Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology
... rat antibody production. Inactivation of rat IgM expression
is the first step in generating rats that ... paper. "Inactivation of endogenous rat antibody expression
is essential for human antibody expression
in genetically engineered animals. To solve this ...
Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions
Antisense Reduction of FGFR4 Gene expression
Lowers Body Weight and
Adiposity and Improves ... cAMP Response Element Binding Protein (CREB)
Lowers Plasma Glucose and Lipids in Diabetic ... B.P. Monia.
Inhibition of Transthyretin expression
by Antisense Oligonucleotides
Lowers RBP4 ...
Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy
... entitled "Enhancer of Zeste Homologue 2 (EZH-2) expression
in breast cancer: a novel marker and potential ... School of Medicine. "We wanted to see how much expression
of the protein was present. We were surprised ... positive. Scientists found that the increased expression
of EZH-2 meant an increase in tumor size and an ...
Genomic Health Study Shows Breast Cancers in Men Display Very Similar Gene Signatures to Those in Women
... - Largest Genomic Study Comparing Gene expression
in Female and Male Patients Presented at ASCO ... is the largest genomic study to compare gene expression
in female and male patients, and results support ... (Abstract #549), analyzed quantitative gene expression
by gender status in estrogen receptor (ER) ...
In Rare Disorder, a Familiar Protein Disrupts Gene Function
... properly. Cohesin's role in dysregulation of gene expression
(regulating the degree to which specific genes ... compared to controls, and also detected gene expression
profiles that were unique to CdLS. Importantly, said Krantz, the expression
levels of genes corresponded to the severity of ...
Another LNA-based RNA Inhibitor Enters Clinical Trials
... animal studies, EZN-3042 inhibited
and tumor growth. It also potentiated the ... against survivin,
inhibits survivin expression
and confers taxol sensitivity"
"EZN-3920, ... RNA antagonist, down
modulates HER3 expression
and PI3K/Akt signaling pathway and ...
ExonHit Reports Proof-of-Concept in Breast Cancer Diagnostic Using its SpliceArray(TM) Platform
... research tools .
They quantify mRNA expression
at the exon level. They also provide ... improvement over DNA arrays which only quantify expression
The study conducted by ... of 165
breast tumor samples that compares gene expression
of malignant versus benign
breast tumors. The ...
Drug Development Program Started Based on CAP(R) Human Cell Line
... strengths of CEVEC's
proprietary CAP(R) cell expression
technology, in combination with the ... and patent-protected
human CAP(R) and CAP-T(TM) expression
systems are ideal for manufacturing
complex ... CEVEC is licensing out its human
platform as well as the biological product ...
Scientists Discover Why Teeth Form in a Single Row
... one of the most common birth defects.
is the process by which information stored in ... and restricted by the effect of Osr2 on the expression
of the Bmp4 gene within the mesenchymal cell ... BMP4 concentration gradient. Osr2 restricts Bmp4 expression
to the tooth mesenchyme under the dental lamina, ...
Quark Pharmaceuticals Announces Dosing of the First Patient in Phase I/II Clinical Trial for Systemically Delivered siRNA Drug Candidate for Delayed Graft Function
... is a siRNA designed to temporarily inhibit the expression
of the pro-apoptotic gene, p53. This siRNA is ... therapeutic concept of temporarily inhibiting the expression
of p53 to protect normal cells from acute injury. ... chemically modified siRNA designed to inhibit the expression
of the gene RTP801 discovered by Quark through ...
WaferGen and University of Texas Southwestern Medical Center Establish Biomarker Research Collaboration for SmartChip(TM) Real-Time PCR System
... Southwestern to Identify and Validate Novel Gene expression
Biomarkers Involved in Wound Healing with Innovative Gene expression
FREMONT, Calif., Jan. 8 ... PCR System in order to identify and validate gene expression
biomarkers related to wound healing. ...
Reprogrammable Cell Type Depends on a Single Gene to Keep Its Identity
... change its identity that it requires the constant expression
of a gene called Prox1 to dissuade it.
... differentiated cell types that require constant expression
of a specific gene to maintain their identity. ... their reprogramming into BECs as indicated by the expression
of specific LEC and BEC proteins. In addition, ...
Chipscreen Biosciences and HUYA Bioscience Int'l Announce Promising Preclincial and Phase I Solid Tumor/Lymphoma Data for Chidamide/HBI-8000, New HDAC Inhibitor for Cancer
... factors. This results in decreased expression
involved in cell differentiation, ... cancer. HDAC inhibitors are able to restore expression
suppressor genes in a highly selective ... also leads, indirectly, to inhibition of the expression
angiogenesis factors, helping to choke off the ...
Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy
... Nuclear Factor Erythroid-2-Related Factor 2 Gene expression
Non-Small Cell Lung Cancer Inhibits Tumor ... Erythroid-2-Related Factor 2 (Nrf2) expression
in vitro and in in
vivo mouse NSCLC xenograft ... modified, siRNA molecule to inhibit the expression
the gene RTP801 discovered by Quark through ...
Mayo Clinic Discovery May Help Diabetic Gastric Problem
... interstitial cells of
Cajal (ICC), and 2) loss of expression
of neuronal nitric oxide synthase
(nNOS). ICC ... in a set of diabetic mice and then looked at expression
HO1. Results showed that production of HO1 was lost in all mice with
gastroparesis and nNOS expression
was decreased. When the team induced ...
Micromet Presents Data at ESMO 2008 on Anti-EpCAM Antibody Adecatumumab (MT201) in Combination with Chemotherapy
... reported to be
43 percent in patients with high expression
of EpCAM, the target of
adecatumumab (3 of 7 ... were detected in
patients with low EpCAM expression
(0 of 8 patients).
"These data demonstrate that ... for a better outcome in
patients with high EpCAM expression
levels is in line with earlier
observations and ...
Genomic Health Announces Data Supporting Use of Oncotype DX(R) to Accurately Assess HER2 Gene Expression in Breast Cancer Patients
- Company to Include Reporting for HER2 Gene expression
in All Oncotype DX Reports ... we provide the
quantitative measure of HER2 gene expression
in Oncotype DX reports," said
Steven Shak, M.D., ... reaction
(RT-PCR) technology to quantify gene expression
of 21 genes, one of which
is HER2. The two ...
Sangamo BioSciences Initiates Phase 2 Clinical Trial of Treatment for Amyotrophic Lateral Sclerosis (ALS)
... factor (ZFP
TF(TM)) designed to upregulate the expression
of the gene encoding vascular
endothelial growth ... officer. "The
drug is designed to activate the expression
of the subject's own VEGF-A
gene. There is ... our approach of using a ZFP
TF to stimulate the expression
of all of the natural forms of a subject's
FDA Clears the Pathwork(R) Tissue of Origin Test for Hard-To-Identify Tumors
... Pathwork Diagnostics' Gene expression
Test Is the First to Receive FDA
Clearance for ... The test analyzes a tumor's gene expression
pattern to help
pinpoint the source of ... genes, in the uncertain
tumor and compares it to expression
patterns of a panel of 15 known tumor
Video: Resveratrol-based Nutriceutical (Longevinex(R)) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Prior Studies
... utilized microrrays which provide data on
level of over 20,000 genes. The study was ... matrix exerted
broader effects upon gene expression
than CR or resveratrol, but
molecularly mimicked ... exhibited
a much broader impact upon gene expression
and more strikingly affected key
genes, like Pdk4 ...
Rosetta Genomics and Collaborators Identify MicroRNAs That Can Accurately Discriminate Between Primary and Metastatic Tumors in the Brain
development and validation of microRNA expression
characterization of brain malignancies. Rosetta Genomics' scientists
measured microRNA expression
in RNA extracted from hundreds of
formalin-fixed, ... MicroRNAs have been shown
to have different expression
profiles in various pathological conditions.
As a ...
Genomic Health Announces Results of Initial Studies to Develop Predictive Tests for Targeted Therapies
... The first study, "Evaluation of tumor gene expression
mutations in formalin-fixed, ... commonly observed in
colon cancer, and for the expression
of 102 previously identified candidate
genes that ... (60 percent). Among
all 226 samples, quantitative expression
of 40 genes was significantly
associated with ...
New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma
... Gene expression
Profiling of Tumor is Correlated With Clinical ... to establish a correlation
between the expression
of given genes and the clinical response induced ... Profiling in Melanoma: abstract # 9045(2)
profiling by microarrays was used to identify ...
Exiqon Forms Research Collaboration With M. D. Anderson Cancer Center
... Exiqon A/S, a
leading supplier of high-value gene expression
analysis products, today
announces that it has ... exceptional clinical expertise and strong gene expression
together to develop next generation ... combine leading-edge scientific
expertise in gene expression
with our proprietary LNA(TM) technology.
Rosetta Genomics to Present Multiple Posters at the 44th Annual Meeting of the American Society of Clinical Oncology (ASCO)
... site to a cancer sample based on the microRNA expression
sample. The overall sensitivity of this ... specificity of 99%.
2. "Differential microRNA expression
in pleural mesothelioma:
Implications for early ... tumors and metastases to the lung.
4. "MicroRNA expression
profile identifies origin of tumors in ...
St. Jude Gene Study Reveals Basis of Anti-Cancer Drug Resistance in Childhood Leukemia
... gene chip to each
gene to measure the level of expression
for those genes in the patient
"In ... in the treated
patients that differed in their expression
level at a very significant
level statistically," ... DNA.
When the researchers compared the gene expression
patterns of patients
who responded well to ...
deCODE Obesity Study Sheds Light on How Genetics Affects Risk and Onset of Common Diseases
... from primary human tissue that variations in gene expression
the up-regulation or downregulation of how ... of genetic markers. The paper, "Genetics
of gene expression
and its effect on disease," is published today ... contribution towards the understanding of gene expression
man and one example of how it can be used to ...
PTC Therapeutics Presents Encouraging Phase 1 Results of its Novel VEGF Inhibitor, PTC299, at 30th Annual San Antonio Breast Cancer Symposium
... PTC299 through PTC's proprietary GEMS
Modulation by Small-Molecules) technology by ... multiple solid tumor types.
Modulation by Small-molecules (GEMS) is PTC's ... and development activities, including the
Modulation by Small- molecules (GEMS) technology ...
Multiple Studies Presented at San Antonio Breast Cancer Symposium Reinforce Clinical Utility of Oncotype DX(R)
... of the company's Oncotype DX(R), a
test to predict the likelihood of recurrence and ... Quantitative Estrogen Receptor and Progesterone expression
with Oncotype DX * A study presented by Kaiser ... a large dynamic range than estrogen receptor expression
measured by IHC, which was generally either ...
HERmark(TM) Assay Results in Metastatic Breast Cancer Presented at the San Antonio Breast Cancer Symposium
... Study details: Those patients with higher HER2 expression
in the upper half of the ... Cox proportional hazards
models identified HER2 expression
(HR = 0.16, p < 0.001) and HER2:HER2
dimer levels ... indicate
that HERmark can precisely measure HER2 expression
and HER2:HER2 dimer
levels in clinical FFPE ...
Genomic Health Announces Eight Oncotype DX(R) Studies to Be Presented at 30th Annual San Antonio Breast Cancer Symposium
... 13-16, 2007. Oncotype DX is a multi-gene expression
physicians use to predict the ... p.m. Abstract #3028 Poster presentation: "Gene expression
by standardized quantitative RT-PCR in the ... Oncotype DX is the first diagnostic multi-gene expression
commercially available that has clinical ...
The New England Journal of Medicine Publishes First Clinical Results for MedImmune's Chitinase-like Protein YKL-40 in Patients With Asthma
... were correlated with asthma severity, airway expression
molecule and parameters of airway ... University of Paris 7. "Importantly, elevated expression
YKL-40 in serum and lung is associated with ... bronchial biopsies taken in the Paris cohort, the expression
was 16.2 positive cells per millimeter ...
Synvista Therapeutics' Alagebrium Shows Potential for use in Treating Diabetes-Related Gastrointestinal Complications
... In this study, Dr. Pasricha examined the expression
of duodenal nNOS
and the role of AGE and RAGE ... that there was a 50% reduction in myenteric
which was reversible by either aminoguanidine ... 15%
or more diabetics. A role for decreased nNOS expression
has been suggested
as a possible cause for the ...
PTC Therapeutics Announces Additional Results from Phase 2 Study of PTC124 in Duchenne Muscular Dystrophy
... with qualitative increases in muscle dystrophin expression
with reductions in serum creatine kinase ... vitro and in vivo evidence of enhanced
and reduced muscle fragility offer signals ... and development activities, including the
Modulation by Small- molecules (GEMS) technology ...
Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week
... mapping, and gene expression
BRANFORD, Conn., Oct. 2 /PRNewswire/ ... Variation in Humans", "Wasp Brain Gene expression
Evolutionary Link between Maternal ... theory. In the study, "Wasp Brain Gene expression
Evolutionary Link between Maternal ...
454 Sequencing(TM) in Science Today: Researchers Uncover a Genetic Basis for Different Social Behaviors in Wasps
... from the
brains of wasps and correlated different expression
patterns to different
social behaviors. The study, entitled "Wasp brain gene expression
an evolutionary link between maternal ... and
accuracy for transcriptome profiling and gene expression
explained Michael Egholm, Ph.D., ...
Gene Fusion Subtypes in Prostate Carcinoma Have Clinical Implications
... Oncomine and Oncomine Concepts Map Integral in expression
and Association ... data analysis tools to a large cancer gene expression
which includes data from 20,000+ ... Oncomine again proved invaluable in
examining the expression
of genes in cancer, and in this case aided in ...
CuraGen Updates CR011-vcMMAE Data at ASCO
... portion of the Phase II study. Selection for enrollment was not based on expression
of GPNMB in patients' tumors. The median number of prior chemotherapy ... in a subset of patients with tumor biopsies, high levels of tumor expression
of GPNMB appeared to correlate with favorable outcome.
"These Phase ...
CMC ICOS Biologics and Implicit Bioscience Ltd Announce IC14 Antibody Manufacturing Agreement and Patent License
... negotiated a non-exclusive license to utilize the CMC proprietary CHEF1(R) expression
technology, a system that rapidly generates production cell lines and ... services includes cell line development using its proprietary CHEF1(R) expression
system, process development, analytical and formulation development, and ...
Genetic Source of Rare Childhood Cancer Found; Gene is Implicated in Other Cancers
... mutation in DICER1, a master controller gene that helps regulate expression
of other genes. The children studied came from families with a history of ... St. Louis. "Very recently, other research found that reduced DICER1 gene expression
in tumor cells is associated with worse outcomes in patients with ovarian, ...