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Differentiation in Medical Technology

Telik Announces Publication of Positive Phase 1 Results of a Multicenter Study of Ezatiostat Hydrochloride (TELINTRA(R), TLK199) Tablets In Patients With Myelodysplastic Syndrome

... the activation of JNK kinase, a key regulator of cellular growth and differentiation of blood. TELINTRA has been shown to stimulate normal multilineage differentiation of blood stem cell precursors and induce cancer cell death in human ...

Keryx Biopharmaceuticals, Inc. Reports Phase 1/2 Data on KRX-0401 (Perifosine) at 50th Annual Meeting of American Society of Hematology

... are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. The effects of perifosine on Akt are of particular ... are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currently in Phase 2 clinical development ...

Reprogrammable Cell Type Depends on a Single Gene to Keep Its Identity

... a member of the St. Jude Department of Genetics and Tumor Cell Biology. differentiation is the process by which genetic activity causes an immature cell type to ... years, some discoveries have challenged the long-standing belief that cell differentiation is an irreversible final process," said Oliver, the paper's senior author. ...

Neuralstem Announces Issuance of Core Technology Patent in Europe

... patent EP0915968, covering the "Isolation, Propagation and Directed differentiation of Stem Cells from Embryonic and Adult Central Nervous System of Mammals." ... and spinal cord in commercial quantities, and the ability to control the differentiation of these cells into mature, physiologically relevant human neurons and ...

Nuvelo Announces Preclinical Data for NU206 Demonstrating Potent Therapeutic Activity in Oral Mucositis Models

... the Wnt pathway, a signaling pathway that is critical for cell growth and differentiation during homeostasis and pathogenesis. "This study reinforces our belief ... program, which targets a range of indications where cell regeneration and differentiation are important to disease processes, including gastrointestinal disease, ...

St. Jude Defines Eye Cancer Gene's Role in Retinal Development

... roles during prenatal development by regulating the proliferation, size, differentiation and survival of cells. Myc genes are also proto-oncogenes--genes in which ... that N-myc is not involved in regulating cell survival or neuronal differentiation in the developing retina. However, the gene is crucial for the ...

FAU Receives Patent for Invention Which Induces and Restores Cardiac Muscle Function

... the mechanisms that regulate myocardial (heart muscle mass) cell differentiation and myofibrillogenesis (the process by which proteins in the heart are ... cells to contract. Identifying the biological factors that induce this differentiation would be a major step forward in the development of therapies. "When an ...

Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis

... homeostasis and bone resorption by acting primarily on target cells in bone and kidney, whereas PTHrP and its analogs regulate cell proliferation and differentiation in developing tissues and appear to play an important role in regulating bone remodeling in adults. While both peptides have demonstrated the ability ...

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

... key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currently in Phase 2 clinical development for multiple tumor types. The Company also actively engages in business ...

Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

... key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currently in Phase 2 clinical development for multiple tumor types. The Company also actively engages in business ...

Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

... key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currently in Phase 2 clinical development for multiple tumor types. The Company also actively engages in business ...

Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer

... key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currently in Phase 2 clinical development for multiple tumor types. The Company also actively engages in business ...

Swine Flu (H1N1) Infectivity to Increase Markedly and Lethality to Remain Low According to Latest Replikin* Peptide Genomic Data

... a year ago the likelihood of the current H1N1 outbreak, used its proprietary FluForecast(TM) software program to make these determinations. "The dual differentiation of these properties may provide advance warning of the future course of H1N1," noted Samuel Bogoch MD PhD, chairman and founder of Replikins Ltd. ...

MultiCell Technologies Signs Liver Stem Cell R&D Agreement To Develop Products for the Study of Liver Cancer

... application (U.S. 2006/0019387A1), and several corresponding issued and pending foreign patents and patent applications related to the isolation and differentiation of liver stem cells. The role of liver stem cells in the carcinogenic process has recently led to a new hypothesis that hepatocellular carcinoma ...

YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB PRESENTATIONS TO BE MADE AT THE 100TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AND EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY

... in head and neck cancer, reportedly not previously observed with radiation alone. These presentations by YM help to demonstrate the nature of differentiation of nimotuzumab from the other anti-EGFR antibodies and show that its intrinsic properties confer a wide therapeutic window compared to Erbitux(R) and ...

InteKrin Therapeutics Announces Enrollment Completion of 360 Patient, 24 week Phase 2b Study

... said Alex DePaoli, M.D. InteKrin's Chief Medical Officer. "This Phase 2b study will provide critical efficacy, safety, and tolerability data to allow differentiation of INT131 from Actos(R) and inform dose selection for the Phase 3 program". "InteKrin is very pleased to achieve this critical development ...

Neuralstem's Human Stem Cells Integrate into Nervous System of Rats with Animal Model of ALS

... the first time, the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities, and the ability to control the differentiation of these cells into mature, physiologically relevant human neurons and glia. Major Central Nervous System diseases targeted by the Company with ...

Keryx Biopharmaceuticals, Inc. Reports Updated Phase 1/2 Data on KRX-0401 (Perifosine) in Combination with Bortezomib (+/- Dexamethasone) at the 12th International Multiple Myeloma Meeting

... key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currently in Phase 2 clinical development for multiple tumor types. The Company also has an in-licensing and ...

Aching Back? Cholesterol Medication Might Help

... Shu-Hua Yang, MD, PhD, is part of a Taiwanese research team that has discovered that Lovastatin, a cholesterol-lowering medication, helps the differentiation of disc cells in vitro. Dr. Yang, who is chief of the department of orthopedics at National Taiwan University Hospital, Yun-Lin-Branch, is ...

Neuralstem's ALS Trial on Clinical Hold

... the first time, the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities, and the ability to control the differentiation of these cells into mature, physiologically relevant human neurons and glia. Major Central Nervous System diseases targeted by the Company with ...

Cardio3 BioSciences Raises EUR13.7 Million in Series B Fundraising and Grant Funding

... and existing investors, will be used to finance the clinical development of the Company's lead product. C-Cure is a unique therapy that allows the differentiation of a patient's own cells into 'cardiopoietic' cells which grow into new heart cells and repair heart muscle. C-Cure holds the promise for a treatment ...

Rosetta Genomics Announces Commercial Availability of its First MicroRNA-Based Diagnostic Test; Will Host Teleconference to Discuss Launch of Future Tests

... at Rosetta Genomics," said Amir Avniel, President and CEO of Rosetta Genomics. "We are excited to be offering the first objective diagnostic test for differentiation of NSCLC patients, which is based on our proprietary microRNA technology. miRview(TM) squamous offers physicians a standardized, quantitative ...

GSK Reports PROMACTA(R) (eltrombopag) Significantly Increased Platelet Counts and Reduced Bleeding in Long-Term Study of Patients With Chronic ITP

... oral, non-peptide thrombopoietin receptor agonist that has been shown in pre-clinical research and clinical trials to stimulate the proliferation and differentiation of megakaryocytes, the bone marrow cells that give rise to blood platelets. PROMACTA was discovered as a result of a research collaboration ...

FDA Approves Promacta(R) (Eltrombopag), the First Oral Medication to Increase Platelet Production for People With Serious Blood Disorder

... oral, non-peptide thrombopoietin receptor agonist that has been shown in pre-clinical research and clinical trials to stimulate the proliferation and differentiation of megakaryocytes, the bone marrow cells that give rise to blood platelets. PROMACTA was discovered as a result of a research collaboration between ...

NicOx Announces Favorable Blood Pressure Data for Naproxcinod in a Large ABPM Study

... an important addition to the consistent data we are accumulating on naproxcinod's potentially non-detrimental blood pressure profile and its clear differentiation from naproxen. We are confident that naproxcinod's potential will be confirmed by the further clinical results expected in the coming months." The ...

Neuralstem Licenses Cleveland Clinic Spinal Cord Injection Technology

... the first time, the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities, and the ability to control the differentiation of these cells into mature, physiologically relevant human neurons and glia. Major Central Nervous System diseases targeted by the Company ...

Johns Hopkins University Researchers to Clinically Assess Rosetta Genomics' miRview(TM) Squamous Assay

... the oncology world." Differentiating squamous from non squamous cell lung cancer presents a challenge to physicians, but until recently this differentiation was not particularly relevant from a therapeutic or prognostic standpoint since no drug was designed for a specific NSCLC sub-type. A recently ...

The First Direct Structural Evidence of SV2A has Been Revealed Thanks to Protein Tomography(TM), and Published in BBRC

... as collaborative contract research projects. The multidisciplinary team of experts at Sidec can provide a strong IP strategy and proven product differentiation to the bio-pharmaceutical industry. Sidec offers their partners a unique visual guidance for target- lead and CD selection to secure a ...

Bioheart Reports Promising Results From SDF-1 Modified MyoCell(R) Therapy in Heart Failure Study

... should provide a strong homing signal for endogenous stem cells involved in myocardial repair. -- SDF-1 modified myoblasts (SDF-MB) could undergo differentiation in the cardiac environment and assist myocardial performance, and provide a continuous source of SDF-1. Study objectives included assessment of ...

Rosetta Genomics and Collaborators Identify MicroRNAs That Can Accurately Discriminate Between Primary and Metastatic Tumors in the Brain

... Study Demonstrates differentiation of Primary Tumors From Metastases in the Brain With Accuracy Near 90% Identifying Whether a Brain Malignancy is a Primary Tumor ...

International Team Locates Key Player in Muscle Regeneration

... muscle tissue. The researchers discovered that cdk9-55, a variation of the gene cdk9, is induced specifically when satellite cells begin differentiation and is necessary for the genetic reprogramming required to complete the muscle tissue regeneration process. "By administering cdk9-55 or a protein ...

Bionovo Discovers New Estrogen Regulatory Elements for Breast Cancer and Osteoporosis Drugs

... The data, which were presented at the Endocrine Society's 90th Annual Meeting, showed that the new regulatory elements are essential for the differentiation of the estrogenic pharmacological activity exerted by different compounds. "Selective estrogen receptor modulators (SERMs) differ from estrogen ...

NicOx Announces Blood Pressure Analysis From 301 Phase 3 Study for Naproxcinod at EULAR

... and naproxen on this safety endpoint. The fact that significance has been observed in a single trial supports our confidence that a clear statistical differentiation will be obtained between naproxcinod and naproxen in the predefined pooled analysis of the OBPM data." Two remaining phase 3 trials for naproxcinod ...

Legacy Good Samaritan Hospital Surgeons Find BSGI Effective in Determining Extent of Breast Cancer in Patients With Known Diagnosis

... Annual meeting held in Cleveland, Ohio. BSGI is a molecular breast imaging technique used for the early detection of breast cancer and in the differentiation of malignant and benign tumors. It relies on advanced gamma imaging technology and mammographic positioning to optimize results. For this study BSGI ...

CureDM's Diabetes Therapy Achieves Major Development Milestone

... were achieved after 25 days of treatment and remained normal after the therapy was stopped. About HIP Human proIslet Peptide (HIP) stimulates the differentiation of pancreatic progenitor cells, which are present in the adult pancreas, into new insulin-producing islets. Each new islet contains pools of beta ...

Alseres Pharmaceuticals Expands Sites for the First Stage of the ALTROPANE(R) Phase III Clinical Trial Program

... misdiagnosis rate in the early stages of Parkinson's disease. Other publications have reported even higher rates of misdiagnosis. The accurate differentiation of Parkinsonian from non-Parkinsonian tremors could allow physicians to initiate earlier referral for specialty care, prescribe effective treatments, ...

St. Jude Finds Signaling System That Halts the Growth of a Childhood Brain Cancer

... neuron progenitors (GNPs). These cells go on to develop into neurons in the cerebellum during the first year of life. But the disruption of this differentiation process can trigger medulloblastoma. Previous research had shown that spurring GNPs to differentiate into neurons requires that BMPs bind to a ...

Lilly and Transition Therapeutics Announce Licensing and Collaboration Agreement

... including haemoglobinA1C, for 6 months post-treatment. These data suggest that gastrin based therapies might have an important role in beta cell differentiation and function, capable of providing sustained glucose control in type 2 diabetes. About Lilly Lilly, a leading innovation-driven corporation, is ...

Bertrand Study Finds Significant Value in Breast-Specific Gamma Imaging (BSGI) as an Adjunctive Procedure in Breast Diagnostics

... Cancer Conference. Breast-Specific Gamma Imaging is a molecular breast imaging technique used for the early detection of breast cancer and in the differentiation of malignant and benign tumors. It relies on advanced gamma imaging technology and mammographic positioning to optimize results. For this study BSGI ...

FDA Grants Priority Review for PROMACTA(R) (eltrombopag)

... oral, non-peptide thrombopoietin receptor agonist that has been shown in pre-clinical research and clinical trials to stimulate the proliferation and differentiation of megakaryocytes, the bone marrow cells that give rise to blood platelets. Eltrombopag was discovered as a result of research collaboration between ...
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