Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis
... trial was to assess safety and evaluate the effect
of three doses of BA058 on bone formation markers ... the critical anatomic sites with less resorptive effect
and less hypercalcemia compared to PTH and its ... by stimulating bone formation with limited effect
on bone resorption and less risk of ....
Video: FDA Approves INVEGA(R) SUSTENNA(TM) for the Acute and Maintenance Treatment of Schizophrenia
... Syndrome (NMS) is a rare, but serious side effect
that could be fatal and has been reported with ... is that it may change your heart rhythm. This effect
is potentially serious. You should talk to your ... a rare, but serious and sometimes permanent side effect
reported with INVEGA((R)) SUSTENNA(TM) and ...
FDA Approves Tekturna HCT(R) as Initial Treatment in Patients Unlikely to Achieve Their Blood Pressure Goals With a Single Agent
... titration from monotherapy. The antihypertensive effect
of Tekturna HCT were largely manifested within 1 week. The maximum antihypertensive effect
was generally attained after about 4 weeks of ...
In clinical studies, the most common side effect
experienced by more patients taking TEKTURNA than ...
King Pharmaceuticals Showcases Data From Pain Pipeline of Medicines Designed to Deter Common Methods of Non-Therapeutic Use
... dose response for niacin-induced flushing, the effect
of food on niacin-induced flushing, and the ... ingredients can generate a temporary, unpleasant effect
if orally over-consumed, turn dissolved tablets ... would be released, mitigating the euphoric effect
of the morphine. The clinical significance of the ...
Spherix Announces Positive Phase 2 Study Results
... g group. Naturlose appears to begin showing an effect
on HbA1c within the range of doses selected for ... or an adjunct therapy. In addition, the effect
on serum lipoproteins may lead to a role for ... dose of Naturlose capable of causing a beneficial effect
on HbA1c, and the safety of such doses. Naturlose ...
Alfacell Provides Shareholder Update
... studies on immune deficient mice to see what effect
Onconase would have on human tumors grafted onto ... showed Onconase has a documented synergistic effect
in Cisplatin sensitive and resistant NSCLC. We ... on animals that Onconase strongly enhances effect
of many types of anticancer drugs. The ...
Ironwood and Forest Present Additional Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation
... in an oral presentation ( Abstract 157: effect
of Linaclotide on IBS-C Symptoms in the First ... McCormick Place, Room E352
Abstract 418: effect
of Linaclotide on Quality of Life in Adults with ... Abstract 1273: Time to Onset of Linaclotide effect
on the Bowel Habits in Patients with Chronic ...
Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types
... suspension) demonstrated a significant antitumor effect
in patients with metastatic neuroendocrine tumors ... at 18 sites in Germany to evaluate the antitumor effect
of Sandostatin LAR in patients with midgut NET. ... approval of Sandostatin LAR did not study effect
on tumor size or rate of growth.
The most ...
Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF Presented at American Thoracic Society (ATS)
... supportive evidence of a pirfenidone treatment effect
was observed on a number of measures, including ... significant and clinically meaningful effect
on both the primary endpoint of change in percent ... supportive of CAPACITY 2. Further, the treatment effect
observed in the CAPACITY studies was generally ...
RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment Delayed the Time to Relapse in Patients with Bipolar I Disorder
... long-term study was conducted to evaluate the effect
of RISPERDAL(R) CONSTA(R) as maintenance therapy ... (NMS) is a rare and potentially fatal side effect
reported with RISPERDAL(R) CONSTA(R) and similar ... (TD) is a serious, sometimes permanent side effect
reported with RISPERDAL(R) CONSTA(R) and similar ...
Melanoma and Pregnancy: What Every Woman Needs to Know About the Risks, Prognosis
... there has been ongoing controversy concerning the effect
of hormones on melanoma," said Dr. Driscoll. ... indicating that hormones did not have a negative effect
on melanoma," said Dr. Driscoll. "Having ... two large population-based studies have found no effect
on prognosis when melanoma is diagnosed during ...
Data Presented at AUA Demonstrate PROVENGE Significantly Prolongs Survival for Men With Advanced Prostate Cancer in Pivotal Phase 3 IMPACT Study
... of the IMPACT study.
"The treatment effect
on overall survival was clinically meaningful, robust and consistent across subpopulations, and the effect
on long-term survival was particularly ... to the results described above, the treatment effect
was consistent across multiple patient subsets ...
Children's Hospital Receives $6.7 Million Grant From Gates Foundation to Study Influenza Vaccine in Pregnant Women in Asia
... field study will help us demonstrate the full effect
of the flu vaccination in low-resource areas."
... study will also help researchers understand the effect
that vaccinating mothers has on unvaccinated ... implications. "If the flu vaccine has as great an effect
in rural settings as in urban ones, the data will ...
New PRO2000 HIV-Prevention Findings Important Milestone on Path Toward Development of Effective Vaginal Microbicide
... BufferGel unfortunately did not show a protective effect
against HIV, the trial indicated that PRO2000 was ... product at this efficacy level. While the 30% effect
within this trial is not statistically ... highly supportive. Additionally, the protective effect
of PRO2000 is corroborated by analysis of various ...
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Announces FDA Filings for Paliperidone Palmitate and INVEGA(R)
... (NMS) is a rare and potentially fatal side effect
reported with paliperidone and similar medicines. ... is that it may change your heart rhythm. This effect
is potentially serious, and you should talk to ... (TD) is a serious, sometimes permanent side effect
reported with paliperidone and similar ...
New Study First to Confirm Sandostatin LAR(R) Depot Controls Tumor Growth in Patients With Rare Gastrointestinal Tumors
... months for patients on placebo. This beneficial effect
was seen in patients with either functioning ... but these are the first data to confirm this effect
from a well-designed, prospective, ... at 18 sites in Germany to evaluate the antitumor effect
of Sandostatin LAR in patients with NETs. The ...
Longevity Seekers Advised to Consume Modest Doses of Red Wine Molecules in Dietary Supplements (Longevinex(R)) Rather than Mega-Dose Resveratrol Alone
... Cause of shortened lifespan
The negative effect
upon lifespan with mega-dose resveratrol may ... per kilogram of
body weight), but the longevity effect
was only demonstrated among mice
engorged with a ...
"A synergistic effect
has been demonstrated with the array of ...
Major deCODE-led Study Underscores Role of the Brain in Obesity
... and to form collaborative relationships, the effect
potential delisting of our common stock from ... and the
completion of clinical trials, the effect
of government regulation and the
regulatory ... dependence on
collaborative relationships, the effect
of competitive products, industry
trends and ...
Alexza's AZ-004 (Staccato(R) Loxapine) Meets Primary Endpoint of Treating Acute Agitation in Patients with Bipolar Disorder in Phase 3 Trial
... drug with
a single breath and achieve therapeutic effect
as quickly as an intravenous
injection -- a ... no
serious adverse events. The only common side effect
reported (> 10% in any
treatment group) was taste (dysgeusia). This side effect
was rated as mild in
all patients and occurred in ...
Research Highlights New Approaches to Prevent Blood Clots in Several High-Risk Patient Populations Including Largest Study Ever to Examine Use of Blood-Thinning Medication in Patients With Cancer
... the anti-Factor Xa activity, or the anticoagulant effect
of the drug, which was sustained for at least ... included the reversal of the anticoagulant effect
of idrabiotaparinux, as there are medically ... anticoagulant. The reversal of the anticoagulant effect
was measured after a 30-minute intravenous ...
First Clinical Experience With Soliris(R) in Treating Patients With Two Rare Complement-Mediated Diseases Presented at ASH Annual Meeting
... and his colleagues investigated the potential effect
eculizumab in two patients with aHUS, a rare ... and his colleagues investigated the potential effect
eculizumab therapy in one patient with CAD, a ... not alter anticoagulant
management because the effect
of withdrawal of anticoagulant therapy ...
Pharmacyclics Announces Completion of Phase 1 Clinical Trial of Factor VIIa Inhibitor PCI-27483
... to evaluate the safety and pharmacologic effect
PCI-27483. A single administration of ...
"PCI-27483 is expected to have a dual effect
of inhibiting tumor growth
and decreasing the ... from preclinical and
clinical studies, expected effect
of our products under development, ...
Pharmos Announces Clinical Results from Phase 2a Trial of Topical Diclofenac NanoEmulsion Cream
... endpoint, nor in several secondary endpoints. The effect
witnessed did not measure up to other topical ... related. No Serious AE's were reported and the effect
of the NanoEmulsion cream on the skin was ... which it demonstrated a statistically significant effect
compared to placebo on the primary efficacy ...
VIA Pharmaceuticals Announces Positive Results of Phase 2 Studies of VIA-2291 in Patients With Serious Cardiovascular Disease
... placebo. In order to further
evaluate VIA-2291's effect
over a longer timeframe, a sub-study of ... The CEA Phase 2 study evaluated VIA-2291's effect
vascular inflammation in 50 ... to provide direct evaluation of
VIA- 2291's effect
on inflammation by analyzing plaque removed from ...
Physicians' Health Study II Finds No Magic Bullet for Preventing Cardiovascular Disease
... of nutrients.
With regard to the possible effect
of vitamin E on increased risk of
hemorrhagic ... trial of male smokers in Finland reported such an effect
in 1994 with
a dose of only 50 IU of vitamin E. Such an effect
was not seen in numerous
other trials using ...
Study Suggests Treatment with Paliperidone ER Significantly Improves Symptoms of Schizoaffective Disorder
... itself was not designed to compare the relative effect
paliperidone ER as a monotherapy or in ... mood stabilizers, however, results showed the effect
ER was evident in both patients ... (NMS) is a rare and potentially fatal
reported with paliperidone and similar medicines. ...
CIMZIA(R) (Certolizumab Pegol) Provides Rapid and Sustained Relief from Signs and Symptoms of Rheumatoid Arthritis for Two Years
... trials produced a
fast and clinically meaningful effect
for RA patients over an extended
period of time," ... data.
Additional data presented focused on the effect
of treatment with
CIMZIA together with MTX in ... There is no evidence that CIMZIA therapy has
on in vivo coagulation.
Cases of worsening ...
Dendreon Announces Interim Data From Phase 3 PROVENGE IMPACT Trial
... continue to its final analysis.
"The treatment effect
we have observed in this interim analysis ... officer of Dendreon. "Given the delayed treatment effect
seen in previous studies, we are pleased ... The hazard ratio is an estimate of the treatment effect
in the treated
versus the control group in a ...
Uroplasty Enrolls First Patients in Urgent(R) PC Clinical Trial
... studies and written extensively on the effect
of neuromodulation in
treating voiding ... We discuss in detail the factors that may effect
of our forward-looking statements ... from infringing our rights; -- the effect
of government regulation, including when and if ...
Access Pharmaceuticals Presents New Data on the Company's Angiolix(R) Therapeutic Monoclonal Antibody
... lactadherin, Angiolix has both
an anti-angiogenic effect
as well as a direct anti-proliferative effect
tumors themselves. In preclinical models of ... (MX-1),
Angiolix had a significant anti-cancer effect
in vivo; ...
Anthera Completes Special Protocol Assessment With FDA and Receives EMEA Scientific Advice on Development Path Toward Varespladib Approval
... Inc. "The anti-inflammatory effect
and safety profile seen
in the varespladib trials ... of
Cardiologists by GlaxoSmithKline on the effect
of their selective ... on a
secondary biological outcome while having no effect
on inflammation or
LDL-C, provides encouraging ...
Five-Year Data Confirm That Early Treatment with Betaseron(R) at First Sign of Disease Can Delay Progression to MS
... early treatment with Betaseron had a
on cognition that became even more pronounced ... (EDSS), with early versus delayed treatment. This effect
appeared at year three, with a significant ... or after two years (p=0.014; Poisson
model). This effect
was mainly due to the differences between the ...
Newly Released Data on Onset of Effect and Patient Perception With SYMBICORT in Adults With Asthma
... and patient perception of onset of effect
assessed in two 12-week randomized, ... Effect
In these studies, perception of onset of effect
was assessed in two
ways.(1) Patients completed the Onset of effect
Diffusion Pharmaceuticals Announces Initiation of a Phase I/II Clinical Trial in Patients with Peripheral Arterial Disease (PAD)
... TSC; establish a dose-response
relationship and effect
of TSC on peak walking time and claudication ... intermittent claudication patients; determine the effect
of TSC on
potential hypoxia biomarkers; and ... a
proof-of-concept Phase I study evaluating the effect
of TSC on the oxygen
levels of brain tumors in ...
Stallergenes: New Study VO 56 Highly Positive Results Conducted in an Allergen Challenge Chamber
- A highly statistically significant effect
of Oralair(R) Grasses versus placebo (p=0.0003) ... - A Cohen score of 0.79 corresponding to a large effect
size Safety results, with only well-known local ... Moreover, it
confirms the therapeutic effect
of Oralair(R) Grasses and the very fast
onset of ...
Alexza Reports 2008 Second Quarter Financial Results and Updates Development of Product Candidates
... meet its two primary
endpoints, which were the effect
of AZ-002 on the incidence of a
doxapram-induced panic attack and the effect
of AZ-002 on the duration of a
doxapram-induced ... and the clear IV-like pharmacological effect
date, Alexza and Symphony Allegro ...
Phase II Data on Lilly's Antibody Show It Affects Amyloid Beta, a Protein Believed To Be Associated with Alzheimer's Disease
... as an indirect measure of the effect
of the antibody on amyloid beta
present in the ... and
cerebrospinal fluid. We hypothesize that this effect
may lead to reduced
formation of amyloid plaques ... To date,
the most frequently occurring side effect
experienced in clinical studies
with LY2062430 ...
Four Alzheimer's Clinical Trials Address a Variety of Treatment Targets - Amyloid, Tau, Synapse Formation
... (p=0.009 and p=0.041,
respectively). PBT2 had no effect
on the ADAS-cog in this trial.
The researchers ... both mild and moderate
Alzheimer's. The overall effect
size was -6.8 ADAS-cog units vs. decline of
7.8 ... at the 60mg dose produced a
significantly larger effect
size at 50 weeks than at 24 weeks implying ...
Soyfoods Do Not Impact Sperm Count
... the higher intake individuals.
This watering-down effect
of sperm concentration should not be ... amounts of isoflavones from soy were fed and no effect
quantity, quality or motility of sperm were ... hormones but rather has suggested a preventive effect
Learn the facts about ...
Independent Analyses of the SEAS, SHARP and IMPROVE-IT Studies of Ezetimibe
... do not provide credible evidence of any adverse effect
Allocation to 5 years of substantial ... has been shown previously to have no apparent effect
on cancer. The
Cholesterol Treatment Trialists' ... vs 72 fatal cases.
If there were a real adverse effect
on cancer incidence or cancer
mortality then ...