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Estrogen in Medical Technology

TWO NEW KLRI PEER-REVIEWED PUBLICATIONS: Hormone Therapy May Reduce Atherosclerosis in Women Close to Menopause; Growth Hormone May Increase Risk of Diabetes, Improve Lipid Profile in Men

... are risks and a potential loss of benefit to estrogen therapy in women who have been postmenopausal for ... research continues to underscore the theory that estrogen may be cardio-protective if administered close to ... (PEPI) trial compared conjugated equine estrogen (CEE) with three different CEE-progestin ...

Estrogen Getting Cool Reception From Dermatologists for Mixed Results in Improving Appearance of Skin

... dermatologists argue that scientific studies of estrogen do not show definitive improvements for skin ... mixed results when examining whether or not estrogen improves the appearance of the skin and why ... their use and the known risks of prolonged estrogen therapy -- including an increased risk of breast ...

Wyeth Reports Publication of Phase 3 Data for Bazedoxifene/Conjugated Estrogens, an Investigational Compound Being Studied for the Treatment of Menopausal Symptoms

... by Wyeth as a TSEC (tissue selective estrogen complex) as it combines a selective estrogen receptor modulator (SERM) with conjugated ... in Menopausal Therapy with a Tissue Selective estrogen Complex (TSEC) Containing Bazedoxifene/Conjugated ...

Bionovo's Estrogen Receptor Beta Selective Drugs Have Unique Gene Expression and Cell Type Specificity

... in multiple cell lines by several of their estrogen receptor beta (ERb) candidates will be published ... endometrial cancer in animal models, unlike many estrogen therapies. This suggests that these plant-derived ... drugs that mediate their effects through estrogen receptors, which are responsible for many ...

UNT Health Science Center's Groundbreaking Research Applied to Protecting Brain After Traumatic Injury

... Center at Fort Worth have determined that rapid estrogen administration can protect the brain following ... animal studies of the protective effects of rapid estrogen treatment to human patients with severe traumatic ... "Our animal research has demonstrated that rapid estrogen intervention protects the brain following injury, ...

Investigational Cancer Drug BSI-201 Showed Clinical Benefit in 62% of Patients with Triple-Negative Metastatic Breast Cancer and Significantly Prolonged Survival

... TNBC, defined as tumors lacking expression of estrogen and progesterone receptors and without ... tumors are routinely tested for the presence of estrogen and progesterone receptors and for the ... receptors; for example, tamoxifen for estrogen receptor and trastuzumab (Herceptin(r)) for HER2. ...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

... breast cancer patients taking hormonal therapies. estrogen is believed to have a direct influence on ... inhibitors reduce the level of circulating estrogen in the body. It has been suggested that reduced estrogen in the body is linked to a decline in cognitive ...

QuatRx Completes Enrollment of Ophena(TM)(Ospemifene Tablets) Final Pivotal Phase 3 Study in Women with Postmenopausal Vaginal Atrophy

... trial for Ophena(TM) , a novel selective estrogen receptor modulator (SERM) for the treatment of ... pain (dyspareunia) and irritation. Declining estrogen levels during menopause can cause tissues of the ... program. Fispemifene is a new selective estrogen receptor antagonist that is in Phase 2 as an oral ...

New Study Suggests Rx Estrogen Delivery Through the Skin May Show Safety Benefits as Opposed to Oral Delivery

... March 31 /PRNewswire/ -- Transdermal delivery of estrogen therapy available by prescription "seems not to ... Menopause Society. Prescription transdermal estrogen therapy is bioidentical to estrogen produced by a woman's ovaries before menopause ...

Radius Initiates Phase 2a Clinical Trial of RAD1901 in Menopausal Hot Flashes

... 2a study of RAD1901, an investigational selective estrogen receptor modulator (SERM) undergoing clinical ... SERM that provides an alternative to estrogen in alleviating menopausal hot flashes, without ... data on changes in pharmacodynamic markers of estrogen effect--follicle-stimulating hormone (FSH), ...

New Analyses Indicate that Divigel(R) (estradiol gel) 0.1% Is a Valuable Option for Certain Postmenopausal Women With Hot Flashes

... - Transdermal estrogen Analyses Continue to Show Benefits of Hormone ... in Orlando, Florida. Divigel(R) is a transdermal estrogen therapy that was approved by the FDA in June ... sign of menopause," said Dr. Ackerman. The estrogen in Divigel(R) is derived from plant sources and ...

Bionovo's VG101 Shows Greater Efficacy Than Estrogen in the Treatment of Vaginal Dryness

... seminal information on the company's second estrogen receptor beta selective drug candidate that will ... mechanism of action of the company's selective estrogen receptor (ER) beta drug candidate and explain the safety advantages of this more highly selective estrogen receptor modulator, VG101, when compared to the ...

QuatRx Pharmaceuticals Announces Additional Data From Phase 3 Study for Ophena(TM) (Ospemifene Tablets) Showing Improvements in Clinical Symptoms of Vulvovaginal Atrophy

... Among women in the study who remained on estrogen therapy, a majority expressed concerns about ... about the health risks associated with estrogen therapy among these women," said Chris Nicholas, ... further support for the need for alternatives to estrogen for the treatment of vulvovaginal atrophy in the ...

Agile Therapeutics Achieves Phase 2 Study Endpoints in Key Clinical Trials with New, Innovative Low-Dose Contraceptive Patch

... The pharmacokinetic (PK) study demonstrated estrogen levels comparable with the well-established, ... women, the Company studied patches with different estrogen and progestin doses for three cycles to identify ... soft, and flexible patch delivers 60 percent less estrogen than the only marketed patch available today, ...

Quatrx Pharmaceuticals Presents Results From Ophena(TM) (Ospemifene Tablets) Phase 3 Study Related to Treatment of Symptoms of Vulvovaginal Atrophy

... meeting in San Francisco. The decline in estrogen levels in women after menopause is ... safety profile. Ophena(TM), a novel selective estrogen receptor modulator (SERM), is being studied as a ... to treat PVS contain estrogen. Treatment with estrogen therapy has been associated with certain health ...

Bionovo Elucidates Mechanism of Breast Cancer Control by Estrogen Receptor Beta

... cells the activation of GADD45 gene via the estrogen receptor beta results in growth arrest. "Breast ... SERMs reduce that risk. This study shows that estrogen receptor beta stops the growth of breast cancer ... target for drugs that selectively regulate estrogen receptor beta." The study was conducted by ...

Bionovo's Drug Candidate for Menopausal Symptoms Shows Effect on Neural Pathways Related to Temperature Regulation

... expressing native estrogen receptors, MF101, an estrogen receptor beta selective modulator, ... are mediated selectively by the activation of estrogen receptor beta. MF101 demonstrated this selective ... with improved safety of MF101 over current estrogen treatment will be greatly welcomed by women ...

Bionovo Discovers New Estrogen Regulatory Elements for Breast Cancer and Osteoporosis Drugs

... exerted by different compounds. "Selective estrogen receptor modulators (SERMs) differ from estrogen in how they regulate gene transcription and ... at Bionovo. "The discovery of these selective estrogen regulatory elements strengthens our SERM ...

Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments

... to postmenopausal women with newly diagnosed estrogen receptor-positive (ER+) breast cancer. Further, ... most important pathways for breast cancer, the estrogen receptor and the HER2/neu pathways. Based on ... for the treatment of postmenopausal women with estrogen receptor-positive ...

QuatRx Pharmaceuticals Announces Presentation of Further Data from Ophena(TM) (Ospemifene) Phase 3 Study for Treatment of Symptoms of Vulvovaginal Atrophy

... University. Ophena(TM) is a novel selective estrogen receptor modulator (SERM) that is being studied ... PVS contain the hormone estrogen. Treatment with estrogen replacement therapy has been associated with ... pain (dyspareunia), and irritation. Declining estrogen levels during menopause can cause tissues of the ...

Divigel(R) (estradiol gel) 0.1 Percent Offers Lowest Approved Dose of Estradiol for Treatment of Moderate to Severe Hot Flashes Associated with Menopause

... in obstetrics and gynecology, and menopause and estrogen therapy will be among the information presented. ... American Menopause Society (NAMS) indicate that estrogen hormone therapy should be used at the lowest ... for the shortest amount of time. "Transdermal estrogen therapies, such as Divigel(R), are emerging as ...

QuatRx Pharmaceuticals Announces Positive Phase 3 Results for Study of Ophena(TM) (ospemifene) to Treat Postmenopausal Vaginal Syndrome

... later in 2008. Ophena(TM) is a novel selective estrogen receptor modulator (SERM) that is being studied ... women affected by PVS, many of whom have had only estrogen therapy as a treatment option for their condition ... believe Ophena(TM) could provide the first non- estrogen prescription treatment alternative for ...

Multiple Studies Presented at San Antonio Breast Cancer Symposium Reinforce Clinical Utility of Oncotype DX(R)

... in treatment planning for women with early-stage estrogen receptor-positive breast cancer," said Lori J. ... Oncotype DX, including its use in estrogen receptor-positive, node- positive breast cancer; ... DX Recurrence Score result in early-stage estrogen receptor-positive breast cancer patients with ...

Anastrozole Confirmed Superior in Breast Cancer Prevention

... Hormone-responsive breast cancers require estrogen stimulation in order to grow. Tamoxifen, a ... on hormone-sensitive cancer cells, preventing estrogen from attaching to the cells. Anastrozole, on the other hand, prevents the manufacture of estrogen by body tissues other than the ovaries (e.g., ...

New Data Reveal Topical Divigel(R) (estradiol gel) 0.1% Significantly Reduces Frequency and Severity of Hot Flashes

... take older hormone therapies with higher doses of estrogen now have the choice of taking Divigel(R), the ... American Menopause Society (NAMS) indicate that estrogen hormone therapy should be used at the lowest ... continuity allowing women to use less estrogen than is needed in a pill because of the way the ...

Cell Therapeutics, Inc. (CTI) Supports Panel Discussion on Women and Lung Cancer on Capitol Hill

... investigational drug, XYOTAX(TM), researching how estrogen levels affect a woman's response to treatment for ... collected from recent XYOTAX trials suggests that estrogen levels may alter the effectiveness of cancer treatment, and that women with higher levels of estrogen had a lower rate of survival in cases of lung ...

Cell Therapeutics, Inc. (CTI) Sponsors Panel Discussion on Women and Lung Cancer on Capitol Hill

... investigational drug, XYOTAX(TM), researching how estrogen levels affect a woman's response to treatment for ... collected from recent XYOTAX trials suggests that estrogen levels may alter the effectiveness of cancer treatment, and that women with higher levels of estrogen had a lower rate of survival in cases of lung ...

QuatRx Completes Patient Enrollment in Phase 3 Study of Ophena(TM) in Women with Postmenopausal Vaginal Syndrome

... Evaluate QuatRx's New-Generation Selective estrogen Receptor Modulator (SERM) ANN ARBOR, Mich., ... Ophena(TM) is a new-generation selective estrogen receptor modulator (SERM) for postmenopausal ... new treatment options in those wanting to avoid estrogen use." About Postmenopausal Vaginal Syndrome ...

New Research Shows Antidepressants May Thwart Breast Cancer Treatment

... 500,000 U.S. women take tamoxifen, a medicine that blocks the effects of estrogen in breast tissue. estrogen can make certain types of breast cancer (hormone-receptor-positive breast ...

Karmanos Cancer Institute Researchers Present Breast Cancer Advancements at Conference

... antitumor agent -- which works best in breast cancers expressing the estrogen receptor (ER) -- estrogen receptors were reinstated in receptor-negative breast cancer cells so that ...

Three Clinical Studies of bioTheranostics Molecular Breast Cancer Diagnostics Presented at San Antonio Breast Cancer Symposium

... biomarkers that refine and improve risk stratification in patients with estrogen receptor (ER)-positive, lymph node-negative breast cancer. Data ... Index) that refines and improves risk stratification in patients with estrogen receptor (ER)-positive, lymph-node negative breast cancer; and the Theros ...

Video: Femara(R) First Aromatase Inhibitor to Indicate Survival Benefit Versus Tamoxifen When Taken for Five Years After Breast Cancer Surgery

... Femara is approved for the treatment of postmenopausal women with estrogen receptor-positive or estrogen receptor-unknown breast cancer that has spread to another part of the body ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... Femara is approved for the treatment of postmenopausal women with estrogen receptor-positive or estrogen receptor-unknown breast cancer that has spread to another part of the body ...

Bionovo Reports on Metabolic Studies Related to Its Menopausal Hot Flash Drug Candidate

... a Bioactive Compound Isolated from the Chinese Herbal Selective estrogen Beta-Receptor Agonist MF101." Liquiritigenin is one of the active ... more potent than the parent compound towards selective activation of the estrogen receptor beta. Enzyme kinetic experiments suggest that clinically relevant ...

QuatRx Initiates Second Phase 3 Study of Ophena(TM) (Ospemifene Tablets) in Women With Postmenopausal Vaginal Syndrome

... the second pivotal Phase 3 clinical trial for Ophena(TM), a new selective estrogen receptor modulator (SERM) for the treatment of postmenopausal vaginal ... vaginal dryness, sexual pain (dyspareunia) and irritation. Declining estrogen levels during menopause can cause tissues of the vaginal lining to grow ...

AviaraDx Confirms That Combination of Two Molecular Biomarkers Improves Prediction of Disease Recurrence in Early Stage Breast Cancer Patients

... to benefit from endocrine therapy by measuring the functionality of the estrogen signaling pathway inside the tumor cell itself. As such, H/I goes beyond conventional estrogen and progesterone receptor (ER/PR) testing. While patients who are ER/PR ...

VIDEO: Femara(R) helps protect against return of breast cancer even when treatment starts several years after completing tamoxifen therapy

... Femara is approved for the treatment of postmenopausal women with estrogen receptor-positive or estrogen receptor-unknown breast cancer that has spread to another part of the body ...

Wyeth Presents New Phase 3 Data and Updates Regulatory Timing for NDA Filing of Bazedoxifene/Conjugated Estrogens

... quality of life. "The pairing of bazedoxifene, a selective estrogen receptor modulator, or SERM, with conjugated estrogens may lead to a new class of menopausal therapy called tissue selective estrogen complex, or TSEC," says Ginger Constantine, M.D., Vice President, Women's ...

Study Suggests Soy Protein May Reduce Prostate Cancer Risk

... be the first study investigating the effects of soy protein consumption on estrogen metabolism and prostate cancer in men. "The intent of the study was to evaluate the effects of consuming soy protein on elimination of estrogen metabolites in the urine of men at a high risk for prostate cancer," said ...

FDA Approves Lilly's Osteoporosis Drug EVISTA(R) (raloxifene HCl) to Reduce The Risk of Invasive Breast Cancer in Two Populations of Postmenopausal Women

... therapy for invasive breast cancer risk reduction." EVISTA, a selective estrogen receptor modulator or SERM (recently classified by the FDA as an estrogen agonist/antagonist), is already approved for the prevention and treatment ...
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