Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... rat antibody production. Inactivation of rat IgM expression is the first step in generating rats that ... paper. "Inactivation of endogenous rat antibody expression is essential for human antibody expression in genetically engineered animals. To solve this ...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... Monia. Antisense Reduction of FGFR4 Gene expression Lowers Body Weight and Adiposity and Improves ... cAMP Response Element Binding Protein (CREB) expression Lowers Plasma Glucose and Lipids in Diabetic ... B.P. Monia. Inhibition of Transthyretin expression by Antisense Oligonucleotides Lowers RBP4 ...

Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy

... entitled "Enhancer of Zeste Homologue 2 (EZH-2) expression in breast cancer: a novel marker and potential ... School of Medicine. "We wanted to see how much expression of the protein was present. We were surprised ... positive. Scientists found that the increased expression of EZH-2 meant an increase in tumor size and an ...

Genomic Health Study Shows Breast Cancers in Men Display Very Similar Gene Signatures to Those in Women

... - Largest Genomic Study Comparing Gene expression in Female and Male Patients Presented at ASCO ... is the largest genomic study to compare gene expression in female and male patients, and results support ... (Abstract #549), analyzed quantitative gene expression by gender status in estrogen receptor (ER) ...

In Rare Disorder, a Familiar Protein Disrupts Gene Function

... properly. Cohesin's role in dysregulation of gene expression (regulating the degree to which specific genes ... compared to controls, and also detected gene expression profiles that were unique to CdLS. Importantly, said Krantz, the expression levels of genes corresponded to the severity of ...

Another LNA-based RNA Inhibitor Enters Clinical Trials

... animal studies, EZN-3042 inhibited Survivin expression and tumor growth. It also potentiated the ... against survivin, inhibits survivin expression and confers taxol sensitivity" "EZN-3920, ... RNA antagonist, down modulates HER3 expression and PI3K/Akt signaling pathway and ...

ExonHit Reports Proof-of-Concept in Breast Cancer Diagnostic Using its SpliceArray(TM) Platform

... research tools [2]. They quantify mRNA expression at the exon level. They also provide ... improvement over DNA arrays which only quantify expression at the gene level. The study conducted by ... of 165 breast tumor samples that compares gene expression of malignant versus benign breast tumors. The ...

Drug Development Program Started Based on CAP(R) Human Cell Line

... strengths of CEVEC's proprietary CAP(R) cell expression technology, in combination with the ... and patent-protected human CAP(R) and CAP-T(TM) expression systems are ideal for manufacturing complex ... CEVEC is licensing out its human cell-based expression platform as well as the biological product ...

Scientists Discover Why Teeth Form in a Single Row

... one of the most common birth defects. Gene expression is the process by which information stored in ... and restricted by the effect of Osr2 on the expression of the Bmp4 gene within the mesenchymal cell ... BMP4 concentration gradient. Osr2 restricts Bmp4 expression to the tooth mesenchyme under the dental lamina, ...

Quark Pharmaceuticals Announces Dosing of the First Patient in Phase I/II Clinical Trial for Systemically Delivered siRNA Drug Candidate for Delayed Graft Function

... is a siRNA designed to temporarily inhibit the expression of the pro-apoptotic gene, p53. This siRNA is ... therapeutic concept of temporarily inhibiting the expression of p53 to protect normal cells from acute injury. ... chemically modified siRNA designed to inhibit the expression of the gene RTP801 discovered by Quark through ...

WaferGen and University of Texas Southwestern Medical Center Establish Biomarker Research Collaboration for SmartChip(TM) Real-Time PCR System

... Southwestern to Identify and Validate Novel Gene expression Biomarkers Involved in Wound Healing with Innovative Gene expression Platform FREMONT, Calif., Jan. 8 ... PCR System in order to identify and validate gene expression biomarkers related to wound healing. ...

Reprogrammable Cell Type Depends on a Single Gene to Keep Its Identity

... change its identity that it requires the constant expression of a gene called Prox1 to dissuade it. ... differentiated cell types that require constant expression of a specific gene to maintain their identity. ... their reprogramming into BECs as indicated by the expression of specific LEC and BEC proteins. In addition, ...

Chipscreen Biosciences and HUYA Bioscience Int'l Announce Promising Preclincial and Phase I Solid Tumor/Lymphoma Data for Chidamide/HBI-8000, New HDAC Inhibitor for Cancer

... factors. This results in decreased expression of proteins involved in cell differentiation, ... cancer. HDAC inhibitors are able to restore expression of tumor suppressor genes in a highly selective ... also leads, indirectly, to inhibition of the expression of angiogenesis factors, helping to choke off the ...

Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy

... Nuclear Factor Erythroid-2-Related Factor 2 Gene expression in Non-Small Cell Lung Cancer Inhibits Tumor ... Erythroid-2-Related Factor 2 (Nrf2) expression in vitro and in in vivo mouse NSCLC xenograft ... modified, siRNA molecule to inhibit the expression of the gene RTP801 discovered by Quark through ...

Mayo Clinic Discovery May Help Diabetic Gastric Problem

... interstitial cells of Cajal (ICC), and 2) loss of expression of neuronal nitric oxide synthase (nNOS). ICC ... in a set of diabetic mice and then looked at expression of HO1. Results showed that production of HO1 was lost in all mice with gastroparesis and nNOS expression was decreased. When the team induced ...

Micromet Presents Data at ESMO 2008 on Anti-EpCAM Antibody Adecatumumab (MT201) in Combination with Chemotherapy

... reported to be 43 percent in patients with high expression of EpCAM, the target of adecatumumab (3 of 7 ... were detected in patients with low EpCAM expression (0 of 8 patients). "These data demonstrate that ... for a better outcome in patients with high EpCAM expression levels is in line with earlier observations and ...

Genomic Health Announces Data Supporting Use of Oncotype DX(R) to Accurately Assess HER2 Gene Expression in Breast Cancer Patients

... - - Company to Include Reporting for HER2 Gene expression in All Oncotype DX Reports ... we provide the quantitative measure of HER2 gene expression in Oncotype DX reports," said Steven Shak, M.D., ... reaction (RT-PCR) technology to quantify gene expression of 21 genes, one of which is HER2. The two ...

Sangamo BioSciences Initiates Phase 2 Clinical Trial of Treatment for Amyotrophic Lateral Sclerosis (ALS)

... factor (ZFP TF(TM)) designed to upregulate the expression of the gene encoding vascular endothelial growth ... officer. "The drug is designed to activate the expression of the subject's own VEGF-A gene. There is ... our approach of using a ZFP TF to stimulate the expression of all of the natural forms of a subject's own ...

FDA Clears the Pathwork(R) Tissue of Origin Test for Hard-To-Identify Tumors

... Pathwork Diagnostics' Gene expression Test Is the First to Receive FDA Clearance for ... The test analyzes a tumor's gene expression pattern to help pinpoint the source of ... genes, in the uncertain tumor and compares it to expression patterns of a panel of 15 known tumor types, ...

Video: Resveratrol-based Nutriceutical (Longevinex(R)) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Prior Studies

... utilized microrrays which provide data on the expression level of over 20,000 genes. The study was ... matrix exerted broader effects upon gene expression than CR or resveratrol, but molecularly mimicked ... exhibited a much broader impact upon gene expression and more strikingly affected key genes, like Pdk4 ...

Rosetta Genomics and Collaborators Identify MicroRNAs That Can Accurately Discriminate Between Primary and Metastatic Tumors in the Brain

... the development and validation of microRNA expression profiles for characterization of brain malignancies. Rosetta Genomics' scientists measured microRNA expression in RNA extracted from hundreds of formalin-fixed, ... MicroRNAs have been shown to have different expression profiles in various pathological conditions. As a ...

Genomic Health Announces Results of Initial Studies to Develop Predictive Tests for Targeted Therapies

... The first study, "Evaluation of tumor gene expression and K-Ras mutations in formalin-fixed, ... commonly observed in colon cancer, and for the expression of 102 previously identified candidate genes that ... (60 percent). Among all 226 samples, quantitative expression of 40 genes was significantly associated with ...

New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma

... Gene expression Profiling of Tumor is Correlated With Clinical ... to establish a correlation between the expression of given genes and the clinical response induced ... Profiling in Melanoma: abstract # 9045(2) Gene expression profiling by microarrays was used to identify ...

Exiqon Forms Research Collaboration With M. D. Anderson Cancer Center

... Exiqon A/S, a leading supplier of high-value gene expression analysis products, today announces that it has ... exceptional clinical expertise and strong gene expression technology together to develop next generation ... combine leading-edge scientific expertise in gene expression with our proprietary LNA(TM) technology. Exiqon's ...

Rosetta Genomics to Present Multiple Posters at the 44th Annual Meeting of the American Society of Clinical Oncology (ASCO)

... site to a cancer sample based on the microRNA expression in the sample. The overall sensitivity of this ... specificity of 99%. 2. "Differential microRNA expression in pleural mesothelioma: Implications for early ... tumors and metastases to the lung. 4. "MicroRNA expression profile identifies origin of tumors in ...

St. Jude Gene Study Reveals Basis of Anti-Cancer Drug Resistance in Childhood Leukemia

... gene chip to each gene to measure the level of expression for those genes in the patient samples. "In ... in the treated patients that differed in their expression level at a very significant level statistically," ... DNA. When the researchers compared the gene expression patterns of patients who responded well to ...

deCODE Obesity Study Sheds Light on How Genetics Affects Risk and Onset of Common Diseases

... from primary human tissue that variations in gene expression -- in the up-regulation or downregulation of how ... of genetic markers. The paper, "Genetics of gene expression and its effect on disease," is published today ... contribution towards the understanding of gene expression in man and one example of how it can be used to ...

PTC Therapeutics Presents Encouraging Phase 1 Results of its Novel VEGF Inhibitor, PTC299, at 30th Annual San Antonio Breast Cancer Symposium

... PTC299 through PTC's proprietary GEMS (Gene expression Modulation by Small-Molecules) technology by ... multiple solid tumor types. About GEMS Gene expression Modulation by Small-molecules (GEMS) is PTC's ... and development activities, including the Gene expression Modulation by Small- molecules (GEMS) technology ...

Multiple Studies Presented at San Antonio Breast Cancer Symposium Reinforce Clinical Utility of Oncotype DX(R)

... of the company's Oncotype DX(R), a multi-gene expression test to predict the likelihood of recurrence and ... Quantitative Estrogen Receptor and Progesterone expression with Oncotype DX * A study presented by Kaiser ... a large dynamic range than estrogen receptor expression measured by IHC, which was generally either ...

HERmark(TM) Assay Results in Metastatic Breast Cancer Presented at the San Antonio Breast Cancer Symposium

... Study details: Those patients with higher HER2 expression levels (i.e. in the upper half of the ... Cox proportional hazards models identified HER2 expression (HR = 0.16, p < 0.001) and HER2:HER2 dimer levels ... indicate that HERmark can precisely measure HER2 expression and HER2:HER2 dimer levels in clinical FFPE ...

Genomic Health Announces Eight Oncotype DX(R) Studies to Be Presented at 30th Annual San Antonio Breast Cancer Symposium

... 13-16, 2007. Oncotype DX is a multi-gene expression test that physicians use to predict the ... p.m. Abstract #3028 Poster presentation: "Gene expression by standardized quantitative RT-PCR in the ... Oncotype DX is the first diagnostic multi-gene expression test commercially available that has clinical ...

The New England Journal of Medicine Publishes First Clinical Results for MedImmune's Chitinase-like Protein YKL-40 in Patients With Asthma

... were correlated with asthma severity, airway expression of the molecule and parameters of airway ... University of Paris 7. "Importantly, elevated expression of YKL-40 in serum and lung is associated with ... bronchial biopsies taken in the Paris cohort, the expression of YKL-40 was 16.2 positive cells per millimeter ...

Synvista Therapeutics' Alagebrium Shows Potential for use in Treating Diabetes-Related Gastrointestinal Complications

... In this study, Dr. Pasricha examined the expression of duodenal nNOS and the role of AGE and RAGE ... that there was a 50% reduction in myenteric nNOS expression which was reversible by either aminoguanidine ... 15% or more diabetics. A role for decreased nNOS expression has been suggested as a possible cause for the ...

PTC Therapeutics Announces Additional Results from Phase 2 Study of PTC124 in Duchenne Muscular Dystrophy

... with qualitative increases in muscle dystrophin expression and with reductions in serum creatine kinase ... vitro and in vivo evidence of enhanced dystrophin expression and reduced muscle fragility offer signals ... and development activities, including the Gene expression Modulation by Small- molecules (GEMS) technology ...

Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week

... mapping, and gene expression analysis BRANFORD, Conn., Oct. 2 /PRNewswire/ ... Variation in Humans", "Wasp Brain Gene expression Supports an Evolutionary Link between Maternal ... theory. In the study, "Wasp Brain Gene expression Supports an Evolutionary Link between Maternal ...

454 Sequencing(TM) in Science Today: Researchers Uncover a Genetic Basis for Different Social Behaviors in Wasps

... from the brains of wasps and correlated different expression patterns to different social behaviors. The study, entitled "Wasp brain gene expression supports an evolutionary link between maternal ... and accuracy for transcriptome profiling and gene expression applications," explained Michael Egholm, Ph.D., ...

Gene Fusion Subtypes in Prostate Carcinoma Have Clinical Implications

... Oncomine and Oncomine Concepts Map Integral in expression and Association ... data analysis tools to a large cancer gene expression database, which includes data from 20,000+ ... Oncomine again proved invaluable in examining the expression of genes in cancer, and in this case aided in ...

CuraGen Updates CR011-vcMMAE Data at ASCO

... portion of the Phase II study. Selection for enrollment was not based on expression of GPNMB in patients' tumors. The median number of prior chemotherapy ... in a subset of patients with tumor biopsies, high levels of tumor expression of GPNMB appeared to correlate with favorable outcome. "These Phase ...

CMC ICOS Biologics and Implicit Bioscience Ltd Announce IC14 Antibody Manufacturing Agreement and Patent License

... negotiated a non-exclusive license to utilize the CMC proprietary CHEF1(R) expression technology, a system that rapidly generates production cell lines and ... services includes cell line development using its proprietary CHEF1(R) expression system, process development, analytical and formulation development, and ...

Genetic Source of Rare Childhood Cancer Found; Gene is Implicated in Other Cancers

... mutation in DICER1, a master controller gene that helps regulate expression of other genes. The children studied came from families with a history of ... St. Louis. "Very recently, other research found that reduced DICER1 gene expression in tumor cells is associated with worse outcomes in patients with ovarian, ...