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Down in Medical Technology

Lenetix Launches Screening Study of New Down Syndrome Test

... non-invasive fetal diagnostic test to detect down syndrome. The Lenetix PloidYX(TM) maternal blood ... abnormalities. Risk assessment for down syndrome is routinely offered to patients in ... status non-invasively, detecting not only down syndrome (Trisomy 21), but other aneuploidies ...

Micromet Expands Committed Equity Financing Facility to $75 Million

... the new CEFF will be reduced by any amounts drawn down on the August 2006 CEFF prior to the date on ... effective. To date, Micromet, has not drawn down any amounts under the August 2006 CEFF. ... as determined at the time of the draw down of such tranche (which percentage ranges from ...

Seventy Years Old and Going Strong With Down Syndrome and No Dementia: The Case of 'Mr. C' Causes Major Interest in the Scientific Community

... the average life expectancy of a person with down syndrome, currently in the late fifties, but in ... which is almost a given for people with typical down syndrome over 65 yeas of age. 'Mr. C,' while ... face on the future of aging for people with down syndrome, as scientists ask the critical ...

Auxilium Pharmaceuticals, Inc. Announces XIAFLEX(TM) Meets Primary Endpoint With Statistical Significance (p<0.001) in CORD I Pivotal Phase III Study for Dupuytren's Contracture

... (50.2 degrees average contracture at baseline down to 12.2 degrees average contracture after ... (49.1 degrees average contracture at baseline down to 45.7 degrees average contracture after placebo ... 13.6% (50 degrees average contracture at baseline down to an average 44.3 degrees after ...

Obesity-Related Hormone is Higher in Children with Down Syndrome

... risk of obesity among children and adults with down syndrome. A research team from The Children's ... The researchers studied 35 children with down syndrome and 33 of their siblings. All of the ... before obesity occurred. The children with down syndrome had significantly higher body ...

Surgeons Develop Innovative Life-Saving Treatments to Correct Massive Bleeding in Trauma Patients

... you might decrease the mortality from 10 percent down to 5 percent. We're talking about a highly lethal ... the metabolic rate of the brain so it slows down but does not completely stop. So instead of ... According to Dr. Alam, once the brain is cooled down to about 10 degrees C, it can stay alive for ...

Nektar Therapeutics Reports Second Quarter 2009 Financial Results

... as compared to a year ago. Total operating costs and expenses were down 19% to $43.5 million in the second quarter of 2009 as compared to $53.8 ... 2008. For the first half of 2009, total operating costs and expenses were down 28% to $83.5 million as compared to $115.6 million in the first half of ...

School of Dentistry Studies Link Between Oral Health and Memory

... /PRNewswire-USNewswire/ -- Keeping your teeth brushed and flossed can cut down on gum disease, drastically reducing risk of heart attack and stroke, ... the benefits of knowing that keeping the mouth free of infection could cut down on cases of dementia." The research builds on an ongoing study of ...

Lupus Foundation of America Fosters the Next Generation of Lupus Researchers by Awarding Gina M. Finzi Memorial Student Summer Fellowships to Five Students

... ongoing efforts to advance the science and medicine of lupus and bring down barriers that have impeded progress in research on the disease. In the ... Genes" The Foundation's national research program, Bringing down the Barriers , also supports important studies in areas of research that ...

Potentia Pharmaceuticals' POT-4 Drug Candidate for Age-Related Macular Degeneration Successfully Completes Phase I Clinical Trial - Prepares for Phase II

... About POT-4 POT-4 is a complement factor C3 inhibitor, which shuts down the complement activation cascade that could otherwise lead to local ... all major complement activation pathways, its inhibition effectively shuts down downstream complement activation that could otherwise lead to local ...

CEL-SCI Corporation Releases Letter to Shareholders

... strength in the bigger biotechnology names. This will hopefully trickle down to the smaller ones like us as well. The huge buyouts in the industry, ... $100 billion in liquidity to the industry, and that too should help us down the road. Let me share with you how we at CEL-SCI are dealing with ...

Breakthrough in Prenatal Screening for Down Syndrome

... second trimester non-invasive fetal chromosomal screening test to detect down syndrome and other genetic fetal conditions. Lenetix presented preliminary ... of current maternal serum screening for fetal aneuploidy, including fetal down syndrome, will lead to better quality of screening and most certainly will ...

Wrist Access Safer, Easier for Many Patients Undergoing Minimally Invasive Treatment of Blocked Heart Arteries

... heart arteries minimally invasively will mean less bleeding, less down time, lower costs and less risk overall, particularly for obese patients, ... at the femoral artery access site. To reduce the risk, patients must lie down for two to six hours after treatment. Also, accessing the femoral artery ...

Parasites That Live Inside Cells Use Loophole to Thwart Immune System

... have discovered a mechanism by which intracellular pathogens can shut down one of the body's key chemical weapons against them: nitric oxide. The ... dishes can block nitric oxide production in macrophages by breaking down the chemical arginine, which the macrophages need to make nitric oxide. ...

Hope for Progeria - Successfully Validated on Mice, a Treatment Could Soon be Tested on Children

... treatment, combining two existing pharmacological molecules, should slow down the progression of this disease which has hitherto remained untreatable. ... affected by progeria in Europe. The aim of this protocol is to slow down the progression of the disease and, if possible, prolong the life ...

PAREXEL Data Reveal A Record High Number of Clinical Trials Initiated

... INDs were submitted for therapeutic biological products in 2007, which was down 27 percent from 114 submitted in 2006. The 114 INDs submitted in 2006 ... compounds represented another 11 percent of the total, although they were down 6 percent in 2007. Overall Clinical Research Activity Just Below Record ...

CEL-SCI Corporation Releases Letter to Shareholders

... CD-4 cells. This is important because: -- The tumor is able to shut down the infiltrating CD-8 cells, but is unable to shut down the CD-4 cell attack, and -- CD-4 cells help break 'tumor tolerance', ...

Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)

... antibody in late stage clinical development that specifically targets RANK Ligand, the essential regulator of osteoclasts (the cells that break down bone). With more than 19,000 patients in trials across indications worldwide, the denosumab development program is the largest ever initiated by ...

Video: New Dove(R) Body Washes with NutriumMoisture(TM) Restore Skin's Natural Moisture

... most effective natural nourishment ever. While moisturizers in other body washes sit on top of skin, new NutriumMoisture penetrates surface skin deep down to replenish skin where it is needed most. By absorbing into the skin, the moisturizing complex is able to deliver hydration for skin barrier ...

FDA Approves Tekturna HCT(R) as Initial Treatment in Patients Unlikely to Achieve Their Blood Pressure Goals With a Single Agent

... especially if you take water pills, are on a low-salt diet, get dialysis treatments, have heart problems, or get sick with vomiting or diarrhea. Lie down if you feel faint or dizzy. Call your doctor right away. In clinical studies, the most common side effect experienced by more patients ...

Results From Drug Trials and New Risk Factors Announced at International Alzheimer's Conference

... research results. Previous studies have suggested that the number of people with Alzheimer's and dementia begins to level off and perhaps even go down a bit in people age 90 and above. Post Traumatic Stress Disorder May Raise Alzheimer's Risk; Moderate Alcohol May Lower It Two ...

Music & Medicine: Unique Collaboration Combines Performing Arts and Science

... as contributors. This Joint Institutional Seed Research grant will allow PMI researchers to quantitatively measure what happens when a player sits down at a keyboard and begins to play. One possible answer to alleviating the pain certain players feel while performing is the ergonomically ...

Denosumab Demonstrates Superiority Over Zometa(R) in Pivotal Phase 3 Head-to-Head Trial in Breast Cancer Patients With Bone Metastases

... antibody in late stage clinical development that specifically targets RANK Ligand, the essential regulator of osteoclasts (the cells that break down bone). With more than 19,000 patients in trials across indications worldwide, the denosumab development program is the largest ever initiated by ...

Why Do African-Americans Fare Worse With Cancer? Access and Economics Are Only Part of the Story

... author, Kathy Albain, M.D., a breast and lung cancer specialist at Loyola University's Cardinal Bernardin Cancer Center, "it always seems to come down to general conclusions that African-Americans may in part have poorer access to quality treatment, may be diagnosed in later stages, and may not have ...

Amicus Therapeutics Commences Phase 3 Trial Evaluating Amigal(TM) for the Treatment of Fabry Disease

... to selectively bind to and stabilize a-Gal A, which facilitates proper trafficking of the enzyme to the lysosomes, where it is needed to break down GL-3. Fabry disease is estimated to affect approximately 5,000 to 10,000 people in the developed world, but recent evidence suggests that the ...

Alfacell Provides Shareholder Update

... be potential buyers of Onconase. We anticipate results shortly. Other studies will be conducted in order to elucidate if Onconase is able to down regulate the protein produced by the MDR1 gene. There is ample evidence this may be the case, and if so, as previously mentioned, Onconase would be a ...

Glybera(TM) Shows Long-Term Health Benefits

... by mutations in the LPL gene, resulting in highly decreased or absent activity of LPL protein in patients. This protein is needed in order to break down large fat-carrying particles that circulate in the blood after each meal. When such particles, called chylomicrons, accumulate in the blood, they may ...

New Poll Finds Disease Prevention is Top Priority for Americans in Health Reform

... each year--about one third of our total health care spending. Simply put, that's too much. Reforming our system to focus on prevention will drive down costs and produce better health outcomes. That's why it is so important that we pass comprehensive health care reform this year." "This poll ...

The Lancet Publishes Direct Comparison Study Between Liraglutide and Exenatide

... liraglutide is attributed to the fact that it slows gastric emptying and leads to increased satiety after meals. Liraglutide is naturally broken down in the body and does not require renal excretion. On May 23, 2008, Novo Nordisk submitted a New Drug Application to the Food and Drug ...

Two-Year Data Show Investigational Drug Liraglutide More Effective at Lowering Blood Sugar Than Glimepiride: Oral 162

... liraglutide is attributed to the fact that it slows gastric emptying and leads to increased satiety after meals. Liraglutide is naturally broken down in the body and does not require renal excretion. On May 23, 2008, Novo Nordisk submitted a New Drug Application to the Food and Drug ...

Researchers at the Karmanos Cancer Institute in Detroit Discover Feasibility of Chemotherapy Alternative

... with capecitabine's manufacturer Roche to perform the study. Dr. Yoo said Karmanos continues to enroll patients in the Phase II study and hopes that down the road, the study will enter a third phase. "We thought it was a good study, one that explores the effects of low-dose, long-term oral ...

Spherix Reports First Quarter 2009 Earnings

... the Phase 3 clinical trial and a related Phase 2 Dose Range trial. Selling, general and administrative expenses for the quarter were $759,270, down from $1.1 million in the first quarter of 2008. The drop was largely the result of the relocation of the Company's Headquarters to a smaller ...

Pharmatek's Highly-Potent and Cytotoxic (HP/C) Facility Positions It as Industry Leader in Development and Manufacturing of HP/C Compounds

... results exceeded the testing goals and demonstrate Pharmatek's engineering controls and practices are effective at controlling airborne particulates down to 0.1ug/m3 levels. "Combined with the facility engineering controls, significantly lower particulate levels are achieved when respiratory ...

Chronic Ankle Pain May Be More Than Just a Sprain

... Swelling and tenderness around the outside of the ankle Pain behind the anklebone Pain that transmits from the ankle down into the foot The use of magnetic resonance imaging (MRI) or ultrasound can be helpful when identifying and diagnosing peroneal ...

Isis and Collaborators Present New Research at the ATVB Annual Conference

... therapeutic benefit of antisense drugs inhibiting 11 beta-HSD1 to treat high triglycerides and diabetes. In a presentation titled "In vivo knock down of apolipoprotein F decreases liver triglyceride levels" S. Khetarpal from University of Pennsylvania presented research demonstrating that ...

Brain Training Improves Memory and Attention and the Effects Last

... stimulation. Marlene Allen, aged 75, of Mill Valley, California participated in the brain exercises arm of the study. "Now I don't have to write down shopping lists. I remember what I need at the store," Ms. Allen said. "And I almost never walk into a room and forget why anymore." "The ...

Complications and Costs for Obesity Surgery Declining

... the number of bariatric surgeries performed by hospitals. For example, laparoscopy reduced the odds of having a complication by 30 percent and drove down hospital payments by 12 percent, while banding reduced hospital payments by 20 percent. ...

New Weight Loss Hope for People with Diabetes

... that integrates good carbohydrates into its meal plan. It's also low in fat and high in fiber. The Glycemic Index measures how quickly food is broken down and absorbed by the body, which impacts blood sugar, a vital factor for people managing their diabetes. The unique combination of NutriSystem D helps ...

Another LNA-based RNA Inhibitor Enters Clinical Trials

... novel pegylated SN-38 drug conjugate, markedly inhibits tumor growth and metastatic spreading of human neuroblastoma" "Androgen receptor (AR) down regulation by locked nucleic acid antisense oligonucleotides specifically inhibits the growth of AR-positive tumor cells" "The antitumor ...

PSA Screening Cuts Deaths by 20%, Says World's Largest Prostate Cancer Study

... Italy, Netherlands, Spain, Sweden and Switzerland - with an overall follow-up of up to 12 years. Participants totalled 182,000 but then narrowed down to 162,000 men in seven countries, aged 55-69; only those who had not been screened could take part. The findings are being unveiled at the annual ...
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