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Finger in Medical Technology

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... genetically modified mammals developed using zinc finger nuclease (ZFN) technology. (Photo: ... "Knockout Rats via Embryo Microinjection of Zinc finger Nucleases," (Geurts, et al.) scientists used ZFNs ... Sigma-Aldrich, the sole source of commercial zinc finger nucleases for the research community, markets ...

Got Pain?

... wrist pain and more than 7 million for hand and finger pain. Common hand and finger problems can include arthritis in the base of the ... Arthritis of the Base of the Thumb and finger ( ...

Sangamo BioSciences Provides Update on Company's 2008 Progress and 2009 Objectives

... companies' collaboration to commercialize zinc finger DNA-binding protein (ZFP) technology for research ... under the trademark CompoZr, the zinc finger nuclease (ZFN) technology makes available, for ... of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs ...

Sangamo BioSciences Announces Achievement of Key Milestone in Cell Engineering Agreement With Genentech

... protein production purposes using Sangamo's proprietary zinc finger DNA-binding protein nuclease (ZFN) technology. Genentech scientists ... Sangamo BioSciences, Inc. is focused on researching and developing zinc finger DNA-binding protein (ZFP) technology for therapeutic gene regulation and ...

Video: Partnership Unites UCB with Consumer Product Innovator OXO(R)

... various grip positions. Easy to remove needle cover - rounded finger loop for easy removal of needle cover; flared needle cap designed to ... Cimzia(R); and lastly, the plastic housing inside with a large finger recess allows patients to easily remove the syringe. ...

New Study Using Combination of Bioengineered Skin and Stem Cells Shows Promise in Treatment of Non-Healing Wounds

... has not by itself been consistently useful in healing scleroderma finger ulcers," said Dr. Falanga. "Through our research, we learned that our ... "On follow-up examination, one patient who had painful and incurable finger ulcers for many years remained healed and free of pain from this ....

Sangamo BioSciences Initiates Phase 2 Clinical Trial of Treatment for Amyotrophic Lateral Sclerosis (ALS)

... drug, SB-509, is an injectable formulation of a plasmid encoding a zinc finger DNA-binding protein transcription factor (ZFP TF(TM)) designed to ... enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific ...

Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant T Cells

... T-cells) can be made resistant to HIV infection by treatment with zinc finger DNA-binding protein nucleases (ZFN(TM)). The data suggest that the ZFN ... enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific ...

Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting

... of Neuroregeneration Using Vascular Endothelial Growth Factor (VEGF) Zinc finger Protein Activator (SB-509) in Diabetic Neuropathy: A Chronic ... enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific ...

Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs

... About SB-509 SB-509 is an injectable formulation of a zinc finger DNA-binding protein transcription factor (ZFP TF(TM)) designed to ... enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific ...

Auxilium Pharmaceuticals, Inc. Announces XIAFLEX(TM) Meets Primary Endpoint With Statistical Significance (p<0.001) in CORD I Pivotal Phase III Study for Dupuytren's Contracture

... or the PIP joint, which is the middle joint in the finger. The little finger and ring finger are most frequently involved. There are currently no drugs approved by the ...

Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of 'Knock-Out' Cell Lines

... today the publication of data demonstrating the use of Sangamo's zinc finger DNA-binding protein nucleases (ZFNs(TM)) in a new approach for rapid ... Sciences ("Targeted Gene Knockout in Mammalian Cells Using Engineered Zinc finger Nucleases"). The data demonstrate that ZFN technology can be used to ...

Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)

... or the PIP joint, which is the middle joint in the finger. The little finger and ring finger are most frequently involved. (1) Badalamente, M. A., Hurst, L. C. et ...

deCODE Discovers Second Common Genetic Risk Factor for Atrial Fibrillation and Stroke

... been replicated in numerous populations by us and others, and the connection to cardioembolic stroke is yet further evidence that we are putting our finger on an important pathway involved in AF and stroke risk. The ability to routinely test for these risk factors means that we can understand whom we ...

Sangamo BioSciences Announces Presentations at Two Upcoming Investor Conferences

... Parkinson's disease and monogenic diseases. Sangamo's core competencies enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) ...

IlluminOss Medical Announces First Human Case Utilizing a Unique, New, Minimally Invasive Technology for Fracture Repair is Performed at Medical Hospital del Trabajadar in Santiago, Chile

... on a 21 year old man with a fracture of the 5th metacarpal. The metacarpals are the bones that extend from the base of the wrist to the base of each finger at the knuckle. The fifth metacarpal runs to the little finger. According to Dr. von Unger, "With traditional methods of treating fractures, ...

Inverness Medical Innovations Participates in Meeting on HIV/AIDS with UN Secretary-General

... program. It is a simple to operate, portable system with a rechargeable battery and provides rapid results in 15 minutes or less. Using a small finger stick blood sample, the platform may be able to deliver not only CD4 cell enumeration but ultimately provide diagnostic capabilities for a wide array ...

Blood Spot Technology at ZRT Highlighted in March Issue of Journal of Diabetes Science & Technology - A Convenient Alternative to Serum Testing for Health Screening

... factors for diabetes and cardiovascular disease, published in the same issue of the journal. The paper, "Cardiometabolic Risk Factors Assessed by a finger Stick Dried Blood Spot Method," by Sanjay Kapur, PhD, Sonia Kapur, PhD, and David Zava, PhD of ZRT Laboratory, Beaverton, Oregon, (J Diabetes Sci ...

Schering-Plough Announces Imperfect Contraceptive Use Impacts Women's Emotional Well-Being

... at about the same time. NUVARING can be removed by hooking the index finger under the forward rim or by grasping the rim between the index and middle finger and pulling it out. After a one-week break, during which a withdrawal bleed usually occurs, a new ring is inserted on the same day of the week as it ...

Sangamo BioSciences Reports 2007 Fourth Quarter and Year-End Financial Results

... over a six month period after a single administration of SB-509. SB-509 is an injectable formulation of plasmid DNA that encodes a zinc finger DNA-binding protein transcription factor (ZFP TF(TM)), designed to upregulate the vascular endothelial growth factor-A (VEGF-A) gene. -- ...

Sangamo BioSciences Announces Completion of Enrollment of Phase 2 Clinical Trial of ZFP Therapeutic for Diabetic Neuropathy

... Completion of enrollment of the trial triggers a milestone payment from JDRF under this agreement. About SB-509 SB-509 is a formulation of a zinc finger DNA-binding protein transcription factor (ZFP TF) designed to upregulate the expression of the gene encoding vascular endothelial growth factor ...

Two Point of Care Tests From Quest Diagnostics Receive FDA 510(k) Clearance

... The HemoCue WBC Analyzer provides a count of a patient's white blood cells in as few as three minutes using a blood sample taken from the patient's finger tip. Unlike conventional methods which measure red and total blood cell counts, the HemoCue WBC Analyzer is the first point of care device to produce ...

Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells

... Parkinson's disease and monogenic diseases. Sangamo's core competencies enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). By engineering ZFPs that recognize a specific DNA sequence Sangamo has created ZFP transcription factors (ZFP TF(TM)) ...

Sangamo BioSciences Announces Presentation of Phase 1 ZFP Therapeutic Data at American Diabetes Association Meeting

... Patients Treated with Vascular Endothelial Growth Factor (VEGF) Zinc finger Protein Activator (SB-509)," results of Sangamo's Phase 1b clinical trial ... in subjects with diabetic neuropathy. SB-509 is a formulation of a zinc finger DNA-binding protein transcription factor (ZFP TF(TM)) designed to ...

Sangamo BioSciences Announces Presentation of ZFP Therapeutic Data From Nerve Regeneration Program at American Society for Neural Therapy and Repair Meeting

... expert in the molecular mechanisms and treatment of SCI. In collaboration with Dr. Fehlings and his colleagues, Sangamo is evaluating a zinc finger DNA-binding protein transcription factor (ZFP TF(TM)), designed to upregulate the expression of the gene encoding vascular endothelial growth factor ...

Pharmacyclics Announces Promising Results From Phase 2 Clinical Trial of Xcytrin in Recurrent, Metastatic Non-Small Cell Lung Cancer

... in this study. The most common grade 3 or 4 adverse events were hypophosphatemia (24%), dyspnea (12%), fatigue (10%), hypoxia (7%), and finger blisters (5%). About Non-Small Cell Lung Cancer The American Cancer Society predicts that there will be more than 213,000 new cases of lung ...

Rapid HIV Testing Increases Possibility of Treatment

... The OraQuick line was first introduced in 2002, and was the first CLIA-waived, rapid, point-of-care test designed to detect antibodies to HIV-1 using finger stick whole blood or venipuncture whole blood specimens. The updated OraQuick ADVANCE Rapid HIV-1/2 Antibody Test FDA approved in October 2004, ...

Hemoglobin Testing at the Point of Care

... a division of Stanbio Laboratory, Boerne, Texas, produces the STATSite MHgb, based on the azidemethemoglobin method and able to use either finger stick or venous whole blood samples. The company says that this CLIA-waived device is the first palm-sized, battery-operated, dedicated hemoglobin ...
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