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Data Presented at the American Academy of Neurology Show XP13512/GSK1838262 Significantly Improved Symptoms of Moderate-to-Severe Primary Restless Legs Syndrome

... on the CGI-I Scale compared to placebo (38.9 percent; P<0.0001). Sleep disturbance is often associated with RLS. In this clinical trial, patients completed ... sleep adequacy, as well as statistically significant reductions in sleep disturbance and daytime somnolence. The PIVOT RLS I clinical trial used a 24-hour ...

Cethromycin Achieves All Endpoints in Second Pivotal Phase III Trial for Treatment of Pneumonia

... Biaxin 1.0%), abdominal pain (cethromycin 1.4%, Biaxin 1.4%) and taste disturbance (cethromycin 7.6%, Biaxin 2.1%). No drug-related serious adverse events ... (4/288) (4/291) (4/260) (8/257) (8/548) (12/548) Taste disturbance 7.6% 2.1% 11.2% 6.2% 9.3% 4.0% ...

Post-Hoc Data Show Daily Activity Participation, Independence and Sleep Quality Improved in Adults with Moderate to Severe Rheumatoid Arthritis After Treatment with ORENCIA(R) (Abatacept)

... ORENCIA group and 0.6 in the placebo group (p-value equals 0.0028), sleep disturbance was -11.3 in the ORENCIA group and -2.9 in the placebo group (p-value ... different in the ATTAIN group. In the AIM study, measurement of sleep disturbance in the ORENCIA group was -13.0 and -8.9 in the placebo group (p-value ...

Risks of Delaying ACL Reconstruction in Young Athletes May Be Too High, Study Shows

... benefits and risks of repairing a torn anterior cruciate ligament (ACL) in young athletes under the age of 14. "The risk of inducing a growth disturbance with early reconstruction of a torn ACL must be balanced against the risk of further knee damage by delaying treatment until closer to skeletal ...

BioCis Pharma Reports Positive Phase IIa Clinical Results in Atopic Dermatitis

... BioCis Pharma. "Skin barrier dysfunction is now recognized as a hallmark feature of atopic dermatitis. Any drug showing capacity for restoring this disturbance has significant potential in atopic dermatitis therapy. Based on our results, ProtoCure(TM) emulsion cream holds great promises in the treatment of ...

Major Restless Legs Study Completes Enrollment With Support From MediciGlobal

... are inherited. A serious and common side effect is sleep disturbance. The recruitment campaign encouraged those diagnosed with RLS and sleep disturbance to seek out the clinical study. An education based approach reached undiagnosed RLS sufferers. Furthermore, MediciGlobal engaged study sites and the ...

Retigabine Significantly Reduces the Number of Seizures in Adults With Inadequately Controlled Partial-Onset Epilepsy

... About Epilepsy Epilepsy, defined by recurrent, unprovoked seizures, is a change in sensation, awareness or behavior caused by an electrical disturbance in the brain. The kind of seizure a person has depends on which part and how much of the brain is affected by the disturbance. Primary generalized ...

New Data Shows Prescription Omega-3 Acid Ethyl Esters Reduced the Incidence of Death in Heart Failure Patients

... rate of treatment discontinuation due to adverse reactions was the same in both groups. The most commonly reported adverse event was gastrointestinal disturbance and the rate of occurrence (3%) was similar in both groups. About LOVAZA LOVAZA is made from nature, and is the first and only U.S. Food and Drug ...

European CHMP Issues Positive Opinion on Cymbalta for the Treatment of Generalised Anxiety Disorder

... and poor concentration. Ability to work is often compromised with the manifestation of physical symptoms such as muscle tension, fatigue, sleep disturbance and nausea.(12) The illness tends to be chronic with periods of exacerbation and remission. Patients report that episodes of generalized anxiety ...

Eribulin Mesylate Demonstrated Anti-Tumor Activity in Heavily Pretreated Patients with Advanced Breast Cancer

... 5.5%, leukopenia (low white blood cell count, 14%), and weakness/fatigue (10%; no Grade 4 events). Grade 3 peripheral neuropathy (a functional disturbance or damage to nerves outside the brain and spinal cord) was reported in 5.5% of patients. No Grade 4 peripheral neuropathy events were reported. No ...

Circulation Publishes Data Showing KYNAPID(TM) (Vernakalant Hydrochloride) Injection Rapidly Converted Short-Duration Atrial Fibrillation to Sinus Rhythm

... dosing in the short-duration AF group. The most common adverse events (AEs) reported within the first 24 hours in patients given KYNAPID were taste disturbance (29.9%), sneezing (16.3%), skin sensation (10.9%), nausea (9%), and hypotension (6.3%). These events were generally transient. Four serious AEs ...

Medivation's Dimebon(TM) Stabilizes Behavioral Symptoms in Alzheimer's Disease Patients, Resulting in Reduced Caregiver Distress

... were seen across most behavioral symptoms and were most prominent in the symptoms of depression, apathy, hallucinations, irritability and motor disturbance (i.e., engaging in repetitive activities, such as pacing around the house). The data were presented today during a poster session on new research ...

New Clinical Data Further Supports Chromium Picolinate's Role in Enhancing Brain Activity in Older Adults

... < .0001). There was no significant difference between the groups with respect to age (72 versus 73 years), education (15.8 versus 17.3 years), mood disturbance (11 versus 4.5 Profile of Mood States score), and level of memory impairment (.89 versus .63 Clinical Dementia Rating sum boxes score). "The ...

Alexza's AZ-104 (Staccato(R) Loxapine) Phase 2a Trial Meets Primary Endpoint of 2-Hour Pain Relief in Patients with Migraine Headache

... 5 2 5 5 Hypoaesthesia, oral 0 2 5 2 Attention disturbance 0 5 0 2 Hypotension 3 0 2 5 About Acute ...

New Data Published in Neurology Show Once-Daily Lamictal XR Significantly Reduced Partial Seizures in Patients with Epilepsy

... electrical disturbances in the brain. The kind of seizure a person has depends on which part and how much of the brain is affected by the electrical disturbance that produces seizures. Generalized seizures are seizures that involve the entire brain from the outset. Partial seizures, which are the most ...

Analysis Shows Vernakalant Hydrochloride Injection Increases Conversion to Normal Heart Rhythm in Acute Atrial Fibrillation Patients Treated Within 48 Hours of Onset

... percent of vernakalant responders required only one dose of the drug. The most common adverse events (AEs) in patients given vernakalant were taste disturbance (32.4 percent), sneezing (16.7 percent), nausea (15.7 percent) and dizziness (11.8 percent). The incidence of serious AEs was similar in the ...

CardioFocus Endoscopic Ablation System Earns CE Mark to Treat Atrial Fibrillation; US Clinical Investigation Underway

... vein isolation for the treatment of atrial fibrillation. The Endoscopic Ablation System has been designed to treat the most common heart rhythm disturbance called atrial fibrillation, a disease affecting more than 5 million people in Europe and in the United States in addition to millions more worldwide. ...

Addex Achieves Statistically Significant Outcome in Phase IIa Clinical Trial With ADX10059 in Gastro-Esophageal Reflux Disease

... period (p = 0.013). Importantly, night time reflux, which is often poorly controlled by conventional acid-suppressing therapies and results in sleep disturbance and increased risk of esophageal damage, was also significantly reduced by ADX10059 (p = 0.0021)., The benefits on the physiological measures of ...

Ceragenix Announces Results from Phase IV Study of EpiCeram Meet All Primary and Secondary Endpoints

... at Day 28; b) Change in patient reported assessments of pruritus (itch); and c) Change in patient reported assessment of disturbance of sleep habits. Study Results Primary Outcome Measure (change in mean SCORAD score measured at Day 28 compared to Baseline). ...

New Data Shows Once a Day Lamictal XR is Effective in Treating Patients with Partial Seizures

... electrical disturbance in the brain. The kind of seizure a person has depends on which part and how much of the brain is affected by the electrical disturbance that produces seizures. Generalized seizures are seizures that involve the entire brain from the outset. Partial seizures, which are more common, ...

Data Suggest Cymbalta Improved Functioning in Patients with Generalized Anxiety Disorder

... each year.(4) Symptoms persist for at least six months and can include exaggerated worry or chronic anxiety, irritability, poor concentration, sleep disturbance and fatigue.(5,6) Generalized anxiety disorder may be brought on, or worsened by, stressful life events. The illness also tends to be chronic with ...

New Point-of-Care Methods to Measure Coronary and Cerebrovascular Risk

... Meanwhile, a skin sterol test called PREVU(x) provides a convenient, non-invasive, Point-of-Care assay. At the root of atherosclerosis is a disturbance of the inner (intimal) wall of the artery. The process is complex, but one component is usually hypertension, which contributes to turbulent blood ...
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