores and ... lead product candidates are treatments for herpes labialis (cold sores), onychomycosis (nail ...

Epiphany Biosciences to Continue Phase 2 Shingles Study After Interim Analysis; Plans Follow-On Clinical Trial Studying Post-Herpetic Neuralgia (PHN)

... valomaciclovir (EPB-348) in patients with acute herpes zoster infection (shingles), will continue as ... PHN. "The spectrum of disease caused by herpes viruses is underappreciated but a disease like ... in multiple conditions associated with herpes viruses and plan to maximize the broad-acting ...

Shingles Pain Treatment Will Benefit More Patients

... of neuropathic pain associated with previous herpes zoster infection (post-herpetic neuralgia, PHN). ... apply to inflamed or injured skin (e.g. active herpes zoster lesions, atopic dermatitis or wounds), ... 4) herpes Viruses Association. Available at: ...

BioVex Announces Regulatory Clearance to Commence a Clinical Study With ImmunoVEX HSV2; A Vaccine Candidate for Genital Herpes

... designed to remove the genes that allow herpes virus to avoid the immune system. This should ... HSV2 completely prevented all symptoms of genital herpes and triggered a powerful immune ... Officer, Dr. Robert Coffin, commented: "Genital herpes is a significant and growing public health issue. ...

Abbott Presents Long-Term Data From Extension Study Showing Adult Crohn's Patients Treated With HUMIRA(R) (Adalimumab) Maintained Remission

... pharyngitis, increased aminotransferases, herpes zoster, myositis, metrorrhagia and ... of treatment with HUMIRA and included cases of herpes simplex, pneumonia, urinary tract infection, pharyngitis, and herpes zoster. Safety of HUMIRA in pediatric patients ...

Epiphany Biosciences Reports Initiation and Enrollment in Valomaciclovir Study for Shingles

... (EPB-348) for the treatment of herpes zoster, also known as shingles. Valomaciclovir is ... "There are roughly one million cases of herpes zoster in the United States annually and current ... diverse populations that can be affected by herpes zoster." The number of elderly patients at-risk ...

Two-Year Phase III Data Presented at AAN 61st Annual Meeting Show Positive Outcome of Cladribine Tablets in Patients With Multiple Sclerosis

... in patients treated with Cladribine Tablets and placebo were similar. herpes zoster infections were reported in 2.3% of patients treated with Cladribine Tablets. These herpes infections were localized to the skin and responded appropriately to ...

Indevus Pharmaceuticals Announces PRO 2000 Found to Show Promise in Large HIV Prevention Study

... Laboratory studies have shown that PRO 2000 is active against HIV, herpes simplex virus, chlamydia and the bacterium that causes gonorrhea. ... PRO 2000 has been found to afford protection in mouse models for genital herpes infection and gonorrhea, and in a simian model for vaginal HIV infection. ...

Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma

... pain (each 15%), bone pain (14%), back pain and hypotension (each 13%), herpes zoster, nasopharyngitis, upper respiratory tract infection, myalgia and ... (14% vs 9%), abdominal pain (14% vs 7%), paresthesia (13% vs 4%), herpes zoster (13% vs 4%), bronchitis (13% vs 8%), hypokalemia (13% vs 7%), ...

Novel VELCADE(R) (Bortezomib) for Injection Based Four-Drug Combination Was Well Tolerated In Previously Untreated Multiple Myeloma Patients

... toxicities reported were febrile neutropenia and reactivation of the herpes Zoster virus infection. -- The overall rate of serious adverse ... pain (each 15%), bone pain (14%), back pain and hypotension (each 13%), herpes zoster, nasopharyngitis, upper respiratory tract infection, myalgia and ...

Durezol(TM) in the Treatment of Uveitis and Ganciclovir in the Treatment of Herpetic Keratitis: Studies of Treatments for Leading Causes of Blindness to Be Presented

... for the treatment of ocular viral infections for more than 10 years. herpes simplex keratitis is the leading cause of corneal blindness in the US, ... cataract formation, secondary ocular infection from pathogens including herpes simplex, and perforation of the globe where there is thinning of the ...

New England Journal of Medicine Publishes Phase III Results of VELCADE(R) (Bortezomib) for Injection in Previously Untreated Multiple Myeloma Patients

... (14% vs 9%), abdominal pain (14% vs 7%), paresthesia (13% vs 4%), herpes zoster (13% vs 4%), bronchitis (13% vs 8%), hypokalemia (13% vs 7%), ... pain (each 15%), bone pain (14%), back pain and hypotension (each 13%), herpes zoster, nasopharyngitis, upper respiratory tract infection, myalgia and ...

ViroPharma Announces Completion of Enrollment in Phase 3 Study of Maribavir in Stem Cell Transplant Patients

... anti-CMV therapies. About Cytomegalovirus CMV is a member of the herpes virus group, which includes the viruses that cause chicken pox, mononucleosis, herpes labialis (cold sores), and herpes genitalis (genital herpes). Like other ...

Vical Receives NIH Grant for an Immunotherapeutic Herpes DNA Vaccine; Herpes Experts at University of Washington and University of Texas to Conduct Preclinical Development

... of Vical's immunotherapeutic plasmid DNA (pDNA) vaccine against herpes simplex virus type 2 (HSV-2), a sexually transmitted virus which is the ... is a member of the herpesvirus family, and is the leading cause of genital herpes worldwide. In the United States, HSV-2 infects some 1.6 million people per ...

NanoBio Corporation Successfully Completes Phase 2b Study in Herpes Labialis

... today from its phase 2b study of NB-001, a topical lotion to treat herpes labialis (cold sores). The randomized, double-blind, vehicle- controlled ... to those people affected by this disease, since the vast majority of herpes labialis sufferers today seek over-the-counter treatments for their cold ...

NanoBio Corporation Presents Preclinical and Interim Clinical Data on Topical Treatments for Herpes Labialis and Onychomycosis at AAD 2008

... safety profile." Final results from a prior phase 2A study in herpes labialis, as well as interim findings from an ongoing phase 2B study, ... and Efficacy of Topical Nanoemulsion NB-001 for the Treatment of herpes Labialis -- Development of a Novel Antiviral Drug (NB-001) for Topical ...

Epiphany Biosciences Reports Initiation of Phase 2 Study of Valomaciclovir for the Treatment of Acute Infectious Mononucleosis

... of anti-viral activity, including inhibition of viral replication of herpes zoster and EBV," said Fred Volinsky, MD, Chief Executive Officer. "EBV has ... Phase 2b study examining the safety and efficacy of valomaciclovir against herpes zoster infection. Epiphany was founded by a world-class virology team, ...

Two Point of Care Tests From Quest Diagnostics Receive FDA 510(k) Clearance

... HSV-2, a test for aiding in the diagnosis of the herpes simplex type-2 virus, the primary cause of genital herpes. This is the ... to return for a second visit to learn their results. The prevalence of herpes has increased dramatically in the last three decades because it is often ...

AlphaVax Announces Results from Initial Testing of Its H1N1 (Swine) Influenza Vaccine

... through a mixture of in-house and partnered programs. The AlphaVax technology is currently being used to advance vaccines for cytomegalovirus, herpes simplex virus, respiratory syncytial virus, a range of cancers, influenza, HIV and a number of biodefense targets. The AlphaVax headquarters and ...

NeurogesX Receives FDA Orphan Drug Designation for Qutenza(TM) for Treatment of Postherpetic Neuralgia

... position through seven years of market exclusivity upon approval." PHN is a chronic painful condition that develops in patients following a herpes zoster (shingles) outbreak. Current treatments for PHN include antidepressants, anticonvulsants, topical anesthetics and opioid analgesics. ...

IMPACT Study Showed Longer Valcyte(R) (valganciclovir hydrochloride tablets) Treatment Demonstrated Better Protection Against Cytomegalovirus (CMV) Disease One Year Post-Transplant

... Belgium and Romania. They were attributed to hemorrhage (one), sepsis (one) or septic shock (two). About CMV CMV belongs to the family of herpes viruses and, as such, is very common among the general population. It is estimated that 50-80% of all adults have been infected with the CMV virus. ...

AlphaVax Announces Promising Results in Melanoma Studies

... cancer clinical trial is planned for later this year. In addition to cancer immunotherapy programs, AlphaVax is developing vaccine products for herpes simplex virus, influenza, respiratory syncytial virus, HIV and a number of biodefense targets. The AlphaVax headquarters and R&D facilities are ...

NovaBay Pharmaceuticals Announces Lead Anti-infective Product Candidate, NVC-422, Shown to be Effective in Treating Topical Fungal Infection

... expansive therapeutic utility against bacteria of all types, including multidrug resistant species; shedding viruses including adenoviruses; and herpes viruses, yeasts and fungi. In addition, in Phase I human studies, NVC-422 has been shown to be safe and well-tolerated in the nose and bladder. ...

Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL

... fungal, and protozoan infections can occur in patients receiving Campath. Administer prophylaxis against Pneumocystis jiroveci pneumonia (PCP) and herpes virus infections. Campath is indicated as a single agent for the treatment of B-cell chronic lymphocytic leukemia (B-CLL). ...

Prolonged Progression-Free Survival Demonstrated by VELCADE(R) (Bortezomib) for Injection Based Induction Regimens in Transplant-Eligible Previously Untreated Multiple Myeloma Patients

... and dizziness (excluding vertigo) (each 17%), pain in limb and abdominal pain (each 15%), bone pain (14%), back pain and hypotension (each 13%), herpes zoster, nasopharyngitis, upper respiratory tract infection, myalgia and pneumonia (each 12%), muscle cramps (11%), and dehydration and anxiety (each ...

Sosei Confirms the Safety of SD118 in Two Phase I Trials

... traumatic diseases including spinal cord injury and nerve compression. Also, it is a common secondary symptom in diseases like diabetes, cancer and herpes zoster infection, and can occur after the use of cytotoxic drugs. The condition has a poor prognosis and is a significant cause of morbidity. The ...

Bayer Announces Upcoming Presentations of Campath(R) and Leukine(R) Data at the 50th Annual Meeting of the American Society of Hematology

... fungal, and protozoan infections can occur in patients receiving Campath. Administer prophylaxis against Pneumocystis jiroveci pneumonia (PCP) and herpes virus infections. Campath is indicated as a single agent for the treatment of B-cell chronic lymphocytic leukemia (B-CLL). ...

Vical Completes Enrollment and Reports Positive Interim Data in CMV Vaccine Phase 2 Trial

... analysis, the company determined that there was no need to continue enrollment in the donor-recipient arm. About CMV CMV is a herpes virus that infects more than half of all adults in the United States by age 40, and is even more widespread in developing countries. While a healthy ...

Sirion Therapeutics Announces Positive Pivotal Uveitis Data for Durezol(TM)

... optic nerve damage, visual acuity and field defects, posterior subcapsular cataract formation, secondary ocular infection from pathogens including herpes simplex, and perforation of the globe where there is thinning of the cornea or sclera. Ocular adverse reactions occurring in 5-15% of subjects in ...

Video: Sirion Therapeutics Launches Durezol for Postoperative Ocular Inflammation and Pain

... optic nerve damage, visual acuity and field defects, posterior subcapsular cataract formation, secondary ocular infection from pathogens including herpes simplex, and perforation of the globe where there is thinning of the cornea or sclera. Ocular adverse reactions occurring in 5-15% of subjects in ...

Continuous Treatment With Abbott's HUMIRA(R) Achieves Superior Long-Term Efficacy for Psoriasis Patients Compared to Interrupting Treatment

... possibly causally related to HUMIRA include lower respiratory infections (including pneumonia, bronchitis), viral infections (including influenza, herpes infections), candidiasis, bacterial infection (including urinary tract infections), upper respiratory infection, dizziness (including vertigo), ...

Pooled-Analysis of 54 Clinical Studies Shows No Increased Risk of Heart Attack With Abacavir Therapy

... taking HIV medicines, your immune system may get stronger and could begin to fight infections that have been hidden in your body, such as pneumonia, herpes virus, or tuberculosis. If you have new symptoms after starting your HIV medicines, be sure to tell your doctor. Changes in body fat may occur in ...

Promise of Vical's CMV Vaccine Noted by Independent Experts

... transplant patients, and could eventually be useful in preventing birth defects caused by CMV infection of pregnant women." About CMV CMV is a herpes virus that infects more than half of all adults in the United States by age 40, and is even more widespread in developing countries. While a healthy ...

BioVex to Report Phase II Clinical Trial Results of OncoVEX GM-CSF in Metastatic Melanoma at the 2008 American Society of Clinical Oncology Meeting

... Senzer, M.D., will present up-to-date results of the abstract entitled "Phase II clinical trial with a second generation, GM-CSF encoding, oncolytic herpes virus in unresectable metastatic melanoma," at the 2008 ASCO Annual Meeting in Chicago, IL on Sunday, June 1 at 9:30am EDT during the melanoma ...

ANX-201 Demonstrates a Unique Resistance Profile in Preclinical Tests

... In other preclinical studies, ANX-201 has shown broad-spectrum antiviral activity against HIV-1, HIV-2, human and avian influenza viruses, and herpes simplex viruses 1 and 2 (HSV-1 and HSV-2). About ADVENTRX Pharmaceuticals ADVENTRX Pharmaceuticals is a biopharmaceutical company focused ...

NanoBio(R) Corporation Completes $30 Million in Equity Funding by Meeting Key Development Milestones

... equity management firm. The funding has enabled NanoBio to conduct phase 2 clinical trials on its two lead products, topical lotions NB-001 for herpes labialis (cold sores) and NB-002 for onychomycosis (nail fungus). Additionally, the funding has supported extensive animal studies supporting the ...

ADVENTRX to Present ANX-201 Preclinical Data at Keystone Symposia HIV Pathogenesis Conference

... In other preclinical studies, ANX-201 has shown broad-spectrum antiviral activity against HIV-1, HIV-2, human and avian influenza viruses, and herpes simplex viruses 1 and 2 (HSV-1 and HSV-2). About ADVENTRX Pharmaceuticals ADVENTRX Pharmaceuticals is a biopharmaceutical research ...

EpiCept Provides Update on Clinical and Regulatory Progress with Ceplene(TM) and EpiCept(TM) NP-1 Cream

... that these conditions affect more than 15 million people in the U.S. and is associated with conditions that injure peripheral nerves, including herpes zoster, or shingles, diabetes, chemotherapy, HIV and other diseases. About EpiCept Corporation EpiCept is focused on unmet needs in the treatment ...
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